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Conserved domains on  [gi|1002224846|ref|XP_015645860|]
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uncharacterized WD repeat-containing protein C17D11.16 [Oryza sativa Japonica Group]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
211-475 1.23e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.36  E-value: 1.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 211 GNFVAVGTMDPAIEIWDLDIVDEVQphmVLGGHSkkkkkvkgkkakkykkgshrSSVLGLAWNKEvRNVLASASADKTVK 290
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGKLLR---TLTGHT--------------------GAVRSVAFSPD-GKLLASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 291 IWDVSVGKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMkDGGQSCNKWSVEAD-VESLAWDPHNEHsFMVS 369
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGgVNSVAFSPDGKL-LASG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 370 LENGMVQAFDKRTassnsnsGRPTFTLHAHEKAVSSISFSPsTPNFLATGSTDKMVKLWDLSNNQpsCIASLNPKLGAIF 449
Cdd:COG2319   307 SDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVT 376

                         250       260
                  ....*....|....*....|....*.
gi 1002224846 450 SVSFSNDSPfLLASGGSKGKLKVWNT 475
Cdd:COG2319   377 SVAFSPDGR-TLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
211-475 1.23e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.36  E-value: 1.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 211 GNFVAVGTMDPAIEIWDLDIVDEVQphmVLGGHSkkkkkvkgkkakkykkgshrSSVLGLAWNKEvRNVLASASADKTVK 290
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGKLLR---TLTGHT--------------------GAVRSVAFSPD-GKLLASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 291 IWDVSVGKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMkDGGQSCNKWSVEAD-VESLAWDPHNEHsFMVS 369
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGgVNSVAFSPDGKL-LASG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 370 LENGMVQAFDKRTassnsnsGRPTFTLHAHEKAVSSISFSPsTPNFLATGSTDKMVKLWDLSNNQpsCIASLNPKLGAIF 449
Cdd:COG2319   307 SDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVT 376

                         250       260
                  ....*....|....*....|....*.
gi 1002224846 450 SVSFSNDSPfLLASGGSKGKLKVWNT 475
Cdd:COG2319   377 SVAFSPDGR-TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 201-478 5.36e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 5.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 201 MDFNlkggDKGNFVAVGTMDPAIEIWDLDivdEVQPHMVLGGHSKKKkkvkgkkakkykkgshrSSVLGLAWNKEvrnvL 280
Cdd:cd00200    15 VAFS----PDGKLLATGSGDGTIKVWDLE---TGELLRTLKGHTGPV-----------------RDVAASADGTY----L 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 281 ASASADKTVKIWDVSVGKCAVTLEHHDDKVQSVAWSrQSPEVLLSGSFDKSVAMNDMKDGGQSCNKWSVEADVESLAWDP 360
Cdd:cd00200    67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 361 HNEHSFmVSLENGMVQAFDKRTassnsnsGRPTFTLHAHEKAVSSISFSPsTPNFLATGSTDKMVKLWDLSNnqPSCIAS 440
Cdd:cd00200   146 DGTFVA-SSSQDGTIKLWDLRT-------GKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST--GKCLGT 214

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1002224846 441 LNPKLGAIFSVSFSNDSpFLLASGGSKGKLKVWNTLTE 478
Cdd:cd00200   215 LRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTG 251
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 264-431 1.85e-16

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 82.44  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 264 RSSVLGLAWNKEVRNVLASASADKTVKIWDVSVGKCAVTLEHHDDKVQSVAWSRQSPEVLLSGSFDKSVAMNDMkDGGQS 343
Cdd:PLN00181  532 RSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVS 610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 344 CNKWSVEADVESLAWDPHNEHSFMVSLENGMVQAFDKRtassnsNSGRPTFTLHAHEKAVSSISFSPSTPnfLATGSTDK 423
Cdd:PLN00181  611 IGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLR------NPKLPLCTMIGHSKTVSYVRFVDSST--LVSSSTDN 682


                  ....*...
gi 1002224846 424 MVKLWDLS 431
Cdd:PLN00181  683 TLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 389-429 2.89e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.89e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1002224846  389 SGRPTFTLHAHEKAVSSISFSPSTpNFLATGSTDKMVKLWD 429
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
390-429 9.59e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 9.59e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1002224846 390 GRPTFTLHAHEKAVSSISFSPStPNFLATGSTDKMVKLWD 429
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
211-475 1.23e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.36  E-value: 1.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 211 GNFVAVGTMDPAIEIWDLDIVDEVQphmVLGGHSkkkkkvkgkkakkykkgshrSSVLGLAWNKEvRNVLASASADKTVK 290
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGKLLR---TLTGHT--------------------GAVRSVAFSPD-GKLLASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 291 IWDVSVGKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMkDGGQSCNKWSVEAD-VESLAWDPHNEHsFMVS 369
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGgVNSVAFSPDGKL-LASG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 370 LENGMVQAFDKRTassnsnsGRPTFTLHAHEKAVSSISFSPsTPNFLATGSTDKMVKLWDLSNNQpsCIASLNPKLGAIF 449
Cdd:COG2319   307 SDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVT 376

                         250       260
                  ....*....|....*....|....*.
gi 1002224846 450 SVSFSNDSPfLLASGGSKGKLKVWNT 475
Cdd:COG2319   377 SVAFSPDGR-TLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
211-482 3.11e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 3.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 211 GNFVAVGTMDPAIEIWDLDIVDEVQphmVLGGHSkkkkkvkgkkakkykkgshrSSVLGLAWNKEvRNVLASASADKTVK 290
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGKLLR---TLTGHS--------------------GAVTSVAFSPD-GKLLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 291 IWDVSVGKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMKDGGQSCNKWSVEADVESLAWDPHNEHsFMVSL 370
Cdd:COG2319   188 LWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL-LASGS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 371 ENGMVQAFDkrtassnSNSGRPTFTLHAHEKAVSSISFSPStPNFLATGSTDKMVKLWDLSNNQpsCIASLNPKLGAIFS 450
Cdd:COG2319   266 ADGTVRLWD-------LATGELLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRS 335

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1002224846 451 VSFSNDSPFLlASGGSKGKLKVWNTLTEPAVA 482
Cdd:COG2319   336 VAFSPDGKTL-ASGSDDGTVRLWDLATGELLR 366
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 201-478 5.36e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 5.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 201 MDFNlkggDKGNFVAVGTMDPAIEIWDLDivdEVQPHMVLGGHSKKKkkvkgkkakkykkgshrSSVLGLAWNKEvrnvL 280
Cdd:cd00200    15 VAFS----PDGKLLATGSGDGTIKVWDLE---TGELLRTLKGHTGPV-----------------RDVAASADGTY----L 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 281 ASASADKTVKIWDVSVGKCAVTLEHHDDKVQSVAWSrQSPEVLLSGSFDKSVAMNDMKDGGQSCNKWSVEADVESLAWDP 360
Cdd:cd00200    67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 361 HNEHSFmVSLENGMVQAFDKRTassnsnsGRPTFTLHAHEKAVSSISFSPsTPNFLATGSTDKMVKLWDLSNnqPSCIAS 440
Cdd:cd00200   146 DGTFVA-SSSQDGTIKLWDLRT-------GKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST--GKCLGT 214

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1002224846 441 LNPKLGAIFSVSFSNDSpFLLASGGSKGKLKVWNTLTE 478
Cdd:cd00200   215 LRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTG 251
WD40 COG2319
WD40 repeat [General function prediction only];
211-477 6.15e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 6.15e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 211 GNFVAVGTMDPAIEIWDldiVDEVQPHMVLGGHSkkkkkvkgkkakkykkgshrSSVLGLAWNKEVRnVLASASADKTVK 290
Cdd:COG2319    90 GRLLASASADGTVRLWD---LATGLLLRTLTGHT--------------------GAVRSVAFSPDGK-TLASGSADGTVR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 291 IWDVSVGKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMKDGGQSCNKWSVEADVESLAWDPHNEHsFMVSL 370
Cdd:COG2319   146 LWDLATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGS 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 371 ENGMVQAFDkrtassnSNSGRPTFTLHAHEKAVSSISFSPStPNFLATGSTDKMVKLWDLSNNQpsCIASLNPKLGAIFS 450
Cdd:COG2319   224 ADGTVRLWD-------LATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNS 293

                         250       260
                  ....*....|....*....|....*..
gi 1002224846 451 VSFSNDSPfLLASGGSKGKLKVWNTLT 477
Cdd:COG2319   294 VAFSPDGK-LLASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 262-482 7.45e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 7.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 262 SHRSSVLGLAWNkEVRNVLASASADKTVKIWDVSVGKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMKDGg 341
Cdd:cd00200     7 GHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETG- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 342 QSCNKW-SVEADVESLAWDPHNehSFMVSLengmvqAFDKRTASSNSNSGRPTFTLHAHEKAVSSISFSPsTPNFLATGS 420
Cdd:cd00200    84 ECVRTLtGHTSYVSSVAFSPDG--RILSSS------SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSS 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002224846 421 TDKMVKLWDLSNNqpSCIASLNPKLGAIFSVSFSNDSpFLLASGGSKGKLKVWNTLTEPAVA 482
Cdd:cd00200   155 QDGTIKLWDLRTG--KCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLG 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 209-429 1.05e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 1.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 209 DKGNFVAVGTMDPAIEIWDldiVDEVQPHMVLGGHSkkkkkvkgkkakkykkgshrSSVLGLAWNKEvRNVLASASADKT 288
Cdd:cd00200   103 PDGRILSSSSRDKTIKVWD---VETGKCLTTLRGHT--------------------DWVNSVAFSPD-GTFVASSSQDGT 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 289 VKIWDVSVGKCAVTLEHHDDKVQSVAWSRQSPEvLLSGSFDKSVAMNDMKDGGQSCNKWSVEADVESLAWDPHNEHsFMV 368
Cdd:cd00200   159 IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-LAS 236

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002224846 369 SLENGMVQAFDKRTassnsnsGRPTFTLHAHEKAVSSISFSPSTpNFLATGSTDKMVKLWD 429
Cdd:cd00200   237 GSEDGTIRVWDLRT-------GECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
211-432 1.41e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 1.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 211 GNFVAVGTMDPAIEIWDldiVDEVQPHMVLGGHSkkkkkvkgkkakkykkgshrSSVLGLAWNKEvRNVLASASADKTVK 290
Cdd:COG2319   216 GKLLASGSADGTVRLWD---LATGKLLRTLTGHS--------------------GSVRSVAFSPD-GRLLASGSADGTVR 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 291 IWDVSVGKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMKDGGQSCNKWSVEADVESLAWDPHNEHSFMVSl 370
Cdd:COG2319   272 LWDLATGELLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS- 349

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002224846 371 ENGMVQAFDKRTassnsnsGRPTFTLHAHEKAVSSISFSPSTpNFLATGSTDKMVKLWDLSN 432
Cdd:COG2319   350 DDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
279-482 8.65e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 8.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 279 VLASASADKTVKIWDVSVGKCAVTLEHHDDKVQSVAWSRqSPEVLLSGSFDKSVAMNDMKDGGQSCNKWSVEADVESLAW 358
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 359 DPhNEHSFMVSLENGMVQAFDKRTassnsnsGRPTFTLHAHEKAVSSISFSPSTpNFLATGSTDKMVKLWDLSNNQpsCI 438
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGK--LL 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002224846 439 ASLNPKLGAIFSVSFSNDSPfLLASGGSKGKLKVWNTLTEPAVA 482
Cdd:COG2319   198 RTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLR 240
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 299-483 1.17e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 1.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 299 CAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMKDGGQSCNKWSVEADVESLAWDPHNeHSFMVSLENGMVQAF 378
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 379 DKRTassnsnsGRPTFTLHAHEKAVSSISFSPSTPnFLATGSTDKMVKLWDLSNNQpsCIASLNPKLGAIFSVSFSNDSP 458
Cdd:cd00200    79 DLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGT 148

                         170       180
                  ....*....|....*....|....*
gi 1002224846 459 FlLASGGSKGKLKVWNTLTEPAVAN 483
Cdd:cd00200   149 F-VASSSQDGTIKLWDLRTGKCVAT 172
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 264-431 1.85e-16

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 82.44  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 264 RSSVLGLAWNKEVRNVLASASADKTVKIWDVSVGKCAVTLEHHDDKVQSVAWSRQSPEVLLSGSFDKSVAMNDMkDGGQS 343
Cdd:PLN00181  532 RSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVS 610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 344 CNKWSVEADVESLAWDPHNEHSFMVSLENGMVQAFDKRtassnsNSGRPTFTLHAHEKAVSSISFSPSTPnfLATGSTDK 423
Cdd:PLN00181  611 IGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLR------NPKLPLCTMIGHSKTVSYVRFVDSST--LVSSSTDN 682


                  ....*...
gi 1002224846 424 MVKLWDLS 431
Cdd:PLN00181  683 TLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 389-429 2.89e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.89e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1002224846  389 SGRPTFTLHAHEKAVSSISFSPSTpNFLATGSTDKMVKLWD 429
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
390-429 9.59e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 9.59e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1002224846 390 GRPTFTLHAHEKAVSSISFSPStPNFLATGSTDKMVKLWD 429
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 263-351 8.98e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.43  E-value: 8.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 263 HRSSVLGLAWNKEVRNVLASASADKTVKIWDVSVGKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSVAMNDMKDGGQ 342
Cdd:PTZ00421  124 HTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDG-SLLCTTSKDKKLNIIDPRDGTI 202


                  ....*....
gi 1002224846 343 SCnkwSVEA 351
Cdd:PTZ00421  203 VS---SVEA 208
PTZ00421 PTZ00421
coronin; Provisional
 350-430 3.15e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 3.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 350 EADVESLAWDPHNEHSFMVSLENGMVQAFDKRTASSNSNSGRPTFTLHAHEKAVSSISFSPSTPNFLATGSTDKMVKLWD 429
Cdd:PTZ00421   75 EGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWD 154


                  .
gi 1002224846 430 L 430
Cdd:PTZ00421  155 V 155
PTZ00420 PTZ00420
coronin; Provisional
 262-432 1.03e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 262 SHRSSVLGLAWNKEVRNVLASASADKTVKIWDV--------SVGKCAVTLEHHDDKVQSVAWSRQSPEVLLSGSFDKSVA 333
Cdd:PTZ00420   72 GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVN 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 334 MNDMKDGGQSCnKWSVEADVESLAWDPHNehsfmvSLENGMVQAFDKRTASSNSNSGRPTFTLHAHEKAVSSI---SFSP 410
Cdd:PTZ00420  152 IWDIENEKRAF-QINMPKKLSSLKWNIKG------NLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIwidGLGG 224

                         170       180
                  ....*....|....*....|....*
gi 1002224846 411 STPNFLATG-STDKM--VKLWDLSN 432
Cdd:PTZ00420  225 DDNYILSTGfSKNNMreMKLWDLKN 249
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 263-293 7.10e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 7.10e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1002224846  263 HRSSVLGLAWNKEvRNVLASASADKTVKIWD 293
Cdd:smart00320  11 HTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 329-474 9.18e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 9.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 329 DKSVAMNDMKDGGQ------------SCNKWSVEADVE------------SLAWDPHNEHsFMVSLENGMVQAFDkrtAS 384
Cdd:PLN00181  438 PPDFYINDSRQGGWidpfleglckylSFSKLRVKADLKqgdllnssnlvcAIGFDRDGEF-FATAGVNKKIKIFE---CE 513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 385 SNSNSGR----PTFTLHAHEKaVSSISFSPSTPNFLATGSTDKMVKLWDLSNNQpsCIASLNPKLGAIFSVSFSNDSPFL 460
Cdd:PLN00181  514 SIIKDGRdihyPVVELASRSK-LSGICWNSYIKSQVASSNFEGVVQVWDVARSQ--LVTEMKEHEKRVWSIDYSSADPTL 590

                         170
                  ....*....|....
gi 1002224846 461 LASGGSKGKLKVWN 474
Cdd:PLN00181  591 LASGSDDGSVKLWS 604
WD40 pfam00400
WD domain, G-beta repeat;
263-293 5.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.63e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1002224846 263 HRSSVLGLAWNKEvRNVLASASADKTVKIWD 293
Cdd:pfam00400  10 HTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 436-474 1.72e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.72e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1002224846  436 SCIASLNPKLGAIFSVSFSNDSPFLlASGGSKGKLKVWN 474
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 265-316 2.70e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1002224846 265 SSVLGLAWNKEvRNVLASASADKTVKIWDVSVGKCAVTLEHHDDKVQSVAWS 316
Cdd:pfam12894  39 LEVTSLAWRPD-GKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 297-332 4.30e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1002224846  297 GKCAVTLEHHDDKVQSVAWSRQSpEVLLSGSFDKSV 332
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTI 36
Nup160 pfam11715
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ...
 277-355 5.55e-03

Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.


Pssm-ID: 432020 [Multi-domain]  Cd Length: 540  Bit Score: 39.37  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224846 277 RNVLASASADKTVKIWDVSVGKCAVT--LEHHDDKVQSVAWSRQSPE----VLLSGSFDKSVAMNDMKDGGQSCNKWSVE 350
Cdd:pfam11715 234 QNFLFTLSLDHTLRVWDLLTGKCLATidLLDLELPQDSSSWLTLDPApsslIRVSGSFRAYLVLTYSPSSNGQFKFWKVK 313


                  ....*
gi 1002224846 351 ADVES 355
Cdd:pfam11715 314 SNDTS 318
WD40 pfam00400
WD domain, G-beta repeat;
297-332 8.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 8.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1002224846 297 GKCAVTLEHHDDKVQSVAWSrQSPEVLLSGSFDKSV 332
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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