|
Name |
Accession |
Description |
Interval |
E-value |
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1079-1421 |
2.88e-103 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 333.11 E-value: 2.88e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1079 ISVVGDVVGPIFPTMPVNATSLIGLPMDCGEQTMFSFAANMYTTLHMRLINQRNLTQEKQSFYYMNIGYQRQLSFMNPDG 1158
Cdd:pfam07678 1 ISVVGDIMGPAIQVVPENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1159 SFSLFRSdwnvSSPSVWLTAYCVRifeeaSFYEWENHLYIDPKVIAQAVSWLLDHQTYEGSFYEVTWLPDRKINSTLHyd 1238
Cdd:pfam07678 81 SYSAFGH----SPGSTWLTAFVLK-----VFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVD-- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1239 gdeshypykssRNISLTAHVLITLETVKDLSdGLGARVALAAANAVRYleQNLQLLELGGRPYEIAIVAYAL-LQAKAST 1317
Cdd:pfam07678 150 -----------GEVSLTAYVTIALLEALDIN-GLLQRVHPSIRKALTY--LEQAQLAGLTSPYTLAILAYALaLAGSPET 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1318 AEQAFNLLRRYRREEGGLVYWGREMVPQPPYKtenqkpfllPRLPYTYDSENIETTAYALLVHVARQEVE-VEPIVKWLN 1396
Cdd:pfam07678 216 REELLKSLDAMAREEGNSRYWERDEKSDPQGV---------PEYPPQAPSLEVETTAYALLAYLLLGDLTyADPIVKWLT 286
|
330 340
....*....|....*....|....*
gi 1032745297 1397 SQRLTDGGWASTQDTAWAMKALMEY 1421
Cdd:pfam07678 287 SQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
1096-1421 |
5.65e-58 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 202.42 E-value: 5.65e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1096 NATSLIGLPMDCGEQTMFSFAANMYTTLHMRLINQrnLTQEKQS--FYYMNIGYQRQLSFMNPDGSFSLFR-SDwnvSSP 1172
Cdd:cd02897 4 NLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQ--LTPEIESkaLGFLRTGYQRQLTYKHSDGSYSAFGeSD---KSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1173 SVWLTAYCVRIFEEASfyeweNHLYIDPKVIAQAVSWLLDHQTYEGSFyevtwlpdRKINSTLHYDGDESHypyksSRNI 1252
Cdd:cd02897 79 STWLTAFVLKSFAQAR-----PFIYIDENVLQQALTWLSSHQKSNGCF--------REVGRVFHKAMQGGV-----DDEV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1253 SLTAHVLITL-ETVKD-----LSDGLGARVALAAANAVryleqnlqllelggrPYEIAIVAYALLQAKASTAEQAFNLLR 1326
Cdd:cd02897 141 ALTAYVLIALlEAGLPserpvVEKALSCLEAALDSISD---------------PYTLALAAYALTLAGSEKRPEALKKLD 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1327 RYRREEGGLVYWGRemvpqpPYKTENQkpfllPRLPYTYDSENIETTAYALLVHVARQEVEVE---PIVKWLNSQRLTDG 1403
Cdd:cd02897 206 ELAISEDGTKHWSR------PPPSEEG-----PSYYWQAPSAEVEMTAYALLALLSAGGEDLAealPIVKWLAKQRNSLG 274
|
330
....*....|....*...
gi 1032745297 1404 GWASTQDTAWAMKALMEY 1421
Cdd:cd02897 275 GFSSTQDTVVALQALAKY 292
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
209-1506 |
3.19e-29 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 127.89 E-value: 3.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 209 QRSMTIFIQCDKPVYMQGQTIRFRTIPINTELKAFDD---TVEVhmLDPYRRIMRRWLSKQSNLGTVSLSYQLSDQPVFG 285
Cdd:COG2373 366 PGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGlplTLEL--TDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTG 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 286 EWIIKVIAQG--QIEEKAIFVEEYYQTRFEVNVTMP-AFFFDNEPyIHGIVQANYTSGAPVHGN-LTLKASFKPinkysq 361
Cdd:COG2373 444 TWRLELYVDPkpALGSKSFRVEEFKPPRFKVDLTLDkEPLKPGDP-VTVTVDARYLFGAPAAGLkVEGEVTLRP------ 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 362 ttgamenIPDRYFNFNEYYpawFNPPDLFRETVPVLRF-----FNGTYRFQYPmselLPYLPNNSDGMEVTVTATVGE-- 434
Cdd:COG2373 517 -------ARTAFPGYPGYR---FGDPDEEFEPEELDLGegtldADGKASLSLP----LPDAPDAPGPLRATVEASVFEsg 582
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 435 -RFLE---EIIVGYSTARIynsSIKIHFFGGSPqvfkPGMPFDLNLVASFHDGSPLRAAQLRgAQL---EVRGDIEMRSG 507
Cdd:COG2373 583 gRPVTrsaTVPVHPADFYV---GIRLPLFDGDP----EGAPATFEVVAVDPDGKPVAGKGLK-VELyreEWRYVWYKSDD 654
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 508 RRS----------LDNQIVRVSPENAAVWSLQID----LRKQFESSQGpqhtqqllNEIVSMRFYAdlTDGEGhhahael 573
Cdd:COG2373 655 GGWryesqekeepVAEGTLTTGADGPASLSLTPVewgrYRLEVKDPDG--------GLATSVRFYA--GGNAS------- 717
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 574 lmLAHESPNQkhikVWTSTEKA--KVGEYLVLHVQSNFyiesfnylvmsKGTILLT--SDE-------HMQQSIKTFAVP 642
Cdd:COG2373 718 --WGAERPDR----LELSLDKEsyKPGETAKLLIQSPF-----------AGRALVTveRDGvletqwvDVKGGGTTVEIP 780
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 643 LSPEMAPVATVLVYHVgKYGDVIADSL------TVPVNgISRNN--FTVFIN-NKKARTGERVEVAV-----YGEAgAYV 708
Cdd:COG2373 781 VTEDWAPNAYVSATLV-RPGDSTANDMparaygVAPLP-VDPPArrLKVELTaPEKLRPGETLTVTVkvkgaAGKA-AEV 857
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 709 ALSGIDRSFYAmqagneLTyanviekmsnfGEQTngthahtwlfhegdPDvvvnfPSSTFgidvnrtFEYIGL-VAFTDa 787
Cdd:COG2373 858 TLAAVDEGILN------LT-----------GYKT--------------PD-----PLDFF-------YGKRALgVETRD- 893
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 788 vIYRRpehcnrtlgYLECLTGRCYRVEQQCDGIMqcddgtdearcpvGNATDIAHFRKwRFNriqrqyeNVWMWR-DINI 866
Cdd:COG2373 894 -LYGR---------LIGAFGGAAGALRSGGDGAL-------------GRGGNPKPPRK-RFK-------PVALFSgPVKT 942
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 867 GPHGRFIFNIDVPK--TPVHWMITAFgmSPTnGFGMLPTALeyIAVLPFYINVEMPEHCKQGEQVGIRVSIFNY----MR 940
Cdd:COG2373 943 DADGKATVSFDLPDfnGTLRVMAVAW--SDD-RFGSAEATV--TVRKPLVVRPSLPRFLAPGDRFELPVDVFNLtgkaGT 1017
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 941 YNIEATVvladsrdykfvhveDNGIVESYNPRTSFGehqfflwIPAQDASIVYIPIVPVRLGDIKVHISATTLIGKDSAT 1020
Cdd:COG2373 1018 VTVTLEA--------------SGGLTLEGEATQTVT-------LAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDARE 1076
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1021 RTLHVEADGLPQYRHQSILLDlSNrayvfqymhvnitETPIIPYEEDRYYIFGSNKATISVVgdvvgpifPTMPVNAT-- 1098
Cdd:COG2373 1077 VELPVRPANPLVTRATSGVLA-PG-------------ESWTLPLDLPGGLRPGTGSLTLSLS--------SSPPLDLAgl 1134
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1099 --SLIGLPMDCGEQTMFSFAANMYTTlhmRLINQRNLT--QEKQSFYYMNIGYQRQLSFMNPDGSFSLFRSDwnvSSPSV 1174
Cdd:COG2373 1135 lrYLLRYPYGCTEQTTSRALPLLYLS---DLAEALGLKgdKDAELRARIQAAIARLLSMQNSDGGFGLWPGG---SESDP 1208
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1175 WLTAYCVRIFEEASfyewENHLYIDPKVIAQAVSWLLDhqtyegsfyevtwlpdrkinsTLHYDGDESHYPYKSSRNISL 1254
Cdd:COG2373 1209 WLTAYATDFLLEAR----EAGYAVPDDALDRALDYLRN---------------------YLRNPWEIEYDDAYRLAVRAY 1263
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1255 TAHVL-----ITLETVKDLSDGLGARVAlaaanavryleqnlqllelggrPYEIAIVAYALLQAK-ASTAEQAFNLLRRY 1328
Cdd:COG2373 1264 ALYVLaragkADLGDLRYLYDRRKDALS----------------------PLAKAQLAAALALLGdKARAEELLAAALAR 1321
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1329 RREEGGLVYWGremvpqppyktenqkpfllprlpYTYDSeNIETTAYAL--LVHVARQEVEVEPIVKWLnSQRLTDGGWA 1406
Cdd:COG2373 1322 LRETGARDYWY-----------------------GDYGS-PLRDQALALalLAELGPDAPLAPKLARWL-AKALKSGRWL 1376
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1407 STQDTAWAMKALMEYtvrsriRDVSQLSVTIEATALPGQTNILHVNNKNLARLQtlhIPEAW---GTVKVQAKGAGyail 1483
Cdd:COG2373 1377 STQETAWALLALAAY------ARAAGASPDFTATLTLDGKTLPLTGRGPLARVT---LPAAEllaGPLTITNTGDG---- 1443
|
1370 1380
....*....|....*....|...
gi 1032745297 1484 qmHVQYNVDIRRFQTKPPVPAFD 1506
Cdd:COG2373 1444 --PLYYTLTLSGYPAEGPPPAAS 1464
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
586-720 |
4.12e-29 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 113.98 E-value: 4.12e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 586 IKVWTSTEKAKVGEYLVLHVQSNF----YIESFNYLVMSKGTILLTSdehMQQSIKTFAVPLSPEMAPVATVLVYHVGKY 661
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFdgtvERDGFTYLVLSKGQIVVVG---RGGVTTSFSLPVTAEMAPSARVVAYYVRVD 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1032745297 662 ---GDVIADSLTVPVNGISRNNFTVFINNKKARTGERVEVAVYGEAGAYVALSGIDRSFYAM 720
Cdd:pfam07703 78 lskPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1536-1630 |
2.37e-28 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 109.97 E-value: 2.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1536 ERSGMAVLDVTIPTGYIIQQQNLDRYILSRQVRNLQRarFQPSKVLFYFDYLDQEETCVNFTIERWYPVANMsRYLPIRV 1615
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVET--VDDGKVILYLDKLSGEPLCFSFRAEQTFPVANL-KPAPVKV 77
|
90
....*....|....*
gi 1032745297 1616 YDYYSPERFNETMFD 1630
Cdd:pfam07677 78 YDYYEPERRATTFYS 92
|
|
| LDLa |
cd00112 |
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
805-832 |
7.04e-06 |
|
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
Pssm-ID: 238060 Cd Length: 35 Bit Score: 44.12 E-value: 7.04e-06
10 20
....*....|....*....|....*...
gi 1032745297 805 CLTGRCYRVEQQCDGIMQCDDGTDEARC 832
Cdd:cd00112 8 CANGRCIPSSWVCDGEDDCGDGSDEENC 35
|
|
| LDLa |
smart00192 |
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
805-829 |
6.77e-04 |
|
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.
Pssm-ID: 197566 Cd Length: 33 Bit Score: 38.77 E-value: 6.77e-04
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1079-1421 |
2.88e-103 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 333.11 E-value: 2.88e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1079 ISVVGDVVGPIFPTMPVNATSLIGLPMDCGEQTMFSFAANMYTTLHMRLINQRNLTQEKQSFYYMNIGYQRQLSFMNPDG 1158
Cdd:pfam07678 1 ISVVGDIMGPAIQVVPENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1159 SFSLFRSdwnvSSPSVWLTAYCVRifeeaSFYEWENHLYIDPKVIAQAVSWLLDHQTYEGSFYEVTWLPDRKINSTLHyd 1238
Cdd:pfam07678 81 SYSAFGH----SPGSTWLTAFVLK-----VFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVD-- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1239 gdeshypykssRNISLTAHVLITLETVKDLSdGLGARVALAAANAVRYleQNLQLLELGGRPYEIAIVAYAL-LQAKAST 1317
Cdd:pfam07678 150 -----------GEVSLTAYVTIALLEALDIN-GLLQRVHPSIRKALTY--LEQAQLAGLTSPYTLAILAYALaLAGSPET 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1318 AEQAFNLLRRYRREEGGLVYWGREMVPQPPYKtenqkpfllPRLPYTYDSENIETTAYALLVHVARQEVE-VEPIVKWLN 1396
Cdd:pfam07678 216 REELLKSLDAMAREEGNSRYWERDEKSDPQGV---------PEYPPQAPSLEVETTAYALLAYLLLGDLTyADPIVKWLT 286
|
330 340
....*....|....*....|....*
gi 1032745297 1397 SQRLTDGGWASTQDTAWAMKALMEY 1421
Cdd:pfam07678 287 SQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
1096-1421 |
5.65e-58 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 202.42 E-value: 5.65e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1096 NATSLIGLPMDCGEQTMFSFAANMYTTLHMRLINQrnLTQEKQS--FYYMNIGYQRQLSFMNPDGSFSLFR-SDwnvSSP 1172
Cdd:cd02897 4 NLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQ--LTPEIESkaLGFLRTGYQRQLTYKHSDGSYSAFGeSD---KSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1173 SVWLTAYCVRIFEEASfyeweNHLYIDPKVIAQAVSWLLDHQTYEGSFyevtwlpdRKINSTLHYDGDESHypyksSRNI 1252
Cdd:cd02897 79 STWLTAFVLKSFAQAR-----PFIYIDENVLQQALTWLSSHQKSNGCF--------REVGRVFHKAMQGGV-----DDEV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1253 SLTAHVLITL-ETVKD-----LSDGLGARVALAAANAVryleqnlqllelggrPYEIAIVAYALLQAKASTAEQAFNLLR 1326
Cdd:cd02897 141 ALTAYVLIALlEAGLPserpvVEKALSCLEAALDSISD---------------PYTLALAAYALTLAGSEKRPEALKKLD 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1327 RYRREEGGLVYWGRemvpqpPYKTENQkpfllPRLPYTYDSENIETTAYALLVHVARQEVEVE---PIVKWLNSQRLTDG 1403
Cdd:cd02897 206 ELAISEDGTKHWSR------PPPSEEG-----PSYYWQAPSAEVEMTAYALLALLSAGGEDLAealPIVKWLAKQRNSLG 274
|
330
....*....|....*...
gi 1032745297 1404 GWASTQDTAWAMKALMEY 1421
Cdd:cd02897 275 GFSSTQDTVVALQALAKY 292
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1096-1421 |
1.26e-57 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 201.08 E-value: 1.26e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1096 NATSLIGLPMDCGEQTMFSFAANMYTTLHMRLINQRNLTQEKQSFYYMNIGYQRQLSFMNPDGSFSLFrsdWNVSSPSVW 1175
Cdd:cd02891 4 NLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAW---GNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1176 LTAYCVRIFEEASfyeweNHLYIDPKVIAQAVSWLLDHQTYEGSFYEVTWLPDRKINSTLHYDgdeshypykssrnISLT 1255
Cdd:cd02891 81 LTAYVVKFLSQAR-----KYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDS-------------VSLT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1256 AHVLITLetvkdlsDGLGARVALAAANAVRYLEQNLQLLElggRPYEIAIVAYAL-LQAKASTAEQAFNLLRRYRREEGG 1334
Cdd:cd02891 143 AYVLIAL-------AEAGKACDASIEKALAYLETQLDGLL---DPYALAILAYALaLAGDSTRADEALKKLLEAAREKGG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1335 LVYWGremvpqppyktenqkpflLPRLPYTYDSENIETTAYALLVHVARQEVE-VEPIVKWLNSQRLTDGGWASTQDTAW 1413
Cdd:cd02891 213 TAHWS------------------LSWPGDYGSSLRVEATAYALLALLKLGDLEeAGPIAKWLAQQRNSGGGFLSTQDTVV 274
|
....*...
gi 1032745297 1414 AMKALMEY 1421
Cdd:cd02891 275 ALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
1099-1421 |
1.73e-44 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 163.98 E-value: 1.73e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1099 SLIGLPMDCGEQTMFSFAANMYTTLHMRLINQRNLTQEK---QSFYYMNIGYQRQLSFMNPDGSFSLFRSdwnvSSPSVW 1175
Cdd:cd02896 7 KLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKLGPErrdEALKYIRQGYQRQLSYRKPDGSYAAWKN----RPSSTW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1176 LTAYCVRIFEEASFYEwenhlYIDPKVIAQAVSWLLDHQTYEGSFYEVTWLPDRKInsTLHYDGDESHypykssrnISLT 1255
Cdd:cd02896 83 LTAFVVKVFSLARKYI-----PVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREM--TGGVEGSEGD--------VSLT 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1256 AHVLITLETVKDLSDGLGARVALAAANAVRYLEQNLQLLElggRPYEIAIVAYALLQAKASTAEQAFNLLRRYRREEGGL 1335
Cdd:cd02896 148 AFVLIALQEARSICPPEVQNLDQSIRKAISYLENQLPNLQ---RPYALAITAYALALADSPLSHAANRKLLSLAKRDGNG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1336 VYWGREmvpqppyktenQKPFLLPRLPYTYDsenIETTAYALLVHVARQEVE-VEPIVKWLNSQRLTDGGWASTQDTAWA 1414
Cdd:cd02896 225 WYWWTI-----------DSPYWPVPGPSAIT---VETTAYALLALLKLGDIEyANPIARWLTEQRNYGGGFGSTQDTVVA 290
|
....*..
gi 1032745297 1415 MKALMEY 1421
Cdd:cd02896 291 LQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
1104-1421 |
3.24e-35 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 136.91 E-value: 3.24e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1104 PMDCGEQTMFSFAANMYTTLHMRLINQRNLTQEkqsfyYMNIGYQRQLSFMNPDGSFSLFRSDwnvSSPSVWLTAYCVRI 1183
Cdd:cd00688 20 QSLCGEQTWSTAWPLLALLLLLAATGIRDKADE-----NIEKGIQRLLSYQLSDGGFSGWGGN---DYPSLWLTAYALKA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1184 FEEASfyeweNHLYIDPKVIAQAVSWLLDHQTYEGSFYevtwlpdrkinstlhYDGDESHYPYKSSRNISLTAHVLITLE 1263
Cdd:cd00688 92 LLLAG-----DYIAVDRIDLARALNWLLSLQNEDGGFR---------------EDGPGNHRIGGDESDVRLTAYALIALA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1264 TVKDLSDglgarvALAAANAVRYLEQNLQLLELGGR-----PYEIAIVAYALLQAK---ASTAEQAFNLLRRYRREEGGL 1335
Cdd:cd00688 152 LLGKLDP------DPLIEKALDYLLSCQNYDGGFGPggeshGYGTACAAAALALLGdldSPDAKKALRWLLSRQRPDGGW 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1336 VYWGRemvpqppyktenqkpfllpRLPYTYDSENIETTAYALL-VHVARQEVEVEPIVKWLNSQRLTDGGWAS------- 1407
Cdd:cd00688 226 GEGRD-------------------RTNKLSDSCYTEWAAYALLaLGKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksyd 286
|
330
....*....|....
gi 1032745297 1408 TQDTAWAMKALMEY 1421
Cdd:cd00688 287 TQHTVFALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
209-1506 |
3.19e-29 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 127.89 E-value: 3.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 209 QRSMTIFIQCDKPVYMQGQTIRFRTIPINTELKAFDD---TVEVhmLDPYRRIMRRWLSKQSNLGTVSLSYQLSDQPVFG 285
Cdd:COG2373 366 PGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGlplTLEL--TDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTG 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 286 EWIIKVIAQG--QIEEKAIFVEEYYQTRFEVNVTMP-AFFFDNEPyIHGIVQANYTSGAPVHGN-LTLKASFKPinkysq 361
Cdd:COG2373 444 TWRLELYVDPkpALGSKSFRVEEFKPPRFKVDLTLDkEPLKPGDP-VTVTVDARYLFGAPAAGLkVEGEVTLRP------ 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 362 ttgamenIPDRYFNFNEYYpawFNPPDLFRETVPVLRF-----FNGTYRFQYPmselLPYLPNNSDGMEVTVTATVGE-- 434
Cdd:COG2373 517 -------ARTAFPGYPGYR---FGDPDEEFEPEELDLGegtldADGKASLSLP----LPDAPDAPGPLRATVEASVFEsg 582
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 435 -RFLE---EIIVGYSTARIynsSIKIHFFGGSPqvfkPGMPFDLNLVASFHDGSPLRAAQLRgAQL---EVRGDIEMRSG 507
Cdd:COG2373 583 gRPVTrsaTVPVHPADFYV---GIRLPLFDGDP----EGAPATFEVVAVDPDGKPVAGKGLK-VELyreEWRYVWYKSDD 654
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 508 RRS----------LDNQIVRVSPENAAVWSLQID----LRKQFESSQGpqhtqqllNEIVSMRFYAdlTDGEGhhahael 573
Cdd:COG2373 655 GGWryesqekeepVAEGTLTTGADGPASLSLTPVewgrYRLEVKDPDG--------GLATSVRFYA--GGNAS------- 717
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 574 lmLAHESPNQkhikVWTSTEKA--KVGEYLVLHVQSNFyiesfnylvmsKGTILLT--SDE-------HMQQSIKTFAVP 642
Cdd:COG2373 718 --WGAERPDR----LELSLDKEsyKPGETAKLLIQSPF-----------AGRALVTveRDGvletqwvDVKGGGTTVEIP 780
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 643 LSPEMAPVATVLVYHVgKYGDVIADSL------TVPVNgISRNN--FTVFIN-NKKARTGERVEVAV-----YGEAgAYV 708
Cdd:COG2373 781 VTEDWAPNAYVSATLV-RPGDSTANDMparaygVAPLP-VDPPArrLKVELTaPEKLRPGETLTVTVkvkgaAGKA-AEV 857
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 709 ALSGIDRSFYAmqagneLTyanviekmsnfGEQTngthahtwlfhegdPDvvvnfPSSTFgidvnrtFEYIGL-VAFTDa 787
Cdd:COG2373 858 TLAAVDEGILN------LT-----------GYKT--------------PD-----PLDFF-------YGKRALgVETRD- 893
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 788 vIYRRpehcnrtlgYLECLTGRCYRVEQQCDGIMqcddgtdearcpvGNATDIAHFRKwRFNriqrqyeNVWMWR-DINI 866
Cdd:COG2373 894 -LYGR---------LIGAFGGAAGALRSGGDGAL-------------GRGGNPKPPRK-RFK-------PVALFSgPVKT 942
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 867 GPHGRFIFNIDVPK--TPVHWMITAFgmSPTnGFGMLPTALeyIAVLPFYINVEMPEHCKQGEQVGIRVSIFNY----MR 940
Cdd:COG2373 943 DADGKATVSFDLPDfnGTLRVMAVAW--SDD-RFGSAEATV--TVRKPLVVRPSLPRFLAPGDRFELPVDVFNLtgkaGT 1017
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 941 YNIEATVvladsrdykfvhveDNGIVESYNPRTSFGehqfflwIPAQDASIVYIPIVPVRLGDIKVHISATTLIGKDSAT 1020
Cdd:COG2373 1018 VTVTLEA--------------SGGLTLEGEATQTVT-------LAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDARE 1076
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1021 RTLHVEADGLPQYRHQSILLDlSNrayvfqymhvnitETPIIPYEEDRYYIFGSNKATISVVgdvvgpifPTMPVNAT-- 1098
Cdd:COG2373 1077 VELPVRPANPLVTRATSGVLA-PG-------------ESWTLPLDLPGGLRPGTGSLTLSLS--------SSPPLDLAgl 1134
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1099 --SLIGLPMDCGEQTMFSFAANMYTTlhmRLINQRNLT--QEKQSFYYMNIGYQRQLSFMNPDGSFSLFRSDwnvSSPSV 1174
Cdd:COG2373 1135 lrYLLRYPYGCTEQTTSRALPLLYLS---DLAEALGLKgdKDAELRARIQAAIARLLSMQNSDGGFGLWPGG---SESDP 1208
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1175 WLTAYCVRIFEEASfyewENHLYIDPKVIAQAVSWLLDhqtyegsfyevtwlpdrkinsTLHYDGDESHYPYKSSRNISL 1254
Cdd:COG2373 1209 WLTAYATDFLLEAR----EAGYAVPDDALDRALDYLRN---------------------YLRNPWEIEYDDAYRLAVRAY 1263
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1255 TAHVL-----ITLETVKDLSDGLGARVAlaaanavryleqnlqllelggrPYEIAIVAYALLQAK-ASTAEQAFNLLRRY 1328
Cdd:COG2373 1264 ALYVLaragkADLGDLRYLYDRRKDALS----------------------PLAKAQLAAALALLGdKARAEELLAAALAR 1321
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1329 RREEGGLVYWGremvpqppyktenqkpfllprlpYTYDSeNIETTAYAL--LVHVARQEVEVEPIVKWLnSQRLTDGGWA 1406
Cdd:COG2373 1322 LRETGARDYWY-----------------------GDYGS-PLRDQALALalLAELGPDAPLAPKLARWL-AKALKSGRWL 1376
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1407 STQDTAWAMKALMEYtvrsriRDVSQLSVTIEATALPGQTNILHVNNKNLARLQtlhIPEAW---GTVKVQAKGAGyail 1483
Cdd:COG2373 1377 STQETAWALLALAAY------ARAAGASPDFTATLTLDGKTLPLTGRGPLARVT---LPAAEllaGPLTITNTGDG---- 1443
|
1370 1380
....*....|....*....|...
gi 1032745297 1484 qmHVQYNVDIRRFQTKPPVPAFD 1506
Cdd:COG2373 1444 --PLYYTLTLSGYPAEGPPPAAS 1464
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
586-720 |
4.12e-29 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 113.98 E-value: 4.12e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 586 IKVWTSTEKAKVGEYLVLHVQSNF----YIESFNYLVMSKGTILLTSdehMQQSIKTFAVPLSPEMAPVATVLVYHVGKY 661
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFdgtvERDGFTYLVLSKGQIVVVG---RGGVTTSFSLPVTAEMAPSARVVAYYVRVD 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1032745297 662 ---GDVIADSLTVPVNGISRNNFTVFINNKKARTGERVEVAVYGEAGAYVALSGIDRSFYAM 720
Cdd:pfam07703 78 lskPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1536-1630 |
2.37e-28 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 109.97 E-value: 2.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 1536 ERSGMAVLDVTIPTGYIIQQQNLDRYILSRQVRNLQRarFQPSKVLFYFDYLDQEETCVNFTIERWYPVANMsRYLPIRV 1615
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVET--VDDGKVILYLDKLSGEPLCFSFRAEQTFPVANL-KPAPVKV 77
|
90
....*....|....*
gi 1032745297 1616 YDYYSPERFNETMFD 1630
Cdd:pfam07677 78 YDYYEPERRATTFYS 92
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
858-949 |
9.56e-23 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 93.81 E-value: 9.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 858 VWMWRDINIGPHGRFIFNIDVPKTPVHWMITAFGMSPTNGFGMLPTAlEYIAVLPFYINVEMPEHCKQGEQVGIRVSIFN 937
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPP-ELVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 1032745297 938 YMRYNIEATVVL 949
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
214-314 |
2.61e-09 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 55.78 E-value: 2.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032745297 214 IFIQCDKPVYMQGQTIRFRTIPINTELKAFDDT-VEVHMLDPYRRIMRRWLSKQSNLGTVSLSYQLSDQPVFGEWIIKVI 292
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLpVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90 100
....*....|....*....|..
gi 1032745297 293 AQGQieekaifvEEYYQTRFEV 314
Cdd:pfam01835 82 DGAG--------GSLGSGSFRV 95
|
|
| LDLa |
cd00112 |
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
805-832 |
7.04e-06 |
|
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
Pssm-ID: 238060 Cd Length: 35 Bit Score: 44.12 E-value: 7.04e-06
10 20
....*....|....*....|....*...
gi 1032745297 805 CLTGRCYRVEQQCDGIMQCDDGTDEARC 832
Cdd:cd00112 8 CANGRCIPSSWVCDGEDDCGDGSDEENC 35
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
306-363 |
2.60e-04 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 41.10 E-value: 2.60e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1032745297 306 EYYQTRFEVNVTMPAFFFDNEPYIHGIVQANYTSGAPVHGNLTLKASFKPINKYSQTT 363
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCFE 58
|
|
| LDLa |
smart00192 |
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
805-829 |
6.77e-04 |
|
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.
Pssm-ID: 197566 Cd Length: 33 Bit Score: 38.77 E-value: 6.77e-04
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| Ldl_recept_a |
pfam00057 |
Low-density lipoprotein receptor domain class A; |
805-832 |
1.10e-03 |
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Low-density lipoprotein receptor domain class A;
Pssm-ID: 395011 Cd Length: 37 Bit Score: 38.00 E-value: 1.10e-03
10 20
....*....|....*....|....*...
gi 1032745297 805 CLTGRCYRVEQQCDGIMQCDDGTDEARC 832
Cdd:pfam00057 10 CGSGECIPRSWVCDGDPDCGDGSDEENC 37
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