NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034612894|ref|XP_016859235|]
View 

lysocardiolipin acyltransferase 1 isoform X2 [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 7.19e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.02  E-value: 7.19e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  55 VALLETMFGVKVIITGDAF-VPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFI 133
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 134 HRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGknL 213
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034612894 214 DAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVH 248
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 1.80e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 73.37  E-value: 1.80e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034612894 233 HLLQGdFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFYFTGQSVIPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 7.19e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.02  E-value: 7.19e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  55 VALLETMFGVKVIITGDAF-VPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFI 133
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 134 HRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGknL 213
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034612894 214 DAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVH 248
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 46-327 4.40e-58

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 192.99  E-value: 4.40e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  46 LVATWLTLPVALLETMFGVKVIITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAM 125
Cdd:PLN02510   61 FFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 126 QAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVD 205
Cdd:PLN02510  141 HIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQ 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 206 RLREgkNLDAVHDITVAYPHNIPQSEKHLLQGDfPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYqgeK 285
Cdd:PLN02510  221 ELRC--SLDAVYDVTIGYKHRCPSFLDNVFGID-PSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---A 294

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1034612894 286 NFYFTGQSV-----IPPCKSELrVLVVKLLSILYWTLFSPAMCLLIY 327
Cdd:PLN02510  295 QGHFPNEGTegelsTLKCLANF-LAVIALTTVFTYLTLFSSVWFKIY 340
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 80-201 9.22e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.17  E-value: 9.22e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894   80 VIIMNHRTRMDWMFLWNCLmrYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFedMIDYFCDIHEPLQ 159
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1034612894  160 LLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLhPRTTGFT 201
Cdd:smart00563  78 LLIFPEGTRSRPGKLLPFKKGAARLALEAGVPIV-PVAIRGT 118
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 1.80e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 73.37  E-value: 1.80e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034612894 233 HLLQGdFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFYFTGQSVIPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 65-223 2.68e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 69.23  E-value: 2.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  65 KVIITGDAFVP-GERSVIIMNHRTRMDWMFLWNCLmrYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSH 143
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 144 FEDMIDYFcdIHEPLQLLIFPEGTdltensksRSNafaeknglqkyEYVLHPRTTGFTFVVDRLRegknldaVHDITVAY 223
Cdd:pfam01553  79 TLEYLVEL--LREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 31-167 4.69e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 70.42  E-value: 4.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  31 LMFVNPSWYRWINNRLVATWLTLpvalletmFGVKVIITGDAFVPGERSVIIM-NHRTRMDWMFLWNCLMRY-SYLrlek 108
Cdd:COG0204     4 LFLLLRRFRYRLVRLWARLLLRL--------LGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV---- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 109 icLKASLKGVPGFGWAMQAAAYIFIHR-KWKDDKSHFEDMIDYfcdIHEPLQLLIFPEGT 167
Cdd:COG0204    72 --AKKELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQAVEA---LKAGESLVIFPEGT 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 63-167 1.78e-05

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 43.87  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  63 GVKVIITGDAFVPGERSVIIM-NHRTRMDwMFLWNCLMRYSYLRLEKIclkaSLKGVPGFGWAMQAAAYIFIHRK-WKDD 140
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLD-PLTLSAAFPPPIVFIAKK----ELKWIPFFGIMLWLTGAIFIDREnIRAI 75

                          90       100
                  ....*....|....*....|....*..
gi 1034612894 141 KSHFEDMIDYfcdIHEPLQLLIFPEGT 167
Cdd:TIGR00530  76 ATALKAAIEV---LKQGRSIGVFPEGT 99
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 7.19e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.02  E-value: 7.19e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  55 VALLETMFGVKVIITGDAF-VPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFI 133
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 134 HRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGknL 213
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034612894 214 DAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVH 248
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 46-327 4.40e-58

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 192.99  E-value: 4.40e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  46 LVATWLTLPVALLETMFGVKVIITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAM 125
Cdd:PLN02510   61 FFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 126 QAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVD 205
Cdd:PLN02510  141 HIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQ 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 206 RLREgkNLDAVHDITVAYPHNIPQSEKHLLQGDfPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYqgeK 285
Cdd:PLN02510  221 ELRC--SLDAVYDVTIGYKHRCPSFLDNVFGID-PSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---A 294

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1034612894 286 NFYFTGQSV-----IPPCKSELrVLVVKLLSILYWTLFSPAMCLLIY 327
Cdd:PLN02510  295 QGHFPNEGTegelsTLKCLANF-LAVIALTTVFTYLTLFSSVWFKIY 340
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 19-345 1.41e-35

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 133.71  E-value: 1.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  19 FGSIFMLSPFL-------PLMFVNP---SWYRWINNRLV-ATWLTLpVALLETMFGVKVIITGDA----FVPGERSVIIM 83
Cdd:PLN02380   12 LGLLFLLSGLIvnliqavCFILVRPlskSLYRRINRAVAeLLWLEL-IWLVDWWAGVKVQLYADEetfeLMGKEHALVIS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  84 NHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIF 163
Cdd:PLN02380   91 NHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVFLERSWAKDENTLKSGFQRLKDFPRPFWLALF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 164 PEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLREgkNLDAVHDITVAYPHNIPQ-SEKHLLQGDfPRE 242
Cdd:PLN02380  171 VEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRS--FVPAIYDVTVAVPKGQPApTMLRIFRGQ-SSV 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 243 IHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFyqgEKNFYFTGQSVIP---PCKSelrvlvvkLLSILYWTlfs 319
Cdd:PLN02380  248 VHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKH---FAEDTFGDQEYQDigrPKKS--------LIVVISWA--- 313

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1034612894 320 pamCLLIY-LYSLVKWYFI------ITIVIFVL 345
Cdd:PLN02380  314 ---CLLILgAIKFLQWLSLlsswkgIASLAAGL 343
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 80-201 9.22e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.17  E-value: 9.22e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894   80 VIIMNHRTRMDWMFLWNCLmrYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFedMIDYFCDIHEPLQ 159
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1034612894  160 LLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLhPRTTGFT 201
Cdd:smart00563  78 LLIFPEGTRSRPGKLLPFKKGAARLALEAGVPIV-PVAIRGT 118
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 1.80e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 73.37  E-value: 1.80e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034612894 233 HLLQGdFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFYFTGQSVIPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 63-247 1.32e-14

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 71.29  E-value: 1.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  63 GVKVIITGDAFVPGERSVIIM-NHRTRMDWMFLWnCLMRYSYLRLEKICLKASLKG-VPGFGWamqaAAYIFIHRKW-KD 139
Cdd:cd06551    11 FVRLEVKGPPPPPGGGPVLFVsNHSSWWDGLILF-LLLERGLRRDVYGLMDEELLErYPFFTR----LGAFSVDRDSpRS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 140 DKSHFEDMIDYFCDIHEplQLLIFPEGTDLTEnsksrsnafaEKNGLQKYEYVLHP-RTTGFTFVVDRLREGKNL-DAVH 217
Cdd:cd06551    86 AAKSLKYVARLLSKPGS--VVWIFPEGTRTRR----------DKRPLQFKPGVAHLaEKAGVPIVPVALRYTFELfEQFP 153

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1034612894 218 DITVAYPHNIPQSEKH---LLQGDFPREIHFHV 247
Cdd:cd06551   154 EIFVRIGPPIPYAETAlgeELAAELANRLTRLL 186
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 65-223 2.68e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 69.23  E-value: 2.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  65 KVIITGDAFVP-GERSVIIMNHRTRMDWMFLWNCLmrYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSH 143
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 144 FEDMIDYFcdIHEPLQLLIFPEGTdltensksRSNafaeknglqkyEYVLHPRTTGFTFVVDRLRegknldaVHDITVAY 223
Cdd:pfam01553  79 TLEYLVEL--LREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 31-167 4.69e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 70.42  E-value: 4.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  31 LMFVNPSWYRWINNRLVATWLTLpvalletmFGVKVIITGDAFVPGERSVIIM-NHRTRMDWMFLWNCLMRY-SYLrlek 108
Cdd:COG0204     4 LFLLLRRFRYRLVRLWARLLLRL--------LGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV---- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 109 icLKASLKGVPGFGWAMQAAAYIFIHR-KWKDDKSHFEDMIDYfcdIHEPLQLLIFPEGT 167
Cdd:COG0204    72 --AKKELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQAVEA---LKAGESLVIFPEGT 126
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 61-167 7.74e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 63.44  E-value: 7.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  61 MFGVKVIITGDAFVPGERSVIIM-NHRTRMDWMFLWNCLMRY-SYLrlekicLKASLKGVPGFGWAMQAAAYIFIHR-KW 137
Cdd:cd07989     7 LLGVRVRVEGLENLPPKGPVIIVaNHQSYLDPLVLGAALPRPiRFV------AKKELFKIPFLGWLLRLLGAIPIDRgNG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034612894 138 KDDKSHFEDMIDYfcdIHEPLQLLIFPEGT 167
Cdd:cd07989    81 RSAREALREAIEA---LKEGESVVIFPEGT 107
PRK14014 PRK14014
putative acyltransferase; Provisional
 7-286 1.07e-10

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 61.79  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894   7 IYFILTLFWGSFfgsIFMLSPFLPLMFVNPSWYR--WINNRLVATWLTLPVALLETMFGVKVIITGDA-FVPGERSVIIM 83
Cdd:PRK14014   17 LLILNTLFWSVP---IIILGLLKLLLPIPAIRRAcsRLLNFIAEAWISINNVILRLLPRTQWDVEGLEgLSKKGWYLVIS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  84 NHRTRMDWMFLwnclMRYSYLR--LEKICLKASLKGVPGFGWAMQAAAYIFIHR------------KWKDDKS------H 143
Cdd:PRK14014   94 NHQSWVDILVL----QYVFNRRipMLKFFLKQELIWVPFLGLAWWALDFPFMKRyskaylaknpelKGKDLETtrraceK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894 144 FEDMidyfcdihePLQLLIFPEGTDLTENSKSRSNAfaeknglqKYEYVLHPRTTGFTFVVDRLreGKNLDAVHDITVAY 223
Cdd:PRK14014  170 FKRM---------PTTIVNFVEGTRFTPEKHQQQQS--------PYQHLLKPKAGGIAFALNAM--GEQFDGLLDVTIVY 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034612894 224 PHNIPqSEKHLLQGDfPREIHFHVHRYPIDTL--------PTSKEDLQLWCHKRWEEKEERLRSFYQGEKN 286
Cdd:PRK14014  231 PDGRP-SFWDLLSGR-VKKIVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLIEQLLAQYNQ 299
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 63-167 1.78e-05

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 43.87  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  63 GVKVIITGDAFVPGERSVIIM-NHRTRMDwMFLWNCLMRYSYLRLEKIclkaSLKGVPGFGWAMQAAAYIFIHRK-WKDD 140
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLD-PLTLSAAFPPPIVFIAKK----ELKWIPFFGIMLWLTGAIFIDREnIRAI 75

                          90       100
                  ....*....|....*....|....*..
gi 1034612894 141 KSHFEDMIDYfcdIHEPLQLLIFPEGT 167
Cdd:TIGR00530  76 ATALKAAIEV---LKQGRSIGVFPEGT 99
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 80-167 2.89e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 38.74  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612894  80 VIIMNHRTRMDWMFLWNCLMrYSYLRlekiclKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQ 159
Cdd:cd07991    27 IIVANHTSFIDPLILFSDLF-PSIVA------KKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIKERATDPNWPP 99


                  ....*...
gi 1034612894 160 LLIFPEGT 167
Cdd:cd07991   100 ILIFPEGT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH