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Conserved domains on  [gi|1002248963|ref|XP_015628650|]
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vacuolar protein-sorting-associated protein 37 homolog 1 isoform X1 [Oryza sativa Japonica Group]

Protein Classification

vacuolar protein sorting family 37 protein( domain architecture ID 12073684)

vacuolar protein sorting family 37 protein similar to vacuolar protein sorting-associated protein 37 (Vps37), which is a component of the ESCRT-I complex, a regulator of vesicular trafficking process

CATH:  1.10.287.660
Gene Ontology:  GO:0000813|GO:0043162|GO:0006623|GO:0006612|GO:0048306
SCOP:  4001064

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 80-224 8.26e-40

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


:

Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 133.90  E-value: 8.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963  80 KDKSVDELQRLLKDKEAYNAFFNSLDQVKTQNNLRDELRKETVQLARENLEKEQRILELRNQCTIIRTtELAAAQDRLAE 159
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLQELLE-ELKALKSEYEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002248963 160 LERQKDEIMRSYSPAALLDKLQKSMAKLDEESEELHQKFLEKDIDLPTFVQKYKKLRAAYHKQAL 224
Cdd:pfam07200  80 KEQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRRE 144
 
Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 80-224 8.26e-40

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 133.90  E-value: 8.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963  80 KDKSVDELQRLLKDKEAYNAFFNSLDQVKTQNNLRDELRKETVQLARENLEKEQRILELRNQCTIIRTtELAAAQDRLAE 159
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLQELLE-ELKALKSEYEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002248963 160 LERQKDEIMRSYSPAALLDKLQKSMAKLDEESEELHQKFLEKDIDLPTFVQKYKKLRAAYHKQAL 224
Cdd:pfam07200  80 KEQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRRE 144
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
70-224 1.38e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963  70 AEAAGIIARLKDKSVDELQRLLKD-KEAYNAFFNSLDQVKTQNNLRDELRK--ETVQLARENLEK-EQRILELRNQCTII 145
Cdd:PRK03918  573 AELLKELEELGFESVEELEERLKElEPFYNEYLELKDAEKELEREEKELKKleEELDKAFEELAEtEKRLEELRKELEEL 652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963 146 R------------------TTELAAAQDRLAELERQKDEIMRSyspaalLDKLQKSMAKLDEESEELhqKFLEKDI-DLP 206
Cdd:PRK03918  653 EkkyseeeyeelreeylelSRELAGLRAELEELEKRREEIKKT------LEKLKEELEEREKAKKEL--EKLEKALeRVE 724

                         170
                  ....*....|....*...
gi 1002248963 207 TFVQKYKKLRAAYHKQAL 224
Cdd:PRK03918  725 ELREKVKKYKALLKERAL 742
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
75-197 2.00e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.07  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963  75 IIARLKDKS-VDELQRLLKDKEAYNAFFNSLDQ-VKTQNNLRDELRKETVQLARENLEKEQRILELRNQCTIIRTTELAA 152
Cdd:COG2433   381 ALEELIEKElPEEEPEAEREKEHEERELTEEEEeIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERRE 460

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1002248963 153 AQDRlAELERQKDEImrsyspaallDKLQKSMAKLDEESEELHQK 197
Cdd:COG2433   461 IRKD-REISRLDREI----------ERLERELEEERERIEELKRK 494
 
Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 80-224 8.26e-40

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 133.90  E-value: 8.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963  80 KDKSVDELQRLLKDKEAYNAFFNSLDQVKTQNNLRDELRKETVQLARENLEKEQRILELRNQCTIIRTtELAAAQDRLAE 159
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLQELLE-ELKALKSEYEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002248963 160 LERQKDEIMRSYSPAALLDKLQKSMAKLDEESEELHQKFLEKDIDLPTFVQKYKKLRAAYHKQAL 224
Cdd:pfam07200  80 KEQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRRE 144
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
70-224 1.38e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963  70 AEAAGIIARLKDKSVDELQRLLKD-KEAYNAFFNSLDQVKTQNNLRDELRK--ETVQLARENLEK-EQRILELRNQCTII 145
Cdd:PRK03918  573 AELLKELEELGFESVEELEERLKElEPFYNEYLELKDAEKELEREEKELKKleEELDKAFEELAEtEKRLEELRKELEEL 652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963 146 R------------------TTELAAAQDRLAELERQKDEIMRSyspaalLDKLQKSMAKLDEESEELhqKFLEKDI-DLP 206
Cdd:PRK03918  653 EkkyseeeyeelreeylelSRELAGLRAELEELEKRREEIKKT------LEKLKEELEEREKAKKEL--EKLEKALeRVE 724

                         170
                  ....*....|....*...
gi 1002248963 207 TFVQKYKKLRAAYHKQAL 224
Cdd:PRK03918  725 ELREKVKKYKALLKERAL 742
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
75-197 2.00e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.07  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963  75 IIARLKDKS-VDELQRLLKDKEAYNAFFNSLDQ-VKTQNNLRDELRKETVQLARENLEKEQRILELRNQCTIIRTTELAA 152
Cdd:COG2433   381 ALEELIEKElPEEEPEAEREKEHEERELTEEEEeIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERRE 460

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1002248963 153 AQDRlAELERQKDEImrsyspaallDKLQKSMAKLDEESEELHQK 197
Cdd:COG2433   461 IRKD-REISRLDREI----------ERLERELEEERERIEELKRK 494
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 76-232 2.23e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 37.98  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963  76 IARLKDKSVDELQRLLKDKEAynaffnsLDQVKTQNNLRDeLRKETVQLARENLEKEQRILELRNQCTIIRTT------E 149
Cdd:COG1579    61 IKRLELEIEEVEARIKKYEEQ-------LGNVRNNKEYEA-LQKEIESLKRRISDLEDEILELMERIEELEEElaeleaE 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002248963 150 LAAAQDRLAELERQKDEImrsyspaalLDKLQKSMAKLDEESEElhqkfLEKDIDlPTFVQKYKKLRAAYHKQALLHLAG 229
Cdd:COG1579   133 LAELEAELEEKKAELDEE---------LAELEAELEELEAEREE-----LAAKIP-PELLALYERIRKRKNGLAVVPVEG 197


                  ...
gi 1002248963 230 KTS 232
Cdd:COG1579   198 GAC 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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