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Conserved domains on  [gi|1443090097|ref|XP_015647075|]
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protein LIFEGUARD 2 [Oryza sativa Japonica Group]

Protein Classification

Bax inhibitor 1 family protein( domain architecture ID 1847)

Bax inhibitor 1 family protein similar to Saccharomyces cerevisiae Bax inhibitor 1 that links the unfolded protein response and programmed cell death, and mediates mitochondrial-dependent apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1-like super family cl00473
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 40-257 1.84e-64

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


The actual alignment was detected with superfamily member cd10429:

Pssm-ID: 469783  Cd Length: 233  Bit Score: 200.91  E-value: 1.84e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  40 PELRWAFIRKVYAIVATQLVVTVAIAAAVYSVPAIRRFFLARTpaslAAFVLVIVAPLIVMLPTMFLRKKHPINLILLAL 119
Cdd:cd10429    24 PEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHP----WLFLISLIGSLILLIALYWKRHSHPVNLILLSL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 120 FTICMSCAIGLGCLSSKAGIaIIEAASLTFGLVFGLTLYTFWAAKrghDFSFLRPFLVAAFLVLVLYGLIQMLVPTGKVA 199
Cdd:cd10429   100 FTLCEAYTVGLVVSFYDGKI-VLQALILTLGVFVGLTAYTFQTKR---DFSSFGALLFILLWALILLALIFQFFPYSPTF 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1443090097 200 TTVYGCVAALVFSGFIIYDTDNLIKRHAYDEYVTAAISLYLDTVNIFIAIFTALDASD 257
Cdd:cd10429   176 ELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 40-257 1.84e-64

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 200.91  E-value: 1.84e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  40 PELRWAFIRKVYAIVATQLVVTVAIAAAVYSVPAIRRFFLARTpaslAAFVLVIVAPLIVMLPTMFLRKKHPINLILLAL 119
Cdd:cd10429    24 PEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHP----WLFLISLIGSLILLIALYWKRHSHPVNLILLSL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 120 FTICMSCAIGLGCLSSKAGIaIIEAASLTFGLVFGLTLYTFWAAKrghDFSFLRPFLVAAFLVLVLYGLIQMLVPTGKVA 199
Cdd:cd10429   100 FTLCEAYTVGLVVSFYDGKI-VLQALILTLGVFVGLTAYTFQTKR---DFSSFGALLFILLWALILLALIFQFFPYSPTF 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1443090097 200 TTVYGCVAALVFSGFIIYDTDNLIKRHAYDEYVTAAISLYLDTVNIFIAIFTALDASD 257
Cdd:cd10429   176 ELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 44-249 2.28e-28

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 107.26  E-value: 2.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  44 WAFIRKVYAIVATQLVVTVAIAAAVYSVPAiRRFFLARTPASLAAFVLVIVAPLIVMLPTMFLRKKHPINLILLALFTIC 123
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPA-LLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 124 MSCAIGLGCLSSKAGIaIIEAASLTFGLVFGLTLYTFWAAKrghDFSFLRPFLVAAFLVLVLYGLIQMLVPtGKVATTVY 203
Cdd:pfam01027  80 MGLTLGPLLLVYTGAI-IATAFLGTAAIFGGLSLYALTTKR---DLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAI 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1443090097 204 GCVAALVFSGFIIYDTDNLIKRHAYDE---YVTAAISLYLDTVNIFIAI 249
Cdd:pfam01027 155 SYLGVLLFSGFILYDTQRIIKRYGEYGdydAILAALSLYLDFINLFLSL 203
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 45-249 3.49e-17

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 77.91  E-value: 3.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  45 AFIRKVYAIVATQLVVTVAIAAAVYSVPAIRRFFLARTPASLAAFVLVIVapLIVMLPTMFLRKKHPINLILLALFTICM 124
Cdd:COG0670    21 KVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLG--LVFLLSKLANRANSAAALALLFAYTALM 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 125 scAIGLGCL----SSKAGIAII-EAASLTFGLVFGLTLYTFwAAKRghDFSFLRPFLVAAFLVLVLYGLIQMLVPTGkVA 199
Cdd:COG0670    99 --GLTLSPIllvyTGLSGPASIaQAFGGTAATFGGLSLYGY-TTKR--DLSFLGSFLFMGLIGLIIASLVNIFLQSP-AL 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1443090097 200 TTVYGCVAALVFSGFIIYDTDNlIKRHAYD--EYVTAAISLYLDTVNIFIAI 249
Cdd:COG0670   173 SLAISVAGVLLFSGLTLYDTQR-IKHGYETnkQYIMAALSLYLDFINLFLSL 223
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 40-257 1.84e-64

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 200.91  E-value: 1.84e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  40 PELRWAFIRKVYAIVATQLVVTVAIAAAVYSVPAIRRFFLARTpaslAAFVLVIVAPLIVMLPTMFLRKKHPINLILLAL 119
Cdd:cd10429    24 PEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHP----WLFLISLIGSLILLIALYWKRHSHPVNLILLSL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 120 FTICMSCAIGLGCLSSKAGIaIIEAASLTFGLVFGLTLYTFWAAKrghDFSFLRPFLVAAFLVLVLYGLIQMLVPTGKVA 199
Cdd:cd10429   100 FTLCEAYTVGLVVSFYDGKI-VLQALILTLGVFVGLTAYTFQTKR---DFSSFGALLFILLWALILLALIFQFFPYSPTF 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1443090097 200 TTVYGCVAALVFSGFIIYDTDNLIKRHAYDEYVTAAISLYLDTVNIFIAIFTALDASD 257
Cdd:cd10429   176 ELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 44-249 2.28e-28

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 107.26  E-value: 2.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  44 WAFIRKVYAIVATQLVVTVAIAAAVYSVPAiRRFFLARTPASLAAFVLVIVAPLIVMLPTMFLRKKHPINLILLALFTIC 123
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPA-LLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 124 MSCAIGLGCLSSKAGIaIIEAASLTFGLVFGLTLYTFWAAKrghDFSFLRPFLVAAFLVLVLYGLIQMLVPtGKVATTVY 203
Cdd:pfam01027  80 MGLTLGPLLLVYTGAI-IATAFLGTAAIFGGLSLYALTTKR---DLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAI 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1443090097 204 GCVAALVFSGFIIYDTDNLIKRHAYDE---YVTAAISLYLDTVNIFIAI 249
Cdd:pfam01027 155 SYLGVLLFSGFILYDTQRIIKRYGEYGdydAILAALSLYLDFINLFLSL 203
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 43-249 9.63e-28

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 105.70  E-value: 9.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  43 RWAFIRKVYAIVATQLVVTVAIAAAVYSVPAIRRFFLARTPASLAAFVLVIVApLIVMLPTMFLRKKHPINLILLALFTI 122
Cdd:cd10428     8 RRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFIT-YIALACCEGLRRRFPWNLILLGIFTL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 123 CMSCAIGLGClSSKAGIAIIEAASLTFGLVFGLTLYTFWAAKrghDFSFLRPFLVAAFLVLVLYGLIQMLVPtGKVATTV 202
Cdd:cd10428    87 AMSYMLGTIA-SFYDTKAVLIAVGITAVVCLGLTLFAFQTKY---DFTSCGGVLFVLSIVLLIFGIVAIFFY-VKWLHIV 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1443090097 203 YGCVAALVFSGFIIYDTDNLIKRHAY----DEYVTAAISLYLDTVNIFIAI 249
Cdd:cd10428   162 YASLGALLFSLYLAVDTQLLMGGRKYelspEEYIFAALNIYVDIVNIFLYI 212
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 45-249 1.01e-17

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 78.76  E-value: 1.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  45 AFIRKVYAIVATQLVVTVAIAAAVYSVPAIRRFFLArtpaslAAFVLVIVAPLIVMLPTMFLRKKHPI--NLILLALFTI 122
Cdd:cd10432     4 SFMKKVYGLMAAGLLLTAVGAYVGASTPALLLIAGS------PLMWVLLIAELALVFGLSFRINKMSVatALPLFFAFAA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 123 CMSCAIGLgCLSSKAGIAIIEAASLTFGLVFGLTLYtfwAAKRGHDFSFLRPFLVAAFLVLVLYGLIQMLVPTGkVATTV 202
Cdd:cd10432    78 LTGLTLSP-ILLVYTGASIAQAFFTTAATFGGLSLY---GYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSS-ALQFA 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1443090097 203 YGCVAALVFSGFIIYDTDNLIKRH-------AYDEYVTAAISLYLDTVNIFIAI 249
Cdd:cd10432   153 ISAIGVLIFSGLIAYDTQRIKRMYeagggesGYKDAIMGALSLYLDFINLFLFL 206
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 45-249 3.49e-17

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 77.91  E-value: 3.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  45 AFIRKVYAIVATQLVVTVAIAAAVYSVPAIRRFFLARTPASLAAFVLVIVapLIVMLPTMFLRKKHPINLILLALFTICM 124
Cdd:COG0670    21 KVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLG--LVFLLSKLANRANSAAALALLFAYTALM 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 125 scAIGLGCL----SSKAGIAII-EAASLTFGLVFGLTLYTFwAAKRghDFSFLRPFLVAAFLVLVLYGLIQMLVPTGkVA 199
Cdd:COG0670    99 --GLTLSPIllvyTGLSGPASIaQAFGGTAATFGGLSLYGY-TTKR--DLSFLGSFLFMGLIGLIIASLVNIFLQSP-AL 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1443090097 200 TTVYGCVAALVFSGFIIYDTDNlIKRHAYD--EYVTAAISLYLDTVNIFIAI 249
Cdd:COG0670   173 SLAISVAGVLLFSGLTLYDTQR-IKHGYETnkQYIMAALSLYLDFINLFLSL 223
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 43-253 1.07e-15

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 73.22  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097  43 RWAFIRKVYAIVATQLVVTVAiaaavysVPAIRRFFLARTPASLAAFVLVIVAPLIVMLPTMfLRKKHPINLILLALFTI 122
Cdd:cd06181     2 TKDFLRKVYMILALQLLLTAA-------TATAFTVCDPGWYWSPALMGLLTSMLALMATAAM-IRAKMPVNLILLFGFTG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 123 CMscAIGLGCLSSKAGIAII-EAASLTFGLVFGLTLYTFWAAKrghDFSFLRPFLVAAFLVLVLYGLIQMLVpTGKVATT 201
Cdd:cd06181    74 LM--GYVVGPLLFFYGPTILlRALGGTALVFFGLTVYALQARK---DFLFLGGPLMAGLGFLLLSFLLNTFF-YSPWLHL 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1443090097 202 VYGCVAALVFSGFIIYDTDNLIKR--HAYDEYVTAAISLYLDTVNIFIAIFTAL 253
Cdd:cd06181   148 VAAAVGLVLFCGFLLYDTQLIIHKaeVGPEDYINACISLYLDIINIFIRLLTIL 201
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 137-258 2.38e-08

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 52.59  E-value: 2.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 137 AGIAIIEAASLTFGLVFGLTLYTFWAAKrghDFSFLRPFLVAAFLVLVLYGLIQMLVPTGKVATTVyGCVAALVFSGFII 216
Cdd:cd10433    89 GGQIIMTALGGTAAIFFGLSAYALTTKK---DFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAI-SAAFVLFSSGFIL 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1443090097 217 YDTDNLIkRHAYDEYVTAAISLYLDTVNIFIAIFTALDASDS 258
Cdd:cd10433   165 YDTSRII-HGGETNYIMATVSLYVSIYNLFVSLLNLLGAFSG 205
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 137-253 1.07e-07

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 51.61  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443090097 137 AGIAIIEAASLTFGLVFGLTlyTFWAAKRGHDFSFLRPFLVAAFLVLVLYGLIQMLVPTGKV------ATTVYGCVAalV 210
Cdd:cd10431   131 GGPLLIRAALYTAGIVGGLS--TVAACAPSEKFLYMGGPLAIGLGVVFASSLGSMFLPPTTAlgaglySVSLYGGLV--L 206

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1443090097 211 FSGFIIYDTDNLIKR---------HAYDEyVTAAISLYLDTVNIFIAIFTAL 253
Cdd:cd10431   207 FGGFLLYDTQKIIKRaethplygvRKYDP-INASMSIYMDTINIFIRLVTIL 257
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 209-249 5.00e-03

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 37.20  E-value: 5.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1443090097 209 LVFSGFIIYDTDNLIKR--HAYDEYVTAAISLYLDTVNIFIAI 249
Cdd:cd10430   162 LVFCGFVLFDTQMIIEKaeNGDRDYIWHALDLFVDFVALFRRL 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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