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Conserved domains on  [gi|1002283555|ref|XP_015646101|]
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uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 502)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 28-89 1.39e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 37.91  E-value: 1.39e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002283555  28 RFKAWLMHFDGDGDEHISRRELRDAIRSGGARF--ATVRAWVNLYlaDKNRNGVIDDGEIKHLM 89
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLseEEIDEMIREV--DKDGDGKIDFEEFLELM 62
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 28-89 1.39e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 37.91  E-value: 1.39e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002283555  28 RFKAWLMHFDGDGDEHISRRELRDAIRSGGARF--ATVRAWVNLYlaDKNRNGVIDDGEIKHLM 89
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLseEEIDEMIREV--DKDGDGKIDFEEFLELM 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
18-89 2.29e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 36.31  E-value: 2.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002283555  18 AAAAAKERLDRFKAWLMHFDGDGDEHISRRELRDAIRSGGARFATVRAWVNlyLADKNRNGVIDDGEIKHLM 89
Cdd:COG5126    60 ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEADELFA--RLDTDGDGKISFEEFVAAV 129
EF-hand_6 pfam13405
EF-hand domain;
28-57 2.86e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 33.69  E-value: 2.86e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1002283555  28 RFKAWLMHFDGDGDEHISRRELRDAIRSGG 57
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSLG 30
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 28-89 1.39e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 37.91  E-value: 1.39e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002283555  28 RFKAWLMHFDGDGDEHISRRELRDAIRSGGARF--ATVRAWVNLYlaDKNRNGVIDDGEIKHLM 89
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLseEEIDEMIREV--DKDGDGKIDFEEFLELM 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
18-89 2.29e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 36.31  E-value: 2.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002283555  18 AAAAAKERLDRFKAWLMHFDGDGDEHISRRELRDAIRSGGARFATVRAWVNlyLADKNRNGVIDDGEIKHLM 89
Cdd:COG5126    60 ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEADELFA--RLDTDGDGKISFEEFVAAV 129
EF-hand_6 pfam13405
EF-hand domain;
28-57 2.86e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 33.69  E-value: 2.86e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1002283555  28 RFKAWLMHFDGDGDEHISRRELRDAIRSGG 57
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSLG 30
EFh_PEF_ALG-2_like cd16185
EF-hand, calcium binding motif, found in homologs of mammalian apoptosis-linked gene 2 protein ...
 30-88 9.85e-03

EF-hand, calcium binding motif, found in homologs of mammalian apoptosis-linked gene 2 protein (ALG-2); The family includes some homologs of mammalian apoptosis-linked gene 2 protein (ALG-2) mainly found in lower eukaryotes, such as a parasitic protist Leishmarua major and a cellular slime mold Dictyostelium discoideum. These homologs contains five EF-hand motifs. Due to the presence of unfavorable residues at the Ca2+-coordinating positions, their non-canonical EF4 and EF5 hands may not bind Ca2+. Two Dictyostelium PEF proteins are the prototypes of this family. They may bind to cytoskeletal proteins and/or signal-transducing proteins localized to detergent-resistant membranes named lipid rafts, and occur as monomers or weak homo- or heterodimers like ALG-2. They can serve as a mediator for Ca2+ signaling-related Dictyostehum programmed cell death (PCD).


Pssm-ID: 320060 [Multi-domain]  Cd Length: 163  Bit Score: 34.50  E-value: 9.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002283555  30 KAWLMHFDGDGDEHISRRELRDAIRSGGARF--ATVRAWVNLYlaDKNRNGVIDDGEIKHL 88
Cdd:cd16185     3 RQWFRAVDRDRSGSIDVNELQKALAGGGLLFslATAEKLIRMF--DRDGNGTIDFEEFAAL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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