NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1002272839|ref|XP_015640726|]
View 

uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 311-623 3.28e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 3.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIWTYDSSTPSSKNatiyCG--SEVSALSWeCRSDRLLLIGTANGGIKAW 388
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGhtGPVRDVAA-SADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 389 NADAKRVVCDLSTSKDfpSVLDLKCSPVEPVFVSAaasrrpgstIFDRTgfasLTVWHMKTWKPLTVLPLGEDPpaITSV 468
Cdd:cd00200    79 DLETGECVRTLTGHTS--YVSSVAFSPDGRILSSS---------SRDKT----IKVWDVETGKCLTTLRGHTDW--VNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 469 CFNHNGKILAASATDGMIHMFDMSAGLQITGWPAHDSPVSSVLFGPAETSIFSLGSDGKIFEWSLHNQGQIlwsrdcsrf 548
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL--------- 212

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002272839 549 CSPESFSKRMHEISLDSDGkRLLVTS---GLVRapIYQVQgHESGLRTL-AHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:cd00200   213 GTLRGHENGVNSVAFSPDG-YLLASGsedGTIR--VWDLR-TGECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 311-623 3.28e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 3.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIWTYDSSTPSSKNatiyCG--SEVSALSWeCRSDRLLLIGTANGGIKAW 388
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGhtGPVRDVAA-SADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 389 NADAKRVVCDLSTSKDfpSVLDLKCSPVEPVFVSAaasrrpgstIFDRTgfasLTVWHMKTWKPLTVLPLGEDPpaITSV 468
Cdd:cd00200    79 DLETGECVRTLTGHTS--YVSSVAFSPDGRILSSS---------SRDKT----IKVWDVETGKCLTTLRGHTDW--VNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 469 CFNHNGKILAASATDGMIHMFDMSAGLQITGWPAHDSPVSSVLFGPAETSIFSLGSDGKIFEWSLHNQGQIlwsrdcsrf 548
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL--------- 212

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002272839 549 CSPESFSKRMHEISLDSDGkRLLVTS---GLVRapIYQVQgHESGLRTL-AHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:cd00200   213 GTLRGHENGVNSVAFSPDG-YLLASGsedGTIR--VWDLR-TGECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
311-623 3.06e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 3.06e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIWTYDSSTPSsknATIYCGSE-VSALSWecRSD-RLLLIGTANGGIKAW 388
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL---RTLTGHSGaVTSVAF--SPDgKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 389 NADAKRVVCDLSTSKDfpSVLDLKCSPVEPVFVSAAAsrrpgstifDRTgfasLTVWHMKTWKPLTVLPLGEDPpaITSV 468
Cdd:COG2319   190 DLATGKLLRTLTGHTG--AVRSVAFSPDGKLLASGSA---------DGT----VRLWDLATGKLLRTLTGHSGS--VRSV 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 469 CFNHNGKILAASATDGMIHMFDMSAGLQITGWPAHDSPVSSVLFGPAETSIFSLGSDGKIFEWSLHNqGQILWsrdcsrf 548
Cdd:COG2319   253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLR------- 324

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002272839 549 cSPESFSKRMHEISLDSDGKRLLVTS--GLVRapIYQVQGHESGLRTLAHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:COG2319   325 -TLTGHTGAVRSVAFSPDGKTLASGSddGTVR--LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 pfam00400
WD domain, G-beta repeat;
311-343 1.74e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.74e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIW 343
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 311-343 3.24e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.24e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1002272839  311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIW 343
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 311-623 3.28e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 3.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIWTYDSSTPSSKNatiyCG--SEVSALSWeCRSDRLLLIGTANGGIKAW 388
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGhtGPVRDVAA-SADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 389 NADAKRVVCDLSTSKDfpSVLDLKCSPVEPVFVSAaasrrpgstIFDRTgfasLTVWHMKTWKPLTVLPLGEDPpaITSV 468
Cdd:cd00200    79 DLETGECVRTLTGHTS--YVSSVAFSPDGRILSSS---------SRDKT----IKVWDVETGKCLTTLRGHTDW--VNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 469 CFNHNGKILAASATDGMIHMFDMSAGLQITGWPAHDSPVSSVLFGPAETSIFSLGSDGKIFEWSLHNQGQIlwsrdcsrf 548
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL--------- 212

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002272839 549 CSPESFSKRMHEISLDSDGkRLLVTS---GLVRapIYQVQgHESGLRTL-AHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:cd00200   213 GTLRGHENGVNSVAFSPDG-YLLASGsedGTIR--VWDLR-TGECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
311-623 3.06e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 3.06e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIWTYDSSTPSsknATIYCGSE-VSALSWecRSD-RLLLIGTANGGIKAW 388
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL---RTLTGHSGaVTSVAF--SPDgKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 389 NADAKRVVCDLSTSKDfpSVLDLKCSPVEPVFVSAAAsrrpgstifDRTgfasLTVWHMKTWKPLTVLPLGEDPpaITSV 468
Cdd:COG2319   190 DLATGKLLRTLTGHTG--AVRSVAFSPDGKLLASGSA---------DGT----VRLWDLATGKLLRTLTGHSGS--VRSV 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 469 CFNHNGKILAASATDGMIHMFDMSAGLQITGWPAHDSPVSSVLFGPAETSIFSLGSDGKIFEWSLHNqGQILWsrdcsrf 548
Cdd:COG2319   253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLR------- 324

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002272839 549 cSPESFSKRMHEISLDSDGKRLLVTS--GLVRapIYQVQGHESGLRTLAHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:COG2319   325 -TLTGHTGAVRSVAFSPDGKTLASGSddGTVR--LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
311-623 2.12e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.48  E-value: 2.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIWtyDSSTPSSKNATIYCGSEVSALSWEcRSDRLLLIGTANGGIKAWNA 390
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLW--DLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 391 DAKRVVCDLSTSKDfpSVLDLKCSPVEPVFVSAAAsrrpgstifDRTgfasLTVWHMKTWKPLTVLPLGEDPpaITSVCF 470
Cdd:COG2319   150 ATGKLLRTLTGHSG--AVTSVAFSPDGKLLASGSD---------DGT----VRLWDLATGKLLRTLTGHTGA--VRSVAF 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 471 NHNGKILAASATDGMIHMFDMSAGLQITGWPAHDSPVSSVLFGPAETSIFSLGSDGKIFEWSLhNQGQILWsrdcsrfcS 550
Cdd:COG2319   213 SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLR--------T 283

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002272839 551 PESFSKRMHEISLDSDGKRLLVTS--GLVRapIYQVQGHESgLRTL-AHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:COG2319   284 LTGHSGGVNSVAFSPDGKLLASGSddGTVR--LWDLATGKL-LRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
293-535 1.78e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 293 QILVTEDDFPEVKV------DFQETFLGHNSSISCCRFSASGSNVASSSVDGTVRIWtyDSSTPSSKNATIYCGSEVSAL 366
Cdd:COG2319   175 KLLASGSDDGTVRLwdlatgKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSV 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 367 SWeCRSDRLLLIGTANGGIKAWNADAKRVVCDLSTSKDfpSVLDLKCSPVEPVFVSAAAsrrpgstifDRTgfasLTVWH 446
Cdd:COG2319   253 AF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLASGSD---------DGT----VRLWD 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 447 MKTWKPLTVLPLGEDPpaITSVCFNHNGKILAASATDGMIHMFDMSAGLQITGWPAHDSPVSSVLFGPAETSIFSLGSDG 526
Cdd:COG2319   317 LATGKLLRTLTGHTGA--VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394


                  ....*....
gi 1002272839 527 KIFEWSLHN 535
Cdd:COG2319   395 TVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
323-623 1.90e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 323 RFSASGSNVASSSVDGTVRIWTYDSSTPSSKNATiycGSEVSALSWECRSDRLLLIGTANGGIKAWNADAKRVVCDLSTS 402
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLG---LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 403 KDFpsvldlkcspvepvfVSAAASRRPGSTIFDRTGFASLTVWHMKTWKPLTVLPLGEDPpaITSVCFNHNGKILAASAT 482
Cdd:COG2319    78 TAA---------------VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 483 DGMIHMFDMSAGLQITGWPAHDSPVSSVLFGPAETSIFSLGSDGKIFEWSLHNqGQILWsrdcsrfcSPESFSKRMHEIS 562
Cdd:COG2319   141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLR--------TLTGHTGAVRSVA 211

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002272839 563 LDSDGKRLLVTS--GLVRapIYQVQGHESGLRTLAHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:COG2319   212 FSPDGKLLASGSadGTVR--LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 311-490 1.16e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIWtyDSSTPSSKnATIYcG--SEVSALSWeCRSDRLLLIGTANGGIKAW 388
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCV-ATLT-GhtGEVNSVAF-SPDGEKLLSSSSDGTIKLW 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002272839 389 NADAKRVVCDLSTSKDFpsVLDLKCSPVEPVFVSAAAsrrpgstifDRTgfasLTVWHMKTWKPLTVLPLGEDPpaITSV 468
Cdd:cd00200   205 DLSTGKCLGTLRGHENG--VNSVAFSPDGYLLASGSE---------DGT----IRVWDLRTGECVQTLSGHTNS--VTSL 267

                         170       180
                  ....*....|....*....|..
gi 1002272839 469 CFNHNGKILAASATDGMIHMFD 490
Cdd:cd00200   268 AWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
311-343 1.74e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.74e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1002272839 311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIW 343
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 311-343 3.24e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.24e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1002272839  311 TFLGHNSSISCCRFSASGSNVASSSVDGTVRIW 343
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 591-623 1.95e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.95e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1002272839  591 LRTL-AHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:smart00320   5 LKTLkGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 450-510 6.22e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 6.22e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002272839 450 WKPLTVLPLGEDPPAITSVCFNHNGKILAASATDGMIHMFDMSAGLQITGWPAHDSPVSSV 510
Cdd:pfam12894  26 WQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
WD40 pfam00400
WD domain, G-beta repeat;
591-623 6.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 6.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1002272839 591 LRTL-AHSASITSVDWHPTLPMYITGSADNSVRV 623
Cdd:pfam00400   4 LKTLeGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 449-490 1.49e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1002272839  449 TWKPLTVLPLGEDPpaITSVCFNHNGKILAASATDGMIHMFD 490
Cdd:smart00320   1 SGELLKTLKGHTGP--VTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH