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Conserved domains on  [gi|1002287817|ref|XP_015648212|]
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uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEUBAD_NFRKB cd21865
DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar ...
 66-173 2.56e-33

DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar proteins; NFRKB, also called DNA-binding protein R kappa-B, or INO80 complex subunit G (INO80G), is a regulatory component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. It modulates the deubiquitinase activity of UCHL5 in the INO80 complex. It binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. The model corresponds to the DEUBAD domain (conserved domain within the UCH regulatory proteins RPN13, NFRKB/INO80G, and ASX) of NFRKB, which binds primarily to the C-terminal ULD domain of UCH-L5.


:

Pssm-ID: 439381  Cd Length: 112  Bit Score: 122.70  E-value: 2.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002287817  66 LYDLPELNDILSLETWNLCLTEDDRFRLAAYLPDM---DQHDFFVTMKELFSGSDLFFGSPVKSFFHRLNGGFYSPEVSQ 142
Cdd:cd21865     2 CEDLEIFKEVLSLETWNSLLSEEEREHLMQFLPQFpenDEEEKEETLRMLFSGENFHFGNPLDKFQEKLKAGHFHPDIAK 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002287817 143 ARELLMIFERRRYYHFLKSHHDGMIFKFASM 173
Cdd:cd21865    82 YRKLLRKAQRKEYKYRLRKYHNRLLKDLLLS 112
 
Name Accession Description Interval E-value
DEUBAD_NFRKB cd21865
DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar ...
 66-173 2.56e-33

DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar proteins; NFRKB, also called DNA-binding protein R kappa-B, or INO80 complex subunit G (INO80G), is a regulatory component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. It modulates the deubiquitinase activity of UCHL5 in the INO80 complex. It binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. The model corresponds to the DEUBAD domain (conserved domain within the UCH regulatory proteins RPN13, NFRKB/INO80G, and ASX) of NFRKB, which binds primarily to the C-terminal ULD domain of UCH-L5.


Pssm-ID: 439381  Cd Length: 112  Bit Score: 122.70  E-value: 2.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002287817  66 LYDLPELNDILSLETWNLCLTEDDRFRLAAYLPDM---DQHDFFVTMKELFSGSDLFFGSPVKSFFHRLNGGFYSPEVSQ 142
Cdd:cd21865     2 CEDLEIFKEVLSLETWNSLLSEEEREHLMQFLPQFpenDEEEKEETLRMLFSGENFHFGNPLDKFQEKLKAGHFHPDIAK 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002287817 143 ARELLMIFERRRYYHFLKSHHDGMIFKFASM 173
Cdd:cd21865    82 YRKLLRKAQRKEYKYRLRKYHNRLLKDLLLS 112
ASXH pfam13919
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ...
 72-145 2.21e-05

Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.


Pssm-ID: 464041  Cd Length: 129  Bit Score: 44.20  E-value: 2.21e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002287817  72 LNDILSLETWNlCLTEDDRFRLAAYLPDMDQHDFFVTMKEL----FSGSDLFFGSPVKSFFHRLNGGFYSPEVSQARE 145
Cdd:pfam13919  29 LRALLNKAAWD-CLPPEEQQELLSLLPDVDHILDPDTDDSRpalpSLRNNEFFRHACARFQEDLAEGRFDPELRQAWK 105
 
Name Accession Description Interval E-value
DEUBAD_NFRKB cd21865
DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar ...
 66-173 2.56e-33

DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar proteins; NFRKB, also called DNA-binding protein R kappa-B, or INO80 complex subunit G (INO80G), is a regulatory component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. It modulates the deubiquitinase activity of UCHL5 in the INO80 complex. It binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. The model corresponds to the DEUBAD domain (conserved domain within the UCH regulatory proteins RPN13, NFRKB/INO80G, and ASX) of NFRKB, which binds primarily to the C-terminal ULD domain of UCH-L5.


Pssm-ID: 439381  Cd Length: 112  Bit Score: 122.70  E-value: 2.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002287817  66 LYDLPELNDILSLETWNLCLTEDDRFRLAAYLPDM---DQHDFFVTMKELFSGSDLFFGSPVKSFFHRLNGGFYSPEVSQ 142
Cdd:cd21865     2 CEDLEIFKEVLSLETWNSLLSEEEREHLMQFLPQFpenDEEEKEETLRMLFSGENFHFGNPLDKFQEKLKAGHFHPDIAK 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002287817 143 ARELLMIFERRRYYHFLKSHHDGMIFKFASM 173
Cdd:cd21865    82 YRKLLRKAQRKEYKYRLRKYHNRLLKDLLLS 112
ASXH pfam13919
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ...
 72-145 2.21e-05

Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.


Pssm-ID: 464041  Cd Length: 129  Bit Score: 44.20  E-value: 2.21e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002287817  72 LNDILSLETWNlCLTEDDRFRLAAYLPDMDQHDFFVTMKEL----FSGSDLFFGSPVKSFFHRLNGGFYSPEVSQARE 145
Cdd:pfam13919  29 LRALLNKAAWD-CLPPEEQQELLSLLPDVDHILDPDTDDSRpalpSLRNNEFFRHACARFQEDLAEGRFDPELRQAWK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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