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Conserved domains on  [gi|1002281493|ref|XP_015645043|]
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reactive Intermediate Deaminase A, chloroplastic [Oryza sativa Japonica Group]

Protein Classification

RidA family protein( domain architecture ID 10794411)

RidA (reactive intermediate/imine deaminase A) family protein similar to 2-iminobutanoate/2-iminopropanoate deaminase, which catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia

CATH:  3.30.1330.40
PubMed:  14624641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 61-180 1.31e-62

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


:

Pssm-ID: 129116  Cd Length: 124  Bit Score: 189.43  E-value: 1.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  61 QTEKAPAALGPYSQAIKANNMVFVSGVLGLNPETGKFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDF 140
Cdd:TIGR00004   5 STDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDLNDF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1002281493 141 KKVNEIYAKYFPAPAPARSTYQVAALPLNARIEIECIAAL 180
Cdd:TIGR00004  85 AEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 61-180 1.31e-62

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 189.43  E-value: 1.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  61 QTEKAPAALGPYSQAIKANNMVFVSGVLGLNPETGKFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDF 140
Cdd:TIGR00004   5 STDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDLNDF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1002281493 141 KKVNEIYAKYFPAPAPARSTYQVAALPLNARIEIECIAAL 180
Cdd:TIGR00004  85 AEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 64-180 2.44e-51

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 160.73  E-value: 2.44e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  64 KAPAALGPYSQAIKANNMVFVSGVLGLNPETGKfVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKV 143
Cdd:COG0251     9 PAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDMADFAAV 87

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1002281493 144 NEIYAKYFPAPAPARSTYQVAALPLNARIEIECIAAL 180
Cdd:COG0251    88 NEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAAL 124
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 64-179 1.28e-50

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 158.62  E-value: 1.28e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  64 KAPAALGPYSQAIKANNMVFVSGVLGLNPETGKFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKV 143
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1002281493 144 NEIYAKYFPAP-APARSTYQVAALPLNARIEIECIAA 179
Cdd:pfam01042  81 NEVYAEYFDADkAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 72-178 1.11e-43

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 140.77  E-value: 1.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  72 YSQAIKANNMVFVSGVLGLNPETGkFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKVNEIYAKYF 151
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDPDGE-LVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                          90       100
                  ....*....|....*....|....*...
gi 1002281493 152 P-APAPARSTYQVAALPLNARIEIECIA 178
Cdd:cd00448    80 GeGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
61-178 9.81e-28

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 100.91  E-value: 9.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  61 QTEKAPAALGPYSQAIKANNMVFVSGVLGLNPETGKfVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDF 140
Cdd:PRK11401    6 ETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1002281493 141 KKVNEIYAKYF---PAPAPARSTYQVAALPLNARIEIECIA 178
Cdd:PRK11401   85 ATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIA 125
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 61-180 1.31e-62

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 189.43  E-value: 1.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  61 QTEKAPAALGPYSQAIKANNMVFVSGVLGLNPETGKFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDF 140
Cdd:TIGR00004   5 STDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDLNDF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1002281493 141 KKVNEIYAKYFPAPAPARSTYQVAALPLNARIEIECIAAL 180
Cdd:TIGR00004  85 AEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 64-180 2.44e-51

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 160.73  E-value: 2.44e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  64 KAPAALGPYSQAIKANNMVFVSGVLGLNPETGKfVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKV 143
Cdd:COG0251     9 PAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDMADFAAV 87

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1002281493 144 NEIYAKYFPAPAPARSTYQVAALPLNARIEIECIAAL 180
Cdd:COG0251    88 NEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAAL 124
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 64-179 1.28e-50

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 158.62  E-value: 1.28e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  64 KAPAALGPYSQAIKANNMVFVSGVLGLNPETGKFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKV 143
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1002281493 144 NEIYAKYFPAP-APARSTYQVAALPLNARIEIECIAA 179
Cdd:pfam01042  81 NEVYAEYFDADkAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 72-178 1.11e-43

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 140.77  E-value: 1.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  72 YSQAIKANNMVFVSGVLGLNPETGkFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKVNEIYAKYF 151
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDPDGE-LVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                          90       100
                  ....*....|....*....|....*...
gi 1002281493 152 P-APAPARSTYQVAALPLNARIEIECIA 178
Cdd:cd00448    80 GeGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
61-178 9.81e-28

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 100.91  E-value: 9.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  61 QTEKAPAALGPYSQAIKANNMVFVSGVLGLNPETGKfVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDF 140
Cdd:PRK11401    6 ETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1002281493 141 KKVNEIYAKYF---PAPAPARSTYQVAALPLNARIEIECIA 178
Cdd:PRK11401   85 ATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIA 125
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 72-178 2.29e-22

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 86.45  E-value: 2.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  72 YSQAIKANNMVFVSGVLGLNPETGkFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKVNEIYAKYF 151
Cdd:cd06154    13 YSRAVRVGNWVFVSGTTGYDYDGM-VMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAHGEVF 91

                          90       100
                  ....*....|....*....|....*...
gi 1002281493 152 PAPAPARSTYQVAALP-LNARIEIECIA 178
Cdd:cd06154    92 GDIRPAATMVVVSLLVdPEMLVEIEVTA 119
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 76-179 7.05e-19

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 76.91  E-value: 7.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  76 IKANNMVFVSGVlglnpeTGKFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKVNEIYAKYFPAPA 155
Cdd:cd06155     4 NRTGGLLWISNV------TASESDETVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPN 77

                          90       100
                  ....*....|....*....|....*.
gi 1002281493 156 P-ARSTyqVAA-LPLNARIEIECIAA 179
Cdd:cd06155    78 PpSRVC--VECgLPEGCDVQLSCVAA 101
RutC TIGR03610
pyrimidine utilization protein C; This protein is observed in operons extremely similar to ...
 66-178 1.82e-18

pyrimidine utilization protein C; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the endoribonuclease L-PSP family defined by pfam01042.


Pssm-ID: 274677  Cd Length: 127  Bit Score: 76.81  E-value: 1.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  66 PAALGPYSQAIKANNMVFVSGVLGLNPETGKFVSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKVNE 145
Cdd:TIGR03610  12 SKPLAPFVPGTLADGVVYVSGTLPFDKDNNVVHVGDAAAQTRHVLETIKSVIETAGGTMDDVTFNHIFIRDWADYAAINE 91

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1002281493 146 IYAKYFPAPAPARSTYQVAALPLNARIEIECIA 178
Cdd:TIGR03610  92 VYAEYFPGEKPARYCIQCGLVKPDALVEIASVA 124
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 72-179 2.10e-18

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 76.04  E-value: 2.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  72 YSQAIKANNMVFVSGVLGLNPetgkfvSESVEEQTEQVMKNMGEILKASGASYSSVVKTTIMLADLQDFKKVNEIYAKYF 151
Cdd:cd06150     3 MSQAVVHNGTVYLAGQVADDT------SADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWV 76

                          90       100
                  ....*....|....*....|....*....
gi 1002281493 152 PA-PAPARSTYQVAALPLNARIEIECIAA 179
Cdd:cd06150    77 PPgHAPARACVEAKLADPGYLVEIVVTAA 105
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 72-180 2.60e-17

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 73.45  E-value: 2.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  72 YSQAIKANNMVFVSGVLGLNPETGkfVSESVEEQTEQVMKNMGEILKASGASYSSVVK-TTIMLADLQDFKKVNEIYAKY 150
Cdd:cd02198     3 YSPAVRVGDTLFVSGQVGSDADGS--VAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVElTTFHVDMAAHLPAFAAVKDEY 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1002281493 151 FPAPAPARSTYQVAAL--PlNARIEIECIAAL 180
Cdd:cd02198    81 FKEPYPAWTAVGVAWLarP-GLLVEIKVVAVR 111
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 72-178 9.81e-15

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 66.56  E-value: 9.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  72 YSQAIKANNMVFVSGVLGLNPETGKFvSESVEEQTEQVMKNMGEILKASG-ASYSSVVKTTIMLADLQD---FKKVNEIY 147
Cdd:cd06152     3 YSQAVRIGDRIEISGQGGWDPDTGKI-PEDLEEEIDQAFDNVELALKAAGgKGWEQVYKVNSYHVDIKNeeaFGLMVENF 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1002281493 148 AKYFPAPAPARSTYQVAALPL-NARIEIECIA 178
Cdd:cd06152    82 KKWMPNHQPIWTCVGVTALGLpGMRVEIEVDA 113
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 81-178 1.05e-08

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 51.17  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  81 MVFVSGVLG--LNPETGKFVSESV---EEQTEQVMKNMGEILKASGASYSSVVKTTIML-ADLQ-----DFKKVNEIYAK 149
Cdd:cd06151    13 TIYLSGTVPavVNASAPKGSPARYgdtETQTISVLKRIETILQSQGLTMGDVVKMRVFLvADPAldgkmDFAGFMKAYRQ 92

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1002281493 150 YFPAPA----PARSTYQVAALPL-NARIEIECIA 178
Cdd:cd06151    93 FFGTAEqpnkPARSTLQVAGLVNpGWLVEIEVVA 126
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 72-178 2.40e-07

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 47.32  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  72 YSQAIKANNMVFVSGVLGLNPETGKFVSESVEEQTEQVMKNMGEILKASGAsySSVVKTTIMLADLQDFKKVNEIYAKYF 151
Cdd:cd06156     1 YSQAIVVPKVAYISGQIGLIPATMTLLEGGITLQAVLSLQHLERVAKAMNV--QWVLAAVCYVTDESSVPIARSAWSKYC 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1002281493 152 PAPAPARSTY-------------QVAALPLNARIEIECIA 178
Cdd:cd06156    79 SELDLEDESRnesddvnpplvivVVPELPRGALVEWQGIA 118
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 65-179 1.19e-05

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 42.83  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  65 APAALGPYSQAIKANNMVFVSGVL----GLNPETGKFVSE-SVEEQTE---QVMKNMGEILKASGASYS---SVVKTTIM 133
Cdd:cd02199     9 APAPVGNYVPAVRTGNLLYVSGQLprvdGKLVYTGKVGADlSVEEGQEaarLCALNALAALKAALGDLDrvkRVVRLTGF 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002281493 134 LADLQDFKK----VN---EIYAKYF-PAPAPARSTYQVAALPLNARIEIECIAA 179
Cdd:cd02199    89 VNSAPDFTEqpkvANgasDLLVEVFgEAGRHARSAVGVASLPLNAAVEVEAIVE 142
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 81-178 2.63e-04

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 38.78  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002281493  81 MVFVSGVLGLNPEtgkfvsESV-----EEQTEQVMKNMGEILKASGASYS-----SVVKTTIMLADLQDFKKVNEIYAKY 150
Cdd:cd06153    14 HLFISGTASIVGH------GTVhpgdvEAQTRETLENIEALLEAAGRGGGaqflaDLLRLKVYLRDREDLPAVRAILAAR 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1002281493 151 FPAPAPArsTYQVAALplnAR----IEIECIA 178
Cdd:cd06153    88 LGPAVPA--VFLQADV---CRpdllVEIEAVA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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