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Conserved domains on  [gi|1002244834|ref|XP_015626607|]
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lysine-specific demethylase JMJ706-like isoform X1 [Oryza sativa Japonica Group]

Protein Classification

JmjN and JmjC domain-containing protein( domain architecture ID 10493098)

protein containing domains JmjN, JmjC, and zf-C5HC2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 235-358 4.06e-42

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


:

Pssm-ID: 396791  Cd Length: 114  Bit Score: 148.99  E-value: 4.06e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244834 235 MLYIGMLFSMFAWHVEDHYLYSINYHHCGASKTWYGIPGKAAPDFEKVVCEHVYdheilsgegeNAAFDVILGKTTMFPP 314
Cdd:pfam02373   1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFG----------GEQPDDLLHLNTIISP 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1002244834 315 NILLRHHVPVYRAIQKPGEFVITFPRAYHSGFSHGFNCGEAVNF 358
Cdd:pfam02373  71 KQLRENGIPVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjN pfam02375
jmjN domain;
59-91 8.53e-15

jmjN domain;


:

Pssm-ID: 460542  Cd Length: 34  Bit Score: 68.47  E-value: 8.53e-15
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1002244834  59 PVFSPSIEEFEDPLVYLNKIAPIAAKYGICKIV 91
Cdd:pfam02375   1 PVFYPTEEEFKDPLKYIEKIRPLGEKYGICKIV 33
zf-C5HC2 pfam02928
C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. ...
 458-510 3.70e-06

C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji. This domain may have a DNA binding function.


:

Pssm-ID: 460750  Cd Length: 54  Bit Score: 44.54  E-value: 3.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002244834 458 CGICRRDCYVAHIMCN-CRIDAICLCHEEEIRRCPCSCDRVVFVRKDIFELETL 510
Cdd:pfam02928   1 CSFCKAYCYLSAVTCSkCSGKVVCLRHAKELCSDCPPSKRTLLYRYTDDELEAL 54
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 235-358 4.06e-42

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 148.99  E-value: 4.06e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244834 235 MLYIGMLFSMFAWHVEDHYLYSINYHHCGASKTWYGIPGKAAPDFEKVVCEHVYdheilsgegeNAAFDVILGKTTMFPP 314
Cdd:pfam02373   1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFG----------GEQPDDLLHLNTIISP 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1002244834 315 NILLRHHVPVYRAIQKPGEFVITFPRAYHSGFSHGFNCGEAVNF 358
Cdd:pfam02373  71 KQLRENGIPVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjN pfam02375
jmjN domain;
59-91 8.53e-15

jmjN domain;


Pssm-ID: 460542  Cd Length: 34  Bit Score: 68.47  E-value: 8.53e-15
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1002244834  59 PVFSPSIEEFEDPLVYLNKIAPIAAKYGICKIV 91
Cdd:pfam02375   1 PVFYPTEEEFKDPLKYIEKIRPLGEKYGICKIV 33
JmjN smart00545
Small domain found in the jumonji family of transcription factors; To date, this domain always ...
 57-93 2.82e-14

Small domain found in the jumonji family of transcription factors; To date, this domain always co-occurs with the JmjC domain (although the reverse is not true).


Pssm-ID: 128818  Cd Length: 42  Bit Score: 67.29  E-value: 2.82e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1002244834   57 ECPVFSPSIEEFEDPLVYLNKIAPIAAKYGICKIVSP 93
Cdd:smart00545   1 EIPVFYPTMEEFKDPLAYISKIRPQAEKYGICKVVPP 37
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 213-264 9.44e-07

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 46.48  E-value: 9.44e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1002244834  213 LSRLPKST--LRLLRAAIPGITD-PMLYIGMLFSMFAWHVEDHYLysINYHHCGA 264
Cdd:smart00558   5 LAKLPFKLnlLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYDL--VNYLHQGA 57
zf-C5HC2 pfam02928
C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. ...
 458-510 3.70e-06

C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji. This domain may have a DNA binding function.


Pssm-ID: 460750  Cd Length: 54  Bit Score: 44.54  E-value: 3.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002244834 458 CGICRRDCYVAHIMCN-CRIDAICLCHEEEIRRCPCSCDRVVFVRKDIFELETL 510
Cdd:pfam02928   1 CSFCKAYCYLSAVTCSkCSGKVVCLRHAKELCSDCPPSKRTLLYRYTDDELEAL 54
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 235-358 4.06e-42

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 148.99  E-value: 4.06e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002244834 235 MLYIGMLFSMFAWHVEDHYLYSINYHHCGASKTWYGIPGKAAPDFEKVVCEHVYdheilsgegeNAAFDVILGKTTMFPP 314
Cdd:pfam02373   1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFG----------GEQPDDLLHLNTIISP 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1002244834 315 NILLRHHVPVYRAIQKPGEFVITFPRAYHSGFSHGFNCGEAVNF 358
Cdd:pfam02373  71 KQLRENGIPVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjN pfam02375
jmjN domain;
59-91 8.53e-15

jmjN domain;


Pssm-ID: 460542  Cd Length: 34  Bit Score: 68.47  E-value: 8.53e-15
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1002244834  59 PVFSPSIEEFEDPLVYLNKIAPIAAKYGICKIV 91
Cdd:pfam02375   1 PVFYPTEEEFKDPLKYIEKIRPLGEKYGICKIV 33
JmjN smart00545
Small domain found in the jumonji family of transcription factors; To date, this domain always ...
 57-93 2.82e-14

Small domain found in the jumonji family of transcription factors; To date, this domain always co-occurs with the JmjC domain (although the reverse is not true).


Pssm-ID: 128818  Cd Length: 42  Bit Score: 67.29  E-value: 2.82e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1002244834   57 ECPVFSPSIEEFEDPLVYLNKIAPIAAKYGICKIVSP 93
Cdd:smart00545   1 EIPVFYPTMEEFKDPLAYISKIRPQAEKYGICKVVPP 37
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 213-264 9.44e-07

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 46.48  E-value: 9.44e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1002244834  213 LSRLPKST--LRLLRAAIPGITD-PMLYIGMLFSMFAWHVEDHYLysINYHHCGA 264
Cdd:smart00558   5 LAKLPFKLnlLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYDL--VNYLHQGA 57
zf-C5HC2 pfam02928
C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. ...
 458-510 3.70e-06

C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji. This domain may have a DNA binding function.


Pssm-ID: 460750  Cd Length: 54  Bit Score: 44.54  E-value: 3.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002244834 458 CGICRRDCYVAHIMCN-CRIDAICLCHEEEIRRCPCSCDRVVFVRKDIFELETL 510
Cdd:pfam02928   1 CSFCKAYCYLSAVTCSkCSGKVVCLRHAKELCSDCPPSKRTLLYRYTDDELEAL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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