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Conserved domains on  [gi|1002284185|ref|XP_015646417|]
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SNF2 domain-containing protein CLASSY 1 [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 753-1015 2.94e-94

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 302.67  E-value: 2.94e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAGSiqvegmDNSNVSTGGCVIAHTPGSGKTLLLISFLVSYMKAHPR-SRPLVLTPKAAIHTWKR 831
Cdd:cd18007      1 LKPHQVEGVRFLWSNLVGT------DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNWED 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  832 EFEKWGIS--LPLHVFHHANRSGKPLGamdsklrsllnnfhrptwtnmrlmdSLDKLFKWHAHPSVLLMTYSSFLGMTKQ 909
Cdd:cd18007     75 EFKKWLPPdlRPLLVLVSLSASKRADA-------------------------RLRKINKWHKEGGVLLIGYELFRNLASN 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  910 DSKVRNRYREFIAEVLMNNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIG-- 987
Cdd:cd18007    130 ATTDPRLKQEFIAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGtl 209

                          250       260
                   ....*....|....*....|....*....
gi 1002284185  988 -DIMSELVPERKRETVGRRAKHQEAVARR 1015
Cdd:cd18007    210 kEFKKKFVKPIEAGQCVDSTEEDVRLMLK 238
HepA super family cl33945
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 747-1277 8.99e-48

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


The actual alignment was detected with superfamily member COG0553:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 183.12  E-value: 8.99e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  747 SDLDPKLLPHQRKALDFLWKNlagsiqvegmdnSNVSTGGCvIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAI 826
Cdd:COG0553    236 AGLKATLRPYQLEGAAWLLFL------------RRLGLGGL-LADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLV 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  827 HTWKREFEKWGISLPLHVFHhanrsgkplgamDSKLRSLLNNFhrptwtnmrlmdsldklfkWHAHPsVLLMTYSSFLgm 906
Cdd:COG0553    303 GNWQRELAKFAPGLRVLVLD------------GTRERAKGANP-------------------FEDAD-LVITSYGLLR-- 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  907 tkqdskvrnRYREFIAEVlmnNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFI 986
Cdd:COG0553    349 ---------RDIELLAAV---DWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLL 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  987 GDimselvperkretvgrrakhqeavaRRAFVEKVGQKIESDNKhirsDGISLLNKLTRGFIDSF---EGAKliNLPGIH 1063
Cdd:COG0553    417 GS-------------------------LKAFRERFARPIEKGDE----EALERLRRLLRPFLLRRtkeDVLK--DLPEKT 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1064 VYTVFMKPTDIQEEMLAKVT--MPKLGSSRFPLEVELLItigsihpwLIKTTK---AVStffSPAEVKK-VERYKRDFAa 1137
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLeyLRRELEGAEGIRRRGLI--------LAALTRlrqICS---HPALLLEeGAELSGRSA- 533

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1138 gcKAKFVIDLLHKSSFRGERVLIFCHNVSPITFLVKLIEmvfgwRLGEEVLVLQGDQELPVRSDVMDKFNGDSAGKrkVL 1217
Cdd:COG0553    534 --KLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLE-----ERGIEYAYLHGGTSAEERDELVDRFQEGPEAP--VF 604

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1218 IASTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRGQERTVYVYLLVASGTWEE 1277
Cdd:COG0553    605 LISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEE 664
SAWADEE super family cl25066
SAWADEE domain; The SAWADEE domain, found in plant homeobox proteins, has a pair of tandem ...
 23-127 3.09e-03

SAWADEE domain; The SAWADEE domain, found in plant homeobox proteins, has a pair of tandem tudor-like folds that bind chromatin.


The actual alignment was detected with superfamily member pfam16719:

Pssm-ID: 465246  Cd Length: 126  Bit Score: 39.19  E-value: 3.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   23 DGSWHGVNcIRIRNGNLFVKFIYSGSTVEHNVD-GDCLRLRSRRATCSDCSNVlKPGVDVCvqsshtpeASSQGGTNAsv 101
Cdd:pfam16719   12 DGAWYDVR-VFLQHRALRVRFEGFGEEEDEWVNvRKRFRERSIPLEDSECRKV-RVGDLVC--------CFQEGGDDA-- 79

                           90       100
                   ....*....|....*....|....*...
gi 1002284185  102 lLRHDARLITI-KKNHQ-EDKCLCLFVV 127
Cdd:pfam16719   80 -LYYDAVVVEIqRKRHDiVEGCRCTFVV 106
 
Name Accession Description Interval E-value
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 753-1015 2.94e-94

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 302.67  E-value: 2.94e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAGSiqvegmDNSNVSTGGCVIAHTPGSGKTLLLISFLVSYMKAHPR-SRPLVLTPKAAIHTWKR 831
Cdd:cd18007      1 LKPHQVEGVRFLWSNLVGT------DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNWED 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  832 EFEKWGIS--LPLHVFHHANRSGKPLGamdsklrsllnnfhrptwtnmrlmdSLDKLFKWHAHPSVLLMTYSSFLGMTKQ 909
Cdd:cd18007     75 EFKKWLPPdlRPLLVLVSLSASKRADA-------------------------RLRKINKWHKEGGVLLIGYELFRNLASN 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  910 DSKVRNRYREFIAEVLMNNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIG-- 987
Cdd:cd18007    130 ATTDPRLKQEFIAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGtl 209

                          250       260
                   ....*....|....*....|....*....
gi 1002284185  988 -DIMSELVPERKRETVGRRAKHQEAVARR 1015
Cdd:cd18007    210 kEFKKKFVKPIEAGQCVDSTEEDVRLMLK 238
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 747-1277 8.99e-48

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 183.12  E-value: 8.99e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  747 SDLDPKLLPHQRKALDFLWKNlagsiqvegmdnSNVSTGGCvIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAI 826
Cdd:COG0553    236 AGLKATLRPYQLEGAAWLLFL------------RRLGLGGL-LADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLV 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  827 HTWKREFEKWGISLPLHVFHhanrsgkplgamDSKLRSLLNNFhrptwtnmrlmdsldklfkWHAHPsVLLMTYSSFLgm 906
Cdd:COG0553    303 GNWQRELAKFAPGLRVLVLD------------GTRERAKGANP-------------------FEDAD-LVITSYGLLR-- 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  907 tkqdskvrnRYREFIAEVlmnNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFI 986
Cdd:COG0553    349 ---------RDIELLAAV---DWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLL 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  987 GDimselvperkretvgrrakhqeavaRRAFVEKVGQKIESDNKhirsDGISLLNKLTRGFIDSF---EGAKliNLPGIH 1063
Cdd:COG0553    417 GS-------------------------LKAFRERFARPIEKGDE----EALERLRRLLRPFLLRRtkeDVLK--DLPEKT 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1064 VYTVFMKPTDIQEEMLAKVT--MPKLGSSRFPLEVELLItigsihpwLIKTTK---AVStffSPAEVKK-VERYKRDFAa 1137
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLeyLRRELEGAEGIRRRGLI--------LAALTRlrqICS---HPALLLEeGAELSGRSA- 533

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1138 gcKAKFVIDLLHKSSFRGERVLIFCHNVSPITFLVKLIEmvfgwRLGEEVLVLQGDQELPVRSDVMDKFNGDSAGKrkVL 1217
Cdd:COG0553    534 --KLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLE-----ERGIEYAYLHGGTSAEERDELVDRFQEGPEAP--VF 604

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1218 IASTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRGQERTVYVYLLVASGTWEE 1277
Cdd:COG0553    605 LISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEE 664
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 1132-1270 3.80e-29

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 113.73  E-value: 3.80e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1132 KRDFAAGCKAKFVIDLLHKSSFRGERVLIFCHNVSPItflvKLIEMVFGWRlGEEVLVLQGDQELPVRSDVMDKFNGDSa 1211
Cdd:cd18793      4 KIEEVVSGKLEALLELLEELREPGEKVLIFSQFTDTL----DILEEALRER-GIKYLRLDGSTSSKERQKLVDRFNEDP- 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002284185 1212 gKRKVLIASTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRGQERTVYVYLLV 1270
Cdd:cd18793     78 -DIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 756-1077 2.23e-22

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 98.91  E-value: 2.23e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  756 HQRKALDFLWKNLAGSIQvegmdnsnvstgGCVIAHTPGSGKTLLLISFL--VSYMKAHPRSRPLVLTPKAAIHTWKREF 833
Cdd:pfam00176    1 YQIEGVNWMLSLENNLGR------------GGILADEMGLGKTLQTISLLlyLKHVDKNWGGPTLIVVPLSLLHNWMNEF 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  834 EKWGISLPLHVFhhanrsgkPLGAMDSKLRSLLNNFHRPTWTNmrlmdsldklfkwhahpsVLLMTYSSFLgmtkqdskv 913
Cdd:pfam00176   69 ERWVSPPALRVV--------VLHGNKRPQERWKNDPNFLADFD------------------VVITTYETLR--------- 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  914 rnRYREFIAEVlmnNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIGDImsel 993
Cdd:pfam00176  114 --KHKELLKKV---HWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSL---- 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  994 vperkretvgrrakhqeavarRAFVEKVGQKIESdnkHIRSDGISLLNKLTRGFIdsFEGAKLI---NLPGIHVYTVFMK 1070
Cdd:pfam00176  185 ---------------------STFRNWFDRPIER---GGGKKGVSRLHKLLKPFL--LRRTKKDvekSLPPKVEYILFCR 238


                   ....*..
gi 1002284185 1071 PTDIQEE 1077
Cdd:pfam00176  239 LSKLQRK 245
DEXDc smart00487
DEAD-like helicases superfamily;
751-986 1.80e-17

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 82.15  E-value: 1.80e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   751 PKLLPHQRKALDFLWKNLagsiqvegmdnsnvstGGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTP-KAAIHTW 829
Cdd:smart00487    7 EPLRPYQKEAIEALLSGL----------------RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQW 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   830 KREFEKWGISLPLHVfhHANRSGKPLGAMDSKLRSllnnfhrptwtnmrlmdsldklfkwhAHPSVLLMTYSSFLGMTKQ 909
Cdd:smart00487   71 AEELKKLGPSLGLKV--VGLYGGDSKREQLRKLES--------------------------GKTDILVTTPGRLLDLLEN 122

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   910 DSKVRNRYRefiaevlmnnpgLLILDEGHN--PRSNKSKLRKLLMKV-KTEFRILLSGTAfqNNFEEYFNTLCLARPRFI 986
Cdd:smart00487  123 DKLSLSNVD------------LVILDEAHRllDGGFGDQLEKLLKLLpKNVQLLLLSATP--PEEIENLLELFLNDPVFI 188
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 1140-1259 8.49e-17

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 77.25  E-value: 8.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1140 KAKFVIDLLHKSsfRGERVLIFCHNVSpitflvKLIEMVFGWRLGEEVLVLQGDQELPVRSDVMDKFNgdsAGKRKVLIA 1219
Cdd:pfam00271    2 KLEALLELLKKE--RGGKVLIFSQTKK------TLEAELLLEKEGIKVARLHGDLSQEEREEILEDFR---KGKIDVLVA 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1002284185 1220 sTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRG 1259
Cdd:pfam00271   71 -TDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
1182-1259 7.76e-11

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 59.53  E-value: 7.76e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002284185  1182 RLGEEVLVLQGDQELPVRSDVMDKFNgdsAGKRKVLIAsTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRG 1259
Cdd:smart00490    9 ELGIKVARLHGGLSQEEREEILDKFN---NGKIKVLVA-TDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 932-1278 2.87e-09

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 61.74  E-value: 2.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  932 LILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIGDImselvperkrETvgrrakhqea 1011
Cdd:PLN03142   295 IIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA----------ET---------- 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1012 varraFVEKVGQKIESDNKHIrsdgISLLNKLTRGF-IDSFEGAKLINLPgihvytvfmkPtdiQEEMLAKVTMPKL--- 1087
Cdd:PLN03142   355 -----FDEWFQISGENDQQEV----VQQLHKVLRPFlLRRLKSDVEKGLP----------P---KKETILKVGMSQMqkq 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1088 ----------------GSSRFPLEVELLITIGSIHPWLIKTTKAVSTFFSPAEVkkVERykrdfaAGckaKFVI--DLLH 1149
Cdd:PLN03142   413 yykallqkdldvvnagGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGEHL--VEN------SG---KMVLldKLLP 481

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1150 KSSFRGERVLIFchnvSPITFLVKLIEMVFGWRlGEEVLVLQGDQELPVRSDVMDKFNGDSAGKRkVLIASTTACAEGIS 1229
Cdd:PLN03142   482 KLKERDSRVLIF----SQMTRLLDILEDYLMYR-GYQYCRIDGNTGGEDRDASIDAFNKPGSEKF-VFLLSTRAGGLGIN 555

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1002284185 1230 LTGASRLVMLDSEWNHSKTRQAIARAFRRGQERTVYVYLLVASGTWEEE 1278
Cdd:PLN03142   556 LATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEK 604
SAWADEE pfam16719
SAWADEE domain; The SAWADEE domain, found in plant homeobox proteins, has a pair of tandem ...
 23-127 3.09e-03

SAWADEE domain; The SAWADEE domain, found in plant homeobox proteins, has a pair of tandem tudor-like folds that bind chromatin.


Pssm-ID: 465246  Cd Length: 126  Bit Score: 39.19  E-value: 3.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   23 DGSWHGVNcIRIRNGNLFVKFIYSGSTVEHNVD-GDCLRLRSRRATCSDCSNVlKPGVDVCvqsshtpeASSQGGTNAsv 101
Cdd:pfam16719   12 DGAWYDVR-VFLQHRALRVRFEGFGEEEDEWVNvRKRFRERSIPLEDSECRKV-RVGDLVC--------CFQEGGDDA-- 79

                           90       100
                   ....*....|....*....|....*...
gi 1002284185  102 lLRHDARLITI-KKNHQ-EDKCLCLFVV 127
Cdd:pfam16719   80 -LYYDAVVVEIqRKRHDiVEGCRCTFVV 106
 
Name Accession Description Interval E-value
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 753-1015 2.94e-94

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 302.67  E-value: 2.94e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAGSiqvegmDNSNVSTGGCVIAHTPGSGKTLLLISFLVSYMKAHPR-SRPLVLTPKAAIHTWKR 831
Cdd:cd18007      1 LKPHQVEGVRFLWSNLVGT------DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNWED 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  832 EFEKWGIS--LPLHVFHHANRSGKPLGamdsklrsllnnfhrptwtnmrlmdSLDKLFKWHAHPSVLLMTYSSFLGMTKQ 909
Cdd:cd18007     75 EFKKWLPPdlRPLLVLVSLSASKRADA-------------------------RLRKINKWHKEGGVLLIGYELFRNLASN 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  910 DSKVRNRYREFIAEVLMNNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIG-- 987
Cdd:cd18007    130 ATTDPRLKQEFIAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGtl 209

                          250       260
                   ....*....|....*....|....*....
gi 1002284185  988 -DIMSELVPERKRETVGRRAKHQEAVARR 1015
Cdd:cd18007    210 kEFKKKFVKPIEAGQCVDSTEEDVRLMLK 238
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 747-1277 8.99e-48

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 183.12  E-value: 8.99e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  747 SDLDPKLLPHQRKALDFLWKNlagsiqvegmdnSNVSTGGCvIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAI 826
Cdd:COG0553    236 AGLKATLRPYQLEGAAWLLFL------------RRLGLGGL-LADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLV 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  827 HTWKREFEKWGISLPLHVFHhanrsgkplgamDSKLRSLLNNFhrptwtnmrlmdsldklfkWHAHPsVLLMTYSSFLgm 906
Cdd:COG0553    303 GNWQRELAKFAPGLRVLVLD------------GTRERAKGANP-------------------FEDAD-LVITSYGLLR-- 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  907 tkqdskvrnRYREFIAEVlmnNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFI 986
Cdd:COG0553    349 ---------RDIELLAAV---DWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLL 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  987 GDimselvperkretvgrrakhqeavaRRAFVEKVGQKIESDNKhirsDGISLLNKLTRGFIDSF---EGAKliNLPGIH 1063
Cdd:COG0553    417 GS-------------------------LKAFRERFARPIEKGDE----EALERLRRLLRPFLLRRtkeDVLK--DLPEKT 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1064 VYTVFMKPTDIQEEMLAKVT--MPKLGSSRFPLEVELLItigsihpwLIKTTK---AVStffSPAEVKK-VERYKRDFAa 1137
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLeyLRRELEGAEGIRRRGLI--------LAALTRlrqICS---HPALLLEeGAELSGRSA- 533

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1138 gcKAKFVIDLLHKSSFRGERVLIFCHNVSPITFLVKLIEmvfgwRLGEEVLVLQGDQELPVRSDVMDKFNGDSAGKrkVL 1217
Cdd:COG0553    534 --KLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLE-----ERGIEYAYLHGGTSAEERDELVDRFQEGPEAP--VF 604

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1218 IASTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRGQERTVYVYLLVASGTWEE 1277
Cdd:COG0553    605 LISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEE 664
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 753-986 1.30e-33

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 128.07  E-value: 1.30e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAGsiqvegmdnsnvsTGGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRP-LVLTPKAAIHTWKR 831
Cdd:cd17919      1 LRPYQLEGLNFLLELYEN-------------GPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPvLVVCPLSVLENWER 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  832 EFEKWGISLPLHVFHHANRSGKPLGAMDSKLRsllnnFHrptwtnmrlmdsldklfkwhahpsVLLMTYSSFLGMTKQDS 911
Cdd:cd17919     68 EFEKWTPDLRVVVYHGSQRERAQIRAKEKLDK-----FD------------------------VVLTTYETLRRDKASLR 118

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002284185  912 KVRnryrefiaevlmnnPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFI 986
Cdd:cd17919    119 KFR--------------WDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 1132-1270 3.80e-29

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 113.73  E-value: 3.80e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1132 KRDFAAGCKAKFVIDLLHKSSFRGERVLIFCHNVSPItflvKLIEMVFGWRlGEEVLVLQGDQELPVRSDVMDKFNGDSa 1211
Cdd:cd18793      4 KIEEVVSGKLEALLELLEELREPGEKVLIFSQFTDTL----DILEEALRER-GIKYLRLDGSTSSKERQKLVDRFNEDP- 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002284185 1212 gKRKVLIASTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRGQERTVYVYLLV 1270
Cdd:cd18793     78 -DIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 753-987 2.97e-26

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 108.36  E-value: 2.97e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLagsiqVEGMDNSNVSTG-GCVIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAIHTWKR 831
Cdd:cd18069      1 LKPHQIGGIRFLYDNI-----IESLERYKGSSGfGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  832 EFEKWgisLPlhvfhhanrsgKPLGAMDSKLRS----LLNNFHRPTWTNMRLMDsldklfKWHAHPSVLLMTYSSFlgmt 907
Cdd:cd18069     76 EFNKW---LP-----------PPEALPNVRPRPfkvfILNDEHKTTAARAKVIE------DWVKDGGVLLMGYEMF---- 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  908 kqdskvRNRyrefiaevlmNNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIG 987
Cdd:cd18069    132 ------RLR----------PGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLG 195
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 753-989 1.03e-24

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 104.29  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAGsiqvegmdNSNVSTGGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRP-----LVLTPKAAIH 827
Cdd:cd18004      1 LRPHQREGVQFLYDCLTG--------RRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPYGKPtakkaLIVCPSSLVG 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  828 TWKREFEKWgisLPLHVFHHANRSGKPLGAMDSKLRSllnnFHRPTWtnmrlmdsldklfkwhahpSVLLMTYSSFLgmt 907
Cdd:cd18004     73 NWKAEFDKW---LGLRRIKVVTADGNAKDVKASLDFF----SSASTY-------------------PVLIISYETLR--- 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  908 kqdsKVRNRYREFIAevlmnnPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIG 987
Cdd:cd18004    124 ----RHAEKLSKKIS------IDLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILG 193


                   ..
gi 1002284185  988 DI 989
Cdd:cd18004    194 SL 195
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 753-989 1.48e-24

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 104.20  E-value: 1.48e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWknlagSIQVEGMDNSNVSTG-GCVIAHTPGSGKTLLLISFLVSYM---KAHPRSRPLVLTPKAAIHT 828
Cdd:cd18068      1 LKPHQVDGVQFMW-----DCCCESLKKTKKSPGsGCILAHCMGLGKTLQVVTFLHTVLlceKLENFSRVLVVCPLNTVLN 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  829 WKREFEKWGislplhvfhhanrsgKPLGAMDSKLRSLLNNFHRPTwtnmrlmDSLDKLFKWHAHPSVLLMTYSSFLGMTK 908
Cdd:cd18068     76 WLNEFEKWQ---------------EGLKDEEKIEVNELATYKRPQ-------ERSYKLQRWQEEGGVMIIGYDMYRILAQ 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  909 QDS-KVRNRYREFIAEVLMN-NPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFI 986
Cdd:cd18068    134 ERNvKSREKLKEIFNKALVDpGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLL 213


                   ...
gi 1002284185  987 GDI 989
Cdd:cd18068    214 GTI 216
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 753-979 8.90e-24

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 101.29  E-value: 8.90e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWK---NLAGSIQVEGMdnsnvstggcviahtpGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAIHTW 829
Cdd:cd18001      1 LYPHQREGVAWLWSlhdGGKGGILADDM----------------GLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHW 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  830 KREFEKWGISLPLHVFHHANRSGKplgamDSKLRSLLNNFhrptwtnmrlmdsldklfkwhahpSVLLMTYSSFLGMTKQ 909
Cdd:cd18001     65 VKEFAKWTPGLRVKVFHGTSKKER-----ERNLERIQRGG------------------------GVLLTTYGMVLSNTEQ 115

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002284185  910 DSKvrNRYREFIAEvlmnnpgLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEY---FNTLC 979
Cdd:cd18001    116 LSA--DDHDEFKWD-------YVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELwalFDFAC 179
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 756-1077 2.23e-22

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 98.91  E-value: 2.23e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  756 HQRKALDFLWKNLAGSIQvegmdnsnvstgGCVIAHTPGSGKTLLLISFL--VSYMKAHPRSRPLVLTPKAAIHTWKREF 833
Cdd:pfam00176    1 YQIEGVNWMLSLENNLGR------------GGILADEMGLGKTLQTISLLlyLKHVDKNWGGPTLIVVPLSLLHNWMNEF 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  834 EKWGISLPLHVFhhanrsgkPLGAMDSKLRSLLNNFHRPTWTNmrlmdsldklfkwhahpsVLLMTYSSFLgmtkqdskv 913
Cdd:pfam00176   69 ERWVSPPALRVV--------VLHGNKRPQERWKNDPNFLADFD------------------VVITTYETLR--------- 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  914 rnRYREFIAEVlmnNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIGDImsel 993
Cdd:pfam00176  114 --KHKELLKKV---HWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSL---- 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  994 vperkretvgrrakhqeavarRAFVEKVGQKIESdnkHIRSDGISLLNKLTRGFIdsFEGAKLI---NLPGIHVYTVFMK 1070
Cdd:pfam00176  185 ---------------------STFRNWFDRPIER---GGGKKGVSRLHKLLKPFL--LRRTKKDvekSLPPKVEYILFCR 238


                   ....*..
gi 1002284185 1071 PTDIQEE 1077
Cdd:pfam00176  239 LSKLQRK 245
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 753-988 1.85e-20

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 92.15  E-value: 1.85e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNlagsiqVEGMDNSNVStgGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRP-----LVLTPKAAIH 827
Cdd:cd18067      1 LRPHQREGVKFLYRC------VTGRRIRGSH--GCIMADEMGLGKTLQCITLMWTLLRQSPQCKPeidkaIVVSPSSLVK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  828 TWKREFEKW--GISLPLHVfhhanrSGKPLGAMDSKLRSllnnfhrptWTNMRLMdsldklfkwHAHPSVLLMTYSSFLG 905
Cdd:cd18067     73 NWANELGKWlgGRLQPLAI------DGGSKKEIDRKLVQ---------WASQQGR---------RVSTPVLIISYETFRL 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  906 MtkqdskvrnryrefiAEVLMNNP-GLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPR 984
Cdd:cd18067    129 H---------------VEVLQKGEvGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPG 193


                   ....
gi 1002284185  985 FIGD 988
Cdd:cd18067    194 ILGT 197
DEXDc smart00487
DEAD-like helicases superfamily;
751-986 1.80e-17

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 82.15  E-value: 1.80e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   751 PKLLPHQRKALDFLWKNLagsiqvegmdnsnvstGGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTP-KAAIHTW 829
Cdd:smart00487    7 EPLRPYQKEAIEALLSGL----------------RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQW 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   830 KREFEKWGISLPLHVfhHANRSGKPLGAMDSKLRSllnnfhrptwtnmrlmdsldklfkwhAHPSVLLMTYSSFLGMTKQ 909
Cdd:smart00487   71 AEELKKLGPSLGLKV--VGLYGGDSKREQLRKLES--------------------------GKTDILVTTPGRLLDLLEN 122

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   910 DSKVRNRYRefiaevlmnnpgLLILDEGHN--PRSNKSKLRKLLMKV-KTEFRILLSGTAfqNNFEEYFNTLCLARPRFI 986
Cdd:smart00487  123 DKLSLSNVD------------LVILDEAHRllDGGFGDQLEKLLKLLpKNVQLLLLSATP--PEEIENLLELFLNDPVFI 188
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 753-1034 2.92e-17

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 82.81  E-value: 2.92e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAGSiqvegmdnsnvstGGCVIAHTPGSGKTLLLISFLVS-----------------YMKAHPRS 815
Cdd:cd18005      1 LRDYQREGVEFMYDLYKNG-------------RGGILGDDMGLGKTVQVIAFLAAvlgktgtrrdrennrprFKKKPPAS 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  816 RP----LVLTPKAAIHTWKREFEKWGiSLPLHVFHHANRSGKPLGAMDSklrsllnnfhrptwtnmRLMDsldklfkwha 891
Cdd:cd18005     68 SAkkpvLIVAPLSVLYNWKDELDTWG-HFEVGVYHGSRKDDELEGRLKA-----------------GRLE---------- 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  892 hpsVLLMTYSSFlgmtkqdskvrnryREFIAEVLMNNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNF 971
Cdd:cd18005    120 ---VVVTTYDTL--------------RRCIDSLNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNM 182

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002284185  972 EEYFNTLCLARPRFIGDImselvpERKRETVGRRAKH-QEAVARRAFVEKvGQKIESDNKHIRS 1034
Cdd:cd18005    183 KELWCLLDWAVPGALGSR------SQFKKHFSEPIKRgQRHTATARELRL-GRKRKQELAVKLS 239
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 1140-1259 8.49e-17

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 77.25  E-value: 8.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1140 KAKFVIDLLHKSsfRGERVLIFCHNVSpitflvKLIEMVFGWRLGEEVLVLQGDQELPVRSDVMDKFNgdsAGKRKVLIA 1219
Cdd:pfam00271    2 KLEALLELLKKE--RGGKVLIFSQTKK------TLEAELLLEKEGIKVARLHGDLSQEEREEILEDFR---KGKIDVLVA 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1002284185 1220 sTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRG 1259
Cdd:pfam00271   71 -TDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 753-991 1.47e-16

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 80.66  E-value: 1.47e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAGSIQVEGMdnsnvstgGCVIAHTPGSGKTLLLISFLVSYMKAHPRS------RPLVLTPKAAI 826
Cdd:cd18066      1 LRPHQREGIEFLYECVMGMRVNERF--------GAILADEMGLGKTLQCISLIWTLLRQGPYGgkpvikRALIVTPGSLV 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  827 HTWKREFEKWGISLPLHVFhhanrsgkpLGAMDSKLRSLLNNfhrptwtnmrlmdsldKLFkwhahpSVLLMTYSSFLGM 906
Cdd:cd18066     73 KNWKKEFQKWLGSERIKVF---------TVDQDHKVEEFIAS----------------PLY------SVLIISYEMLLRS 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  907 TKQDSKVrnryrefiaevlmnNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFI 986
Cdd:cd18066    122 LDQISKL--------------NFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGIL 187


                   ....*
gi 1002284185  987 GDIMS 991
Cdd:cd18066    188 GSLST 192
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 753-973 1.04e-14

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 73.90  E-value: 1.04e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWK---NLAGSIqvegmdnsnvstggcvIAHTPGSGKTLLLISFLVSYMKAHPRSRP-LVLTPKAAIHT 828
Cdd:cd18000      1 LFKYQQTGVQWLWElhcQRVGGI----------------LGDEMGLGKTIQIIAFLAALHHSKLGLGPsLIVCPATVLKQ 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  829 WKREFEKWGISLPLHVFHHANRSGKPLGAMDSKLRSLLnnfhrptwtnmrlmdSLDKLFKWHAhpsVLLMTYSsflGMTK 908
Cdd:cd18000     65 WVKEFHRWWPPFRVVVLHSSGSGTGSEEKLGSIERKSQ---------------LIRKVVGDGG---ILITTYE---GFRK 123

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002284185  909 QDSKVRNRyrefiaevlmnNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEE 973
Cdd:cd18000    124 HKDLLLNH-----------NWQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKE 177
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 787-986 1.50e-14

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 73.57  E-value: 1.50e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  787 CVIAHTPGSGKTLLLISFLvSYMKAHPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFHhanrsgkplGAMDSKlrsl 865
Cdd:cd17998     22 GILADEMGLGKTIQVIAFL-AYLKEIGIPGPhLVVVPSSTLDNWLREFKRWCPSLKVEPYY---------GSQEER---- 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  866 lnnfhrptwTNMRlMDSLDKLFKWhahpSVLLMTYSSFLGMTKQDSKVRNRYREFIaevlmnnpgllILDEGHNPRSNKS 945
Cdd:cd17998     88 ---------KHLR-YDILKGLEDF----DVIVTTYNLATSNPDDRSFFKRLKLNYV-----------VYDEGHMLKNMTS 142

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1002284185  946 KLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPR-FI 986
Cdd:cd17998    143 ERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPKpFI 184
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 794-988 3.07e-14

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 73.51  E-value: 3.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  794 GSGKTLLLISFLvSYMKaHPRSRP---LVLTPKAAIHTWKREFEKWGISLPLHVFHHANRSgkplgamdsklrsllnnfh 870
Cdd:cd17997     32 GLGKTLQTISLL-GYLK-HYKNINgphLIIVPKSTLDNWMREFKRWCPSLRVVVLIGDKEE------------------- 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  871 RPTWTNMRLMDSldklfKWhahpSVLLMTYSSFLGMTKQDSKVRNRYrefiaevlmnnpglLILDEGHNPRSNKSKLRKL 950
Cdd:cd17997     91 RADIIRDVLLPG-----KF----DVCITSYEMVIKEKTVLKKFNWRY--------------IIIDEAHRIKNEKSKLSQI 147

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1002284185  951 LMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIGD 988
Cdd:cd17997    148 VRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTS 185
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 786-978 4.19e-13

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 69.97  E-value: 4.19e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  786 GCVIAHTPGSGKTLLLISFLVS-YMKAHPRSRPLVLTPKAAIHTWKREFEKWgisLPLH-VFHHANRSGKplgamdsKLR 863
Cdd:cd17995     21 NCILADEMGLGKTIQSIAFLEHlYQVEGIRGPFLVIAPLSTIPNWQREFETW---TDMNvVVYHGSGESR-------QII 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  864 SLLNNFHRPTWTNmrlmdSLDKLFKWHahpsVLLMTYSSFlgMTKQDSKVRNRYRefiaevlmnnpgLLILDEGHNPRSN 943
Cdd:cd17995     91 QQYEMYFKDAQGR-----KKKGVYKFD----VLITTYEMV--IADAEELRKIPWR------------VVVVDEAHRLKNR 147

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1002284185  944 KSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTL 978
Cdd:cd17995    148 NSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLL 182
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 753-987 5.65e-13

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 70.01  E-value: 5.65e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLwknlagsiqvegmdnsnVSTGGcVIAHTPGSGKTLLLISFLVS-----------YMKAHPRSRP---- 817
Cdd:cd18008      1 LLPYQKQGLAWM-----------------LPRGG-ILADEMGLGKTIQALALILAtrpqdpkipeeLEENSSDPKKlyls 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  818 ---LVLTPKAAIHTWKREFEK--WGISLPLHVFHHANRSgkplgamdsklrsllnnfhrptwtnmrlmDSLDKLfkwhAH 892
Cdd:cd18008     63 kttLIVVPLSLLSQWKDEIEKhtKPGSLKVYVYHGSKRI-----------------------------KSIEEL----SD 109

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  893 PSVLLMTYSSFLG-MTKQDSKVRNRYREFIAEVLMNNPGL-LILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNN 970
Cdd:cd18008    110 YDIVITTYGTLASeFPKNKKGGGRDSKEKEASPLHRIRWYrVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNS 189

                          250
                   ....*....|....*..
gi 1002284185  971 FEEYFNTLclarpRFIG 987
Cdd:cd18008    190 LDDLYSLL-----RFLR 201
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
747-1322 3.21e-12

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 70.82  E-value: 3.21e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  747 SDLDPKLLPHQRKALDFLWKNLAGSiqvegmdnsnvsTGGCVIAHTPGSGKTLLlISFLVSYMKAHPRSrpLVLTP-KAA 825
Cdd:COG1061     75 SGTSFELRPYQQEALEALLAALERG------------GGRGLVVAPTGTGKTVL-ALALAAELLRGKRV--LVLVPrREL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  826 IHTWKREFEKWgislplhvfhhanrsgkplgamdsklrsllnnfhrptwtnmrLMDSLDKLFKWHAHPSVLLMTYSSFlg 905
Cdd:COG1061    140 LEQWAEELRRF------------------------------------------LGDPLAGGGKKDSDAPITVATYQSL-- 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  906 mtkqdskvrnrYREFIAEVLMNNPGLLILDEGHNPRSNKskLRKLLMKVKTEFRILLSGTafqnnfeeyfntlclarprf 985
Cdd:COG1061    176 -----------ARRAHLDELGDRFGLVIIDEAHHAGAPS--YRRILEAFPAAYRLGLTAT-------------------- 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  986 igdimselvPERkretvgrrakhqeavarrafvekvgqkieSDNKHIrsdgisllnkltrgFIDSFEGaklinlpgiHVY 1065
Cdd:COG1061    223 ---------PFR-----------------------------SDGREI--------------LLFLFDG---------IVY 241

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1066 TVfmKPTD-IQEEMLAKVTMpklgssrFPLEVELlitigsihpwliktTKAVSTFFSPAEvkkveRYKRDFAAGCKAK-F 1143
Cdd:COG1061    242 EY--SLKEaIEDGYLAPPEY-------YGIRVDL--------------TDERAEYDALSE-----RLREALAADAERKdK 293

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1144 VIDLLHKSSFRGERVLIFCHNVSPITFLVKLIEmvfgwRLGEEVLVLQGDQELPVRSDVMDKFngdSAGKRKVLIASTTA 1223
Cdd:COG1061    294 ILRELLREHPDDRKTLVFCSSVDHAEALAELLN-----EAGIRAAVVTGDTPKKEREEILEAF---RDGELRILVTVDVL 365

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1224 cAEGISLTGASRLVMLDSewNHSKTR--QAIARAFRRGQ-ERTVYVYLLVASGTWEEEKYNSNRRKAWMSKMVFLGRYVD 1300
Cdd:COG1061    366 -NEGVDVPRLDVAILLRP--TGSPREfiQRLGRGLRPAPgKEDALVYDFVGNDVPVLEELAKDLRDLAGYRVEFLDEEES 442

                          570       580
                   ....*....|....*....|..
gi 1002284185 1301 DSSQNRVTDIDDEVLKELADED 1322
Cdd:COG1061    443 EELALLIAVKPALEVKGELEEE 464
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 785-1048 4.77e-12

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 66.82  E-value: 4.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  785 GGCvIAHTPGSGKTLLLISFLvSYMKAHPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFHHANRSgkplgamDSKLR 863
Cdd:cd18012     25 GGI-LADDMGLGKTLQTLALL-LSRKEEGRKGPsLVVAPTSLIYNWEEEAAKFAPELKVLVIHGTKRK-------REKLR 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  864 SLLNNFhrptwtnmrlmdsldklfkwhahpsVLLMTYSSFlgmtKQDSkvrnryrEFIAEVLMNnpgLLILDEGHNPRSN 943
Cdd:cd18012     96 ALEDYD-------------------------LVITSYGLL----RRDI-------ELLKEVKFH---YLVLDEAQNIKNP 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  944 KSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLclarpRFigdIMSELVPERKRetvgrrakhqeavarraFVEKVGQ 1023
Cdd:cd18012    137 QTKTAKAVKALKADHRLALTGTPIENHLGELWSIF-----DF---LNPGLLGSYKR-----------------FKKRFAK 191

                          250       260
                   ....*....|....*....|....*
gi 1002284185 1024 KIEsdnKHIRSDGISLLNKLTRGFI 1048
Cdd:cd18012    192 PIE---KDGDEEALEELKKLISPFI 213
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 753-1005 5.03e-12

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 66.54  E-value: 5.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALdflwknlagsiqVEGMDNSNVstgGCVIAHTPGSGKT---LLLISFLvsyMKAHPRSRPLVLTPKAAIHTW 829
Cdd:cd18011      1 PLPHQIDAV------------LRALRKPPV---RLLLADEVGLGKTieaGLIIKEL---LLRGDAKRVLILCPASLVEQW 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  830 KREFEkwgislplhvfhhaNRSGKPLGAMDSK-LRSLLNNFHRPtwtnmrlmdsldklfkWHAHPSVLlmtyssflgmTK 908
Cdd:cd18011     63 QDELQ--------------DKFGLPFLILDREtAAQLRRLIGNP----------------FEEFPIVI----------VS 102

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  909 QDSKVRNRYREfiAEVLMNNPGLLILDEGHNPRSN----KSKLRKLLMKVKTEFR--ILLSGTAFQNNFEEYFNTLCLAR 982
Cdd:cd18011    103 LDLLKRSEERR--GLLLSEEWDLVVVDEAHKLRNSgggkETKRYKLGRLLAKRARhvLLLTATPHNGKEEDFRALLSLLD 180

                          250       260
                   ....*....|....*....|...
gi 1002284185  983 PRFIGDIMSELVPERKRETVGRR 1005
Cdd:cd18011    181 PGRFAVLGRFLRLDGLREVLAKV 203
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 773-983 4.12e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 64.64  E-value: 4.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  773 QVEGMD---NSNVSTGGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFhha 848
Cdd:cd18054     25 QLEGLNwlaHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPfLLVVPLSTLTSWQREFEIWAPEINVVVY--- 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  849 nrsgkpLGAMDSKlrsllNNFHRPTWTNMRlmdslDKLFKWHAhpsvLLMTYSSFLgmtkQDSKVRNRYrefiaevlmnN 928
Cdd:cd18054    102 ------IGDLMSR-----NTIREYEWIHSQ-----TKRLKFNA----LITTYEILL----KDKTVLGSI----------N 147

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1002284185  929 PGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP 983
Cdd:cd18054    148 WAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP 202
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 753-985 5.42e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 64.32  E-value: 5.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAgsiqvEGMDNsnvstggcVIAHTPGSGKTLLLISFLVS-YMKAHPRSRPLVLTPKAAIHTWKR 831
Cdd:cd18057      1 LHPYQLEGLNWLRFSWA-----QGTDT--------ILADEMGLGKTVQTIVFLYSlYKEGHSKGPYLVSAPLSTIINWER 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  832 EFEKWGISlplhvFHHANRSGkplgamDSKLRSLLNNFHRPTWTNMrlMDSLDKLFKWHAHPSVLLMTYSSFLGMTKQDS 911
Cdd:cd18057     68 EFEMWAPD-----FYVVTYTG------DKESRSVIRENEFSFEDNA--IRSGKKVFRMKKEAQIKFHVLLTSYELITIDQ 134

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002284185  912 KVRNRYREfiaevlmnnpGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP-RF 985
Cdd:cd18057    135 AILGSIEW----------ACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPeRF 199
HELICc smart00490
helicase superfamily c-terminal domain;
1182-1259 7.76e-11

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 59.53  E-value: 7.76e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002284185  1182 RLGEEVLVLQGDQELPVRSDVMDKFNgdsAGKRKVLIAsTTACAEGISLTGASRLVMLDSEWNHSKTRQAIARAFRRG 1259
Cdd:smart00490    9 ELGIKVARLHGGLSQEEREEILDKFN---NGKIKVLVA-TDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 788-985 5.07e-10

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 61.18  E-value: 5.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  788 VIAHTPGSGKTLLLISFLVS-YMKAHPRSRPLVLTPKAAIHTWKREFEKWGISLPLHVFhhanrsgkpLGAMDSKLRSLL 866
Cdd:cd18055     23 ILADEMGLGKTIQTIVFLYSlYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVTY---------TGDKDSRAIIRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  867 NNFhrpTWTNmRLMDSLDKLFKWHAHPSVLLMTYSSFLGMTKQDSKVRNRYREfiaevlmnnpGLLILDEGHNPRSNKSK 946
Cdd:cd18055     94 NEF---SFDD-NAVKGGKKAFKMKREAQVKFHVLLTSYELVTIDQAALGSIRW----------ACLVVDEAHRLKNNQSK 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1002284185  947 LRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP-RF 985
Cdd:cd18055    160 FFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPeRF 199
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 788-983 9.92e-10

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 60.45  E-value: 9.92e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  788 VIAHTPGSGKTLLLISfLVSYMKaHPRSRP---LVLTPKAAIHTWKREFEKWGISLplhvfhhanRSGKPLGAMDSKLRS 864
Cdd:cd18064     38 ILADEMGLGKTLQTIS-LLGYMK-HYRNIPgphMVLVPKSTLHNWMAEFKRWVPTL---------RAVCLIGDKDQRAAF 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  865 LLNNFHRPTWtnmrlmdsldklfkwhahpSVLLMTYSSFLgmtkqdsKVRNRYREFiaevlmnNPGLLILDEGHNPRSNK 944
Cdd:cd18064    107 VRDVLLPGEW-------------------DVCVTSYEMLI-------KEKSVFKKF-------NWRYLVIDEAHRIKNEK 153

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1002284185  945 SKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP 983
Cdd:cd18064    154 SKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLP 192
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 787-983 1.24e-09

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 60.07  E-value: 1.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  787 CVIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAIHTWKREFEKWgISLPLHVFHhanrsgkplGAMDSklRSLL 866
Cdd:cd18060     22 CILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTW-TEMNTIVYH---------GSLAS--RQMI 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  867 NNFHrptwtnMRLMDSLDKLFKWHAHPSVLLMTYSSFLGMTKQDSKVRNRyrefiaevlmnnpgLLILDEGHNPRSNKSK 946
Cdd:cd18060     90 QQYE------MYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWR--------------CVIIDEAHRLKNRNCK 149

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1002284185  947 LRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP 983
Cdd:cd18060    150 LLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEP 186
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 773-983 1.54e-09

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 59.67  E-value: 1.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  773 QVEGMD---NSNVSTGGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAIHTWKREFEKWgISLPLHVFHHAN 849
Cdd:cd18058      5 QLEGMNwllFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTW-TEMNAIVYHGSQ 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  850 RSgkplgamdsklRSLLNNF---HRPTWTNMrlmdsLDKLFKWHahpsVLLMTYSSFLGMTKQDSKVRNRyrefiaevlm 926
Cdd:cd18058     84 IS-----------RQMIQQYemyYRDEQGNP-----LSGIFKFQ----VVITTFEMILADCPELKKINWS---------- 133

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002284185  927 nnpgLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP 983
Cdd:cd18058    134 ----CVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEP 186
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 794-973 1.81e-09

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 59.69  E-value: 1.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  794 GSGKTLLLISfLVSYMKAHPRSR-P-LVLTPKAAIHTWKREFEKWGISLPLHVFhhanrSGKPlgamdsKLRSLLNNFHR 871
Cdd:cd17996     32 GLGKTIQTIS-LITYLMEKKKNNgPyLVIVPLSTLSNWVSEFEKWAPSVSKIVY-----KGTP------DVRKKLQSQIR 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  872 PTWTNmrlmdsldklfkwhahpsVLLMTYSSFLGMTKQDSKVRNRYrefiaevlmnnpglLILDEGHNPRSNKSKLRKLL 951
Cdd:cd17996    100 AGKFN------------------VLLTTYEYIIKDKPLLSKIKWKY--------------MIIDEGHRMKNAQSKLTQTL 147

                          170       180
                   ....*....|....*....|...
gi 1002284185  952 MK-VKTEFRILLSGTAFQNNFEE 973
Cdd:cd17996    148 NTyYHARYRLLLTGTPLQNNLPE 170
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 788-985 1.97e-09

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 58.60  E-value: 1.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  788 VIAHTPGSGKTLLLISFLVS-YMKAHPRSRPLVLTPKAAIHTWKREFEKWGISLPLHVFH--HANRSGKPLGAMDSKLrs 864
Cdd:cd17994     23 ILADEMGLGKTIQTIVFLYSlYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVTYVgdHVLLTSYELISIDQAI-- 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  865 llnnfhrptwtnmrlMDSLDklfkWhahpsvllmtyssflgmtkqdskvrnryrefiaevlmnnpGLLILDEGHNPRSNK 944
Cdd:cd17994    101 ---------------LGSID----W----------------------------------------AVLVVDEAHRLKNNQ 121

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1002284185  945 SKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTL-CLARPRF 985
Cdd:cd17994    122 SKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLnFLTPERF 163
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 787-985 2.69e-09

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 58.86  E-value: 2.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  787 CVIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAIHTWKREFEKWgISLPLHVFHhanrsgkplGAMDSklRSLL 866
Cdd:cd18061     22 CILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTW-TDLNVVVYH---------GSLIS--RQMI 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  867 NNFHrptwtnMRLMDSLDKLFKWHAHPSVLLMTYSSFLGMTKQDSKVRNRyrefiaevlmnnpgLLILDEGHNPRSNKSK 946
Cdd:cd18061     90 QQYE------MYFRDSQGRIIRGAYRFQAIITTFEMILGGCPELNAIDWR--------------CVIIDEAHRLKNKNCK 149

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1002284185  947 LRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP-RF 985
Cdd:cd18061    150 LLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPlRF 189
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 932-1278 2.87e-09

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 61.74  E-value: 2.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  932 LILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIGDImselvperkrETvgrrakhqea 1011
Cdd:PLN03142   295 IIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA----------ET---------- 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1012 varraFVEKVGQKIESDNKHIrsdgISLLNKLTRGF-IDSFEGAKLINLPgihvytvfmkPtdiQEEMLAKVTMPKL--- 1087
Cdd:PLN03142   355 -----FDEWFQISGENDQQEV----VQQLHKVLRPFlLRRLKSDVEKGLP----------P---KKETILKVGMSQMqkq 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1088 ----------------GSSRFPLEVELLITIGSIHPWLIKTTKAVSTFFSPAEVkkVERykrdfaAGckaKFVI--DLLH 1149
Cdd:PLN03142   413 yykallqkdldvvnagGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGEHL--VEN------SG---KMVLldKLLP 481

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185 1150 KSSFRGERVLIFchnvSPITFLVKLIEMVFGWRlGEEVLVLQGDQELPVRSDVMDKFNGDSAGKRkVLIASTTACAEGIS 1229
Cdd:PLN03142   482 KLKERDSRVLIF----SQMTRLLDILEDYLMYR-GYQYCRIDGNTGGEDRDASIDAFNKPGSEKF-VFLLSTRAGGLGIN 555

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1002284185 1230 LTGASRLVMLDSEWNHSKTRQAIARAFRRGQERTVYVYLLVASGTWEEE 1278
Cdd:PLN03142   556 LATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEK 604
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 794-973 8.11e-09

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 57.36  E-value: 8.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  794 GSGKTLLLISFLVSYMKAHPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFHhanrsGKPlgamdsKLRSLLnnfhRP 872
Cdd:cd18003     29 GLGKTIQTIALLAHLACEKGNWGPhLIVVPTSVMLNWEMEFKRWCPGFKILTYY-----GSA------KERKLK----RQ 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  873 TWTnmrlmdsldKLFKWHahpsVLLMTYSSFLgmtkQDSKVRNRYREfiaevlmnnpGLLILDEGHNPRSNKSKLRKLLM 952
Cdd:cd18003     94 GWM---------KPNSFH----VCITSYQLVV----QDHQVFKRKKW----------KYLILDEAHNIKNFKSQRWQTLL 146

                          170       180
                   ....*....|....*....|.
gi 1002284185  953 KVKTEFRILLSGTAFQNNFEE 973
Cdd:cd18003    147 NFNTQRRLLLTGTPLQNSLME 167
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 783-985 1.01e-08

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 57.35  E-value: 1.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  783 STGGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAIHTWKREFEKWgISLPLHVFHHANRSGKPLGAMDSKL 862
Cdd:cd18059     18 NTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTW-TELNVVVYHGSQASRRTIQLYEMYF 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  863 RSllnnfhrptwTNMRLMDSldkLFKWHAhpsvLLMTYSSFLGMTKQDSKVRNRyrefiaevlmnnpgLLILDEGHNPRS 942
Cdd:cd18059     97 KD----------PQGRVIKG---SYKFHA----IITTFEMILTDCPELRNIPWR--------------CVVIDEAHRLKN 145

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1002284185  943 NKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP-RF 985
Cdd:cd18059    146 RNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPsRF 189
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 773-978 1.16e-08

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 57.40  E-value: 1.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  773 QVEGMD-----NSNVSTGgcVIAHTPGSGKTLLLISFLvSYMKAHPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFH 846
Cdd:cd18009      8 QLEGMEwlrmlWENGING--ILADEMGLGKTIQTIALL-AHLRERGVWGPfLVIAPLSTLPNWVNEFARFTPSVPVLLYH 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  847 hanrsgkplGAMDSKLRSLLNNFHRPTwtnmRLMDsldklfkwhaHPSVLlmtySSFlGMTKQDSKVRNRYREFiaevlm 926
Cdd:cd18009     85 ---------GTKEERERLRKKIMKREG----TLQD----------FPVVV----TSY-EIAMRDRKALQHYAWK------ 130

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1002284185  927 nnpgLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTL 978
Cdd:cd18009    131 ----YLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLL 178
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 788-983 1.65e-08

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 56.95  E-value: 1.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  788 VIAHTPGSGKTLLLISfLVSYMKaHPRSRP---LVLTPKAAIHTWKREFEKWGISLPLHVFhhanrsgkpLGAMDSKLRS 864
Cdd:cd18065     38 ILADEMGLGKTLQTIA-LLGYLK-HYRNIPgphMVLVPKSTLHNWMNEFKRWVPSLRAVCL---------IGDKDARAAF 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  865 LLNNFHRPTWtnmrlmdsldklfkwhahpSVLLMTYSSFLGMTKQDSKVRNRYrefiaevlmnnpglLILDEGHNPRSNK 944
Cdd:cd18065    107 IRDVMMPGEW-------------------DVCVTSYEMVIKEKSVFKKFNWRY--------------LVIDEAHRIKNEK 153

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1002284185  945 SKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP 983
Cdd:cd18065    154 SKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLP 192
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 787-1010 1.65e-08

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 56.60  E-value: 1.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  787 CVIAHTPGSGKTLLLISFLVSYMKAHPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFhhanrsgkpLGamDSKLRSL 865
Cdd:cd17993     23 GILADEMGLGKTVQTISFLSYLFHSQQQYGPfLVVVPLSTMPAWQREFAKWAPDMNVIVY---------LG--DIKSRDT 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  866 LNNFHRPTWTNMRLmdsldKLfkwhahpSVLLMTYSSFLgmtKQDSKVRNRYREFIAevlmnnpglliLDEGHNPRSNKS 945
Cdd:cd17993     92 IREYEFYFSQTKKL-----KF-------NVLLTTYEIIL---KDKAFLGSIKWQYLA-----------VDEAHRLKNDES 145

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002284185  946 KLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP-RFIGDIMSELVPERKRETvGRRAKHQE 1010
Cdd:cd17993    146 LLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPgKFDIWEEFEEEHDEEQEK-GIADLHKE 210
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 787-983 2.24e-08

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 56.60  E-value: 2.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  787 CVIAHTPGSGKTLLLISFLVSYMKAHPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFhhanrsgkpLGAMDSKLRSL 865
Cdd:cd18053     42 CILADEMGLGKTIQTISFLNYLFHEHQLYGPfLLVVPLSTLTSWQREIQTWAPQMNAVVY---------LGDINSRNMIR 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  866 LNNFHRPTWTNMRLmdsldklfkwhahpSVLLMTYSSFLgmtKQDSKVRNRYREFIAevlmnnpglliLDEGHNPRSNKS 945
Cdd:cd18053    113 THEWMHPQTKRLKF--------------NILLTTYEILL---KDKSFLGGLNWAFIG-----------VDEAHRLKNDDS 164

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1002284185  946 KLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP 983
Cdd:cd18053    165 LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP 202
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 753-985 3.62e-08

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 55.84  E-value: 3.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAgsiqvEGMDNsnvstggcVIAHTPGSGKTLLLISFLVS-YMKAHPRSRPLVLTPKAAIHTWKR 831
Cdd:cd18056      1 LHPYQLEGLNWLRFSWA-----QGTDT--------ILADEMGLGKTVQTAVFLYSlYKEGHSKGPFLVSAPLSTIINWER 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  832 EFEKWGISLPLHVFhhanrsgkpLGAMDSK--LRSLLNNFHRPTWTNMRLMDSLDKLFKWHAHpsVLLMTYSsflgMTKQ 909
Cdd:cd18056     68 EFEMWAPDMYVVTY---------VGDKDSRaiIRENEFSFEDNAIRGGKKASRMKKEASVKFH--VLLTSYE----LITI 132

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002284185  910 DSKVRNRYrefiaevlmnNPGLLILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP-RF 985
Cdd:cd18056    133 DMAILGSI----------DWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPeRF 199
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 786-983 4.60e-08

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 55.14  E-value: 4.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  786 GCVIAHTPGSGKTLLLISFLVSYMKAHPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFhhanrsgkplgAMDSKLRs 864
Cdd:cd18006     21 GCILGDEMGLGKTCQTISLLWYLAGRLKLLGPfLVLCPLSVLDNWKEELNRFAPDLSVITY-----------MGDKEKR- 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  865 llnnfhrptwtnMRLMDSLDKLFKWHahpsVLLMTYSSFLgmtKQDSkvrnryreFIAEVlmnNPGLLILDEGHNPRSNK 944
Cdd:cd18006     89 ------------LDLQQDIKSTNRFH----VLLTTYEICL---KDAS--------FLKSF---PWASLVVDEAHRLKNQN 138

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1002284185  945 SKLRKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARP 983
Cdd:cd18006    139 SLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEP 177
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 753-990 4.64e-07

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 52.21  E-value: 4.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFlwknlagsiqveGMDNSnvstGGCVIAHTPGSGKTLLLISFLVSYMKAHPRsrpLVLTPKAAIHTWKRE 832
Cdd:cd18010      1 LLPFQREGVCF------------ALRRG----GRVLIADEMGLGKTVQAIAIAAYYREEWPL---LIVCPSSLRLTWADE 61

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  833 FEKWGISLPLHVFHHANRSGKPLGAMDSKlrsllnnfhrptwtnmrlmdsldklfkwhahpsVLLMTYSSFLGMTKQDSK 912
Cdd:cd18010     62 IERWLPSLPPDDIQVIVKSKDGLRDGDAK---------------------------------VVIVSYDLLRRLEKQLLA 108

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  913 VrnryrefiaevlmnNPGLLILDEGHNPRSNKSKLRKLLMKV--KTEFRILLSGTAFQNNFEEYFNTLCLARPRFIGDIM 990
Cdd:cd18010    109 R--------------KFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFH 174
ResIII pfam04851
Type III restriction enzyme, res subunit;
752-965 7.13e-07

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 50.36  E-value: 7.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  752 KLLPHQRKALDFLWKNLAgsiqvegmdnsNVSTGGCvIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPKAAIHT-WK 830
Cdd:pfam04851    3 ELRPYQIEAIENLLESIK-----------NGQKRGL-IVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRKDLLEqAL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  831 REFEKWGISlplHVFHHANRSGkplgamDSKLRSLLNNFhrptwtnmrlmdsldklfkwhahpsVLLMTYSSFlgmtkqD 910
Cdd:pfam04851   71 EEFKKFLPN---YVEIGEIISG------DKKDESVDDNK-------------------------IVVTTIQSL------Y 110

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1002284185  911 SKVRNRYREFIAevlmNNPGLLILDEGHnpRSNKSKLRKLLMKVKTEFRILLSGT 965
Cdd:pfam04851  111 KALELASLELLP----DFFDVIIIDEAH--RSGASSYRNILEYFKPAFLLGLTAT 159
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 794-989 6.38e-06

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 48.89  E-value: 6.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  794 GSGKTLLLISFLVS--YMKA---HPRSRP-LVLTPKAAIHTWKREFEKWGISLPLHVFHHANrsgkpLGAMDSKLRSLLN 867
Cdd:cd17999     29 GLGKTLQTLCILASdhHKRAnsfNSENLPsLVVCPPTLVGHWVAEIKKYFPNAFLKPLAYVG-----PPQERRRLREQGE 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  868 NfHRptwtnmrlmdsldklfkwhahpsVLLMTYSSflgmtkqdskVRNRYrEFIAEVLMNnpgLLILDEGHNPRSNKSKL 947
Cdd:cd17999    104 K-HN-----------------------VIVASYDV----------LRNDI-EVLTKIEWN---YCVLDEGHIIKNSKTKL 145

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1002284185  948 RKLLMKVKTEFRILLSGTAFQNNFEEYFNTLCLARPRFIGDI 989
Cdd:cd17999    146 SKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTE 187
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 753-978 6.61e-06

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 49.00  E-value: 6.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLW-----KNLAGSIQVEGMDNSNVSTG-----------GCVIAHTPGSGKTLLLISFLVSymkahprSR 816
Cdd:cd18071      1 LLPHQKQALAWMVsrensQDLPPFWEEAVGLFLNTITNfsqkkrpelvrGGILADDMGLGKTLTTISLILA-------NF 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  817 PLVLTPKAAIHTWKREFE---KWGIsLPLHVFHHANRSGKP--LGAMDsklrsllnnfhrptwtnmrlmdsldklfkwha 891
Cdd:cd18071     74 TLIVCPLSVLSNWETQFEehvKPGQ-LKVYTYHGGERNRDPklLSKYD-------------------------------- 120

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  892 hpsVLLMTYSSFLG--MTKQDSKVRNryrefiaevlMNnpGL-LILDEGHNPRSNKSKLRKLLMKVKTEFRILLSGTAFQ 968
Cdd:cd18071    121 ---IVLTTYNTLASdfGAKGDSPLHT----------IN--WLrVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQ 185

                          250
                   ....*....|
gi 1002284185  969 NNFEEYFNTL 978
Cdd:cd18071    186 NSPKDLGSLL 195
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 753-965 1.05e-03

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 40.75  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  753 LLPHQRKALDFLWKNLAGSiqvegmdnsnvstGGCVIAHTpGSGKTLLLISFLVSYMKAhprsRPLVLTPKAAI-HTWKR 831
Cdd:cd17926      1 LRPYQEEALEAWLAHKNNR-------------RGILVLPT-GSGKTLTALALIAYLKEL----RTLIVVPTDALlDQWKE 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  832 EFEKWGISLPLHVFhhanRSGKplgamdsklrsllnnfhrptwtnmrLMDSLDKlfkwhahpSVLLMTYSSflgMTKQDS 911
Cdd:cd17926     63 RFEDFLGDSSIGLI----GGGK-------------------------KKDFDDA--------NVVVATYQS---LSNLAE 102

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1002284185  912 KVRNRYREFiaevlmnnpGLLILDEGHnpRSNKSKLRKLLMKVKTEFRILLSGT 965
Cdd:cd17926    103 EEKDLFDQF---------GLLIVDEAH--HLPAKTFSEILKELNAKYRLGLTAT 145
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 1142-1220 1.11e-03

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 40.57  E-value: 1.11e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002284185 1142 KFVIDLLHKSSFRGERVLIFCHNVSPITFLVKLIEmvfgwRLGEEVLVLQGDQELPVRSDVMDKFNgdsAGKRKVLIAS 1220
Cdd:cd18787     14 KLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLE-----ELGIKVAALHGDLSQEERERALKKFR---SGKVRVLVAT 84
SAWADEE pfam16719
SAWADEE domain; The SAWADEE domain, found in plant homeobox proteins, has a pair of tandem ...
 23-127 3.09e-03

SAWADEE domain; The SAWADEE domain, found in plant homeobox proteins, has a pair of tandem tudor-like folds that bind chromatin.


Pssm-ID: 465246  Cd Length: 126  Bit Score: 39.19  E-value: 3.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185   23 DGSWHGVNcIRIRNGNLFVKFIYSGSTVEHNVD-GDCLRLRSRRATCSDCSNVlKPGVDVCvqsshtpeASSQGGTNAsv 101
Cdd:pfam16719   12 DGAWYDVR-VFLQHRALRVRFEGFGEEEDEWVNvRKRFRERSIPLEDSECRKV-RVGDLVC--------CFQEGGDDA-- 79

                           90       100
                   ....*....|....*....|....*...
gi 1002284185  102 lLRHDARLITI-KKNHQ-EDKCLCLFVV 127
Cdd:pfam16719   80 -LYYDAVVVEIqRKRHDiVEGCRCTFVV 106
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 755-836 7.16e-03

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 39.64  E-value: 7.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002284185  755 PHQRKALDFLWKNLagsiqvegmdnsnvstgGCVIAHTPGSGKTLLLISFLVSYMKAHPRSRPLVLTPK-AAIHTWKREF 833
Cdd:cd18013      3 PYQKVAINFIIEHP-----------------YCGLFLDMGLGKTVTTLTALSDLQLDDFTRRVLVIAPLrVARSTWPDEV 65


                   ...
gi 1002284185  834 EKW 836
Cdd:cd18013     66 EKW 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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