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Conserved domains on  [gi|1002244608|ref|XP_015626489|]
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uncharacterized protein LOC4328457 [Oryza sativa Japonica Group]

Protein Classification

class I SAM-dependent rRNA methyltransferase( domain architecture ID 11437764)

class I SAM-dependent rRNA methyltransferase catalyzes the methylation of one or more specific ribosomal RNA residues using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0006364
PubMed:  12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 62-464 4.38e-138

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


:

Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 402.25  E-value: 4.38e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608  62 RVVLKKGKTQIFRDGSPMVYSGAVDRIIGRPPPktGDVVLVADGAEKPIGWGLYNSVSMFCVRLMQLEEEAKRDptcaln 141
Cdd:COG1092     1 KVRLKPGKERRLRRGHPWVFSNEIDRVEGELEP--GDLVEVEDADGRFLGRGYYNPHSQIAVRLLSRDPDEPID------ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 142 mERLLEARILSAVDLRRSLgLPSVHTNAYRLINSEGDRLSGLIVDIFADVAVVASSAAWVEKYRHEIQFLVNKVSDVNHI 221
Cdd:COG1092    73 -AAFFANRLRKALALRRKL-AKREGTNAYRLVHGEADGLPGLIVDRYGDVLVVQEYSAGMERRRDEILEALVEVLGPEGI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 222 KWRSSTDILKEEGLDvsEQKDPESSSHCGTVEVMENDVLYLVSL-EGQKTGFYADQRENRHFISTLSKDQRVLDLCCYSG 300
Cdd:COG1092   151 YLRSDVRVRQLEGLP--QYEGVLYGEAPEEVEVEENGLKFLVDLtDGQKTGLFLDQRENRARVAELAKGKRVLNLFSYTG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 301 GFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTqRISFVKEDATAFMKGAISRNEVWDLVILDPPKLAPRKKVLQ 380
Cdd:COG1092   229 GFSVHAAAGGAKSVTSVDLSATALEWAKENAALNGLDD-RHEFVQADAFDWLRELAREGERFDLIILDPPAFAKSKKDLF 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 381 SASGMYRSLNALAMQVVKPGGLLMTCSCSGAMTQSgLFLRTIQGAASMTGRKVTVLRQAGAACDHPVDPAYPEGRYLSNY 460
Cdd:COG1092   308 DAQRDYKDLNRLALKLLAPGGILVTSSCSRHFSLD-LFLEILARAARDAGRRVRIIERLTQPPDHPVLPAFPEGEYLKGL 386


                  ....
gi 1002244608 461 LLRV 464
Cdd:COG1092   387 LLRV 390
 
Name Accession Description Interval E-value
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 62-464 4.38e-138

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 402.25  E-value: 4.38e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608  62 RVVLKKGKTQIFRDGSPMVYSGAVDRIIGRPPPktGDVVLVADGAEKPIGWGLYNSVSMFCVRLMQLEEEAKRDptcaln 141
Cdd:COG1092     1 KVRLKPGKERRLRRGHPWVFSNEIDRVEGELEP--GDLVEVEDADGRFLGRGYYNPHSQIAVRLLSRDPDEPID------ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 142 mERLLEARILSAVDLRRSLgLPSVHTNAYRLINSEGDRLSGLIVDIFADVAVVASSAAWVEKYRHEIQFLVNKVSDVNHI 221
Cdd:COG1092    73 -AAFFANRLRKALALRRKL-AKREGTNAYRLVHGEADGLPGLIVDRYGDVLVVQEYSAGMERRRDEILEALVEVLGPEGI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 222 KWRSSTDILKEEGLDvsEQKDPESSSHCGTVEVMENDVLYLVSL-EGQKTGFYADQRENRHFISTLSKDQRVLDLCCYSG 300
Cdd:COG1092   151 YLRSDVRVRQLEGLP--QYEGVLYGEAPEEVEVEENGLKFLVDLtDGQKTGLFLDQRENRARVAELAKGKRVLNLFSYTG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 301 GFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTqRISFVKEDATAFMKGAISRNEVWDLVILDPPKLAPRKKVLQ 380
Cdd:COG1092   229 GFSVHAAAGGAKSVTSVDLSATALEWAKENAALNGLDD-RHEFVQADAFDWLRELAREGERFDLIILDPPAFAKSKKDLF 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 381 SASGMYRSLNALAMQVVKPGGLLMTCSCSGAMTQSgLFLRTIQGAASMTGRKVTVLRQAGAACDHPVDPAYPEGRYLSNY 460
Cdd:COG1092   308 DAQRDYKDLNRLALKLLAPGGILVTSSCSRHFSLD-LFLEILARAARDAGRRVRIIERLTQPPDHPVLPAFPEGEYLKGL 386


                  ....
gi 1002244608 461 LLRV 464
Cdd:COG1092   387 LLRV 390
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
61-464 4.27e-66

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 217.40  E-value: 4.27e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608  61 ARVVLKKGKTQIFRDGSPMVYSGAVDRIIGRPPPktGDVVLVADGAEKPIGWGLYNSVSMFCVRLMQLEEEAKRDptCAL 140
Cdd:PRK15128    3 VRLVLAKGREKSLLRRHPWVFSGAVARMEGKASL--GETIDIVDHQGKWLARGAYSPASQIRARVWTFDPDESID--IAF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 141 NMERLLEARILSAVDLRRSlGLpsvhtNAYRLINSEGDRLSGLIVDIFADVAVVASSAAWVEKYRHEIQFLVNKVSDVNH 220
Cdd:PRK15128   79 FTRRLQQAQKWRDWLAQKD-GL-----DSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 221 IKWRSSTDILKEEGLDVSeQKDPESSSHCGTVEVMENDVLYLVSLE-GQKTGFYADQRENRHFISTLSKDQRVLDLCCYS 299
Cdd:PRK15128  153 IYDRSDVAVRKKEGMELT-QGPVTGELPPALLPIEEHGMKLLVDIQgGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 300 GGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTQRISFVKEDATAFMKGAISRNEVWDLVILDPPKLAPRKKVL 379
Cdd:PRK15128  232 GGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQL 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 380 QSASGMYRSLNALAMQVVKPGGLLMTCSCSGAMTqSGLFLRTIQGAASMTGRKVTVLRQAGAACDHPVDPAYPEGRYLSN 459
Cdd:PRK15128  312 MGACRGYKDINMLAIQLLNPGGILLTFSCSGLMT-SDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKG 390


                  ....*
gi 1002244608 460 YLLRV 464
Cdd:PRK15128  391 FACRV 395
RlmI_M_like cd11572
Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; This middle or ...
 145-239 1.10e-25

Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; This middle or central domain is typically found between an N-terminal PUA domain and a C-terminal SAM-dependent methyltransferase domain, such as in the Escherichia coli ribosomal RNA large subunit methyltransferase RlmI (YccW). It may be involved in binding to the RNA substrate.


Pssm-ID: 211413 [Multi-domain]  Cd Length: 99  Bit Score: 100.23  E-value: 1.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 145 LLEARILSAVDLRRSLGLPsvHTNAYRLINSEGDRLSGLIVDIFADVAVVASSAAWVEKYRHEIQFLVNKVSDVNHIKWR 224
Cdd:cd11572     2 FFKRRIEKALALRKRLLLD--DTNAYRLVHGEGDGLPGLIVDRYGDVLVVQILSAGMERLKELIVEALKELLGPKGIYER 79

                          90
                  ....*....|....*
gi 1002244608 225 SSTDILKEEGLDVSE 239
Cdd:cd11572    80 SDAAVRELEGLPEEV 94
Methyltrans_SAM pfam10672
S-adenosylmethionine-dependent methyltransferase; Members of this family are ...
 254-429 1.21e-16

S-adenosylmethionine-dependent methyltransferase; Members of this family are S-adenosylmethionine-dependent methyltransferases from gamma-proteobacterial species. The diversity in the roles of methylation is matched by the almost bewildering number of methyltransferase enzymes that catalyze the methylation reaction. Although several classes of methyltransferase enzymes are known, the great majority of methylation reactions are catalyzed by the S-adenosylmethionine-dependent methyltransferases.


Pssm-ID: 287624 [Multi-domain]  Cd Length: 286  Bit Score: 79.92  E-value: 1.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 254 VMENDVLYLVSL-EGQKTGFYADQRENRHFISTLSKDQRVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNII 332
Cdd:pfam10672  88 VVENGLKYQLDIgRNQNFGLFLDMRLGRRWVQENAKGKNVLNLFAYTCGFSVAAIAGGASQVVNVDMARGSLNKGRDNHR 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 333 LNKLDTQRISFVKEDataFMK--GAISRNEVWDLVILDPPKLAPRKKVLQSAsgmYRSLNALAMQVVKPGGLLMTCSCSG 410
Cdd:pfam10672 168 LNGHDLGRVSFLGHD---IFKswGKIKKLGPYDLVIIDPPSFQKGSFALTKD---YKKILRRLPELLVEGGTVLACVNSP 241

                         170
                  ....*....|....*....
gi 1002244608 411 AMTQSGLFLRTIQGAASMT 429
Cdd:pfam10672 242 AVGPDFLIEEMAEEAPSLH 260
PUA smart00359
Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase;
62-127 2.36e-07

Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase;


Pssm-ID: 214635 [Multi-domain]  Cd Length: 76  Bit Score: 48.02  E-value: 2.36e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002244608   62 RVVLKKGKTQIFRDGSpMVYSGAVDRIIGRPPPktGDVVLVADGAEKPIGWGLYNSVSMFCVRLMQ 127
Cdd:smart00359   2 KVVVDDGAEKAILNGA-SLLAPGVVRVDGDIKE--GDVVVIVDEKGEPLGIGLANMSSEEIARIKG 64
 
Name Accession Description Interval E-value
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 62-464 4.38e-138

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 402.25  E-value: 4.38e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608  62 RVVLKKGKTQIFRDGSPMVYSGAVDRIIGRPPPktGDVVLVADGAEKPIGWGLYNSVSMFCVRLMQLEEEAKRDptcaln 141
Cdd:COG1092     1 KVRLKPGKERRLRRGHPWVFSNEIDRVEGELEP--GDLVEVEDADGRFLGRGYYNPHSQIAVRLLSRDPDEPID------ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 142 mERLLEARILSAVDLRRSLgLPSVHTNAYRLINSEGDRLSGLIVDIFADVAVVASSAAWVEKYRHEIQFLVNKVSDVNHI 221
Cdd:COG1092    73 -AAFFANRLRKALALRRKL-AKREGTNAYRLVHGEADGLPGLIVDRYGDVLVVQEYSAGMERRRDEILEALVEVLGPEGI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 222 KWRSSTDILKEEGLDvsEQKDPESSSHCGTVEVMENDVLYLVSL-EGQKTGFYADQRENRHFISTLSKDQRVLDLCCYSG 300
Cdd:COG1092   151 YLRSDVRVRQLEGLP--QYEGVLYGEAPEEVEVEENGLKFLVDLtDGQKTGLFLDQRENRARVAELAKGKRVLNLFSYTG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 301 GFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTqRISFVKEDATAFMKGAISRNEVWDLVILDPPKLAPRKKVLQ 380
Cdd:COG1092   229 GFSVHAAAGGAKSVTSVDLSATALEWAKENAALNGLDD-RHEFVQADAFDWLRELAREGERFDLIILDPPAFAKSKKDLF 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 381 SASGMYRSLNALAMQVVKPGGLLMTCSCSGAMTQSgLFLRTIQGAASMTGRKVTVLRQAGAACDHPVDPAYPEGRYLSNY 460
Cdd:COG1092   308 DAQRDYKDLNRLALKLLAPGGILVTSSCSRHFSLD-LFLEILARAARDAGRRVRIIERLTQPPDHPVLPAFPEGEYLKGL 386


                  ....
gi 1002244608 461 LLRV 464
Cdd:COG1092   387 LLRV 390
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
61-464 4.27e-66

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 217.40  E-value: 4.27e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608  61 ARVVLKKGKTQIFRDGSPMVYSGAVDRIIGRPPPktGDVVLVADGAEKPIGWGLYNSVSMFCVRLMQLEEEAKRDptCAL 140
Cdd:PRK15128    3 VRLVLAKGREKSLLRRHPWVFSGAVARMEGKASL--GETIDIVDHQGKWLARGAYSPASQIRARVWTFDPDESID--IAF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 141 NMERLLEARILSAVDLRRSlGLpsvhtNAYRLINSEGDRLSGLIVDIFADVAVVASSAAWVEKYRHEIQFLVNKVSDVNH 220
Cdd:PRK15128   79 FTRRLQQAQKWRDWLAQKD-GL-----DSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 221 IKWRSSTDILKEEGLDVSeQKDPESSSHCGTVEVMENDVLYLVSLE-GQKTGFYADQRENRHFISTLSKDQRVLDLCCYS 299
Cdd:PRK15128  153 IYDRSDVAVRKKEGMELT-QGPVTGELPPALLPIEEHGMKLLVDIQgGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 300 GGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTQRISFVKEDATAFMKGAISRNEVWDLVILDPPKLAPRKKVL 379
Cdd:PRK15128  232 GGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQL 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 380 QSASGMYRSLNALAMQVVKPGGLLMTCSCSGAMTqSGLFLRTIQGAASMTGRKVTVLRQAGAACDHPVDPAYPEGRYLSN 459
Cdd:PRK15128  312 MGACRGYKDINMLAIQLLNPGGILLTFSCSGLMT-SDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKG 390


                  ....*
gi 1002244608 460 YLLRV 464
Cdd:PRK15128  391 FACRV 395
RlmI_M_like cd11572
Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; This middle or ...
 145-239 1.10e-25

Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; This middle or central domain is typically found between an N-terminal PUA domain and a C-terminal SAM-dependent methyltransferase domain, such as in the Escherichia coli ribosomal RNA large subunit methyltransferase RlmI (YccW). It may be involved in binding to the RNA substrate.


Pssm-ID: 211413 [Multi-domain]  Cd Length: 99  Bit Score: 100.23  E-value: 1.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 145 LLEARILSAVDLRRSLGLPsvHTNAYRLINSEGDRLSGLIVDIFADVAVVASSAAWVEKYRHEIQFLVNKVSDVNHIKWR 224
Cdd:cd11572     2 FFKRRIEKALALRKRLLLD--DTNAYRLVHGEGDGLPGLIVDRYGDVLVVQILSAGMERLKELIVEALKELLGPKGIYER 79

                          90
                  ....*....|....*
gi 1002244608 225 SSTDILKEEGLDVSE 239
Cdd:cd11572    80 SDAAVRELEGLPEEV 94
PUA_RlmI cd21153
PUA RNA-binding domain of the SAM-dependent methyltransferase RlmI and related proteins; The ...
 61-131 4.81e-23

PUA RNA-binding domain of the SAM-dependent methyltransferase RlmI and related proteins; The RNA-binding PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was detected in a number of proteins involved in RNA metabolism. Members of this subfamily contain PUA domains that co-occur N-terminal to SAM-dependent methyltransferase domains and include Escherichia coli RlmI (rRNA large subunit methyltransferase gene I, also called YccW) and Thermus thermophilus methyltransferase RlmO, which are 5-methylcytosine methyltransferases (m5C MTases) that play a role in modifying 23S rRNA. This subfamily also includes Pyrococcus horikoshii PH1915 that may play a role as a 5-methyluridine MTase, and/or perform similar roles.


Pssm-ID: 409295 [Multi-domain]  Cd Length: 70  Bit Score: 92.26  E-value: 4.81e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002244608  61 ARVVLKKGKTQIFRDGSPMVYSGAVDRIIGrpPPKTGDVVLVADGAEKPIGWGLYNSVSMFCVRLMQLEEE 131
Cdd:cd21153     1 PRIVLKKGKEKSLRRGHPWIFSGAIDRIEG--KPEPGDLVDVYDHKGKFLGTGLYNPHSQIRVRVLSFDKE 69
Methyltrans_SAM pfam10672
S-adenosylmethionine-dependent methyltransferase; Members of this family are ...
 254-429 1.21e-16

S-adenosylmethionine-dependent methyltransferase; Members of this family are S-adenosylmethionine-dependent methyltransferases from gamma-proteobacterial species. The diversity in the roles of methylation is matched by the almost bewildering number of methyltransferase enzymes that catalyze the methylation reaction. Although several classes of methyltransferase enzymes are known, the great majority of methylation reactions are catalyzed by the S-adenosylmethionine-dependent methyltransferases.


Pssm-ID: 287624 [Multi-domain]  Cd Length: 286  Bit Score: 79.92  E-value: 1.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 254 VMENDVLYLVSL-EGQKTGFYADQRENRHFISTLSKDQRVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNII 332
Cdd:pfam10672  88 VVENGLKYQLDIgRNQNFGLFLDMRLGRRWVQENAKGKNVLNLFAYTCGFSVAAIAGGASQVVNVDMARGSLNKGRDNHR 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 333 LNKLDTQRISFVKEDataFMK--GAISRNEVWDLVILDPPKLAPRKKVLQSAsgmYRSLNALAMQVVKPGGLLMTCSCSG 410
Cdd:pfam10672 168 LNGHDLGRVSFLGHD---IFKswGKIKKLGPYDLVIIDPPSFQKGSFALTKD---YKKILRRLPELLVEGGTVLACVNSP 241

                         170
                  ....*....|....*....
gi 1002244608 411 AMTQSGLFLRTIQGAASMT 429
Cdd:pfam10672 242 AVGPDFLIEEMAEEAPSLH 260
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 286-370 3.12e-12

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 67.89  E-value: 3.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 286 LSKDQRVLDLCCYSGGFALNAAKGGAnNVIGIDSSASALDLANKNIILNKLDtqRISFVKEDATAFMKgAISRNEVWDLV 365
Cdd:COG2265   231 LTGGERVLDLYCGVGTFALPLARRAK-KVIGVEIVPEAVEDARENARLNGLK--NVEFVAGDLEEVLP-ELLWGGRPDVV 306


                  ....*
gi 1002244608 366 ILDPP 370
Cdd:COG2265   307 VLDPP 311
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 291-406 4.68e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 4.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 291 RVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDtqRISFVKEDATAFMKGAISRnevWDLVILDPP 370
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLAD--NVEVLKGDAEELPPEADES---FDVIISDPP 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1002244608 371 klaprkkvLQSASGMYRSLNALAMQVVKPGGLLMTC 406
Cdd:cd02440    76 --------LHHLVEDLARFLEEARRLLKPGGVLVLT 103
PUA_3 pfam17785
PUA-like domain; This PUA-like domain is found at the N-terminus of SAM-dependent ...
 63-126 6.30e-10

PUA-like domain; This PUA-like domain is found at the N-terminus of SAM-dependent methyltransferases.


Pssm-ID: 436043 [Multi-domain]  Cd Length: 64  Bit Score: 54.79  E-value: 6.30e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002244608  63 VVLKKGKTQIFRDGSPMVYSGAVDRIigRPPPKTGDVVLVADGAEKPIGWGLYNSVSMFCVRLM 126
Cdd:pfam17785   1 VTLKKKAEKRLKRGHPWIYSNEIERV--EGDLEEGDLVRVVDSDGRFLGTGYYNPQSKIAVRVL 62
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 292-401 2.37e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.49  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 292 VLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLdtqRISFVKEDATAFmkgaISRNEVWDLVI----- 366
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL---NVEFVQGDAEDL----PFPDGSFDLVVssgvl 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1002244608 367 --LDPPKlapRKKVLQSasgMYRslnalamqVVKPGG 401
Cdd:pfam13649  74 hhLPDPD---LEAALRE---IAR--------VLKPGG 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 283-443 4.08e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.38  E-value: 4.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 283 ISTLSKDQRVLDLCCYSGGFAL-NAAKGGANnVIGIDSSASALDLANKNIILNKLDtqRISFVKEDATAFmkgAISRNEV 361
Cdd:COG0500    21 LERLPKGGRVLDLGCGTGRNLLaLAARFGGR-VIGIDLSPEAIALARARAAKAGLG--NVEFLVADLAEL---DPLPAES 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 362 WDLVI-------LDPpklAPRKKVLQSASgmyrslnalamQVVKPGGLL------MTCSCSGAMTQSGLFLRTIQGAASM 428
Cdd:COG0500    95 FDLVVafgvlhhLPP---EEREALLRELA-----------RALKPGGVLllsasdAAAALSLARLLLLATASLLELLLLL 160

                         170
                  ....*....|....*
gi 1002244608 429 TGRKVTVLRQAGAAC 443
Cdd:COG0500   161 RLLALELYLRALLAA 175
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 289-370 4.45e-08

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 52.78  E-value: 4.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 289 DQRVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIilNKLD-TQRISFVKEDATAFMKGAisRNEVWDLVIL 367
Cdd:COG0742    42 GARVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVIRKNL--EKLGlEDRARVIRGDALRFLKRL--AGEPFDLVFL 117


                  ...
gi 1002244608 368 DPP 370
Cdd:COG0742   118 DPP 120
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
288-370 7.20e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 52.60  E-value: 7.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 288 KDQRVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNiiLNKLDTqRISFVKEDATafmkgAISRNEVWDLVIL 367
Cdd:COG2263    45 EGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIAREN--AERLGV-RVDFIRADVT-----RIPLGGSVDTVVM 116


                  ...
gi 1002244608 368 DPP 370
Cdd:COG2263   117 NPP 119
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
291-403 1.84e-07

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 52.60  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 291 RVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTQRISFVKEDATAFMKGAisRNEVWDLVILDPP 370
Cdd:COG2521   135 RVLDTCTGLGYTAIEALKRGAREVITVEKDPNVLELAELNPWSRELANERIKIILGDASEVIKTF--PDESFDAIIHDPP 212

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1002244608 371 KLAprkkvlqSASGMYrSLN---ALAmQVVKPGGLL 403
Cdd:COG2521   213 RFS-------LAGELY-SLEfyrELY-RVLKPGGRL 239
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 280-404 2.01e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.99  E-value: 2.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 280 RHFISTLS--KDQRVLDLCCYSGGFALNAAKGGAnNVIGIDSSASALDLANKNIILNKLdtqRISFVKEDATA--Fmkga 355
Cdd:COG2226    12 EALLAALGlrPGARVLDLGCGTGRLALALAERGA-RVTGVDISPEMLELARERAAEAGL---NVEFVVGDAEDlpF---- 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002244608 356 isRNEVWDLVIL--------DPPklaprkKVLQSasgMYRslnalamqVVKPGGLLM 404
Cdd:COG2226    84 --PDGSFDLVISsfvlhhlpDPE------RALAE---IAR--------VLKPGGRLV 121
PUA smart00359
Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase;
62-127 2.36e-07

Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase;


Pssm-ID: 214635 [Multi-domain]  Cd Length: 76  Bit Score: 48.02  E-value: 2.36e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002244608   62 RVVLKKGKTQIFRDGSpMVYSGAVDRIIGRPPPktGDVVLVADGAEKPIGWGLYNSVSMFCVRLMQ 127
Cdd:smart00359   2 KVVVDDGAEKAILNGA-SLLAPGVVRVDGDIKE--GDVVVIVDEKGEPLGIGLANMSSEEIARIKG 64
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
290-371 2.39e-07

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 52.18  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 290 QRVLDLCCYSGGFALNAAKGGAnNVIGIDSSASALDLANKNIilNKLDTQRISFVKEDATAFmkgAISRNEVWDLVILDP 369
Cdd:PRK03522  175 RSMWDLFCGVGGFGLHCATPGM-QLTGIEISAEAIACAKQSA--AELGLTNVQFQALDSTQF---ATAQGEVPDLVLVNP 248


                  ..
gi 1002244608 370 PK 371
Cdd:PRK03522  249 PR 250
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 291-404 2.86e-07

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 51.69  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 291 RVLDLCCYSGGFALNAAK--GGAnNVIGIDSSASALDLANKNIILNKLDtQRISFVKEDATAfmkgAISRNEVWDLVI-- 366
Cdd:COG2890   115 RVLDLGTGSGAIALALAKerPDA-RVTAVDISPDALAVARRNAERLGLE-DRVRFLQGDLFE----PLPGDGRFDLIVsn 188

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002244608 367 -----------LDP------PKLAprkkvLQS-ASGM--YRSLNALAMQVVKPGGLLM 404
Cdd:COG2890   189 ppyipedeialLPPevrdhePRLA-----LDGgEDGLdfYRRIIAQAPRLLKPGGWLL 241
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 286-440 4.18e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 49.34  E-value: 4.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 286 LSKDQRVLDLCCYSGGFALNAAK--GGANNVIGIDSSASALDLANKNIILNKLDtqRISFVKEDATAfMKGAISRNEVwD 363
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEAIEKARENAQKLGFD--NVEFEQGDIEE-LPELLEDDKF-D 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 364 LVILDPPKLA-PRK-KVLQSASgmyrslnalamQVVKPGGLLMTCSCSGA------MTQSGLFLRTIQGAASMTGRKVTV 435
Cdd:pfam13847  77 VVISNCVLNHiPDPdKVLQEIL-----------RVLKPGGRLIISDPDSLaelpahVKEDSTYYAGCVGGAILKKKLYEL 145


                  ....*
gi 1002244608 436 LRQAG 440
Cdd:pfam13847 146 LEEAG 150
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
291-405 4.76e-07

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 49.93  E-value: 4.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 291 RVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTQRIsfvKEDATAFMKGAISRNEVWDLVILDPP 370
Cdd:pfam03602  44 RVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQILKENLQLLGLPGAVL---VMDALLALLRLAGKGPVFDIVFLDPP 120

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1002244608 371 klaprkkvlqSASGMYR-SLNALA-MQVVKPGGLLMT 405
Cdd:pfam03602 121 ----------YAKGLIEeVLDLLAeKGWLKPNALIYV 147
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 281-370 6.98e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 50.14  E-value: 6.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 281 HFIStLSKDQRVLDLCCYSG--GFALnAAKGGANNVIGIDSSASALDLANKNIILNKLDtQRISFVKEDATAFmkGAISR 358
Cdd:COG4123    31 AFAP-VKKGGRVLDLGTGTGviALML-AQRSPGARITGVEIQPEAAELARRNVALNGLE-DRITVIHGDLKEF--AAELP 105

                          90
                  ....*....|..
gi 1002244608 359 NEVWDLVILDPP 370
Cdd:COG4123   106 PGSFDLVVSNPP 117
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 274-404 2.12e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 47.62  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 274 ADQRENRHFISTL--SKDQRVLDLCCYSGGFALNAAK-GGAnNVIGIDSSASALDLANKNIILNKLDtQRISFVKEDATA 350
Cdd:COG2230    35 AQEAKLDLILRKLglKPGMRVLDIGCGWGGLALYLARrYGV-RVTGVTLSPEQLEYARERAAEAGLA-DRVEVRLADYRD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002244608 351 FmkgaiSRNEVWDLVIldppklaprkkvlqsASGM--------YRSLNALAMQVVKPGGLLM 404
Cdd:COG2230   113 L-----PADGQFDAIV---------------SIGMfehvgpenYPAYFAKVARLLKPGGRLL 154
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 279-404 4.02e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 47.84  E-value: 4.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 279 NRHFISTL--SKDQRVLDLCCYSGGFALNAAK-GGAN-NVIGIDSSASALDLANKNIILNKLDtQRISFVKEDATA--Fm 352
Cdd:PRK00216   40 RRKTIKWLgvRPGDKVLDLACGTGDLAIALAKaVGKTgEVVGLDFSEGMLAVGREKLRDLGLS-GNVEFVQGDAEAlpF- 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 353 kgaisRNEVWDLV--------ILDPPklaprkKVLQSasgMYRslnalamqVVKPGGLLM 404
Cdd:PRK00216  118 -----PDNSFDAVtiafglrnVPDID------KALRE---MYR--------VLKPGGRLV 155
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
274-351 8.18e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 46.95  E-value: 8.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 274 ADQRENRHFISTLS----KDQRVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDtQRISFVKEDAT 349
Cdd:COG4076    17 NDVERNDAFKAAIErvvkPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLS-DRITVINADAT 95


                  ..
gi 1002244608 350 AF 351
Cdd:COG4076    96 DL 97
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
291-404 1.13e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.04  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 291 RVLDLCCYSGGF--ALNAAKGGANnVIGIDSSASALDLANKNIilnkldtQRISFVKEDATAFmkgaiSRNEVWDLVIL- 367
Cdd:COG4106     4 RVLDLGCGTGRLtaLLAERFPGAR-VTGVDLSPEMLARARARL-------PNVRFVVADLRDL-----DPPEPFDLVVSn 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1002244608 368 -------DPPKLAPRkkvlqsasgMYRSLnalamqvvKPGGLLM 404
Cdd:COG4106    71 aalhwlpDHAALLAR---------LAAAL--------APGGVLA 97
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 280-437 1.39e-05

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 46.78  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 280 RHFISTLSKD-QRVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTqRISFVKEDATAFmkgaISR 358
Cdd:COG2520   171 RLRIAELVKPgERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKENIRLNKVED-RVTPILGDAREV----APE 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 359 NEVW-DLVILDPPKLAprkkvlqsasgmYRSLNAlAMQVVKPGGLL---MTCSCSGAMTQSglfLRTIQGAASMTGRKVT 434
Cdd:COG2520   246 LEGKaDRIIMNLPHSA------------DEFLDA-ALRALKPGGVIhyyEIVPEEDPFERA---EERIEEAAEEAGYEVE 309


                  ...
gi 1002244608 435 VLR 437
Cdd:COG2520   310 ILE 312
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 291-404 2.86e-05

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 45.54  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 291 RVLDLCCYSG--GFALNAAKGGAnNVIGIDSSASALDLANKNIILNKLDtqRISFVKEDATAfmkgAISRNEVwDLVI-- 366
Cdd:PRK09328  111 RVLDLGTGSGaiALALAKERPDA-EVTAVDISPEALAVARRNAKHGLGA--RVEFLQGDWFE----PLPGGRF-DLIVsn 182

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002244608 367 ------LDPPKLAPrkKVLQS---------ASGM--YRSLNALAMQVVKPGGLLM 404
Cdd:PRK09328  183 ppyipeADIHLLQP--EVRDHephlalfggEDGLdfYRRIIEQAPRYLKPGGWLL 235
PRK14967 PRK14967
putative methyltransferase; Provisional
 271-444 4.37e-05

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 44.66  E-value: 4.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 271 GFYADQRENRHFISTLSKD-----QRVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDtqrISFVK 345
Cdd:PRK14967   14 GVYRPQEDTQLLADALAAEglgpgRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVD---VDVRR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 346 EDATAFMKGaisrnEVWDLVILDPPkLAPRKKVLQSASGMYRSLNAlamqvvKPGGLLM---TCSCSGAMTQSGLFLRTI 422
Cdd:PRK14967   91 GDWARAVEF-----RPFDVVVSNPP-YVPAPPDAPPSRGPARAWDA------GPDGRAVldrLCDAAPALLAPGGSLLLV 158

                         170       180
                  ....*....|....*....|..
gi 1002244608 423 QGAASMTGRKVTVLRQAGAACD 444
Cdd:PRK14967  159 QSELSGVERTLTRLSEAGLDAE 180
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 291-403 6.90e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 43.64  E-value: 6.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 291 RVLDLCCYSGGFALNAAKGGAN-NVIGIDSSASALDLANKNIILNKLDtqRISFVKEDATAfmkgAISRNEVwDLVILDP 369
Cdd:COG2813    52 RVLDLGCGYGVIGLALAKRNPEaRVTLVDVNARAVELARANAAANGLE--NVEVLWSDGLS----GVPDGSF-DLILSNP 124

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1002244608 370 P---KLAPRKKVLQSasgMYR-SLNALamqvvKPGGLL 403
Cdd:COG2813   125 PfhaGRAVDKEVAHA---LIAdAARHL-----RPGGEL 154
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 289-409 3.67e-04

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 41.64  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 289 DQRVLDLCCYSGG-----FALNAAKGganNVIGIDSSASALDLANKNIilNKLDTQRISFVKEDATAFMK---------- 353
Cdd:pfam01189   9 GETILDMCAAPGGktthiAELMKNQG---TVVAVDINKHRLKRVAENI--HRLGVTNTIILNGDGRQPDQwlggvlfdri 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002244608 354 ---------GAISRN-EV-WDLVILDPPKLAPRKKVLQSAsgmyrslnalAMQVVKPGGLLMTCSCS 409
Cdd:pfam01189  84 lldapcsgtGVIRRHpDVkWLRQEADIAQLAQLQKELLSA----------AIDLLKPGGVLVYSTCS 140
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
286-403 4.99e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 41.70  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 286 LSKDQRVLDLCCYSG--GFAlnAAKGGANNVIGIDSSASALDLANKNIILNKLDtQRISFVkedatafmKGAISRNEVWD 363
Cdd:COG2264   146 LKPGKTVLDVGCGSGilAIA--AAKLGAKRVLAVDIDPVAVEAARENAELNGVE-DRIEVV--------LGDLLEDGPYD 214

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1002244608 364 LV---ILDPP--KLAPrkkvlqsasgmyrslnaLAMQVVKPGGLL 403
Cdd:COG2264   215 LVvanILANPliELAP-----------------DLAALLKPGGYL 242
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
288-432 6.25e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 41.29  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 288 KDQRVLDLCCYSGGFALNAAKGGANNVIGIDSSASALDLANKNIILNKLDTQRisFVKEDATAFmkgaisrnevwDLV-- 365
Cdd:PRK00517  119 PGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAARENAELNGVELNV--YLPQGDLKA-----------DVIva 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 366 -ILDPP--KLAPrkkvlqsasgMYRSLnalamqvVKPGGLLMTcscSG-----------AMTQSGLFLRTI---QGAASM 428
Cdd:PRK00517  186 nILANPllELAP----------DLARL-------LKPGGRLIL---SGileeqadevleAYEEAGFTLDEVlerGEWVAL 245


                  ....
gi 1002244608 429 TGRK 432
Cdd:PRK00517  246 VGKK 249
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
286-378 1.20e-03

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 41.30  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 286 LSKDQRVLDLCCYSGGFALNAAKGGAnNVIGIDSSASALDLANKNIILNKLDtqRISFVKEDATAFMKGAISRNEVWDLV 365
Cdd:PRK13168  295 PQPGDRVLDLFCGLGNFTLPLARQAA-EVVGVEGVEAMVERARENARRNGLD--NVTFYHANLEEDFTDQPWALGGFDKV 371

                          90       100
                  ....*....|....*....|....*
gi 1002244608 366 ILDPP------------KLAPRKKV 378
Cdd:PRK13168  372 LLDPPragaaevmqalaKLGPKRIV 396
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 286-401 3.25e-03

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 38.34  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 286 LSKDQRVLDLCCYSGGFALNAAKGGANNVIGIDSsasaldlaNKNIILNKLDTQRISFVKEDATAFMKGAISRNEVW--- 362
Cdd:pfam01728  19 LKPGKTVLDLGAAPGGWSQVALQRGAGKVVGVDL--------GPMQLWKPRNDPGVTFIQGDIRDPETLDLLEELLGrkv 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1002244608 363 DLVILDppkLAPR---KKVLQSASGMYRSLNAL--AMQVVKPGG 401
Cdd:pfam01728  91 DLVLSD---GSPFisgNKVLDHLRSLDLVKAALevALELLRKGG 131
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 292-405 7.18e-03

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 37.27  E-value: 7.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244608 292 VLDLCCYSGGFALNAAKggAN---NVIGIDSSASALDLANKNIilNKLDTQRISFVKEDATAFMKGAISRNEVWDLVIL- 367
Cdd:pfam02390   5 FLEIGCGMGGFLVAMAK--ANpdkNFIGIEIRVPGVAKALKKI--DALGLQNLRILCGNALDVLPNYFPPGSLQKIFINf 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1002244608 368 -DP-PKLAPRKK-VLQSAsgmyrsLNALAMQVVKPGGLLMT 405
Cdd:pfam02390  81 pDPwPKKRHHKRrLLQPE------FLKEYARVLKPGGVLHL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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