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Conserved domains on  [gi|1002278499|ref|XP_015643577|]
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enhancer of mRNA-decapping protein 4 isoform X1 [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ge1_WD40 super family cl25640
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 202-481 6.04e-24

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


The actual alignment was detected with superfamily member pfam16529:

Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 104.46  E-value: 6.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  202 QLEVTPITKYTSDPGLVLGRQIAVNRT--YIVYGLKLGN----IRVLNINTALRSLLRGHTQRVTDMAFFAEDVHRLASA 275
Cdd:pfam16529    4 KVKLKNIVDYKWERKYYPGQLVAVHRDgkYLAYAIKVKNgggmVRVINIETSERALLKGMTGEVLDLAFAHTDCVILACV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  276 SVDGRIYVWKIDEGPDEQnkpqitgKIEIAIQIVGDAETYHP---RICW------------------------HSHKQEI 328
Cdd:pfam16529   84 DDVGNLFVYKVDQIEGKI-------LCNLLLHIEDPIGTYPSeyhRVIWcpyipeddetesddddeskllvllRGDKAEI 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  329 LFVGVANcvlkidtTKVGRGmdfsreePLKcpLDKLVDGvHLVGKHDADITDLSLSQWMTTrLASASKDGMVKIW----- 403
Cdd:pfam16529  157 WNVDMIV-------SEHGSG-------PLQ--PAALESG-YIEIEEHSLLVDAAFSPDGTA-LATASLDGEVKFFqiylf 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  404 DDRKSVPLSVLKPHDGQAVYSVSFL----TAPEHPQHINLITAGPLNREVKIWAstndegwllpsdSETWRCTQTLELVS 479
Cdd:pfam16529  219 DNRNPRCLHEWKPHDGKPLSSLFFLdnhkKPPEVQFWRFAITGADNNSELKLWS------------CESWTCLQTIRFVP 286


                   ..
gi 1002278499  480 SL 481
Cdd:pfam16529  287 DP 288
MISS super family cl25801
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 42-97 1.94e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


The actual alignment was detected with superfamily member pfam15822:

Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 41.51  E-value: 1.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002278499   42 PAPAGIFP---------GAAAPAPHHGVVVPPPmtsgGGPYSYPPATPPFHRGPYLPPYPNDPHL 97
Cdd:pfam15822   62 PAPTGMYPsipltgpspGPPAPFPPSGPSCPPP----GGPYPAPTVPGPGPIGPYPTPNMPFPEL 122
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 202-481 6.04e-24

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 104.46  E-value: 6.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  202 QLEVTPITKYTSDPGLVLGRQIAVNRT--YIVYGLKLGN----IRVLNINTALRSLLRGHTQRVTDMAFFAEDVHRLASA 275
Cdd:pfam16529    4 KVKLKNIVDYKWERKYYPGQLVAVHRDgkYLAYAIKVKNgggmVRVINIETSERALLKGMTGEVLDLAFAHTDCVILACV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  276 SVDGRIYVWKIDEGPDEQnkpqitgKIEIAIQIVGDAETYHP---RICW------------------------HSHKQEI 328
Cdd:pfam16529   84 DDVGNLFVYKVDQIEGKI-------LCNLLLHIEDPIGTYPSeyhRVIWcpyipeddetesddddeskllvllRGDKAEI 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  329 LFVGVANcvlkidtTKVGRGmdfsreePLKcpLDKLVDGvHLVGKHDADITDLSLSQWMTTrLASASKDGMVKIW----- 403
Cdd:pfam16529  157 WNVDMIV-------SEHGSG-------PLQ--PAALESG-YIEIEEHSLLVDAAFSPDGTA-LATASLDGEVKFFqiylf 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  404 DDRKSVPLSVLKPHDGQAVYSVSFL----TAPEHPQHINLITAGPLNREVKIWAstndegwllpsdSETWRCTQTLELVS 479
Cdd:pfam16529  219 DNRNPRCLHEWKPHDGKPLSSLFFLdnhkKPPEVQFWRFAITGADNNSELKLWS------------CESWTCLQTIRFVP 286


                   ..
gi 1002278499  480 SL 481
Cdd:pfam16529  287 DP 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-513 7.10e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 7.10e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  248 LRSLLRGHTQRVTDMAFFAeDVHRLASASVDGRIYVWKIDEGPDEQnkpQITGKIEIAIQIVgdaetyhpricWHSHKQE 327
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR---TLKGHTGPVRDVA-----------ASADGTY 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  328 ILFVGVANCVL--KIDTTKVGR----------GMDFSREEPL--------KCPLDKLVDG--VHLVGKHDADITDLSLSQ 385
Cdd:cd00200     66 LASGSSDKTIRlwDLETGECVRtltghtsyvsSVAFSPDGRIlssssrdkTIKVWDVETGkcLTTLRGHTDWVNSVAFSP 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  386 wMTTRLASASKDGMVKIWDDRKSVPLSVLKPHDGQaVYSVSFltapeHPQHINLITAGpLNREVKIWastndegwllpsD 465
Cdd:cd00200    146 -DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAF-----SPDGEKLLSSS-SDGTIKLW------------D 205

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1002278499  466 SETWRCTQTLElvsslEHrfeEAFFNQVAVLPQaSLILLANAKKNAIY 513
Cdd:cd00200    206 LSTGKCLGTLR-----GH---ENGVNSVAFSPD-GYLLASGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
228-452 6.19e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 6.19e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  228 TYIVYGLKLGNIRVLNINT-ALRSLLRGHTQRVTDMAFfAEDVHRLASASVDGRIYVWKIDEGPDEQNKPQITGKIEiAI 306
Cdd:COG2319    217 KLLASGSADGTVRLWDLATgKLLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN-SV 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  307 QIVGDAETyhpricwhshkqeiLFVGVANCVLKIdttkvgrgMDFSREEPLKcpldklvdgvHLVGkHDADITDLSLSQW 386
Cdd:COG2319    295 AFSPDGKL--------------LASGSDDGTVRL--------WDLATGKLLR----------TLTG-HTGAVRSVAFSPD 341

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002278499  387 mTTRLASASKDGMVKIWDDRKSVPLSVLKPHDGqAVYSVSFltAPEHPQhinLITAGpLNREVKIW 452
Cdd:COG2319    342 -GKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAF--SPDGRT---LASGS-ADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 252-285 3.62e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.62e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1002278499   252 LRGHTQRVTDMAFFaEDVHRLASASVDGRIYVWK 285
Cdd:smart00320    8 LKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 42-97 1.94e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 41.51  E-value: 1.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002278499   42 PAPAGIFP---------GAAAPAPHHGVVVPPPmtsgGGPYSYPPATPPFHRGPYLPPYPNDPHL 97
Cdd:pfam15822   62 PAPTGMYPsipltgpspGPPAPFPPSGPSCPPP----GGPYPAPTVPGPGPIGPYPTPNMPFPEL 122
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 202-481 6.04e-24

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 104.46  E-value: 6.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  202 QLEVTPITKYTSDPGLVLGRQIAVNRT--YIVYGLKLGN----IRVLNINTALRSLLRGHTQRVTDMAFFAEDVHRLASA 275
Cdd:pfam16529    4 KVKLKNIVDYKWERKYYPGQLVAVHRDgkYLAYAIKVKNgggmVRVINIETSERALLKGMTGEVLDLAFAHTDCVILACV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  276 SVDGRIYVWKIDEGPDEQnkpqitgKIEIAIQIVGDAETYHP---RICW------------------------HSHKQEI 328
Cdd:pfam16529   84 DDVGNLFVYKVDQIEGKI-------LCNLLLHIEDPIGTYPSeyhRVIWcpyipeddetesddddeskllvllRGDKAEI 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  329 LFVGVANcvlkidtTKVGRGmdfsreePLKcpLDKLVDGvHLVGKHDADITDLSLSQWMTTrLASASKDGMVKIW----- 403
Cdd:pfam16529  157 WNVDMIV-------SEHGSG-------PLQ--PAALESG-YIEIEEHSLLVDAAFSPDGTA-LATASLDGEVKFFqiylf 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  404 DDRKSVPLSVLKPHDGQAVYSVSFL----TAPEHPQHINLITAGPLNREVKIWAstndegwllpsdSETWRCTQTLELVS 479
Cdd:pfam16529  219 DNRNPRCLHEWKPHDGKPLSSLFFLdnhkKPPEVQFWRFAITGADNNSELKLWS------------CESWTCLQTIRFVP 286


                   ..
gi 1002278499  480 SL 481
Cdd:pfam16529  287 DP 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-513 7.10e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 7.10e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  248 LRSLLRGHTQRVTDMAFFAeDVHRLASASVDGRIYVWKIDEGPDEQnkpQITGKIEIAIQIVgdaetyhpricWHSHKQE 327
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR---TLKGHTGPVRDVA-----------ASADGTY 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  328 ILFVGVANCVL--KIDTTKVGR----------GMDFSREEPL--------KCPLDKLVDG--VHLVGKHDADITDLSLSQ 385
Cdd:cd00200     66 LASGSSDKTIRlwDLETGECVRtltghtsyvsSVAFSPDGRIlssssrdkTIKVWDVETGkcLTTLRGHTDWVNSVAFSP 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  386 wMTTRLASASKDGMVKIWDDRKSVPLSVLKPHDGQaVYSVSFltapeHPQHINLITAGpLNREVKIWastndegwllpsD 465
Cdd:cd00200    146 -DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAF-----SPDGEKLLSSS-SDGTIKLW------------D 205

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1002278499  466 SETWRCTQTLElvsslEHrfeEAFFNQVAVLPQaSLILLANAKKNAIY 513
Cdd:cd00200    206 LSTGKCLGTLR-----GH---ENGVNSVAFSPD-GYLLASGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
228-452 6.19e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 6.19e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  228 TYIVYGLKLGNIRVLNINT-ALRSLLRGHTQRVTDMAFfAEDVHRLASASVDGRIYVWKIDEGPDEQNKPQITGKIEiAI 306
Cdd:COG2319    217 KLLASGSADGTVRLWDLATgKLLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN-SV 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  307 QIVGDAETyhpricwhshkqeiLFVGVANCVLKIdttkvgrgMDFSREEPLKcpldklvdgvHLVGkHDADITDLSLSQW 386
Cdd:COG2319    295 AFSPDGKL--------------LASGSDDGTVRL--------WDLATGKLLR----------TLTG-HTGAVRSVAFSPD 341

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002278499  387 mTTRLASASKDGMVKIWDDRKSVPLSVLKPHDGqAVYSVSFltAPEHPQhinLITAGpLNREVKIW 452
Cdd:COG2319    342 -GKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAF--SPDGRT---LASGS-ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
178-476 2.00e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 2.00e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  178 RLLGPGDRAVHDVDSRLPGEAQPPQLEVTPITKYTSDPGLVLGRQIAVNRTYIVYGLKLGNIRVLNINT-ALRSLLRGHT 256
Cdd:COG2319     41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATgLLLRTLTGHT 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  257 QRVTDMAFfAEDVHRLASASVDGRIYVWKIDEGPDEQNKPQITGKIE-IAIqivgdaetyhpricwhSHKQEILFVGVAN 335
Cdd:COG2319    121 GAVRSVAF-SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTsVAF----------------SPDGKLLASGSDD 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  336 CVLKIDTTKVGRgmdfsreeplkcpldklvdGVHLVGKHDADITDLSLS---QWmttrLASASKDGMVKIWDDRKSVPLS 412
Cdd:COG2319    184 GTVRLWDLATGK-------------------LLRTLTGHTGAVRSVAFSpdgKL----LASGSADGTVRLWDLATGKLLR 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002278499  413 VLKPHDGqAVYSVSFltapeHPQHINLITAGpLNREVKIWastndegwllpsDSETWRCTQTLE 476
Cdd:COG2319    241 TLTGHSG-SVRSVAF-----SPDGRLLASGS-ADGTVRLW------------DLATGELLRTLT 285
WD40 COG2319
WD40 repeat [General function prediction only];
237-476 9.23e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 9.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  237 GNIRVLNINT-ALRSLLRGHTQRVTDMAFFAeDVHRLASASVDGRIYVWKIDEGPDEQNKPQITGKIEiaiqivgdaety 315
Cdd:COG2319    142 GTVRLWDLATgKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR------------ 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  316 hpRICWhSHKQEILFVGVANCVLKI---DTTKVgrgmdfsreeplkcpldklvdgVHLVGKHDADITDLSLS---QWmtt 389
Cdd:COG2319    209 --SVAF-SPDGKLLASGSADGTVRLwdlATGKL----------------------LRTLTGHSGSVRSVAFSpdgRL--- 260

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  390 rLASASKDGMVKIWDDRKSVPLSVLKPHDGqAVYSVSFltapeHPQHINLITAGpLNREVKIWastndegwllpsDSETW 469
Cdd:COG2319    261 -LASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAF-----SPDGKLLASGS-DDGTVRLW------------DLATG 320


                   ....*..
gi 1002278499  470 RCTQTLE 476
Cdd:COG2319    321 KLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
228-476 4.87e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 4.87e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  228 TYIVYGLKLGNIRVLNINT-ALRSLLRGHTQRVTDMAfFAEDVHRLASASVDGRIYVWKIDegpdeqnkpqiTGKIeiaI 306
Cdd:COG2319    175 KLLASGSDDGTVRLWDLATgKLLRTLTGHTGAVRSVA-FSPDGKLLASGSADGTVRLWDLA-----------TGKL---L 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  307 QIVGDAETYHPRICWhSHKQEILFVGVANCVLKI---DTTKVgrgmdfsreeplkcpldklvdgVHLVGKHDADITDLSL 383
Cdd:COG2319    240 RTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRLwdlATGEL----------------------LRTLTGHSGGVNSVAF 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  384 S---QWmttrLASASKDGMVKIWDDRKSVPLSVLKPHDGqAVYSVSFltapeHPQHINLITAGPlNREVKIWastndegw 460
Cdd:COG2319    297 SpdgKL----LASGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAF-----SPDGKTLASGSD-DGTVRLW-------- 357

                          250
                   ....*....|....*.
gi 1002278499  461 llpsDSETWRCTQTLE 476
Cdd:COG2319    358 ----DLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-453 1.49e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 1.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  207 PITKYTSDPGLVLGRQIAVNRTYIVYGLKLGNIRVLNINTA-LRSLLRGHTQRVTDmAFFAEDVHRLASASVDGRIYVWK 285
Cdd:cd00200     85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGkCLTTLRGHTDWVNS-VAFSPDGTFVASSSQDGTIKLWD 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  286 IDEGpdeqnKPQITgkieiaiqIVGdaetyH----PRICWHsHKQEILFVGVANCVLKIDTTKVGrgmdfsreeplKCpl 361
Cdd:cd00200    164 LRTG-----KCVAT--------LTG-----HtgevNSVAFS-PDGEKLLSSSSDGTIKLWDLSTG-----------KC-- 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002278499  362 dklvdgVHLVGKHDADITDLSlsqWMTTR--LASASKDGMVKIWDDRKSVPLSVLKPHDGqAVYSVSFltapeHPQHINL 439
Cdd:cd00200    212 ------LGTLRGHENGVNSVA---FSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTN-SVTSLAW-----SPDGKRL 276

                          250
                   ....*....|....
gi 1002278499  440 ITAGpLNREVKIWA 453
Cdd:cd00200    277 ASGS-ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
237-287 2.60e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 2.60e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1002278499  237 GNIRVLNINT-ALRSLLRGHTQRVTDMAFfAEDVHRLASASVDGRIYVWKID 287
Cdd:COG2319    352 GTVRLWDLATgELLRTLTGHTGAVTSVAF-SPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 252-285 3.62e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.62e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1002278499   252 LRGHTQRVTDMAFFaEDVHRLASASVDGRIYVWK 285
Cdd:smart00320    8 LKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
252-284 5.16e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 5.16e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1002278499  252 LRGHTQRVTDMAFfAEDVHRLASASVDGRIYVW 284
Cdd:pfam00400    7 LEGHTGSVTSLAF-SPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 374-404 7.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 7.26e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1002278499   374 HDADITDLSLSQwMTTRLASASKDGMVKIWD 404
Cdd:smart00320   11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 42-97 1.94e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 41.51  E-value: 1.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002278499   42 PAPAGIFP---------GAAAPAPHHGVVVPPPmtsgGGPYSYPPATPPFHRGPYLPPYPNDPHL 97
Cdd:pfam15822   62 PAPTGMYPsipltgpspGPPAPFPPSGPSCPPP----GGPYPAPTVPGPGPIGPYPTPNMPFPEL 122
WD40 pfam00400
WD domain, G-beta repeat;
374-404 2.28e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 2.28e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1002278499  374 HDADITDLSLSQwMTTRLASASKDGMVKIWD 404
Cdd:pfam00400   10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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