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Conserved domains on  [gi|1002273389|ref|XP_015641007|]
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protein arginine N-methyltransferase 7 isoform X3 [Oryza sativa Japonica Group]

Protein Classification

COG4076 superfamily protein( domain architecture ID 1905023)

COG4076 superfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
70-233 3.17e-43

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 155.96  E-value: 3.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  70 YLDMLNDSARNRAYRRAIEAAVtDPSSRVLDIGAGTGLLSMMAARALAavggetrgGSVSACESYLPMGKLMRRVLRANG 149
Cdd:COG4076    12 HHPMLNDVERNDAFKAAIERVV-KPGDVVLDIGTGSGLLSMLAARAGA--------KKVYAVEVNPDIAAVARRIIAANG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389 150 MENRVKVFHKRSDELkvrdDLDSPADILVSEILDSELLGEGLIPTLQQAYDMLLAKNPKIVPYRATTYGQLVESTF-LWK 228
Cdd:COG4076    83 LSDRITVINADATDL----DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVdAEG 158


                  ....*
gi 1002273389 229 LHDLH 233
Cdd:COG4076   159 FEDWQ 163
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
70-233 3.17e-43

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 155.96  E-value: 3.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  70 YLDMLNDSARNRAYRRAIEAAVtDPSSRVLDIGAGTGLLSMMAARALAavggetrgGSVSACESYLPMGKLMRRVLRANG 149
Cdd:COG4076    12 HHPMLNDVERNDAFKAAIERVV-KPGDVVLDIGTGSGLLSMLAARAGA--------KKVYAVEVNPDIAAVARRIIAANG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389 150 MENRVKVFHKRSDELkvrdDLDSPADILVSEILDSELLGEGLIPTLQQAYDMLLAKNPKIVPYRATTYGQLVESTF-LWK 228
Cdd:COG4076    83 LSDRITVINADATDL----DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVdAEG 158


                  ....*
gi 1002273389 229 LHDLH 233
Cdd:COG4076   159 FEDWQ 163
PRK14968 PRK14968
putative methyltransferase; Provisional
 87-115 5.47e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.73  E-value: 5.47e-03
                          10        20
                  ....*....|....*....|....*....
gi 1002273389  87 IEAAVTDPSSRVLDIGAGTGLLSMMAARA 115
Cdd:PRK14968   16 AENAVDKKGDRVLEVGTGSGIVAIVAAKN 44
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-210 7.23e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 36.64  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  97 RVLDIGAGTGLLSMMAARALaavggetrGGSVSACEsYLPMG-KLMRRVLRANGMENrVKVFHkrSDELKVRDDLDSPAD 175
Cdd:cd02440     1 RVLDLGCGTGALALALASGP--------GARVTGVD-ISPVAlELARKAAAALLADN-VEVLK--GDAEELPPEADESFD 68

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1002273389 176 ILVSEILDSELLgEGLIPTLQQAYDmLLAKNPKIV 210
Cdd:cd02440    69 VIISDPPLHHLV-EDLARFLEEARR-LLKPGGVLV 101
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
70-233 3.17e-43

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 155.96  E-value: 3.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  70 YLDMLNDSARNRAYRRAIEAAVtDPSSRVLDIGAGTGLLSMMAARALAavggetrgGSVSACESYLPMGKLMRRVLRANG 149
Cdd:COG4076    12 HHPMLNDVERNDAFKAAIERVV-KPGDVVLDIGTGSGLLSMLAARAGA--------KKVYAVEVNPDIAAVARRIIAANG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389 150 MENRVKVFHKRSDELkvrdDLDSPADILVSEILDSELLGEGLIPTLQQAYDMLLAKNPKIVPYRATTYGQLVESTF-LWK 228
Cdd:COG4076    83 LSDRITVINADATDL----DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVdAEG 158


                  ....*
gi 1002273389 229 LHDLH 233
Cdd:COG4076   159 FEDWQ 163
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 72-202 1.48e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 45.69  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  72 DMLNDSARNRAYRRAIEAAVTDPSSRVLDIGAGTGLLSMMAARAL-AAVGGETRggSVSACEsylpmgkLMRRVLRANGM 150
Cdd:COG2230    29 DDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYgVRVTGVTL--SPEQLE-------YARERAAEAGL 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002273389 151 ENRVKVFHKrsDelkVRD-DLDSPADILVS-EILdsELLGEGLIPT-LQQAYDML 202
Cdd:COG2230   100 ADRVEVRLA--D---YRDlPADGQFDAIVSiGMF--EHVGPENYPAyFAKVARLL 147
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 94-158 1.51e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 47.06  E-value: 1.51e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002273389  94 PSSRVLDIGAGTGLLS-MMAARalaavggeTRGGSVSACESYLPMGKLMRRVLRANGMENRVKVFH 158
Cdd:COG4123    37 KGGRVLDLGTGTGVIAlMLAQR--------SPGARITGVEIQPEAAELARRNVALNGLEDRITVIH 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 82-169 1.08e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.67  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  82 AYRRAIEAAVTDPSSRVLDIGAGTGLLSMMAARalaavggetRGGSVSACESYLPMGKLMRRvlRANGMENRVKVFHKRS 161
Cdd:COG2226    10 GREALLAALGLRPGARVLDLGCGTGRLALALAE---------RGARVTGVDISPEMLELARE--RAAEAGLNVEFVVGDA 78


                  ....*...
gi 1002273389 162 DELKVRDD 169
Cdd:COG2226    79 EDLPFPDG 86
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
85-195 5.27e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 42.47  E-value: 5.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  85 RAIEAAVTdPSSRVLDIGAGTGLLSMMAARALAavggetrgGSVSAC----ESYlpmgklmrRV----LRANGMENRVKV 156
Cdd:COG2264   140 EALEKLLK-PGKTVLDVGCGSGILAIAAAKLGA--------KRVLAVdidpVAV--------EAarenAELNGVEDRIEV 202

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1002273389 157 FHkrSDELKvrddlDSPADILVSEILDSELLgeGLIPTL 195
Cdd:COG2264   203 VL--GDLLE-----DGPYDLVVANILANPLI--ELAPDL 232
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 75-168 5.52e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 40.39  E-value: 5.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  75 NDSARNRAYRRAIEAAVTD---PSSRVLDIGAGTGLLSMMAARalaavggetRGGSVSACEsylpMGKLMRRVLRANGME 151
Cdd:COG2227     2 SDPDARDFWDRRLAALLARllpAGGRVLDVGCGTGRLALALAR---------RGADVTGVD----ISPEALEIARERAAE 68

                          90
                  ....*....|....*..
gi 1002273389 152 NRVKVFHKRSDELKVRD 168
Cdd:COG2227    69 LNVDFVQGDLEDLPLED 85
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 97-182 6.42e-04

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 41.79  E-value: 6.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  97 RVLDIGAGTGLLSMMAARALAAvggetrggSVSACEsYLPMGklmRRVLRANGMENRVKVFHKRSDelkVRD-DLDSPAD 175
Cdd:COG3897    73 RVLELGCGLGLVGIAAAKAGAA--------DVTATD-YDPEA---LAALRLNAALNGVAITTRLGD---WRDpPAAGGFD 137


                  ....*...
gi 1002273389 176 -ILVSEIL 182
Cdd:COG3897   138 lILGGDVL 145
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
81-122 2.57e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 39.60  E-value: 2.57e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1002273389  81 RAYRRAIEAAVTDPSSRVLDIGAGTGLLsmmaARALAAVGGE 122
Cdd:COG4976    33 LLAEELLARLPPGPFGRVLDLGCGTGLL----GEALRPRGYR 70
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 85-158 4.46e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 38.92  E-value: 4.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002273389  85 RAIEAAVTDPSSRVLDIGAGTG----LLSMMAARalaavggetrggsVSACESYLPMGKLMRRVLRANGMENrVKVFH 158
Cdd:COG2518    57 RMLEALDLKPGDRVLEIGTGSGyqaaVLARLAGR-------------VYSVERDPELAERARERLAALGYDN-VTVRV 120
PRK14968 PRK14968
putative methyltransferase; Provisional
 87-115 5.47e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.73  E-value: 5.47e-03
                          10        20
                  ....*....|....*....|....*....
gi 1002273389  87 IEAAVTDPSSRVLDIGAGTGLLSMMAARA 115
Cdd:PRK14968   16 AENAVDKKGDRVLEVGTGSGIVAIVAAKN 44
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-210 7.23e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 36.64  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  97 RVLDIGAGTGLLSMMAARALaavggetrGGSVSACEsYLPMG-KLMRRVLRANGMENrVKVFHkrSDELKVRDDLDSPAD 175
Cdd:cd02440     1 RVLDLGCGTGALALALASGP--------GARVTGVD-ISPVAlELARKAAAALLADN-VEVLK--GDAEELPPEADESFD 68

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1002273389 176 ILVSEILDSELLgEGLIPTLQQAYDmLLAKNPKIV 210
Cdd:cd02440    69 VIISDPPLHHLV-EDLARFLEEARR-LLKPGGVLV 101
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 83-178 8.16e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 39.00  E-value: 8.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002273389  83 YRRAIEAAVTDPSSRVLDIGAGTGLLSMMAARalaavggetRGGSVSACESYLPMGKLMRRVLRANGMENrVKVFHKRSD 162
Cdd:COG2265   222 YAAALEWLDLTGGERVLDLYCGVGTFALPLAR---------RAKKVIGVEIVPEAVEDARENARLNGLKN-VEFVAGDLE 291

                          90
                  ....*....|....*.
gi 1002273389 163 ELKVRDDLDSPADILV 178
Cdd:COG2265   292 EVLPELLWGGRPDVVV 307
PRK14967 PRK14967
putative methyltransferase; Provisional
 85-118 9.66e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 38.11  E-value: 9.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1002273389  85 RAIEAAVTDPSSRVLDIGAGTGLLSMMAARALAA 118
Cdd:PRK14967   27 DALAAEGLGPGRRVLDLCTGSGALAVAAAAAGAG 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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