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Conserved domains on  [gi|1002255537|ref|XP_015632050|]
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mitochondrial import inner membrane translocase subunit TIM22-4 isoform X1 [Oryza sativa Japonica Group]

Protein Classification

Tim17/Tim22/Tim23/Pmp24 family protein( domain architecture ID 10493815)

Tim17/Tim22/Tim23/Pmp24 family protein such as the mitochondrial import inner membrane translocase subunit Tim22, an essential core component of the TIM22 complex, which mediates the insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane

Gene Ontology:  GO:0016020
PubMed:  27760563|33297490

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 62-153 1.33e-25

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


:

Pssm-ID: 460567  Cd Length: 109  Bit Score: 94.55  E-value: 1.33e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002255537  62 FFGALENPITAeeMTARQQIVYQAKQMGRRSISNAKTFAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALaaKGG 141
Cdd:pfam02466  21 LVYGARNRPPP--LTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPWNSIAAGALTGALL--RGG 96

                          90
                  ....*....|..
gi 1002255537 142 PKATCVGCVGFA 153
Cdd:pfam02466  97 PRAAAVGGAVGA 108
 
Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 62-153 1.33e-25

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 94.55  E-value: 1.33e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002255537  62 FFGALENPITAeeMTARQQIVYQAKQMGRRSISNAKTFAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALaaKGG 141
Cdd:pfam02466  21 LVYGARNRPPP--LTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPWNSIAAGALTGALL--RGG 96

                          90
                  ....*....|..
gi 1002255537 142 PKATCVGCVGFA 153
Cdd:pfam02466  97 PRAAAVGGAVGA 108
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 71-156 3.90e-18

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 77.59  E-value: 3.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002255537  71 TAEEMTARQQIVYQAKQMGRRSISNAKTFAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALAAKGGPKATCVGCV 150
Cdd:COG5596    95 TIDCTPFRLQLKEQLNNAGKRGFFTGKNLGVLGLIYAGINSIITALRAKHDIANAIAAGAFTGAALASSAGPQAMPMGGA 174


                  ....*.
gi 1002255537 151 GFATFS 156
Cdd:COG5596   175 GFAAFS 180
3a0801so1tim17 TIGR00980
mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, ...
 89-145 2.10e-09

mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130053  Cd Length: 170  Bit Score: 53.69  E-value: 2.10e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002255537  89 GRRSISNAKT--------FAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALAAKGGPKAT 145
Cdd:TIGR00980  46 LVGAMRAIKTrapvlggnFAVWGGLFSTIDCAVVAIRKKEDPWNSIISGFLTGAALAVRGGPRAM 110
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 99-143 3.84e-07

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 47.35  E-value: 3.84e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1002255537  99 FAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALAAKGGPK 143
Cdd:PTZ00236   66 FAIWGGLFSTFDCTLQYLRGKEDHWNAIASGFFTGGVLAIRGGWR 110
 
Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 62-153 1.33e-25

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 94.55  E-value: 1.33e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002255537  62 FFGALENPITAeeMTARQQIVYQAKQMGRRSISNAKTFAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALaaKGG 141
Cdd:pfam02466  21 LVYGARNRPPP--LTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPWNSIAAGALTGALL--RGG 96

                          90
                  ....*....|..
gi 1002255537 142 PKATCVGCVGFA 153
Cdd:pfam02466  97 PRAAAVGGAVGA 108
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 71-156 3.90e-18

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 77.59  E-value: 3.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002255537  71 TAEEMTARQQIVYQAKQMGRRSISNAKTFAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALAAKGGPKATCVGCV 150
Cdd:COG5596    95 TIDCTPFRLQLKEQLNNAGKRGFFTGKNLGVLGLIYAGINSIITALRAKHDIANAIAAGAFTGAALASSAGPQAMPMGGA 174


                  ....*.
gi 1002255537 151 GFATFS 156
Cdd:COG5596   175 GFAAFS 180
3a0801so1tim17 TIGR00980
mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, ...
 89-145 2.10e-09

mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130053  Cd Length: 170  Bit Score: 53.69  E-value: 2.10e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002255537  89 GRRSISNAKT--------FAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALAAKGGPKAT 145
Cdd:TIGR00980  46 LVGAMRAIKTrapvlggnFAVWGGLFSTIDCAVVAIRKKEDPWNSIISGFLTGAALAVRGGPRAM 110
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 99-143 3.84e-07

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 47.35  E-value: 3.84e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1002255537  99 FAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALAAKGGPK 143
Cdd:PTZ00236   66 FAIWGGLFSTFDCTLQYLRGKEDHWNAIASGFFTGGVLAIRGGWR 110
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 76-148 7.00e-07

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 46.75  E-value: 7.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002255537  76 TARQQIVYQAKQMGRRSISNAKTFAVMGLIFSAAECVIEKARAKHDTTNSAVAGCVTGGALAAKGGPKATCVG 148
Cdd:TIGR00983  66 WTKLRLNQILNMVTRRGPFWGNTLGILALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKSTRGLRGMARS 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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