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Conserved domains on  [gi|1002285930|ref|XP_015647261|]
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ETO1-like protein 1 [Oryza sativa Japonica Group]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 1004771)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1), an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes; contains tetratricopeptide repeats

CATH:  1.25.40.10
Gene Ontology:  GO:0010105|GO:0016567|GO:0005515
PubMed:  17120193|27521773|30708253|10517866|21153002
SCOP:  4001139|4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 181-262 5.97e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18190:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 83  Bit Score: 87.96  E-value: 5.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 181 VTFQIRDGKVTCNRCKIASLSIPFWSMLNGPFTESQLDLVDLSENGISLEGMRAVSEFSCTYSLEDLPLETLLEILVFAN 260
Cdd:cd18190     2 LVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELAS 81


                  ..
gi 1002285930 261 TF 262
Cdd:cd18190    82 KF 83
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 383-833 1.65e-12

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 71.65  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 383 FHQLGCIRLLRKEYNEAEHQFSVAFS--AGHVYSIAGLARIAGTRGRKGLAYEKLSSVITSSvP--LGWMYMERSLYSEG 458
Cdd:TIGR02917 468 HNLLGAIYLGKGDLAKAREAFEKALSiePDFFPAAANLARIDIQEGNPDDAIQRFEKVLTID-PknLRAILALAGLYLRT 546

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 459 DKK---LGDLDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRLL-GFKLALECLELRICLYLALEDYKSAIcdiha 534
Cdd:TIGR02917 547 GNEeeaVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAAdAAPDSPEAWLMLGRAQLAAGDLNKAV----- 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 535 iltlsPEYRMLEGRVAASKIGTLLGAHVeqwntaecwlqlYERWSSVDdiGSLSVIYRMLESDAAKGVLYFRQSLLLLRL 614
Cdd:TIGR02917 622 -----SSFKKLLALQPDSALALLLLADA------------YAVMKNYA--KAITSLKRALELKPDNTEAQIGLAQLLLAA 682

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 615 NCPEAAMRSLQLARQHAATEHERLVYEGWLLYDTGHCEEALQKAEESISIQRSFEAFFLKAYVLADSGVDPSYSATvisl 694
Cdd:TIGR02917 683 KRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAEAVKT---- 758

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 695 LEDALKcpsDRLRKGQALNNLGGVYVDCEKLDAAADCYTSALKI--RHTRAHQGLARVhfLRNNRDAAYEEM-TKLIEKA 771
Cdd:TIGR02917 759 LEAWLK---THPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKapDNAVVLNNLAWL--YLELKDPRALEYaERALKLA 833

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 772 KNNASA--------YEKRseycEREQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIA 833
Cdd:TIGR02917 834 PNIPAIldtlgwllVEKG----EADRALPLLRKAVNIAPEAAAIRYHLALALLATGRKAEARKELDKLLN 899
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
799-875 1.85e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 1.85e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002285930 799 QLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIAFKADLH-LLHLRAAFHEHIGDVPSALRDCRAALSLDPNHQEML 875
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAeALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL 79
 
Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 181-262 5.97e-21

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 87.96  E-value: 5.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 181 VTFQIRDGKVTCNRCKIASLSIPFWSMLNGPFTESQLDLVDLSENGISLEGMRAVSEFSCTYSLEDLPLETLLEILVFAN 260
Cdd:cd18190     2 LVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELAS 81


                  ..
gi 1002285930 261 TF 262
Cdd:cd18190    82 KF 83
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 383-833 1.65e-12

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 71.65  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 383 FHQLGCIRLLRKEYNEAEHQFSVAFS--AGHVYSIAGLARIAGTRGRKGLAYEKLSSVITSSvP--LGWMYMERSLYSEG 458
Cdd:TIGR02917 468 HNLLGAIYLGKGDLAKAREAFEKALSiePDFFPAAANLARIDIQEGNPDDAIQRFEKVLTID-PknLRAILALAGLYLRT 546

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 459 DKK---LGDLDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRLL-GFKLALECLELRICLYLALEDYKSAIcdiha 534
Cdd:TIGR02917 547 GNEeeaVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAAdAAPDSPEAWLMLGRAQLAAGDLNKAV----- 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 535 iltlsPEYRMLEGRVAASKIGTLLGAHVeqwntaecwlqlYERWSSVDdiGSLSVIYRMLESDAAKGVLYFRQSLLLLRL 614
Cdd:TIGR02917 622 -----SSFKKLLALQPDSALALLLLADA------------YAVMKNYA--KAITSLKRALELKPDNTEAQIGLAQLLLAA 682

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 615 NCPEAAMRSLQLARQHAATEHERLVYEGWLLYDTGHCEEALQKAEESISIQRSFEAFFLKAYVLADSGVDPSYSATvisl 694
Cdd:TIGR02917 683 KRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAEAVKT---- 758

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 695 LEDALKcpsDRLRKGQALNNLGGVYVDCEKLDAAADCYTSALKI--RHTRAHQGLARVhfLRNNRDAAYEEM-TKLIEKA 771
Cdd:TIGR02917 759 LEAWLK---THPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKapDNAVVLNNLAWL--YLELKDPRALEYaERALKLA 833

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 772 KNNASA--------YEKRseycEREQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIA 833
Cdd:TIGR02917 834 PNIPAIldtlgwllVEKG----EADRALPLLRKAVNIAPEAAAIRYHLALALLATGRKAEARKELDKLLN 899
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 692-877 8.74e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.68  E-value: 8.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 692 ISLLEDALKCPSDRLrkgQALNNLGGVYVDCEKLDAAADCYTSALKIRHTR--AHQGLARVHFLRNNRDAAYEEMTKLIE 769
Cdd:COG2956    28 IDLLEEALELDPETV---EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRaeALLELAQDYLKAGLLDRAEELLEKLLE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 770 KAKNNASAYEKRSEYCER----EQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIAF-KADLHLLHLR 844
Cdd:COG2956   105 LDPDDAEALRLLAEIYEQegdwEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLdPDCARALLLL 184

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1002285930 845 AAFHEHIGDVPSALRDCRAALSLDPNHQEMLEL 877
Cdd:COG2956   185 AELYLEQGDYEEAIAALERALEQDPDYLPALPR 217
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 181-278 6.79e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 45.37  E-value: 6.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930  181 VTFQIRDGKVTCNRCKIASLSIPFWSMLNGPFTESQLDLVDLSEngISLEGMRAVSEFSCTYSLeDLPLETLLEILVFAN 260
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKL-DLPEENVEELLELAD 78

                           90
                   ....*....|....*...
gi 1002285930  261 TFCCDRLKDACDRKLASF 278
Cdd:smart00225  79 YLQIPGLVELCEEFLLKL 96
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
799-875 1.85e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 1.85e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002285930 799 QLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIAFKADLH-LLHLRAAFHEHIGDVPSALRDCRAALSLDPNHQEML 875
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAeALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL 79
 
Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 181-262 5.97e-21

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 87.96  E-value: 5.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 181 VTFQIRDGKVTCNRCKIASLSIPFWSMLNGPFTESQLDLVDLSENGISLEGMRAVSEFSCTYSLEDLPLETLLEILVFAN 260
Cdd:cd18190     2 LVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELAS 81


                  ..
gi 1002285930 261 TF 262
Cdd:cd18190    82 KF 83
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 383-833 1.65e-12

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 71.65  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 383 FHQLGCIRLLRKEYNEAEHQFSVAFS--AGHVYSIAGLARIAGTRGRKGLAYEKLSSVITSSvP--LGWMYMERSLYSEG 458
Cdd:TIGR02917 468 HNLLGAIYLGKGDLAKAREAFEKALSiePDFFPAAANLARIDIQEGNPDDAIQRFEKVLTID-PknLRAILALAGLYLRT 546

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 459 DKK---LGDLDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRLL-GFKLALECLELRICLYLALEDYKSAIcdiha 534
Cdd:TIGR02917 547 GNEeeaVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAAdAAPDSPEAWLMLGRAQLAAGDLNKAV----- 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 535 iltlsPEYRMLEGRVAASKIGTLLGAHVeqwntaecwlqlYERWSSVDdiGSLSVIYRMLESDAAKGVLYFRQSLLLLRL 614
Cdd:TIGR02917 622 -----SSFKKLLALQPDSALALLLLADA------------YAVMKNYA--KAITSLKRALELKPDNTEAQIGLAQLLLAA 682

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 615 NCPEAAMRSLQLARQHAATEHERLVYEGWLLYDTGHCEEALQKAEESISIQRSFEAFFLKAYVLADSGVDPSYSATvisl 694
Cdd:TIGR02917 683 KRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAEAVKT---- 758

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 695 LEDALKcpsDRLRKGQALNNLGGVYVDCEKLDAAADCYTSALKI--RHTRAHQGLARVhfLRNNRDAAYEEM-TKLIEKA 771
Cdd:TIGR02917 759 LEAWLK---THPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKapDNAVVLNNLAWL--YLELKDPRALEYaERALKLA 833

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 772 KNNASA--------YEKRseycEREQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIA 833
Cdd:TIGR02917 834 PNIPAIldtlgwllVEKG----EADRALPLLRKAVNIAPEAAAIRYHLALALLATGRKAEARKELDKLLN 899
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 692-877 8.74e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.68  E-value: 8.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 692 ISLLEDALKCPSDRLrkgQALNNLGGVYVDCEKLDAAADCYTSALKIRHTR--AHQGLARVHFLRNNRDAAYEEMTKLIE 769
Cdd:COG2956    28 IDLLEEALELDPETV---EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRaeALLELAQDYLKAGLLDRAEELLEKLLE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 770 KAKNNASAYEKRSEYCER----EQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIAF-KADLHLLHLR 844
Cdd:COG2956   105 LDPDDAEALRLLAEIYEQegdwEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLdPDCARALLLL 184

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1002285930 845 AAFHEHIGDVPSALRDCRAALSLDPNHQEMLEL 877
Cdd:COG2956   185 AELYLEQGDYEEAIAALERALEQDPDYLPALPR 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
710-875 2.03e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.03  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 710 QALNNLGGVYVDCEKLDAAADCYTSALKI--RHTRAHQGLARVHFLRNNRDAAYEEMTKLIEKAKNNASAYekrseycer 787
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELdpDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL--------- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 788 eqtmtdlqivtqldplrvypyRYRAAVLMDSHKEKEAIAELTRAIAFKADLHLLHL-RAAFHEHIGDVPSALRDCRAALS 866
Cdd:COG0457    80 ---------------------NNLGLALQALGRYEEALEDYDKALELDPDDAEALYnLGLALLELGRYDEAIEAYERALE 138


                  ....*....
gi 1002285930 867 LDPNHQEML 875
Cdd:COG0457   139 LDPDDADAL 147
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 598-868 9.91e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 9.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 598 AAKGVLYFRQSLLLLRLNCPEAAMRSLQLARQHAATEHERLVYEGWLLYDTGHCEEALQKAEESISI-QRSFEAFFLKAY 676
Cdd:COG2956     5 VAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERdPDRAEALLELAQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 677 VLADSGVDpsysATVISLLEDALKCPSDRLrkgQALNNLGGVYVDCEKLDAAADCYTSALKIRHTRAH--QGLARVHFLR 754
Cdd:COG2956    85 DYLKAGLL----DRAEELLEKLLELDPDDA---EALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHayCELAELYLEQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 755 NNRDAAYEEMTKLIEKAKNNASAYEKRSEYCEREQTMTD----LQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTR 830
Cdd:COG2956   158 GDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEaiaaLERALEQDPDYLPALPRLAELYEKLGDPEEALELLRK 237

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1002285930 831 AIAFKADLHLLHLRAAFHEHIGDVPSALRDCRAALSLD 868
Cdd:COG2956   238 ALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 181-271 2.29e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 55.71  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 181 VTFQIRDGKVTCNRCKIASLSIPFWSMLNGPFTESQLDLVDLSenGISLEGMRAVSEFSCTYSLEDLPLETLLEILVFAN 260
Cdd:cd18300    12 VTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELP--GVSKETFLALLEYLYTDQAPILEDGDCVGLIVLAN 89

                          90
                  ....*....|.
gi 1002285930 261 TFCCDRLKDAC 271
Cdd:cd18300    90 RLCLPRLVALC 100
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
594-867 4.89e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.09  E-value: 4.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 594 LESDAAKGVLYFRQSLLLLRLNCPEAAMRSLQLARQHAATEHERLVYEGWLLYDTGHCEEALQKAEESISIqrsfeaffl 673
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 674 kayvladsgvDPSYSatvislledalkcpsdrlrkgQALNNLGGVYVDCEKLDAAADCYTSALKIR--HTRAHQGLARVH 751
Cdd:COG0457    72 ----------DPDDA---------------------EALNNLGLALQALGRYEEALEDYDKALELDpdDAEALYNLGLAL 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 752 FLRNNRDAAYEEMTKLIEKAKNNASAYEKRSE-YCEREQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTR 830
Cdd:COG0457   121 LELGRYDEAIEAYERALELDPDDADALYNLGIaLEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALL 200

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1002285930 831 AIAFKADLHLLHLRAAFHEHIGDVPSALRDCRAALSL 867
Cdd:COG0457   201 LALEQALRKKLAILTLAALAELLLLALALLLALRLAA 237
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 742-871 5.51e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.58  E-value: 5.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 742 RAHQGLARVHFLRNNRDAAYEEMTKLIEKAKNNASAYEKRSEYCER----EQTMTDLQIVTQLDPLRVYPYRYRAAVLMD 817
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQlgdlDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002285930 818 SHKEKEAIAELTRAIA-FKADLHLLHLRAAFHEHIGDVPSALRDCRAALSLDPNH 871
Cdd:COG4783    85 AGDYDEALALLEKALKlDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 391-885 2.97e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 391 LLRKEYNEAEHQFSVA--FSAGHVYSIAGLARIAGTRGRKGLAYEKLSSVITSSVPL--GWMYMERSLYSEGDKK--LGD 464
Cdd:TIGR02917 136 LGLGQLELAQKSYEQAlaIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNvdALLLKGDLLLSLGNIElaLAA 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 465 LDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRLLG-FKLALECLELRICLYLALEDYKSAICDIHAILTLSPEYr 543
Cdd:TIGR02917 216 YRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKkAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEY- 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 544 mLEGRVAASKIGTLLGAHVE------------------------------QWNTAECWLQLYERWSSVDD--IGSLSVIY 591
Cdd:TIGR02917 295 -LPALLLAGASEYQLGNLEQayqylnqilkyapnshqarrllasiqlrlgRVDEAIATLSPALGLDPDDPaaLSLLGEAY 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 592 rMLESDAAKGVLYF---------------RQSLLLLRLNCPEAAMRSLQLARQhaateherlvyegwLLYDTGHCEEAL- 655
Cdd:TIGR02917 374 -LALGDFEKAAEYLakateldpenaaartQLGISKLSQGDPSEAIADLETAAQ--------------LDPELGRADLLLi 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 656 ------QKAEESISIQRSFEA--------FFLKAYVLADSGVdpsySATVISLLEDALKCPSDRLrkgQALNNLGGVYVD 721
Cdd:TIGR02917 439 lsylrsGQFDKALAAAKKLEKkqpdnaslHNLLGAIYLGKGD----LAKAREAFEKALSIEPDFF---PAAANLARIDIQ 511

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 722 CEKLDAAADCYTSALKI--RHTRAHQGLARVHFLRNNRDA-------AYEEMTKLIEKAKNNASAYEKRSEYCEREQTMT 792
Cdd:TIGR02917 512 EGNPDDAIQRFEKVLTIdpKNLRAILALAGLYLRTGNEEEavawlekAAELNPQEIEPALALAQYYLGKGQLKKALAILN 591

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 793 DLQiVTQLDPLRVYPYRYRAAvLMDSHKEKeAIAELTRAIAFKADLHLLHLRAAF-HEHIGDVPSALRDCRAALSLDPNH 871
Cdd:TIGR02917 592 EAA-DAAPDSPEAWLMLGRAQ-LAAGDLNK-AVSSFKKLLALQPDSALALLLLADaYAVMKNYAKAITSLKRALELKPDN 668

                         570
                  ....*....|....
gi 1002285930 872 QEMLELQKRVNSQE 885
Cdd:TIGR02917 669 TEAQIGLAQLLLAA 682
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 710-837 9.02e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 9.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 710 QALNNLGGVYVDCEKLDAAADCYTSALKI--RHTRAHQGLARVHFLRNNRDAAYEEMTKLIEKAKNNASAYEKRSEYCER 787
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELdpDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1002285930 788 ----EQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIAFKAD 837
Cdd:COG4783    85 agdyDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 629-869 1.32e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.38  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 629 QHAATEHERLVYEGWLLYDTGHCEEALQKAEEsisIQRSFEAFFLKAYVLADSGVDPSYSATVISLLEDALKCPSDRLRK 708
Cdd:COG3914     1 AAAAALLALAALAAAALLAAAAAAELALAAEL---EAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 709 GQALNNLGGVYVDCEKLDAAADCYTSALKI--RHTRAHQGLARVHFLRNNRDAAYEEMTKLIEKAKNNASAYEKRSEYCE 786
Cdd:COG3914    78 AALLELAALLLQALGRYEEALALYRRALALnpDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 787 R----EQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIAFK---ADLHLLHLRAAFHEHIGDVPSALR 859
Cdd:COG3914   158 RlgrlEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDpdnADAHSNLLFALRQACDWEVYDRFE 237

                         250
                  ....*....|
gi 1002285930 860 DCRAALSLDP 869
Cdd:COG3914   238 ELLAALARGP 247
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
710-881 2.40e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.53  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 710 QALNNLGGVYVDCEKLDAAADCYTSALKI--RHTRAHQGLARVHFLRNNRDAAYEemtkliekaknnasayekrseycer 787
Cdd:COG4785    74 QLYYERGVAYDSLGDYDLAIADFDQALELdpDLAEAYNNRGLAYLLLGDYDAALE------------------------- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 788 eqtmtDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIAFKADLHLLHLRAAFHEHIGDVPSALRDCRA---- 863
Cdd:COG4785   129 -----DFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEdwat 203

                         170
                  ....*....|....*...
gi 1002285930 864 ALSLDPNHQEMLELQKRV 881
Cdd:COG4785   204 AYLLQGDTEEARELFKLA 221
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 723-875 3.60e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 50.76  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 723 EKLDAAADCYTSALKIRHTRAHQGLARVHFLRNNRDAAYEEMTKLIEKAKNNASAYEKRSEYcerEQTMTDLQIVTQLDP 802
Cdd:COG3914    33 EAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRY---EEALALYRRALALNP 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002285930 803 LRVYPYRYRAAVLMDSHKEKEAIAELTRAIAFKADLHLLHL-RAAFHEHIGDVPSALRDCRAALSLDPNHQEML 875
Cdd:COG3914   110 DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLnLGEALRRLGRLEEAIAALRRALELDPDNAEAL 183
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 181-278 6.79e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 45.37  E-value: 6.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930  181 VTFQIRDGKVTCNRCKIASLSIPFWSMLNGPFTESQLDLVDLSEngISLEGMRAVSEFSCTYSLeDLPLETLLEILVFAN 260
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKL-DLPEENVEELLELAD 78

                           90
                   ....*....|....*...
gi 1002285930  261 TFCCDRLKDACDRKLASF 278
Cdd:smart00225  79 YLQIPGLVELCEEFLLKL 96
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
747-873 1.06e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.60  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 747 LARVHFLRNNRDAAYEEMTKLIEKAKNNASAYEKRSEY-------CEREQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSH 819
Cdd:COG4785     8 LLLALALAAAAASKAAILLAALLFAAVLALAIALADLAlalaaaaLAAAALAAERIDRALALPDLAQLYYERGVAYDSLG 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002285930 820 KEKEAIAELTRAIAFKADL-HLLHLRAAFHEHIGDVPSALRDCRAALSLDPNHQE 873
Cdd:COG4785    88 DYDLAIADFDQALELDPDLaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAY 142
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 445-871 1.75e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 445 LGWMYMERSLYSEGDKklgDLDKATEL--DPTLTYPYMYRAASLMRKKDARLALEEINRLLGFKLALECLELRICLYLAL 522
Cdd:TIGR02917  62 LGKIYLALGDYAAAEK---ELRKALSLgyPKNQVLPLLARAYLLQGKFQQVLDELPGKTLLDDEGAAELLALRGLAYLGL 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 523 EDYKSAICDIHAILTLSP---------------EYRMLEGRVAASKIGTLLGAHVEQWNtaecwLQLYERWSSVDDIGSL 587
Cdd:TIGR02917 139 GQLELAQKSYEQALAIDPrslyaklglaqlalaENRFDEARALIDEVLTADPGNVDALL-----LKGDLLLSLGNIELAL 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 588 SVI--YRMLESDAAKGvlYFRQSLLLLRLNCPEAAMRSLQLARQHAATEHERLVYEGWLLYDTGHCEEALQKAEESISIQ 665
Cdd:TIGR02917 214 AAYrkAIALRPNNIAV--LLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSA 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 666 RSF---------EAFFLKAYVLADsgvdpsysatviSLLEDALK-CPSDRlrkgQALNNLGGVYVDCEKLDAAADCYTSA 735
Cdd:TIGR02917 292 PEYlpalllagaSEYQLGNLEQAY------------QYLNQILKyAPNSH----QARRLLASIQLRLGRVDEAIATLSPA 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 736 LKI--RHTRAHQGLARVHFLRNNRDAAYEEMTKLIEKAKNNASAYEK----RSEYCEREQTMTDLQIVTQLDPLRVYPYR 809
Cdd:TIGR02917 356 LGLdpDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQlgisKLSQGDPSEAIADLETAAQLDPELGRADL 435

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002285930 810 YRAAVLMDSHKEKEAIAELTRAIAFKADLHLLH-LRAAFHEHIGDVPSALRDCRAALSLDPNH 871
Cdd:TIGR02917 436 LLILSYLRSGQFDKALAAAKKLEKKQPDNASLHnLLGAIYLGKGDLAKAREAFEKALSIEPDF 498
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 727-882 5.94e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 5.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 727 AAADCYTSALKIR--HTRAHQGLARVHFLRNNRDAAYEEMTKLIEKAKNNASAyekrseycereqtmtdlqivtqldplr 804
Cdd:COG4235     1 EAIARLRQALAANpnDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADA--------------------------- 53

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002285930 805 vypYRYRAAVLMDSHKEKEAIAELTRAIAFK-ADLHLLHLRAAFHEHIGDVPSALRDCRAALSLDPNHQEMLELQKRVN 882
Cdd:COG4235    54 ---LLDLAEALLAAGDTEEAEELLERALALDpDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIA 129
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 692-778 1.05e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.07  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 692 ISLLEDALKC-PSDrlrkGQALNNLGGVYVDCEKLDAAADCYTSALKI--RHTRAHQGLARVHFLRNNRDAAYEEMTKLI 768
Cdd:COG4235     3 IARLRQALAAnPND----AEGWLLLGRAYLRLGRYDEALAAYEKALRLdpDNADALLDLAEALLAAGDTEEAEELLERAL 78

                          90
                  ....*....|
gi 1002285930 769 EKAKNNASAY 778
Cdd:COG4235    79 ALDPDNPEAL 88
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
799-875 1.85e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 1.85e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002285930 799 QLDPLRVYPYRYRAAVLMDSHKEKEAIAELTRAIAFKADLH-LLHLRAAFHEHIGDVPSALRDCRAALSLDPNHQEML 875
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAeALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL 79
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 598-738 6.17e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 6.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 598 AAKGVLYFRQSLLLLRLNCPEAAMRSLQLARQHAATEHERLVYEGWLLYDTGHCEEALQKAEESISIQ-RSFEAFFLKAY 676
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDpDEPEARLNLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002285930 677 VLADSGvDPSYSatvISLLEDALKC----PSDRLRKGQALNNLGgvyvdceKLDAAADCYTSALKI 738
Cdd:COG4783    81 ALLKAG-DYDEA---LALLEKALKLdpehPEAYLRLARAYRALG-------RPDEAIAALEKALEL 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
382-577 8.19e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.92  E-value: 8.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 382 AFHQLGCIRLLRKEYNEAEHQF--SVAFSAGHVYSIAGLARIAGTRGRKGLAYEKLSSVIT--SSVPLGWMYMERSLYSE 457
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYekALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEldPDDAEALNNLGLALQAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 458 GDKK--LGDLDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRLLGFKLAL-ECLELRICLYLALEDYKSAICDIHA 534
Cdd:COG0457    90 GRYEeaLEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDaDALYNLGIALEKLGRYEEALELLEK 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1002285930 535 ILTLSPEYRMLEGRVAASKIGTLLGAHVEQWNTAECWLQLYER 577
Cdd:COG0457   170 LEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLA 212
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
384-555 1.89e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.67  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 384 HQLGCIRLLRKEYNEAEHQFSVAFSA---GHVYSIAGLARIAGTRGRKGLAYEKLSSVITSSVPLGWMYMERSLYSEG-- 458
Cdd:COG4785     3 ALALALLLALALAAAAASKAAILLAAllfAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYERGva 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 459 -------DKKLGDLDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRllgfklaleCLEL----------RICLYLA 521
Cdd:COG4785    83 ydslgdyDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDR---------ALELdpdyayaylnRGIALYY 153

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1002285930 522 LEDYKSAICDIHAILTLSPE--YRMLEGRVAASKIG 555
Cdd:COG4785   154 LGRYELAIADLEKALELDPNdpERALWLYLAERKLD 189
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 181-262 2.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 181 VTFQIRDGKVTCNRCKIASLSIPFWSMLNGPFTESQLDLVDLseNGISLEGMRAVSEFSCTYSLeDLPLETLLEILVFAN 260
Cdd:cd18186     4 VTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIEL--DDVSPEAFEALLDYIYTGEL-ELSEENVEELLAAAD 80


                  ..
gi 1002285930 261 TF 262
Cdd:cd18186    81 KL 82
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
709-771 2.38e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 2.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002285930 709 GQALNNLGGVYVDCEKLDAAADcYTSALKI--RHTRAHQGLARVHFLRNNRDAAYEEMTKLIEKA 771
Cdd:COG3063    26 ADALNNLGLLLLEQGRYDEAIA-LEKALKLdpNNAEALLNLAELLLELGDYDEALAYLERALELD 89
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 445-551 3.02e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.83  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 445 LGWMYMERSLYsegDKKLGDLDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRLLgfKLALECLELRICL---YLA 521
Cdd:COG4235    23 LGRAYLRLGRY---DEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERAL--ALDPDNPEALYLLglaAFQ 97

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1002285930 522 LEDYKSAICDIHAILTLSP---EYRMLEGRVAA 551
Cdd:COG4235    98 QGDYAEAIAAWQKLLALLPadaPARLLEASIAE 130
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
382-560 3.45e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 382 AFHQLGCIRLLRKEYNEAEHQF--SVAFSAGHVYSIAGLARIAGTRGRKGLAYEKLSSVIT--SSVPLGWMYMERSLYSE 457
Cdd:COG0457    44 ALYNLGLAYLRLGRYEEALADYeqALELDPDDAEALNNLGLALQALGRYEEALEDYDKALEldPDDAEALYNLGLALLEL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 458 GDKK--LGDLDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRLLGFKLALECLELRICLYLALEDYKSAICDIHAI 535
Cdd:COG0457   124 GRYDeaIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLAL 203

                         170       180
                  ....*....|....*....|....*
gi 1002285930 536 LTLSPEYRMLEGRVAASKIGTLLGA 560
Cdd:COG0457   204 EQALRKKLAILTLAALAELLLLALA 228
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
750-839 3.76e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 750 VHFLRNNRDAAYEEMTKLIEKAKNNASAYEKRSE-YCEREQTMT--DLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIA 826
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLlLLEQGRYDEaiALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                          90
                  ....*....|...
gi 1002285930 827 ELTRAIAFKADLH 839
Cdd:COG3063    81 YLERALELDPSAL 93
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 725-869 4.71e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.79  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 725 LDAAADCYTSALKIRHTRAHQGLARVHFLRNNRDAAYEEMTKLIEKAKNNASAYEKRSEYCEREQtmtDLQIVTQLDPLR 804
Cdd:COG5010    11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLA---LLEQALQLDPNN 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002285930 805 VYPYRYRAAVLMDSHKEKEAIAELTRAIAFK-ADLHLLHLRAAFHEHIGDVPSALRDCRAALSLDP 869
Cdd:COG5010    88 PELYYNLALLYSRSGDKDEAKEYYEKALALSpDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 181-270 5.81e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 37.62  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 181 VTFQIRDGKVTCNRCKIASLSIPFWSMLNGPFTESQLDLVDLseNGISLEGMRAVSEFscTYS-LEDLPL-ETLLEILVF 258
Cdd:cd18286    20 ITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITL--TGVSHAAVSFVLLF--IYGgVLDLPDdVNLGELLSL 95

                          90
                  ....*....|..
gi 1002285930 259 ANTFCCDRLKDA 270
Cdd:cd18286    96 ADMYGLDGLKDV 107
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
444-529 5.81e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.13  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 444 PLGWMYMERSLYSEG--DKKLGDLDKATELDPTLTYPYMYRAASLMRKKDARLALEEINRLLGFKLALECLELRICLYLA 521
Cdd:COG4785   107 AEAYNNRGLAYLLLGdyDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAER 186


                  ....*...
gi 1002285930 522 LEDYKSAI 529
Cdd:COG4785   187 KLDPEKAL 194
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
777-870 7.45e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 7.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002285930 777 AYEKRSEYcerEQTMTDLQIVTQLDPLRVYPYRYRAAVLMDSHKEKEAIAeLTRAIAFKADL-HLLHLRAAFHEHIGDVP 855
Cdd:COG3063     1 LYLKLGDL---EEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNaEALLNLAELLLELGDYD 76

                          90
                  ....*....|....*
gi 1002285930 856 SALRDCRAALSLDPN 870
Cdd:COG3063    77 EALAYLERALELDPS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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