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Conserved domains on  [gi|1002293091|ref|XP_015650887|]
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eukaryotic translation initiation factor 3 subunit I isoform X1 [Oryza sativa Japonica Group]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-314 5.86e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.25  E-value: 5.86e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   2 RPILMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDV 81
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  82 QTGRELFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLN 158
Cdd:COG2319   192 ATGKLLRTLTgHTGAVRSVAFS-PDGklLASGSADG------TVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 159 RTIITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTER-PVNA 237
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRS 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002293091 238 VDISPLLDHVVIGGGQDAmnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRSFSSGGEDGYVRL 314
Cdd:COG2319   336 VAFSPDGKTLASGSDDGT--VRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-314 5.86e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.25  E-value: 5.86e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   2 RPILMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDV 81
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  82 QTGRELFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLN 158
Cdd:COG2319   192 ATGKLLRTLTgHTGAVRSVAFS-PDGklLASGSADG------TVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 159 RTIITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTER-PVNA 237
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRS 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002293091 238 VDISPLLDHVVIGGGQDAmnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRSFSSGGEDGYVRL 314
Cdd:COG2319   336 VAFSPDGKTLASGSDDGT--VRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-314 3.76e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.27  E-value: 3.76e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  87 LFTFR-FDAPARSVEFaIGDGLAVITT--DN--FMENVPTAQVKRiaedpddqseesllVITGIKGRINRAVWGPLNRTI 161
Cdd:cd00200    86 VRTLTgHTSYVSSVAF-SPDGRILSSSsrDKtiKVWDVETGKCLT--------------TLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 162 ITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDI 240
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002293091 241 SPlLDHVVIGGGQDamnvtmtdrraGKFeaKFFHKILQEEIGGVKGHFGPINALAFNPDGRSFSSGGEDGYVRL 314
Cdd:cd00200   228 SP-DGYLLASGSED-----------GTI--RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-80 1.60e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.60e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002293091   41 NGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 2.51e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.51e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1002293091  42 GDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-314 5.86e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.25  E-value: 5.86e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   2 RPILMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDV 81
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  82 QTGRELFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLN 158
Cdd:COG2319   192 ATGKLLRTLTgHTGAVRSVAFS-PDGklLASGSADG------TVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 159 RTIITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTER-PVNA 237
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRS 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002293091 238 VDISPLLDHVVIGGGQDAmnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRSFSSGGEDGYVRL 314
Cdd:COG2319   336 VAFSPDGKTLASGSDDGT--VRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
8-314 1.20e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 1.20e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   8 GHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGREL 87
Cdd:COG2319    76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  88 FTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvptaQVKRIaedpDDQSEESLLVITGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319   156 RTLTgHSGAVTSVAFS-PDGklLASGSDDG--------TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 165 GEDATIRIWDTETGQCLKEsdkEQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPL 243
Cdd:COG2319   223 SADGTVRLWDLATGKLLRT---LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPD 299

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002293091 244 LDHVVIGGGQDAmnVTMTDRRAGKfeakffhkilqeEIGGVKGHFGPINALAFNPDGRSFSSGGEDGYVRL 314
Cdd:COG2319   300 GKLLASGSDDGT--VRLWDLATGK------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-314 3.76e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.27  E-value: 3.76e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  87 LFTFR-FDAPARSVEFaIGDGLAVITT--DN--FMENVPTAQVKRiaedpddqseesllVITGIKGRINRAVWGPLNRTI 161
Cdd:cd00200    86 VRTLTgHTSYVSSVAF-SPDGRILSSSsrDKtiKVWDVETGKCLT--------------TLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 162 ITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDI 240
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002293091 241 SPlLDHVVIGGGQDamnvtmtdrraGKFeaKFFHKILQEEIGGVKGHFGPINALAFNPDGRSFSSGGEDGYVRL 314
Cdd:cd00200   228 SP-DGYLLASGSED-----------GTI--RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
8-314 3.90e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 3.90e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   8 GHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGREL 87
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  88 FTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319   114 RTLTgHTGAVRSVAFS-PDGktLASGSADG------TVRLWDLA------TGKLLRTLTGHSGAVTSVAFSPDGKLLASG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 165 GEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPl 243
Cdd:COG2319   181 SDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSP- 256

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002293091 244 lD-HVVIGGGQDAMnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRSFSSGGEDGYVRL 314
Cdd:COG2319   257 -DgRLLASGSADGT-VRLWDLATGELLRTL------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
7-222 1.75e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 1.75e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  87 LFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLNRTIIT 163
Cdd:COG2319   281 LRTLTgHSGGVNSVAFS-PDGklLASGSDDG------TVRLWDLA------TGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002293091 164 AGEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRT 222
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTL---TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-319 2.96e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 2.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  45 LGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRELFTFR--FDAPARSVEFAIGDGLAVITTDNfmenvpTA 122
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghTGPVRDVAASADGTYLASGSSDK------TI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 123 QVKriaedpDDQSEESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWDTETGQCLKEsdkEQGHQKTITSLSKSAD 202
Cdd:cd00200    76 RLW------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT---LRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 203 wSHFLT-GSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPLLDHVVIGGGqdAMNVTMTDRRAGKfeakffhkilqeE 280
Cdd:cd00200   147 -GTFVAsSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSS--DGTIKLWDLSTGK------------C 211

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1002293091 281 IGGVKGHFGPINALAFNPDGRSFSSGGEDGYVRLHHFDS 319
Cdd:cd00200   212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-219 2.04e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 2.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   6 MKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGR 85
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  86 ELFTFR-FDAPARSVEFaIGDGLAVITT--DNfmenvptaQVKRIaedpDDQSEESLLVITGIKGRINRAVWGPLNRTII 162
Cdd:cd00200   169 CVATLTgHTGEVNSVAF-SPDGEKLLSSssDG--------TIKLW----DLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002293091 163 TAGEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:cd00200   236 SGSEDGTIRVWDLRTGECVQTL---SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
5-177 6.15e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 6.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091   5 LMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTG 84
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091  85 RELFTFrfdaparsvefaigdglavittdnfmenvptaqvkriaedpddqseesllviTGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319   363 ELLRTL----------------------------------------------------TGHTGAVTSVAFSPDGRTLASG 390

                         170
                  ....*....|...
gi 1002293091 165 GEDATIRIWDTET 177
Cdd:COG2319   391 SADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-80 5.43e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 5.43e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002293091   5 LMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
153-319 1.38e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 153 VWGPLNRTIITAGEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTE 232
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLL---LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293091 233 R-PVNAVDISPLLDHVVIGGGQDAmnVTMTDRRAGkfeakffhkilqEEIGGVKGHFGPINALAFNPDGRSFSSGGEDGY 311
Cdd:COG2319    78 TaAVLSVAFSPDGRLLASASADGT--VRLWDLATG------------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143


                  ....*...
gi 1002293091 312 VRLHHFDS 319
Cdd:COG2319   144 VRLWDLAT 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-80 1.60e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.60e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002293091   41 NGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 2.51e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.51e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1002293091  42 GDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
285-314 3.78e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.78e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1002293091 285 KGHFGPINALAFNPDGRSFSSGGEDGYVRL 314
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 285-316 3.91e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.91e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1002293091  285 KGHFGPINALAFNPDGRSFSSGGEDGYVRLHH 316
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-219 7.40e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.40e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1002293091  177 TGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:smart00320   1 SGELLKTL---KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-219 1.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.22e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1002293091 188 QGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 2.51e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1002293091  135 SEESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
137-174 3.01e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1002293091 137 ESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWD 174
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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