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Conserved domains on  [gi|1002257346|ref|XP_015632993|]
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uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 6-41 1.63e-10

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438928  Cd Length: 39  Bit Score: 55.93  E-value: 1.63e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRR 41
Cdd:cd22157     3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPS 38
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 300-401 9.50e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd19171:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 153  Bit Score: 39.72  E-value: 9.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257346 300 KMKWELKHDkhirhILLGRNNRQGLGPWILQDInhQKNPYIYEY-DEII--EAPNQKKVECEQAALEKFEWISDDENVLD 376
Cdd:cd19171     7 KLKTEWRSN-----VYLARSRIQGLGLYAARDI--EKHTMVIEYiGEIIrnEVANRREKIYESQNRGIYMFRIDNDWVID 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1002257346 377 NedIVTGGYHEYIN----------IIGFHPYKEII 401
Cdd:cd19171    80 A--TMTGGPARYINhscnpncvaeVVTFDKEKKII 112
 
Name Accession Description Interval E-value
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 6-41 1.63e-10

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 55.93  E-value: 1.63e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRR 41
Cdd:cd22157     3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPS 38
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 6-44 6.04e-09

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 51.39  E-value: 6.04e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRLLR 44
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
6-44 1.51e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 50.13  E-value: 1.51e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1002257346    6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRLLR 44
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 300-401 9.50e-04

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 39.72  E-value: 9.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257346 300 KMKWELKHDkhirhILLGRNNRQGLGPWILQDInhQKNPYIYEY-DEII--EAPNQKKVECEQAALEKFEWISDDENVLD 376
Cdd:cd19171     7 KLKTEWRSN-----VYLARSRIQGLGLYAARDI--EKHTMVIEYiGEIIrnEVANRREKIYESQNRGIYMFRIDNDWVID 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1002257346 377 NedIVTGGYHEYIN----------IIGFHPYKEII 401
Cdd:cd19171    80 A--TMTGGPARYINhscnpncvaeVVTFDKEKKII 112
 
Name Accession Description Interval E-value
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 6-41 1.63e-10

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 55.93  E-value: 1.63e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRR 41
Cdd:cd22157     3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPS 38
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 6-44 6.04e-09

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 51.39  E-value: 6.04e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRLLR 44
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
6-44 1.51e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 50.13  E-value: 1.51e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1002257346    6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRLLR 44
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 6-45 2.61e-08

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 49.63  E-value: 2.61e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRLLRA 45
Cdd:cd22151     3 LPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWEN 42
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 3-42 2.69e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 49.79  E-value: 2.69e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1002257346   3 VAALPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRL 42
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSL 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 6-38 4.54e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 45.90  E-value: 4.54e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVD 38
Cdd:cd09917     3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 3-54 2.84e-06

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 44.97  E-value: 2.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1002257346   3 VAALPDDVLAEVLRRLAPRSLA-ACRCVCKPWRDLVDD-----RRLLRADLLPRSLAG 54
Cdd:cd22168     4 ISDLPEDVLLEILSLVPARDLIlSCRLVCSRWRDLVDLptlwkRKCQREGFILKDWDG 61
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
 3-38 8.94e-06

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 42.79  E-value: 8.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1002257346   3 VAALPDDVLAEVLRRLAPRSLAA-CRCVCKPWRDLVD 38
Cdd:cd22169     1 LSLLPEELLLLVLSHVPARTLVTrCRLVCRDWRDLVD 37
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
 4-38 9.00e-06

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 42.38  E-value: 9.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002257346   4 AALPDDVLAEVLRRLAPRSL-AACRCVCKPWRDLVD 38
Cdd:cd22083     2 NEIPEELLLEILTHVPATSLiTNCRLVCTLWRDIID 37
F-box_AtARP8-like cd22156
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ...
 6-42 5.35e-05

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438927  Cd Length: 45  Bit Score: 40.44  E-value: 5.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRL 42
Cdd:cd22156     5 LPEDVLMQILRLLGPKDAAKLCLVCKSWRYLVSDNRL 41
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 6-45 5.54e-04

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 37.55  E-value: 5.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRLLRA 45
Cdd:cd22152     5 LPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRV 44
F-box_FBXO34-like cd22105
F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and ...
 6-46 6.45e-04

F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and similar proteins; This family includes FBXO34 (also called FBX34) and FBXO46 (also called FBX46), both of which are substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. The SCF(FBOX46) complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438877  Cd Length: 47  Bit Score: 37.38  E-value: 6.45e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1002257346   6 LPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRLLRAD 46
Cdd:cd22105     4 LPDHVLSKIFSHLPTRSLAALKCTCKDFKWLIEMFDVRGSD 44
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 5-44 8.74e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 36.94  E-value: 8.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1002257346   5 ALPDDVLAEVLRRLAPRSLAACRCVCKPWRDLVDDRRLLR 44
Cdd:cd22123     3 QLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 300-401 9.50e-04

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 39.72  E-value: 9.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257346 300 KMKWELKHDkhirhILLGRNNRQGLGPWILQDInhQKNPYIYEY-DEII--EAPNQKKVECEQAALEKFEWISDDENVLD 376
Cdd:cd19171     7 KLKTEWRSN-----VYLARSRIQGLGLYAARDI--EKHTMVIEYiGEIIrnEVANRREKIYESQNRGIYMFRIDNDWVID 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1002257346 377 NedIVTGGYHEYIN----------IIGFHPYKEII 401
Cdd:cd19171    80 A--TMTGGPARYINhscnpncvaeVVTFDKEKKII 112
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 6-39 1.11e-03

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 36.55  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1002257346   6 LPDDVLAEVLRRLAP-RSLAACRCVCKPWRDLVDD 39
Cdd:cd22110     4 LPEEILEYILSYLSPyGDLKSAALVCKRWHRIIKG 38
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 4-39 1.51e-03

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438924  Cd Length: 45  Bit Score: 36.25  E-value: 1.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1002257346   4 AALPDDVLAEVLRRL--------APRSLAACRCVCKPWRDLVDD 39
Cdd:cd22153     2 ANLPPELLRDIIQRVeesesawpSRKNVVACASVCKSWREITKE 45
F-box_FBXO2 cd22167
F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called ...
 6-38 3.27e-03

F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called FBX2, is a neuron-specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It binds specifically to proteins attached with N-linked high-mannose type oligosaccharides, and subsequently contributes to ubiquitination of glycoproteins. FBXO2 regulates amyloid precursor protein (APP) levels and processing in the brain, and may play a role in modulating Alzheimer disease (AD) pathogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438938 [Multi-domain]  Cd Length: 72  Bit Score: 36.26  E-value: 3.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1002257346   6 LPDDVLAEVLRRLAPRSLA-ACRCVCKPWRDLVD 38
Cdd:cd22167     4 LPEAVLVRILAYLPAEELVlVCRLVCSQWKELVD 37
F-box_FBXL8 cd22121
F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also ...
 5-37 5.16e-03

F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438893  Cd Length: 35  Bit Score: 34.64  E-value: 5.16e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1002257346   5 ALPDDVLAEVLRRLAPRSLAACRCVCKPWRDLV 37
Cdd:cd22121     2 ALPEEILVHIFRHLSLRDRYAAAQVCKHWREAA 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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