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Conserved domains on  [gi|1034633540|ref|XP_016861977|]
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plasma membrane calcium-transporting ATPase 2 isoform X5 [Homo sapiens]

Protein Classification

plasma membrane calcium-transporting ATPase( domain architecture ID 13522140)

plasma membrane calcium-transporting ATPase functions to export Ca(2+) from cells and plays a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca super family cl36924
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1056 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


The actual alignment was detected with superfamily member TIGR01517:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1323.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgkmqdgnvdasqskakqqdgaaame 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQ------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  328 mqplksaEGGDaddrkkasmhkkeKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQ 407
Cdd:TIGR01517  271 -------AGEE-------------ETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQ 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  408 YFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGD 487
Cdd:TIGR01517  328 TFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGE 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  488 VHYKEIPD--PSSINTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEK 564
Cdd:TIGR01517  408 QRFNVRDEivLRNLPAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEK 482
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  565 LYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVA 644
Cdd:TIGR01517  483 VVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLA 561
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  645 YRDFPSSPEPDWDNENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfL 724
Cdd:TIGR01517  562 YRDFAPEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--L 636
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  725 CLEGKEFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGF 804
Cdd:TIGR01517  637 AMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGF 703
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  805 AMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWV 882
Cdd:TIGR01517  704 SMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWV 783
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  883 NLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSE 962
Cdd:TIGR01517  784 NLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGE 862
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  963 HYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLG 1042
Cdd:TIGR01517  863 LNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGML 942
                         1050
                   ....*....|....
gi 1034633540 1043 ELVWGQVIATIPTS 1056
Cdd:TIGR01517  943 SLIFGVLLRLIPVE 956
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1095-1137 5.39e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 61.27  E-value: 5.39e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633540 1095 GQILWFRGLNRIQTQIEVVNTFKSGA--SFQGALRRQS--SVTSQSQ 1137
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLreGIQKPYLRNSihSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1056 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1323.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgkmqdgnvdasqskakqqdgaaame 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQ------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  328 mqplksaEGGDaddrkkasmhkkeKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQ 407
Cdd:TIGR01517  271 -------AGEE-------------ETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQ 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  408 YFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGD 487
Cdd:TIGR01517  328 TFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGE 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  488 VHYKEIPD--PSSINTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEK 564
Cdd:TIGR01517  408 QRFNVRDEivLRNLPAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEK 482
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  565 LYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVA 644
Cdd:TIGR01517  483 VVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLA 561
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  645 YRDFPSSPEPDWDNENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfL 724
Cdd:TIGR01517  562 YRDFAPEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--L 636
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  725 CLEGKEFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGF 804
Cdd:TIGR01517  637 AMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGF 703
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  805 AMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWV 882
Cdd:TIGR01517  704 SMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWV 783
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  883 NLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSE 962
Cdd:TIGR01517  784 NLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGE 862
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  963 HYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLG 1042
Cdd:TIGR01517  863 LNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGML 942
                         1050
                   ....*....|....
gi 1034633540 1043 ELVWGQVIATIPTS 1056
Cdd:TIGR01517  943 SLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
75-920 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1316.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   75 LEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGnegcataqggaedegEAEAGWIEG 154
Cdd:cd02081      1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG---------------EGKTGWIEG 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  155 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDL 234
Cdd:cd02081     66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  235 KIDESSLTGESDQVRKSVD---KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgkmqdgnvd 311
Cdd:cd02081    145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRA-------------------- 204
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  312 asqskakqqdgaaamemqplksaeggdaddrkkasmHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFV 391
Cdd:cd02081    205 ------------------------------------ENEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFV 248
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  392 VNKKPWlpecTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTG 471
Cdd:cd02081    249 NDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTG 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  472 TLTTNRMTVVQAYVGdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgNKTECGLLGFVLDLKQ 551
Cdd:cd02081    325 TLTQNRMTVVQGYIG-------------------------------------------------NKTECALLGFVLELGG 355
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  552 DYePVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEpRVFRPRDRDEMVKKVIE 631
Cdd:cd02081    356 DY-RYREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRVIE 433
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  632 PMACDGLRTICVAYRDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTA 707
Cdd:cd02081    434 PMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTA 513
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  708 RAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSthteqRQVVAVT 787
Cdd:cd02081    514 RAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVT 588
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  788 GDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGAC 867
Cdd:cd02081    589 GDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAV 668
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034633540  868 ITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTM 920
Cdd:cd02081    669 VTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
52-1050 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 674.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVtliileiaaiisL--------GLSF 123
Cdd:COG0474     12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP------------LilillaaaVISA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  124 yhppgegnegcATaqggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQI 203
Cdd:COG0474     77 -----------LL--------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEI 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  204 PVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSV----------DKDPMLLSGTHVMEGSGRMLV 273
Cdd:COG0474    132 PAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVV 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  274 TAVGVNSQTGIIFTLLGAGgeeeekkdkkgkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkasmhKKEKS 353
Cdd:COG0474    212 VATGMNTEFGKIAKLLQEA--------------------------------------------------------EEEKT 235
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  354 VLQGKLTKLAVQIGKAGLVMSAITVIILVLYftvdtfvvnKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVT 433
Cdd:COG0474    236 PLQKQLDRLGKLLAIIALVLAALVFLIGLLR---------GGPLL------------EALLFAVALAVAAIPEGLPAVVT 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  434 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipDPSSINTKTMELLINAIAI 513
Cdd:COG0474    295 ITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAAL 370
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  514 NSAYTtkiLPPEKEgalprqVGNKTECGLLGFVLDLKQDYEPVRSQMPeekLYKVYTFNSVRKSMSTVIKLPDESFRMYS 593
Cdd:COG0474    371 CSDAQ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIV 438
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  594 KGASEIVLKKCCKILNGaGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVAYRDFPSSPEPDwdnENDILNELTCICVVG 673
Cdd:COG0474    439 KGAPEVVLALCTRVLTG-GGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVG 513
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  674 IEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDflCLEGKEFNRrirneKGEIE-QERIDKIwp 752
Cdd:COG0474    514 MIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSDEElAEAVEDV-- 584
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  753 klRVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSI 830
Cdd:COG0474    585 --DVFARVSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATI 655
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  831 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYG 910
Cdd:COG0474    656 VAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRW 735
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  911 RNKPLISRTMMKNILGHAVYQLALIFTLLFVGekmfqIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRN 990
Cdd:COG0474    736 PDEPILSRFLLLRILLLGLLIAIFTLLTFALA-----LARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RS 802
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034633540  991 VFD-GIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVI 1050
Cdd:COG0474    803 FFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
872-1050 2.10e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 172.81  E-value: 2.10e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  872 SPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSG 951
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  952 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQ 1029
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 1034633540 1030 LDQWMWCIFIGLGELVWGQVI 1050
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
52-862 1.03e-42

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 169.48  E-value: 1.03e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQD-----VTLiileiaaiisLGLSFYhp 126
Cdd:PRK10517    53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNpfnilLTI----------LGAISY-- 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  127 pgegnegcATaqggaEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVVRAGQV--- 200
Cdd:PRK10517   118 --------AT-----EDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVINDkge 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  201 ---VQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRK-----------SVDKDPMLLSGTHVME 266
Cdd:PRK10517   173 ngwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVS 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  267 GSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgkmQDGNVDASQSKAKqqdgaaamemqplksaeggdaddrkKAS 346
Cdd:PRK10517   253 GTAQAVVIATGANTWFGQLAGRVSE--------------QDSEPNAFQQGIS-------------------------RVS 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  347 MhkkeksvlqgKLTKLAvqigkagLVMSAitVIILVLYFTvdtfvvnKKPWlpectpvyvqyfVKFFIIGVTVLVVAVPE 426
Cdd:PRK10517   294 W----------LLIRFM-------LVMAP--VVLLINGYT-------KGDW------------WEAALFALSVAVGLTPE 335
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  427 GLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYVgDVHYKeipdpssintKTMEL 506
Cdd:PRK10517   336 MLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI-VLENHT-DISGK----------TSERV 403
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  507 LINAIaINSAYTTKIlppekEGALPRQVgnkTECGLLGFVLDLKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPD 586
Cdd:PRK10517   404 LHSAW-LNSHYQTGL-----KNLLDTAV---LEGVDEESARSLASRWQKI-DEIP---------FDFERRRMSVVVAENT 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  587 ESFRMYSKGASEIVLKKCCKI-LNGAGEPRVfrpRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEpDWD--NENDil 663
Cdd:PRK10517   465 EHHQLICKGALEEILNVCSQVrHNGEIVPLD---DIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQraDESD-- 538
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  664 neLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGedflCLEGkefnrrirnekGEIE 743
Cdd:PRK10517   539 --LILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE----VLIG-----------SDIE 601
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  744 Q---ERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDI 820
Cdd:PRK10517   602 TlsdDELANLAERTTLFARLTPMHKERIVTLLKREGH-----VVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADI 675
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633540  821 ILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 862
Cdd:PRK10517   676 ILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1095-1137 5.39e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 61.27  E-value: 5.39e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633540 1095 GQILWFRGLNRIQTQIEVVNTFKSGA--SFQGALRRQS--SVTSQSQ 1137
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLreGIQKPYLRNSihSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1056 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1323.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgkmqdgnvdasqskakqqdgaaame 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQ------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  328 mqplksaEGGDaddrkkasmhkkeKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQ 407
Cdd:TIGR01517  271 -------AGEE-------------ETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQ 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  408 YFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGD 487
Cdd:TIGR01517  328 TFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGE 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  488 VHYKEIPD--PSSINTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEK 564
Cdd:TIGR01517  408 QRFNVRDEivLRNLPAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEK 482
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  565 LYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVA 644
Cdd:TIGR01517  483 VVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLA 561
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  645 YRDFPSSPEPDWDNENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfL 724
Cdd:TIGR01517  562 YRDFAPEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--L 636
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  725 CLEGKEFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGF 804
Cdd:TIGR01517  637 AMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGF 703
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  805 AMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWV 882
Cdd:TIGR01517  704 SMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWV 783
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  883 NLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSE 962
Cdd:TIGR01517  784 NLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGE 862
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  963 HYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLG 1042
Cdd:TIGR01517  863 LNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGML 942
                         1050
                   ....*....|....
gi 1034633540 1043 ELVWGQVIATIPTS 1056
Cdd:TIGR01517  943 SLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
75-920 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1316.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   75 LEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGnegcataqggaedegEAEAGWIEG 154
Cdd:cd02081      1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG---------------EGKTGWIEG 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  155 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDL 234
Cdd:cd02081     66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  235 KIDESSLTGESDQVRKSVD---KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgkmqdgnvd 311
Cdd:cd02081    145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRA-------------------- 204
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  312 asqskakqqdgaaamemqplksaeggdaddrkkasmHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFV 391
Cdd:cd02081    205 ------------------------------------ENEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFV 248
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  392 VNKKPWlpecTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTG 471
Cdd:cd02081    249 NDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTG 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  472 TLTTNRMTVVQAYVGdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgNKTECGLLGFVLDLKQ 551
Cdd:cd02081    325 TLTQNRMTVVQGYIG-------------------------------------------------NKTECALLGFVLELGG 355
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  552 DYePVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEpRVFRPRDRDEMVKKVIE 631
Cdd:cd02081    356 DY-RYREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRVIE 433
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  632 PMACDGLRTICVAYRDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTA 707
Cdd:cd02081    434 PMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTA 513
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  708 RAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSthteqRQVVAVT 787
Cdd:cd02081    514 RAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVT 588
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  788 GDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGAC 867
Cdd:cd02081    589 GDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAV 668
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034633540  868 ITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTM 920
Cdd:cd02081    669 VTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
52-1050 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 674.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVtliileiaaiisL--------GLSF 123
Cdd:COG0474     12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP------------LilillaaaVISA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  124 yhppgegnegcATaqggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQI 203
Cdd:COG0474     77 -----------LL--------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEI 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  204 PVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSV----------DKDPMLLSGTHVMEGSGRMLV 273
Cdd:COG0474    132 PAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVV 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  274 TAVGVNSQTGIIFTLLGAGgeeeekkdkkgkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkasmhKKEKS 353
Cdd:COG0474    212 VATGMNTEFGKIAKLLQEA--------------------------------------------------------EEEKT 235
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  354 VLQGKLTKLAVQIGKAGLVMSAITVIILVLYftvdtfvvnKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVT 433
Cdd:COG0474    236 PLQKQLDRLGKLLAIIALVLAALVFLIGLLR---------GGPLL------------EALLFAVALAVAAIPEGLPAVVT 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  434 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipDPSSINTKTMELLINAIAI 513
Cdd:COG0474    295 ITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAAL 370
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  514 NSAYTtkiLPPEKEgalprqVGNKTECGLLGFVLDLKQDYEPVRSQMPeekLYKVYTFNSVRKSMSTVIKLPDESFRMYS 593
Cdd:COG0474    371 CSDAQ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIV 438
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  594 KGASEIVLKKCCKILNGaGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVAYRDFPSSPEPDwdnENDILNELTCICVVG 673
Cdd:COG0474    439 KGAPEVVLALCTRVLTG-GGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVG 513
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  674 IEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDflCLEGKEFNRrirneKGEIE-QERIDKIwp 752
Cdd:COG0474    514 MIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSDEElAEAVEDV-- 584
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  753 klRVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSI 830
Cdd:COG0474    585 --DVFARVSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATI 655
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  831 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYG 910
Cdd:COG0474    656 VAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRW 735
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  911 RNKPLISRTMMKNILGHAVYQLALIFTLLFVGekmfqIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRN 990
Cdd:COG0474    736 PDEPILSRFLLLRILLLGLLIAIFTLLTFALA-----LARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RS 802
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034633540  991 VFD-GIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVI 1050
Cdd:COG0474    803 FFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
76-908 8.96e-158

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 485.97  E-value: 8.96e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   76 EKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLsfyhppgegnegcataqggaedegeaeAGWIEGA 155
Cdd:cd02089      8 ERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL---------------------------GEYVDAI 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  156 AILLSVICVVLVTAFNDWSKEKQFRGLQSRieQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK 235
Cdd:cd02089     61 VIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLR 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  236 IDESSLTGESDQVRKSVDKDP-----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGgeeeekkdkkgk 304
Cdd:cd02089    139 VEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEET------------ 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  305 mqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkasmhKKEKSVLQGKLTKLAVQIGKAGLvmsAITVIILVLY 384
Cdd:cd02089    207 --------------------------------------------EEEKTPLQKRLDQLGKRLAIAAL---IICALVFALG 239
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  385 ftvdtfVVNKKPWLPEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA 464
Cdd:cd02089    240 ------LLRGEDLLDM------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSV 301
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  465 ICSDKTGTLTTNRMTVVQAYVgdvhykeIPDPSSIntktmellinAIaINSAYTTKILPPEKEGALPRQvgnktecgllg 544
Cdd:cd02089    302 ICSDKTGTLTQNKMTVEKIYT-------IGDPTET----------AL-IRAARKAGLDKEELEKKYPRI----------- 352
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  545 fvldlkqdyepvrSQMPeeklykvytFNSVRKSMSTVIKLPDEsFRMYSKGASEIVLKKCCKILNGaGEPRVFRPRDRDE 624
Cdd:cd02089    353 -------------AEIP---------FDSERKLMTTVHKDAGK-YIVFTKGAPDVLLPRCTYIYIN-GQVRPLTEEDRAK 408
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  625 mVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDN-ENDilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDN 703
Cdd:cd02089    409 -ILAVNEEFSEEALRVLAVAYKPLDEDPTESSEDlEND----LIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDH 483
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  704 INTARAIAIKCGIIHPGEdfLCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthteQRQ- 782
Cdd:cd02089    484 KLTARAIAKELGILEDGD--KALTGEELD--------KMSDEELEKKVEQISVYARVSPEHKLRIVKAL-------QRKg 546
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  783 -VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIV 861
Cdd:cd02089    547 kIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILT 626
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633540  862 AFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKP 908
Cdd:cd02089    627 MLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
157-894 1.30e-147

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 454.85  E-value: 1.30e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  157 ILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVvQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKI 236
Cdd:TIGR01494    2 ILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  237 DESSLTGESDQVRKSVDKDP-MLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeeekkdkkgkmqdgnvdasqs 315
Cdd:TIGR01494   80 DESSLTGESLPVLKTALPDGdAVFAGTINFGGTLIVKVTATGILTTVGKI------------------------------ 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  316 kakqqdgAAAMemqplksaeggdaddrkKASMHkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFvvnkk 395
Cdd:TIGR01494  130 -------AVVV-----------------YTGFS--TKTPLQSKADKFENFIFILFLLLLALAVFLLLPIGGWDGN----- 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  396 pwlpectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT 475
Cdd:TIGR01494  179 ------------SIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTT 246
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  476 NRMTVVQAYVGDVHYKEIPDPSSINtktmellinaiainsayttkilppekeGALPRQVGNKTECGLLGFV-LDLKQDYE 554
Cdd:TIGR01494  247 NKMTLQKVIIIGGVEEASLALALLA---------------------------ASLEYLSGHPLERAIVKSAeGVIKSDEI 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  555 PVrsqmpEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNgageprvfrprdrdemVKKVIEPMA 634
Cdd:TIGR01494  300 NV-----EYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNEND----------------YDEKVDEYA 358
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  635 CDGLRTICVAYRDFPsspepdwdnendilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKC 714
Cdd:TIGR01494  359 RQGLRVLAFASKKLP--------------DDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKEL 424
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  715 GIIhpgedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDG 794
Cdd:TIGR01494  425 GID--------------------------------------VFARVKPEEKAAIVEALQEKGRT-----VAMTGDGVNDA 461
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  795 PALKKADVGFAMGIAgtDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACItqdspl 874
Cdd:TIGR01494  462 PALKKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI------ 533
                          730       740
                   ....*....|....*....|
gi 1034633540  875 kavqmlwvNLIMDTFASLAL 894
Cdd:TIGR01494  534 --------ILLPPLLAALAL 545
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
151-1041 7.74e-140

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 443.63  E-value: 7.74e-140
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQkfTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd02080     56 WVDAIVIFGVVLINAIIGYIQEGKAEKALAAIKNMLSPEA--TVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIE 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  231 GNDLKIDESSLTGESDQVRKSVDKDP----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekkd 300
Cdd:cd02080    134 ARNLQIDESALTGESVPVEKQEGPLEedtplgdrknMAYSGTLVTAGSATGVVVATGADTEIGRINQLLA---------- 203
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  301 kkgkmqdgNVDASQSkakqqdgaaamemqPLksaeggdaddrkkasmhkkeksvlQGKLTKLAVQIGKAGLVMSAITVII 380
Cdd:cd02080    204 --------EVEQLAT--------------PL------------------------TRQIAKFSKALLIVILVLAALTFVF 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  381 lvlyftvdTFVVNKKPWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMG 460
Cdd:cd02080    238 --------GLLRGDYSL------------VELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLG 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  461 NATAICSDKTGTLTTNRMTVVQAYvgdvhykeipdpssintktmeLLINAIAInsayttkilppEKEGALPRQVGNKTEC 540
Cdd:cd02080    298 SVTVICSDKTGTLTRNEMTVQAIV---------------------TLCNDAQL-----------HQEDGHWKITGDPTEG 345
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  541 GLLGFVLDLKQDYEPVRSQMPEEKlykVYTFNSVRKSMSTVIKLPDESfRMYSKGASEIVLKKCCKILNGAGEprvfRPR 620
Cdd:cd02080    346 ALLVLAAKAGLDPDRLASSYPRVD---KIPFDSAYRYMATLHRDDGQR-VIYVKGAPERLLDMCDQELLDGGV----SPL 417
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  621 DRDEMVKKViEPMACDGLRTICVAYRDFPssPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVT 700
Cdd:cd02080    418 DRAYWEAEA-EDLAKQGLRVLAFAYREVD--SEVEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMIT 494
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  701 GDNINTARAIAIKCGIIHPGEdflCLEGKEFNRRIRNEKGEIEQERidkiwpklRVLARSSPTDKHTLVKGIidsthTEQ 780
Cdd:cd02080    495 GDHAETARAIGAQLGLGDGKK---VLTGAELDALDDEELAEAVDEV--------DVFARTSPEHKLRLVRAL-----QAR 558
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  781 RQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV---V 857
Cdd:cd02080    559 GEVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLgegL 638
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  858 AVIVA-FTGACItqdsPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIF 936
Cdd:cd02080    639 VIIVAiLFGVTL----PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLGGAF 714
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  937 TL-LFVGEKMFQIDSGRnaplhsppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCTIVLGTFAIQIV 1014
Cdd:cd02080    715 GLfLWALDRGYSLETAR------------TMAVNTIVVAQIFYLFNCRSLH--RSILKlGVFSNKILFLGIGALILLQLA 780
                          890       900
                   ....*....|....*....|....*....
gi 1034633540 1015 IVQ--FGGKPFSCSPLQLDQWMWCIFIGL 1041
Cdd:cd02080    781 FTYlpFMNSLFGTAPIDLVDWAIILLVGI 809
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
52-917 5.97e-130

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 422.08  E-value: 5.97e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   52 DTEAICRRLKTSPVEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYhppgegn 131
Cdd:cd02083      4 TVEEVLAYFGVDPTRGL--SDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF------- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  132 egcataqggaEDEGEAEAGWIEGAAILLSVIC--VVLVtafndWskekQFRGLQSRIEQEQKF-----TVVRAGQVVQ-I 203
Cdd:cd02083     75 ----------EEGEEGVTAFVEPFVILLILIAnaVVGV-----W----QERNAEKAIEALKEYepemaKVLRNGKGVQrI 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  204 PVAEIVVGDIAQVKYGDLLPADG--LFIQGNDLKIDESSLTGESDQVRKSVD--KDP---------MLLSGTHVMEGSGR 270
Cdd:cd02083    136 RARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVAAGKAR 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  271 MLVTAVGVNSQTGIIftllgaggeeeekkdkkgkmqdgnvdasqskakqQDGAAAMEmqplksaeggdaddrkkasmhkK 350
Cdd:cd02083    216 GVVVGTGLNTEIGKI----------------------------------RDEMAETE----------------------E 239
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  351 EKSVLQGKLTKLAVQIGKAglvmsaITVI-ILVlyftvdtFVVNKKPWlpeCTPVYVQYFVK----FFIIGVTVLVVAVP 425
Cdd:cd02083    240 EKTPLQQKLDEFGEQLSKV------ISVIcVAV-------WAINIGHF---NDPAHGGSWIKgaiyYFKIAVALAVAAIP 303
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  426 EGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-----GDVHYKEIP------ 494
Cdd:cd02083    304 EGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIldkveDDSSLNEFEvtgsty 383
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  495 --------DPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFV------------LDLKQDYE 554
Cdd:cd02083    384 apegevfkNGKKVKAGQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVekmnvfntdksgLSKRERAN 463
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  555 PVRSQMpEEKLYKVYT--FNSVRKSMSTVIKLPDESF--RMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVI 630
Cdd:cd02083    464 ACNDVI-EQLWKKEFTleFSRDRKSMSVYCSPTKASGgnKLFVKGAPEGVLERCTHVRVGGGKVVPLTAAIKILILKKVW 542
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  631 EpMACDGLRTICVAYRDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINT 706
Cdd:cd02083    543 G-YGTDTLRCLALATKDTPPKPEDmdleDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGT 621
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  707 ARAIAIKCGIIHPGEDFlclEGKEFNRRIRNEKGEIEQEridKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAV 786
Cdd:cd02083    622 AEAICRRIGIFGEDEDT---TGKSYTGREFDDLSPEEQR---EACRRARLFSRVEPSHKSKIVELL-----QSQGEITAM 690
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  787 TGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGA 866
Cdd:cd02083    691 TGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTA 769
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034633540  867 CITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLIS 917
Cdd:cd02083    770 ALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
142-1041 1.06e-124

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 406.09  E-value: 1.06e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  142 EDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSrIEQEQKfTVVRAGQVVQIPVAEIVVGDIAQVKYGDL 221
Cdd:TIGR01116   27 EEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKE-YESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDK 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  222 LPADGLFIQGNDLKIDESSLTGESDQVRKSV-----------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllg 290
Cdd:TIGR01116  105 VPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpderavnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIGKI----- 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  291 aggeeeekkdkkgkmQDGNVDASQskakqqdgaaamemqplksaeggdaddrkkasmhkkEKSVLQGKLTKLAVQIGKag 370
Cdd:TIGR01116  180 ---------------RDEMRAAEQ------------------------------------EDTPLQKKLDEFGELLSK-- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  371 lVMSAITVIIlvlyftvdtFVVNKKPWLPECTPV-YVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL 449
Cdd:TIGR01116  207 -VIGLICILV---------WVINIGHFNDPALGGgWIQGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAI 276
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  450 VRHLDACETMGNATAICSDKTGTLTTNRMTVV----------QAYVGDVH----------YKEIPDPSSINTKTMELLIN 509
Cdd:TIGR01116  277 VRKLPSVETLGCTTVICSDKTGTLTTNQMSVCkvvaldpsssSLNEFCVTgttyapeggvIKDDGPVAGGQDAGLEELAT 356
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  510 AIAINSayTTKILPPEKEGALPRqVGNKTECGLLGFV--LDLKQDYEPVRS---------QMPEEKLYKVYT--FNSVRK 576
Cdd:TIGR01116  357 IAALCN--DSSLDFNERKGVYEK-VGEATEAALKVLVekMGLPATKNGVSSkrrpalgcnSVWNDKFKKLATleFSRDRK 433
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  577 SMSTVIKlPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPE--- 653
Cdd:TIGR01116  434 SMSVLCK-PSTGNKLFVKGAPEGVLERCTHILNGDGRAVPLTDKMKNTILSVIKEMGTTKALRCLALAFKDIPDPREedl 512
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  654 -PDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGED--FLCLEGKE 730
Cdd:TIGR01116  513 lSDPANFEAIESDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGRE 592
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  731 FNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAG 810
Cdd:TIGR01116  593 FD--------EMGPAKQRAACRSAVLFSRVEPSHKSELVELL-----QEQGEIVAMTGDGVNDAPALKKADIGIAMG-SG 658
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  811 TDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFA 890
Cdd:TIGR01116  659 TEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLP 738
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  891 SLALATEPPTETLLLRKPYGRNKPLIS-----RTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAP--------LH 957
Cdd:TIGR01116  739 ATALGFNPPDKDIMWKPPRRPDEPLITgwlffRYLVVGVYVGLATVGGFVWWYLLTHFTGCDEDSFTTCPdfedpdcyVF 818
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  958 SPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVI--VQFGGKPFSCSPLQLDQWMW 1035
Cdd:TIGR01116  819 EGKQPARTISLSVLVVIEMFNALNALSEDQSLLRM-PPWVNKWLIGAICLSMALHFLIlyVPFLSRIFGVTPLSLTDWLM 897

                   ....*.
gi 1034633540 1036 CIFIGL 1041
Cdd:TIGR01116  898 VLKLSL 903
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
151-1015 3.85e-122

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 399.52  E-value: 3.85e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd02086     56 WIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIE 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  231 GNDLKIDESSLTGESDQVRKSV-------------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeee 297
Cdd:cd02086    134 TKNFETDEALLTGESLPVIKDAelvfgkeedvsvgDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKAL-------- 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  298 kkdkkgkmqdgnvdasqskakqQDGAAAMEMQPLKSAEGGDADDRKKASMH---KKEKSVLQGKLTKLAVqigkaglVMS 374
Cdd:cd02086    206 ----------------------RGKGGLISRDRVKSWLYGTLIVTWDAVGRflgTNVGTPLQRKLSKLAY-------LLF 256
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  375 AITVIILVLYFTVDTFVVNKKpwlpectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 454
Cdd:cd02086    257 FIAVILAIIVFAVNKFDVDNE----------------VIIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  455 ACETMGNATAICSDKTGTLTTNRMTVVQAYVgdvhykeipdPSSintktmelLINAIAINSAyttkilppeKEGALPRQV 534
Cdd:cd02086    321 ALEALGAVTDICSDKTGTLTQGKMVVRQVWI----------PAA--------LCNIATVFKD---------EETDCWKAH 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  535 GNKTECGLLGFV--LDLKQDYEPVRSQmPEEKLYKVYTFNSVRKSMSTVI--KLPDESFrMYSKGASEIVLKkCCKILNG 610
Cdd:cd02086    374 GDPTEIALQVFAtkFDMGKNALTKGGS-AQFQHVAEFPFDSTVKRMSVVYynNQAGDYY-AYMKGAVERVLE-CCSSMYG 450
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  611 AGEPRVFRPRDRDEMVKKViEPMACDGLRTICVAYRDF-------PSSPEPDWDNEnDILNELTCICVVGIEDPVRPEVP 683
Cdd:cd02086    451 KDGIIPLDDEFRKTIIKNV-ESLASQGLRVLAFASRSFtkaqfndDQLKNITLSRA-DAESDLTFLGLVGIYDPPRNESA 528
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  684 EAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE--------DFLCLEGKEFNRrirnekgeIEQERIDKIwPKL- 754
Cdd:cd02086    529 GAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNSyhysqeimDSMVMTASQFDG--------LSDEEVDAL-PVLp 599
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  755 RVLARSSPTDKhtlVKgIIDSTHTEQRqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAV 834
Cdd:cd02086    600 LVIARCSPQTK---VR-MIEALHRRKK-FCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVNAI 674
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  835 MWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPY 909
Cdd:cd02086    675 EEGRRMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDglsvfPLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPH 754
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  910 GRNKPLISRTMMKNILghaVYQLALIFTLL--FVGeKMFQIDSGRnapLHSPPSEHYTI-----------IFNTFVMMQL 976
Cdd:cd02086    755 DLKVGIFTRELIIDTF---VYGTFMGVLCLasFTL-VIYGIGNGD---LGSDCNESYNSscedvfraraaVFATLTWCAL 827
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034633540  977 F---NEINARK----IHGE-----RNVFDGIFRNP-IFCTIVLGTFAIQIVI 1015
Cdd:cd02086    828 IlawEVVDMRRsffnMHPDtdspvKSFFKTLWKNKfLFWSVVLGFVSVFPTL 879
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
156-1029 2.48e-117

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 382.90  E-value: 2.48e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  156 AILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEqkFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK 235
Cdd:cd02085     52 SITVAILIVVTVAFVQEYRSEKSLEALNKLVPPE--CHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLS 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  236 IDESSLTGESDQVRKSVD-------KDPMLLS-----GTHVMEGSGRMLVTAVGVNSQTGIIFtllgaggeeeekkdkkg 303
Cdd:cd02085    130 IDESSLTGETEPCSKTTEvipkasnGDLTTRSniafmGTLVRCGHGKGIVIGTGENSEFGEVF----------------- 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  304 kmqdgnvdasqskakqqdgaaamEMqplksaeggdaddrkkasMHKKE--KSVLQGKLTKLAVQigkaglvMSAITVIIL 381
Cdd:cd02085    193 -----------------------KM------------------MQAEEapKTPLQKSMDKLGKQ-------LSLYSFIII 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  382 VLYFTVDTFvvNKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGN 461
Cdd:cd02085    225 GVIMLIGWL--QGKNLL------------EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGC 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  462 ATAICSDKTGTLTTNRMTVVQAYVGDVhykeipdpssintktmellinaiaINSAYTTKILPPekegalprqvGNKTECG 541
Cdd:cd02085    291 VNVICSDKTGTLTKNEMTVTKIVTGCV------------------------CNNAVIRNNTLM----------GQPTEGA 336
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  542 LLgfVLDLKQDYEPVRSqmpEEKLYKVYTFNSVRKSMSTVIKLPDESFR---MYSKGASEIVLKKCCKILNGAGEPRVFR 618
Cdd:cd02085    337 LI--ALAMKMGLSDIRE---TYIRKQEIPFSSEQKWMAVKCIPKYNSDNeeiYFMKGALEQVLDYCTTYNSSDGSALPLT 411
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  619 PRDRDEmVKKVIEPMACDGLRTICVAyrdfpSSPEpdwdnendiLNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRM 698
Cdd:cd02085    412 QQQRSE-INEEEKEMGSKGLRVLALA-----SGPE---------LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKM 476
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  699 VTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTht 778
Cdd:cd02085    477 ITGDAQETAIAIGSSLGLYSPSL--QALSGEEVDQ--------MSDSQLASVVRKVTVFYRASPRHKLKIVKALQKSG-- 544
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  779 eqrQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVA 858
Cdd:cd02085    545 ---AVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAA 621
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  859 VIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAvyqlALIFT- 937
Cdd:cd02085    622 LSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSA----AIIVSg 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  938 LLFVGEKmfQIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARkiHGERNVFD-GIFRNPIFCTIVLGTFAIQIVIV 1016
Cdd:cd02085    698 TLWVFWK--EMSDDNVTPRDT------TMTFTCFVFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIGQLLVI 767
                          890
                   ....*....|...
gi 1034633540 1017 QFggkpfscSPLQ 1029
Cdd:cd02085    768 YF-------PPLQ 773
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
465-894 9.16e-97

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 311.31  E-value: 9.16e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  465 ICSDKTGTLTTNRMTVVqayvgDVHYKEIPdpssintktmellinaiainsayttkilppekegalprqvgnktecgllg 544
Cdd:cd01431      2 ICSDKTGTLTKNGMTVT-----KLFIEEIP-------------------------------------------------- 26
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  545 fvldlkqdyepvrsqmpeeklykvytFNSVRKSMSTVIKLPDEsFRMYSKGASEIVLKKCCKILngageprvfrPRDRDE 624
Cdd:cd01431     27 --------------------------FNSTRKRMSVVVRLPGR-YRAIVKGAPETILSRCSHAL----------TEEDRN 69
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  625 MVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENdilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 704
Cdd:cd01431     70 KIEKAQEESAREGLRVLALAYREFDPETSKEAVELN-----LVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNP 144
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  705 NTARAIAIKCGIIHPGEDFLCLEgkefnrrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVV 784
Cdd:cd01431    145 LTAIAIAREIGIDTKASGVILGE----------EADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGE-----VV 209
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  785 AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFT 864
Cdd:cd01431    210 AMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIAL 289
                          410       420       430
                   ....*....|....*....|....*....|
gi 1034633540  865 GACITQDSPLKAVQMLWVNLIMDTFASLAL 894
Cdd:cd01431    290 ALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
155-897 6.01e-93

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 311.66  E-value: 6.01e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  155 AAILLSVICV-VLVTAFNDWSKEKQFRGLqsRIEQEQKFTVVRA--GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQG 231
Cdd:cd07539     60 AVLIVGVLTVnAVIGGVQRLRAERALAAL--LAQQQQPARVVRApaGRTQTVPAESLVPGDVIELRAGEVVPADARLLEA 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  232 NDLKIDESSLTGESDQVRKSVDKDP---------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekkdkk 302
Cdd:cd07539    138 DDLEVDESALTGESLPVDKQVAPTPgapladracMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVA------------ 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  303 gkmqdgnvdasqskakqqdgaaamemqPLKSAEGgdaddrkkasmhkkeksvLQGKLTKLAVQigkaglvMSAITVIILV 382
Cdd:cd07539    206 ---------------------------PVETATG------------------VQAQLRELTSQ-------LLPLSLGGGA 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  383 LYFTVDtfVVNKKPWLPectpvyvqyFVKffiIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNA 462
Cdd:cd07539    234 AVTGLG--LLRGAPLRQ---------AVA---DGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRV 299
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  463 TAICSDKTGTLTTNRMTVVQayvgdvhykeipdpssintktmellinaiainsayttkILPPEKEgaLPrqvgnktecgl 542
Cdd:cd07539    300 DTICFDKTGTLTENRLRVVQ--------------------------------------VRPPLAE--LP----------- 328
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  543 lgfvldlkqdyepvrsqmpeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGePRVFRPRDR 622
Cdd:cd07539    329 ----------------------------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRMTGGQ-VVPLTEADR 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  623 DeMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDilnELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGD 702
Cdd:cd07539    380 Q-AIEEVNELLAGQGLRVLAVAYRTLDAGTTHAVEAVVD---DLELLGLLGLADTARPGAAALIAALHDAGIDVVMITGD 455
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  703 NINTARAIAIKCGIihpGEDFLCLEGKEFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrq 782
Cdd:cd07539    456 HPITARAIAKELGL---PRDAEVVTGAELDA--------LDEEALTGLVADIDVFARVSPEQKLQIVQALQAAGR----- 519
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  783 VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 862
Cdd:cd07539    520 VVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVMFT 599
                          730       740       750
                   ....*....|....*....|....*....|....*
gi 1034633540  863 FTGACITQDSPLKAVQMLWVNLIMDTFASLALATE 897
Cdd:cd07539    600 LIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
156-941 3.15e-91

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 313.90  E-value: 3.15e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  156 AILLSVicVVLVTAFNDWSKEKQfrglQSRIEQE------QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:cd02608     72 GIVLAA--VVIVTGCFSYYQEAK----SSKIMDSfknmvpQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRII 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  230 QGNDLKIDESSLTGESDQVRKSVD---KDPM------LLSgTHVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkd 300
Cdd:cd02608    146 SAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS-TNCVEGTARGIVINTGDRTVMGRIATL------------ 212
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  301 kkgkmqdgnvdASQskakqqdgaaamemqplksaeggdaddrkkasmhkkeksvLQGKLTKLAVQIGKAGLVMSAITVII 380
Cdd:cd02608    213 -----------ASG----------------------------------------LEVGKTPIAREIEHFIHIITGVAVFL 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  381 LVLYFTVDtfVVNKKPWLPECtpvyvqyfvkFFIIGVtvlVVA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETM 459
Cdd:cd02608    242 GVSFFILS--LILGYTWLEAV----------IFLIGI---IVAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETL 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  460 GNATAICSDKTGTLTTNRMTVVQA-YVGDVHYKEIPDPSSINTKT------MELLINAIAINSAyttKILPPEKEGALPR 532
Cdd:cd02608    307 GSTSTICSDKTGTLTQNRMTVAHMwFDNQIHEADTTEDQSGASFDkssatwLALSRIAGLCNRA---EFKAGQENVPILK 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  533 QV--GNKTECGLLGFVLDLKQDYEPVRSQMPeeKLYKVyTFNSVRK---SMSTVIKLPDESFRMYSKGASEIVLKKCCKI 607
Cdd:cd02608    384 RDvnGDASESALLKCIELSCGSVMEMRERNP--KVAEI-PFNSTNKyqlSIHENEDPGDPRYLLVMKGAPERILDRCSTI 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  608 L-NGAGEPrvfrprdRDEMVKKVIEP--MACDGL--RTI--CVAY---RDFPSSPEPDWDNENDILNELtciCVVGIE-- 675
Cdd:cd02608    461 LiNGKEQP-------LDEEMKEAFQNayLELGGLgeRVLgfCHLYlpdDKFPEGFKFDTDEVNFPTENL---CFVGLMsm 530
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  676 -DPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpkl 754
Cdd:cd02608    531 iDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGII------------------------------------- 573
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  755 rVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 832
Cdd:cd02608    574 -VFARTSPQQKLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVT 645
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  833 AVMWGRNVYDSISKFLQFQLTVNvVAVIVAFTgACITQDSPLK--AVQMLWVNLIMDTFASLALATEPPTETLLLRKPyg 910
Cdd:cd02608    646 GVEEGRLIFDNLKKSIAYTLTSN-IPEITPFL-IFIIANIPLPlgTITILCIDLGTDMVPAISLAYEKAESDIMKRQP-- 721
                          810       820       830
                   ....*....|....*....|....*....|....*.
gi 1034633540  911 RNkPLISRTMMKNILGHAVYQLALI-----FTLLFV 941
Cdd:cd02608    722 RN-PKTDKLVNERLISMAYGQIGMIqalagFFTYFV 756
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
71-931 2.32e-90

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 305.14  E-value: 2.32e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   71 TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLsfyhppgegnegcataqggaedeGEAEag 150
Cdd:cd07538      3 TEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL-----------------------GDPR-- 57
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  151 wiEGAAILLSVICVVLVTAFNDWSKEKQFRGLqsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd07538     58 --EGLILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLE 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  231 GNDLKIDESSLTGESDQVRKSVD----------KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeeekkd 300
Cdd:cd07538    134 NDDLGVDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI--------------- 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  301 kkgkmqdgnvdasqskakqqdGAAAMEMQplksaeggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVII 380
Cdd:cd07538    199 ---------------------GKSLAEMD--------------------DEPTPLQKQTGRLVKLCALAALVFCALIVAV 237
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  381 lvlyftvdtFVVNKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMG 460
Cdd:cd07538    238 ---------YGVTRGDWI------------QAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLG 296
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  461 NATAICSDKTGTLTTNRMTVVQAYVgdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgnktec 540
Cdd:cd07538    297 SITVLCVDKTGTLTKNQMEVVELTS------------------------------------------------------- 321
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  541 gllgfvldlkqdyePVRSqmpeeklykvYTFNSVRKSMSTVIKLPDESFrMYSKGASEIVLKKCckilngageprVFRPR 620
Cdd:cd07538    322 --------------LVRE----------YPLRPELRMMGQVWKRPEGAF-AAAKGSPEAIIRLC-----------RLNPD 365
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  621 DRDEMVKKVIEpMACDGLRTICVAyrdfpsSPEPDWDNENDILNELTCICV--VGIEDPVRPEVPEAIRKCQRAGITVRM 698
Cdd:cd07538    366 EKAAIEDAVSE-MAGEGLRVLAVA------ACRIDESFLPDDLEDAVFIFVglIGLADPLREDVPEAVRICCEAGIRVVM 438
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  699 VTGDNINTARAIAIKCGIIH-----PGEDFLCLEGKEFNRRIRNekgeieqeridkiwpkLRVLARSSPTDKHTLVKGIi 773
Cdd:cd07538    439 ITGDNPATAKAIAKQIGLDNtdnviTGQELDAMSDEELAEKVRD----------------VNIFARVVPEQKLRIVQAF- 501
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  774 dsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 853
Cdd:cd07538    502 ----KANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFA 577
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034633540  854 VNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISrtmmKNILGHAVYQ 931
Cdd:cd07538    578 IHVPIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLVIKAILQ 651
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
190-934 2.32e-86

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 302.10  E-value: 2.32e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVD---KDPM-----LLSG 261
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  262 THVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkmqdgnvdasqskakqqdgaaamemqplksAEGgdadd 341
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMGRIASL---------------------------------------------ASG----- 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  342 rkkasmhkkeksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDtfVVNKKPWLPECtpvyvqyfvkFFIIGVtvLV 421
Cdd:TIGR01106  251 -------------LENGKTPIAIEIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLIGI--IV 303
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  422 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV------QAYVGDV---HYKE 492
Cdd:TIGR01106  304 ANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAhmwfdnQIHEADTtedQSGV 383
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  493 IPDPSSINTKTMELLinAIAINSAyttkILPPEKEGA--LPRQV-GNKTECGLLGFVLDLKQDYEPVRSQMPeeKLYKVy 569
Cdd:TIGR01106  384 SFDKSSATWLALSRI--AGLCNRA----VFKAGQENVpiLKRAVaGDASESALLKCIELCLGSVMEMRERNP--KVVEI- 454
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  570 TFNSVRKSMSTVIKLPDES---FRMYSKGASEIVLKKCCKIL-NGAGEPRvfrprdrDEMVKKVIEP--MACDGL--RTI 641
Cdd:TIGR01106  455 PFNSTNKYQLSIHENEDPRdprHLLVMKGAPERILERCSSILiHGKEQPL-------DEELKEAFQNayLELGGLgeRVL 527
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  642 --CVAY---RDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGI 716
Cdd:TIGR01106  528 gfCHLYlpdEQFPEGFQFDTDDVNFPTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI 607
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  717 IHPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERIDKIwpkLR-----VLARSSPTDKHTLVKGIidsth 777
Cdd:TIGR01106  608 ISEGnetvEDIaarLNIPVSQVNPRDAKacvvhgsDLKDMTSEQLDEI---LKyhteiVFARTSPQQKLIIVEGC----- 679
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  778 teQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVN 855
Cdd:TIGR01106  680 --QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN 757
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  856 V--VAVIVAFTGACITQdsPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGR------NKPLISRT-----MMK 922
Cdd:TIGR01106  758 IpeITPFLIFIIANIPL--PLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPktdklvNERLISMAygqigMIQ 835
                          810
                   ....*....|..
gi 1034633540  923 NILGHAVYQLAL 934
Cdd:TIGR01106  836 ALGGFFTYFVIL 847
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
151-952 6.51e-83

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 293.46  E-value: 6.51e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:TIGR01523   81 WIEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAH--VIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIE 158
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  231 GNDLKIDESSLTGESDQVRKSV-------------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeee 297
Cdd:TIGR01523  159 TKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIGAI------------ 226
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  298 kkdkkgkmqdgnvdasqSKAKQQDGAAamemqpLKSAEGGDADDRKKASMH--KKEKSV------------LQGKLTKLA 363
Cdd:TIGR01523  227 -----------------AAGLQGDGGL------FQRPEKDDPNKRRKLNKWilKVTKKVtgaflglnvgtpLHRKLSKLA 283
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  364 VqigkaglVMSAITVIILVLYFTVDTFVVNKKpwlpectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM 443
Cdd:TIGR01523  284 V-------ILFCIAIIFAIIVMAAHKFDVDKE----------------VAIYAICLAISIIPESLIAVLSITMAMGAANM 340
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  444 MKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEI---PDPSSINTKTMELLIN----AIAINSA 516
Cdd:TIGR01523  341 SKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIPRFGTISIdnsDDAFNPNEGNVSGIPRfspyEYSHNEA 420
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  517 YTTKILPPEK----EGALPRQV--------------------------------GNKTECGLlgFVLDLKQDYePVRSQM 560
Cdd:TIGR01523  421 ADQDILKEFKdelkEIDLPEDIdmdlfiklletaalaniatvfkddatdcwkahGDPTEIAI--HVFAKKFDL-PHNALT 497
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  561 PEEKLYKV-------------------------YTFNSVRKSMSTVIK-LPDESFRMYSKGASEIVLKkCCKILNGAGEP 614
Cdd:TIGR01523  498 GEEDLLKSnendqsslsqhnekpgsaqfefiaeFPFDSEIKRMASIYEdNHGETYNIYAKGAFERIIE-CCSSSNGKDGV 576
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  615 RVFRPRDRD-EMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILN------ELTCICVVGIEDPVRPEVPEAIR 687
Cdd:TIGR01523  577 KISPLEDCDrELIIANMESLAAEGLRVLAFASKSFDKADNNDDQLKNETLNrataesDLEFLGLIGIYDPPRNESAGAVE 656
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  688 KCQRAGITVRMVTGDNINTARAIAIKCGII--------HPGEDFLCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLAR 759
Cdd:TIGR01523  657 KCHQAGINVHMLTGDFPETAKAIAQEVGIIppnfihdrDEIMDSMVMTGSQFD--------ALSDEEVDDLKALCLVIAR 728
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  760 SSPTDKhtlVKgIIDSTHtEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRN 839
Cdd:TIGR01523  729 CAPQTK---VK-MIEALH-RRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRR 803
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  840 VYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKP 914
Cdd:TIGR01523  804 MFDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVG 883
                          890       900       910
                   ....*....|....*....|....*....|....*...
gi 1034633540  915 LISRTMMKNILGHAVYqLALIFTLLFVGeKMFQIDSGR 952
Cdd:TIGR01523  884 IFQKELIIDMFAYGFF-LGGSCLASFTG-ILYGFGSGN 919
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
152-902 5.47e-72

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 256.39  E-value: 5.47e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  152 IEGAAIL---------LSVICVVLVT-AFNDWSKEKQFRGLQSRIEQ--EQKFTVVRAGQVVQIPVAEIVVGDIAQVKYG 219
Cdd:cd02076     42 LEAAAILaaalgdwvdFAIILLLLLInAGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIG 121
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  220 DLLPADGLFIQGNDLKIDESSLTGESDQVRKSvdKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekk 299
Cdd:cd02076    122 DIVPADARLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVA--------- 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  300 dkkgkmqdgnvdasqskakqqdgaaamemqplkSAEGgdaddrkkasmhkkeksvlQGKLTKLAVQIGKAGLVMSAITV- 378
Cdd:cd02076    191 ---------------------------------SAEE-------------------QGHLQKVLNKIGNFLILLALILVl 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  379 -IILVLYFTVDTFVvnkkpwlpectpvyvqYFVKFFIIgvtVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 457
Cdd:cd02076    219 iIVIVALYRHDPFL----------------EILQFVLV---LLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIE 279
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  458 TMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEipdpssintktmELLINAiainsAYTTKilpPEKEGALPRQVgnk 537
Cdd:cd02076    280 ELAGVDILCSDKTGTLTLNKLSLDEPYSLEGDGKD------------ELLLLA-----ALASD---TENPDAIDTAI--- 336
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  538 tecglLGFVldlkQDYEPVRSQMPEEKLYKvytFNSVRK-SMSTVIKLPDESFRmYSKGASEIVLKKCCKilngageprv 616
Cdd:cd02076    337 -----LNAL----DDYKPDLAGYKQLKFTP---FDPVDKrTEATVEDPDGERFK-VTKGAPQVILELVGN---------- 393
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  617 frPRDRDEMVKKVIEPMACDGLRTICVAYRDfpssPEPDWDnendILNELTCIcvvgieDPVRPEVPEAIRKCQRAGITV 696
Cdd:cd02076    394 --DEAIRQAVEEKIDELASRGYRSLGVARKE----DGGRWE----LLGLLPLF------DPPRPDSKATIARAKELGVRV 457
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  697 RMVTGDNINTARAIAIKCGI---IHPGEDFLCLEGKefnrriRNEKGEIEQERIDKiwpkLRVLARSSPTDKHTLVKGII 773
Cdd:cd02076    458 KMITGDQLAIAKETARQLGMgtnILSAERLKLGGGG------GGMPGSELIEFIED----ADGFAEVFPEHKYRIVEALQ 527
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  774 DSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 853
Cdd:cd02076    528 QRGH-----LVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIA 601
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034633540  854 VnVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATE--PPTET 902
Cdd:cd02076    602 E-TLRILVFFTLGILILNFYPLPLIMIVLIAILNDGATLTIAYDnvPPSPR 651
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
71-896 3.22e-68

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 245.24  E-value: 3.22e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   71 TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNegcataqggaedegeaeag 150
Cdd:cd02077      3 TNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD------------------- 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  151 wIEGAAILLS-VICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQ-IPVAEIVVGDIAQVKYGDLLPADGLF 228
Cdd:cd02077     64 -LVGALIILLmVLISGLLDFIQEIRSLKAAEKLKKMVKN--TATVIRDGSKYMeIPIDELVPGDIVYLSAGDMIPADVRI 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  229 IQGNDLKIDESSLTGESDQVRKSV-----------DKDPMLLSGTHVMEGSGRMLVTAVGVNsqtgiifTLLGaggeeee 297
Cdd:cd02077    141 IQSKDLFVSQSSLTGESEPVEKHAtakktkdesilELENICFMGTNVVSGSALAVVIATGND-------TYFG------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  298 kkdkkgkmqdgnvdasqskakqqdgaaamemqplkSAEGGDADDRKKASMHKKEKSVlqgklTKLavqigkaglvmsaIT 377
Cdd:cd02077    207 -----------------------------------SIAKSITEKRPETSFDKGINKV-----SKL-------------LI 233
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  378 VIILVLYFTVdtFVVN---KKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 454
Cdd:cd02077    234 RFMLVMVPVV--FLINgltKGDWL------------EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLN 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  455 ACETMGNATAICSDKTGTLTTNRMTVVQAYvgdvhykeipdpsSINTKTMELLINAIAINSAYTTKILPPeKEGALPRQV 534
Cdd:cd02077    300 AIQNFGAMDILCTDKTGTLTQDKIVLERHL-------------DVNGKESERVLRLAYLNSYFQTGLKNL-LDKAIIDHA 365
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  535 GNKTECGLlgfvldlKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI-LNGAGE 613
Cdd:cd02077    366 EEANANGL-------IQDYTKI-DEIP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHVeVNGEVV 428
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  614 PRVFRPRdrdEMVKKVIEPMACDGLRTICVAYRDFPSspePDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAG 693
Cdd:cd02077    429 PLTDTLR---EKILAQVEELNREGLRVLAIAYKKLPA---PEGEYSVKDEKELILIGFLAFLDPPKESAAQAIKALKKNG 502
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  694 ITVRMVTGDNINTARAIAIKCGIihPGEDflCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIi 773
Cdd:cd02077    503 VNVKILTGDNEIVTKAICKQVGL--DINR--VLTGSEIE--------ALSDEELAKIVEETNIFAKLSPLQKARIIQAL- 569
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  774 dsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 853
Cdd:cd02077    570 ----KKNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTAS 644
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 1034633540  854 VN---VVAVIVAftgACITQDSPLKAVQMLWVNLIMDtFASLALAT 896
Cdd:cd02077    645 SNfgnVFSVLVA---SAFLPFLPMLPIQLLLQNLLYD-FSQLAIPF 686
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
191-901 8.26e-66

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 235.64  E-value: 8.26e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  191 KFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGR 270
Cdd:cd02609     93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPKKAGDK--LLSGSFVVSGAAY 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  271 MLVTAVGVNSQtgiiftllgaggeeeekkdkkgkmqdgnvdASQ--SKAKQqdgaaamemqplksaeggdaddrkkasmH 348
Cdd:cd02609    171 ARVTAVGAESY------------------------------AAKltLEAKK----------------------------H 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  349 KKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFtVDTFVVNKKPWlpectpvyvqyfvKFFIIG-VTVLVVAVPEG 427
Cdd:cd02609    193 KLINSELLNSINKILK-------FTSFIIIPLGLLLF-VEALFRRGGGW-------------RQAVVStVAALLGMIPEG 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  428 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIpdpssiNTKTMELL 507
Cdd:cd02609    252 LVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEANEAE------AAAALAAF 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  508 INAIAINSAyTTKILppekegalprqvgnktecgLLGFVLDLKQdyePVRSQMPeeklykvytFNSVRKsMSTVIKLPDE 587
Cdd:cd02609    326 VAASEDNNA-TMQAI-------------------RAAFFGNNRF---EVTSIIP---------FSSARK-WSAVEFRDGG 372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  588 SFRMyskGASEIVLkkcckilngageprvfrpRDRDEMVKKVIEPMACDGLRTICVAYrdfpSSPEPDWDNendILNELT 667
Cdd:cd02609    373 TWVL---GAPEVLL------------------GDLPSEVLSRVNELAAQGYRVLLLAR----SAGALTHEQ---LPVGLE 424
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  668 CICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGiihpgedflcLEGKEFNRRIRNEKGEIEQERI 747
Cdd:cd02609    425 PLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG----------LEGAESYIDASTLTTDEELAEA 494
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  748 DKiwpKLRVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNF 827
Cdd:cd02609    495 VE---NYTVFGRVTPEQKRQLVQALQALGHT-----VAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDF 565
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034633540  828 SSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTE 901
Cdd:cd02609    566 SALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKR 639
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
193-865 4.88e-53

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 199.21  E-value: 4.88e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRML 272
Cdd:COG2217    216 RVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLRVR 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  273 VTAVGVNSQ-TGIIftllgaggeeeekkdkkgKMQDgnvDASQSKAKQQdgaaamemqplksaeggdaddrkkasmhkke 351
Cdd:COG2217    293 VTKVGSDTTlARII------------------RLVE---EAQSSKAPIQ------------------------------- 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  352 ksvlqgkltKLAVQIgkaglvmSAI-TVIILVLyfTVDTFVVnkkpWLpectpVYVQYFVKFFIIGVTVLVVAVPEGLPL 430
Cdd:COG2217    321 ---------RLADRI-------ARYfVPAVLAI--AALTFLV----WL-----LFGGDFSTALYRAVAVLVIACPCALGL 373
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  431 AVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSSINT--KTMELLI 508
Cdd:COG2217    374 ATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVT-----DVVPLDGLDEDELLAlaAALEQGS 448
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  509 N---AIAINSAYTTKILPPEKegalPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklp 585
Cdd:COG2217    449 EhplARAIVAAAKERGLELPE----VEDFEAIPGKGVEATV---------------DGKRVLV----------------- 492
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  586 desfrmyskgaseivlkkcckilngaGEPRVFRPR--DRDEMVKKVIEPMACDGLRTICVAyrdfpsspepdWDNEndil 663
Cdd:COG2217    493 --------------------------GSPRLLEEEgiDLPEALEERAEELEAEGKTVVYVA-----------VDGR---- 531
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  664 neltCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrirnekgeie 743
Cdd:COG2217    532 ----LLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGIDE------------------------- 582
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  744 qeridkiwpklrVLARSSPTDKHTLVKGIIdsthtEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 823
Cdd:COG2217    583 ------------VRAEVLPEDKAAAVRELQ-----AQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLM 644
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 1034633540  824 DDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 865
Cdd:COG2217    645 RDDLRGVPDAIRLSRATMRIIRQNLFWAFGYNVIGIPLAAGG 686
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
172-865 5.74e-50

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 186.68  E-value: 5.74e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  172 DWSKEKQFRGLQSRIE-QEQKFTVVRA-GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVR 249
Cdd:TIGR01525   36 ERAKSRASDALSALLAlAPSTARVLQGdGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  250 KSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkgkmqdgnVDASQSKAKQQDGAAAMEmq 329
Cdd:TIGR01525  115 KKEGDE--VFAGTINGDGSLTIRVTKLGEDSTLAQIVELV--------------------EEAQSSKAPIQRLADRIA-- 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  330 plksaeggdaddrkkasmhkkeksvlqGKLTKLAVqigkaglvmsAITVIILVLYFTVdtfvvnkKPWLPECtpvyvqyf 409
Cdd:TIGR01525  171 ---------------------------SYYVPAVL----------AIALLTFVVWLAL-------GALWREA-------- 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  410 vkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-GDV 488
Cdd:TIGR01525  199 ---LYRALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIEPlDDA 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  489 HYKEIPDPSSintkTMELLIN---AIAINSAYTTKILPPekegaLPRQVGNKTECGLLGFVldlkQDYEPVRSQMPEEkl 565
Cdd:TIGR01525  276 SEEELLALAA----ALEQSSShplARAIVRYAKERGLEL-----PPEDVEEVPGKGVEATV----DGGREVRIGNPRF-- 340
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  566 ykvytfnsvrksmstviklpdesfrMYSKGASEIVLKKCCKILNGAGEprvfrprdrdemvkkviepmacdGLRTICVAY 645
Cdd:TIGR01525  341 -------------------------LGNRELAIEPISASPDLLNEGES-----------------------QGKTVVFVA 372
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  646 RDfpsspepdwdnendilNELtcICVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAIKCGIihpgedfl 724
Cdd:TIGR01525  373 VD----------------GEL--LGVIALRDQLRPEAKEAIAALKRAGgIKLVMLTGDNRSAAEAVAAELGI-------- 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  725 clegkefnrrirnekgeiEQEridkiwpklrVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGF 804
Cdd:TIGR01525  427 ------------------DDE----------VHAELLPEDKLAIVKKL-----QEEGGPVAMVGDGINDAPALAAADVGI 473
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034633540  805 AMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 865
Cdd:TIGR01525  474 AMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLAAGG 533
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
872-1050 2.10e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 172.81  E-value: 2.10e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  872 SPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSG 951
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  952 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQ 1029
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 1034633540 1030 LDQWMWCIFIGLGELVWGQVI 1050
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
193-834 7.11e-47

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 179.21  E-value: 7.11e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRML 272
Cdd:cd02094    142 RVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DK-VIGGTINGNGSLLVR 218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  273 VTAVGVNSQTGIIFTLLGaggeeeekkdkkgkmqdgnvDASQSKAKQQdgaaamemqplksaeggdaddrkkasmhkkek 352
Cdd:cd02094    219 ATRVGADTTLAQIIRLVE--------------------EAQGSKAPIQ-------------------------------- 246
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  353 svlqgkltKLAVQIgkaglvmSAITV-IILVLyfTVDTFVVnkkpWL---PECTPVYVqyfvkfFIIGVTVLVVAVPEGL 428
Cdd:cd02094    247 --------RLADRV-------SGVFVpVVIAI--AILTFLV----WLllgPEPALTFA------LVAAVAVLVIACPCAL 299
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  429 PLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHykeiPDPSSINTKTMEL-- 506
Cdd:cd02094    300 GLATPTAIMVGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVT-----DVV----PLPGDDEDELLRLaa 370
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  507 ---------LINAIaINSAYTTKILPPEKEG--ALPrqvGnkteCGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvr 575
Cdd:cd02094    371 sleqgsehpLAKAI-VAAAKEKGLELPEVEDfeAIP---G----KGVRGTV---------------DGRRVLV------- 420
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  576 ksmstviklpdesfrmyskGASEIVLKKCCKILNGAGEprvfrprdrdemvkkvIEPMACDGLRTICVAYrdfpsspepd 655
Cdd:cd02094    421 -------------------GNRRLMEENGIDLSALEAE----------------ALALEEEGKTVVLVAV---------- 455
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  656 wDNEndilneltCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrri 735
Cdd:cd02094    456 -DGE--------LAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI------------------- 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  736 rnekgeieqeriDKiwpklrVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAK 815
Cdd:cd02094    508 ------------DE------VIAEVLPEDKAEKVKKL-----QAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAI 563
                          650
                   ....*....|....*....
gi 1034633540  816 EASDIILTDDNFSSIVKAV 834
Cdd:cd02094    564 ESADIVLMRGDLRGVVTAI 582
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
172-865 9.90e-47

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 178.18  E-value: 9.90e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  172 DWSKEKQFRGLQSRIEQEQKF-TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRK 250
Cdd:cd02079    106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  251 SVDkDPmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkgkmqdgnVDASQSKAKqqdgaaamemqp 330
Cdd:cd02079    185 GAG-DT-VFAGTINLNGPLTIEVTKTGEDTTLAKIIRLV--------------------EEAQSSKPP------------ 230
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  331 lksaeggdaddrkkasmhkkeksvLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdtfvvnkkpwlpecTPVYVQYFV 410
Cdd:cd02079    231 ------------------------LQRLADRFARYFTPAVLVLAALVFLF---------------------WPLVGGPPS 265
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  411 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV--VQAYVGDV 488
Cdd:cd02079    266 LALYRALAVLVVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVteIEPLEGFS 345
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  489 HYKEIPDPSSINTKTMELLinAIAINSAYTTKILPPEKEGalprQVGNKTECGLLGFVLDlkqdyepvrsqmpeeklykv 568
Cdd:cd02079    346 EDELLALAAALEQHSEHPL--ARAIVEAAEEKGLPPLEVE----DVEEIPGKGISGEVDG-------------------- 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  569 ytfnsvrksmstviklpdesfRMYSKGASEIVlkkcckilngageprvfrprdRDEMVKKVIEPMACDGLRTICVAYRDF 648
Cdd:cd02079    400 ---------------------REVLIGSLSFA---------------------EEEGLVEAADALSDAGKTSAVYVGRDG 437
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  649 psspepdwdnendilnelTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflcleg 728
Cdd:cd02079    438 ------------------KLVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI------------ 487
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  729 kefnrrirnekgeieqeridkiwpkLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGi 808
Cdd:cd02079    488 -------------------------DEVHAGLLPEDKLAIVKAL-----QAEGGPVAMVGDGINDAPALAQADVGIAMG- 536
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034633540  809 AGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 865
Cdd:cd02079    537 SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
151-865 3.06e-45

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 172.51  E-value: 3.06e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  151 WIEGAAILLSVIcvvLVTAFNDWSKEKQFRGLQSRIEQE-QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:TIGR01512   18 YLEGALLLLLFS---IGETLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  230 QGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkgkmqdgn 309
Cdd:TIGR01512   95 SGTSS-VDESALTGESVPVEKAPGDE--VFAGAINLDGVLTIEVTKLPADSTIAKIVNLV-------------------- 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  310 VDASQSKAKqqdgaaamemqplksaeggdaddrkkasmhkkeksvLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdt 389
Cdd:TIGR01512  152 EEAQSRKAP------------------------------------TQRFIDRFARYYTPAVLAIALAAALV--------- 186
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  390 fvvnkkPWLPECTPvyvqyFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 469
Cdd:TIGR01512  187 ------PPLLGAGP-----FLEWIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTVAFDK 255
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  470 TGTLTTNRMTVVqayvgDVHYKEIPDPSSINT--KTMELL---INAIAINSAYTTKILPPEkegalPRQVGNKTECGLLG 544
Cdd:TIGR01512  256 TGTLTTGKPKVT-----DVHPADGHSESEVLRlaAAAEQGsthPLARAIVDYARARELAPP-----VEDVEEVPGEGVRA 325
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  545 FVldlkqdyepvrsqmpeeklykvytfnsvrksmstviklpdesfrmyskgaseivlkkcckilnGAGEPRVFRPRDRDE 624
Cdd:TIGR01512  326 VV---------------------------------------------------------------DGGEVRIGNPRSLSE 342
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  625 MVKKVIEPMaCDGLRTICVAYRDFpsspepdwdnendilnelTCICVVGIEDPVRPEVPEAIRKCQRAGI-TVRMVTGDN 703
Cdd:TIGR01512  343 AVGASIAVP-ESAGKTIVLVARDG------------------TLLGYIALSDELRPDAAEAIAELKALGIkRLVMLTGDR 403
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  704 INTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKGIIDSTHteqrqV 783
Cdd:TIGR01512  404 RAVAEAVARELGID-------------------------------------EVHAELLPEDKLEIVKELREKAG-----P 441
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  784 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAF 863
Cdd:TIGR01512  442 VAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLILLAL 521

                   ..
gi 1034633540  864 TG 865
Cdd:TIGR01512  522 FG 523
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
194-862 2.35e-44

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 170.15  E-value: 2.35e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRMLV 273
Cdd:TIGR01511   96 LTKDGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRA 172
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  274 TAVGVNSQTGIIFTLLGaggeeeekkdkkgkmqdgnvDASQSKAKqqdgaaameMQPLksaeggdADdrkkasmhkkeks 353
Cdd:TIGR01511  173 TATGEDTTLAQIVRLVR--------------------QAQQSKAP---------IQRL-------AD------------- 203
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  354 vlqgKLTKLavqigkagLVMSAITVIILvlyftvdTFVVnkkpWLpectpvyvqyfvkF-FIIGVTVLVVAVPEGLPLAV 432
Cdd:TIGR01511  204 ----KVAGY--------FVPVVIAIALI-------TFVI----WL-------------FaLEFAVTVLIIACPCALGLAT 247
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  433 TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHykeiPDPSSINTKTMELlINAIA 512
Cdd:TIGR01511  248 PTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVT-----DVH----VFGDRDRTELLAL-AAALE 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  513 INS---------AYTtkilppEKEGALPRQVGN-KTECGLlgfvlDLKQDYEPVRSQMPEEKLYKVYTfnsvrksmstvI 582
Cdd:TIGR01511  318 AGSehplakaivSYA------KEKGITLVTVSDfKAIPGI-----GVEGTVEGTKIQLGNEKLLGENA-----------I 375
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  583 KLPDESfrmysKGASEIVLkkcckilngageprvfrprdrdemvkkviepmacdglrticvayrdfpsspepdwdneNDI 662
Cdd:TIGR01511  376 KIDGKA-----GQGSTVVL----------------------------------------------------------VAV 392
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  663 LNELTCIcvVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgei 742
Cdd:TIGR01511  393 NGELAGV--FALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI-------------------------- 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  743 eqeridkiwpklRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIIL 822
Cdd:TIGR01511  445 ------------DVRAEVLPDDKAALIKKL-----QEKGPVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVL 506
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1034633540  823 TDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 862
Cdd:TIGR01511  507 LRNDLNDVATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
52-862 1.03e-42

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 169.48  E-value: 1.03e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQD-----VTLiileiaaiisLGLSFYhp 126
Cdd:PRK10517    53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNpfnilLTI----------LGAISY-- 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  127 pgegnegcATaqggaEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVVRAGQV--- 200
Cdd:PRK10517   118 --------AT-----EDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVINDkge 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  201 ---VQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRK-----------SVDKDPMLLSGTHVME 266
Cdd:PRK10517   173 ngwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVS 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  267 GSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgkmQDGNVDASQSKAKqqdgaaamemqplksaeggdaddrkKAS 346
Cdd:PRK10517   253 GTAQAVVIATGANTWFGQLAGRVSE--------------QDSEPNAFQQGIS-------------------------RVS 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  347 MhkkeksvlqgKLTKLAvqigkagLVMSAitVIILVLYFTvdtfvvnKKPWlpectpvyvqyfVKFFIIGVTVLVVAVPE 426
Cdd:PRK10517   294 W----------LLIRFM-------LVMAP--VVLLINGYT-------KGDW------------WEAALFALSVAVGLTPE 335
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  427 GLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYVgDVHYKeipdpssintKTMEL 506
Cdd:PRK10517   336 MLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI-VLENHT-DISGK----------TSERV 403
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  507 LINAIaINSAYTTKIlppekEGALPRQVgnkTECGLLGFVLDLKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPD 586
Cdd:PRK10517   404 LHSAW-LNSHYQTGL-----KNLLDTAV---LEGVDEESARSLASRWQKI-DEIP---------FDFERRRMSVVVAENT 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  587 ESFRMYSKGASEIVLKKCCKI-LNGAGEPRVfrpRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEpDWD--NENDil 663
Cdd:PRK10517   465 EHHQLICKGALEEILNVCSQVrHNGEIVPLD---DIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQraDESD-- 538
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  664 neLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGedflCLEGkefnrrirnekGEIE 743
Cdd:PRK10517   539 --LILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE----VLIG-----------SDIE 601
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  744 Q---ERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDI 820
Cdd:PRK10517   602 TlsdDELANLAERTTLFARLTPMHKERIVTLLKREGH-----VVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADI 675
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633540  821 ILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 862
Cdd:PRK10517   676 ILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
158-936 5.98e-37

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 150.78  E-value: 5.98e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  158 LLSVICVVLVTA----FNDWSKEKQFRGLQSRieqeqKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGND 233
Cdd:cd02073     52 LLPLLFVLGVTAikegYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSE 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  234 LK----IDESSLTGESD-QVRKSVDKDPMLLSGTHVMEGSGRMLVtavgvNSQTGIIFTLlgaggeeeekkdkkgkmqDG 308
Cdd:cd02073    127 PDglcyVETANLDGETNlKIRQALPETALLLSEEDLARFSGEIEC-----EQPNNDLYTF------------------NG 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  309 NVDASQSKA----KQQ---DGAAamemqpLKSAE---------GGDAddrkKASMHKKEKSVLQGKLTKLAVQIgkagLV 372
Cdd:cd02073    184 TLELNGGRElplsPDNlllRGCT------LRNTEwvygvvvytGHET----KLMLNSGGTPLKRSSIEKKMNRF----II 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  373 MSAITVIILVLYFTVDTFVVNKK-----PWL--PECTPVYVQYFVKF--FIIgvtVLVVAVPegLPLAVTISLAYSV--- 440
Cdd:cd02073    250 AIFCILIVMCLISAIGKGIWLSKhgrdlWYLlpKEERSPALEFFFDFltFII---LYNNLIP--ISLYVTIEVVKFLqsf 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  441 -----KKMMKDNN----LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipdpssintktmeLLINAI 511
Cdd:cd02073    325 finwdLDMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDY---------------GFFLAL 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  512 AI-NSAYTTKILPPEK---------EGALPRQvgnkteCGLLGFVLdLKQDYEPV-RSQMPEEKLYK---VYTFNSVRKS 577
Cdd:cd02073    390 ALcHTVVPEKDDHPGQlvyqasspdEAALVEA------ARDLGFVF-LSRTPDTVtINALGEEEEYEilhILEFNSDRKR 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  578 MSTVIKLPDESFRMYSKGASEIVLKKCckilngAGEPRVFRprdrdEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWD 657
Cdd:cd02073    463 MSVIVRDPDGRILLYCKGADSVIFERL------SPSSLELV-----EKTQEHLEDFASEGLRTLCLAYREISEEEYEEWN 531
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  658 NE-------------------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIH 718
Cdd:cd02073    532 EKydeastalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLS 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  719 PG-EDF-LCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLA------RSSPTDKHTLVKGIIDSThteqRQVVAVTGDG 790
Cdd:cd02073    612 EDmENLaLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLVKKSK----KAVTLAIGDG 679
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  791 TNDGPALKKADVGfaMGIAGtdvaKE------ASDIILTddNFSSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIV-- 861
Cdd:cd02073    680 ANDVSMIQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFYKNIAFYLTqf 751
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  862 ---AFTGAciTQDSPLKAVQMLWVNLImdtFASLalatePP----------TETLLLRKP----YGRNKPLIS-RTMMKN 923
Cdd:cd02073    752 wyqFFNGF--SGQTLYDSWYLTLYNVL---FTSL-----PPlvigifdqdvSAETLLRYPelykPGQLNELFNwKVFLYW 821
                          890
                   ....*....|...
gi 1034633540  924 ILgHAVYQLALIF 936
Cdd:cd02073    822 IL-DGIYQSLIIF 833
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
194-862 3.47e-36

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 146.68  E-value: 3.47e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESdqvrKSVDKDP--MLLSGTHVMEGSGRM 271
Cdd:cd07552    135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGES----KPVEKKPgdEVIGGSVNGNGTLEV 209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  272 LVTAVGVNSQTGIIFTLLGaggeeeekkdkkgkmqdgnvDASQSKAKQQDGAaamemqplksaeggdadDRkkasmhkke 351
Cdd:cd07552    210 KVTKTGEDSYLSQVMELVA--------------------QAQASKSRAENLA-----------------DK--------- 243
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  352 ksvLQGKLTKLAVQIGkaglvmsAITVIILVLYFTVDTFVvnkkpwlpectpvyvqyfvkffIIGVTVLVVAVPEGL--- 428
Cdd:cd07552    244 ---VAGWLFYIALGVG-------IIAFIIWLILGDLAFAL----------------------ERAVTVLVIACPHALgla 291
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  429 -PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-GDVHYKEIpdpssinTKTMEL 506
Cdd:cd07552    292 iPLVVARSTSIAAKNGL----LIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITfDEYDEDEI-------LSLAAA 360
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  507 LIN------AIAINSAYTTKILPPEKegalPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVYTFNSVRKSMst 580
Cdd:cd07552    361 LEAgsehplAQAIVSAAKEKGIRPVE----VENFENIPGVGVEGTV---------------NGKRYQVVSPKYLKELG-- 419
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  581 vIKLPDESFRMY-SKGASEIVLkkcckilngageprvfrprdrdemvkkviepmacdglrticvayrdfpsspepdwdne 659
Cdd:cd07552    420 -LKYDEELVKRLaQQGNTVSFL---------------------------------------------------------- 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  660 ndiLNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnek 739
Cdd:cd07552    441 ---IQDGEVIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGID---------------------- 495
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  740 geieqeridkiwpklRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASD 819
Cdd:cd07552    496 ---------------EYFAEVLPEDKAKKVK-----ELQAEGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESAD 554
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 1034633540  820 IILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 862
Cdd:cd07552    555 VVLVKSDPRDIVDFLELAKATYRKMKQNLWWGAGYNVIAIPLA 597
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
193-921 5.07e-35

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 144.78  E-value: 5.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  193 TVVR------AGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQV----------RKSVDKDP 256
Cdd:PRK15122   151 TVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVekydtlgavaGKSADALA 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  257 -----------MLLSGTHVMEGSGRMLVTAVGVNSQTGiiftllgaggeeeekkdkkgkmqdgnvdasqSKAKQQDGaaa 325
Cdd:PRK15122   231 ddegslldlpnICFMGTNVVSGTATAVVVATGSRTYFG-------------------------------SLAKSIVG--- 276
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  326 memqplksaeggdadDRKKASMHKKEKSVlqgklTKLAVqigKAGLVMsaITVIILVLYFTvdtfvvnKKPWLPECTpvy 405
Cdd:PRK15122   277 ---------------TRAQTAFDRGVNSV-----SWLLI---RFMLVM--VPVVLLINGFT-------KGDWLEALL--- 321
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  406 vqyfvkfFiigvtVLVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ 482
Cdd:PRK15122   322 -------F-----ALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEH 389
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  483 AYvgDVHYKEipdpssiNTKTMELlinaIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFvldLKQDYEPvrsqmpe 562
Cdd:PRK15122   390 HL--DVSGRK-------DERVLQL----AWLNSFHQSGMKNLMDQAVVAFAEGNPEIVKPAGY---RKVDELP------- 446
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  563 eklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGaGEPRVFRPRDRDEMVKKVIEPMAcDGLRTIC 642
Cdd:PRK15122   447 --------FDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVRDG-DTVRPLDEARRERLLALAEAYNA-DGFRVLL 516
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  643 VAYRDFPSSPEPDW---DNENDILNE--LTCIcvvgieDPVRPEVPEAIRKCQRAGITVRMVTGDN-INTARaIAIKCGI 716
Cdd:PRK15122   517 VATREIPGGESRAQystADERDLVIRgfLTFL------DPPKESAAPAIAALRENGVAVKVLTGDNpIVTAK-ICREVGL 589
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  717 iHPGEDflcLEGKEFNRRIRNEKGEIEQERIdkiwpklrVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPA 796
Cdd:PRK15122   590 -EPGEP---LLGTEIEAMDDAALAREVEERT--------VFAKLTPLQKSRVLKALQANGHT-----VGFLGDGINDAPA 652
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  797 LKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVAftGACITQd 871
Cdd:PRK15122   653 LRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgNVFSVLVA--SAFIPF- 726
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034633540  872 SPLKAVQMLWVNLIMDtFASLALatepPTETL---LLRKPYGRNKPLISRTMM 921
Cdd:PRK15122   727 LPMLAIHLLLQNLMYD-ISQLSL----PWDKMdkeFLRKPRKWDAKNIGRFML 774
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
164-863 5.98e-35

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 145.22  E-value: 5.98e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  164 VVLVT----AFNDWSkekqfRGLQSRIEQEQKFTV-VRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK--- 235
Cdd:TIGR01652   60 VLIVTaikeAIEDIR-----RRRRDKEVNNRLTEVlEGHGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvc 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  236 -IDESSLTGESD-QVRKSVDKDPMLLSGTHVMEGSGRmlVTAVGVNSQtgiIFTLLGaggEEEEKKDKKGKMQDGNVDAS 313
Cdd:TIGR01652  135 yVETANLDGETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQG---NMTINGDRQYPLSPDNILLR 206
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  314 QSKAKQQDGAAAMEMqplksAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDtfvvN 393
Cdd:TIGR01652  207 GCTLRNTDWVIGVVV-----YTGHDTKLMRNATQAPSKRSRLEKELNFLIIILFCLLFVLCLISSVGAGIWNDAH----G 277
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  394 KKPW---LPECTPVYVQYFVKFFIIGVTVLVVAVPegLPLAVTISLAYSVKKMMKDNNL------------VRHLDACET 458
Cdd:TIGR01652  278 KDLWyirLDVSERNAAANGFFSFLTFLILFSSLIP--ISLYVSLELVKSVQAYFINSDLqmyhektdtpasVRTSNLNEE 355
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  459 MGNATAICSDKTGTLTTNRMTVVQAYVGDVHY-----------------------KEIPDPSSINTKTMELL-------I 508
Cdd:TIGR01652  356 LGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgdgfteikdgirerlgsyvenenSMLVESKGFTFVDPRLVdllktnkP 435
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  509 NAIAINSAYTT-----KILP---PEKEGALPRQVGNKTECGL------LGFVLDLKQDY-----EPVRSQMPEEKLYKVY 569
Cdd:TIGR01652  436 NAKRINEFFLAlalchTVVPefnDDGPEEITYQAASPDEAALvkaardVGFVFFERTPKsisllIEMHGETKEYEILNVL 515
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  570 TFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKkcckILNGAGeprvfrpRDRDEMVKKVIEPMACDGLRTICVAYRDFP 649
Cdd:TIGR01652  516 EFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK----RLSSGG-------NQVNEETKEHLENYASEGLRTLCIAYRELS 584
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  650 SSPEPDW-----------DNENDILNE--------LTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 710
Cdd:TIGR01652  585 EEEYEEWneeyneastalTDREEKLDVvaesiekdLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINI 664
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  711 AIKCGIIHPGEDFL---------CLEGKEFNRRIRNEKGEIEQERIDK---------------IWPKLR----------- 755
Cdd:TIGR01652  665 GYSCRLLSRNMEQIvitsdsldaTRSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgkslgyaLDEELEkeflqlalkck 744
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  756 -VLA-RSSPTDKHTLVKGIIDSThteQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNFSSIV 831
Cdd:TIGR01652  745 aVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMASDFAIG--QFRFLT 816
                          810       820       830
                   ....*....|....*....|....*....|...
gi 1034633540  832 KAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAF 863
Cdd:TIGR01652  817 KLLLVhGRWSYKRISKMILYFFYKNLIFAIIQF 849
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
160-942 3.72e-32

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 135.96  E-value: 3.72e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  160 SVICVVLVTAFND---WSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY--GDLLPADGLFIQGnDL 234
Cdd:TIGR01657  196 SLCIVFMSSTSISlsvYQIRKQMQRLRDMVHKPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSG-SC 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  235 KIDESSLTGESDQVRK----------------SVDKDPMLLSGTHVMegsgrmlvtavgvnsqtgiiftllgaggeeeek 298
Cdd:TIGR01657  275 IVNESMLTGESVPVLKfpipdngdddedlflyETSKKHVLFGGTKIL--------------------------------- 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  299 kdkkgkmqdgnvdasQSKAKQQDGAAamemqplksaeggdaddrkKASMHKKEKSVLQGKL-----------TKLAVQIG 367
Cdd:TIGR01657  322 ---------------QIRPYPGDTGC-------------------LAIVVRTGFSTSKGQLvrsilypkprvFKFYKDSF 367
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  368 KAGLVMSAITVIILVlyFTVDTFVVNKKPwlpectpvyvqyfVKFFIIGVT-VLVVAVPEGLPLAVTISLAYSVKKMMKD 446
Cdd:TIGR01657  368 KFILFLAVLALIGFI--YTIIELIKDGRP-------------LGKIILRSLdIITIVVPPALPAELSIGINNSLARLKKK 432
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  447 NNLVRHLDACETMGNATAICSDKTGTLTTNRMTV--VQAYVGDVHY-KEIPDPSSINtktMELLINAIAINSAyTTKIlp 523
Cdd:TIGR01657  433 GIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDLrgVQGLSGNQEFlKIVTEDSSLK---PSITHKALATCHS-LTKL-- 506
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  524 pekEGALprqVGNKTECGLLGFV-LDLKQDYE---------PVRSQMPEEKLY--KVYTFNSVRKSMSTVIKLPDESFRM 591
Cdd:TIGR01657  507 ---EGKL---VGDPLDKKMFEATgWTLEEDDEsaeptsilaVVRTDDPPQELSiiRRFQFSSALQRMSVIVSTNDERSPD 580
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  592 -YSKGASEIVLKKCCKilngagePRVfrPRDRDEMVKKVIEpmacDGLRTICVAYRDFPSSPepdWD-----NENDILNE 665
Cdd:TIGR01657  581 aFVKGAPETIQSLCSP-------ETV--PSDYQEVLKSYTR----EGYRVLALAYKELPKLT---LQkaqdlSRDAVESN 644
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  666 LTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII------------------------HPGE 721
Cdd:TIGR01657  645 LTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVnpsntlilaeaeppesgkpnqikfEVID 724
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  722 DF---------------------------LCLEGKEFNRRIRNEKgeieqERIDKIWPKLRVLARSSPTDKHTLVKgiid 774
Cdd:TIGR01657  725 SIpfastqveipyplgqdsvedllasryhLAMSGKAFAVLQAHSP-----ELLLRLLSHTTVFARMAPDQKETLVE---- 795
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  775 sTHTEQRQVVAVTGDGTNDGPALKKADVGFAM-----GIAGTDVAKEAS-----DIILTddnfssivkavmwGR-NVYDS 843
Cdd:TIGR01657  796 -LLQKLDYTVGMCGDGANDCGALKQADVGISLseaeaSVAAPFTSKLASiscvpNVIRE-------------GRcALVTS 861
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  844 ISKFlQFQLTVNVVAVIVAFTGACItqDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRnkpLISRTMMKN 923
Cdd:TIGR01657  862 FQMF-KYMALYSLIQFYSVSILYLI--GSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTS 935
                          890
                   ....*....|....*....
gi 1034633540  924 ILGhavyQLALIFTLLFVG 942
Cdd:TIGR01657  936 VLI----QFVLHILSQVYL 950
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
172-865 5.43e-31

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 130.09  E-value: 5.43e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  172 DWSKEKQFRGL-QSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRK 250
Cdd:cd07550     81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  251 SVDKdpMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkgkmqdgnvdasqskakqqdgaaamemqp 330
Cdd:cd07550    160 REGD--LVFASTVVEEGQLVIRAERVGRETRAARIAELI----------------------------------------- 196
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  331 lksaeggdaddrKKASMHKKEKsvlQGKLTKLAVQIGKAGLVMSAITviilvlyftvdtfvvnkkpwlpectpvyvqyfv 410
Cdd:cd07550    197 ------------EQSPSLKARI---QNYAERLADRLVPPTLGLAGLV--------------------------------- 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  411 kFFIIG-----VTVLVV----AVPEGLPLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVV 481
Cdd:cd07550    229 -YALTGdisraAAVLLVdfscGIRLSTPVAVLSALNHAARHGI----LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVT 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  482 QAyvgdvhykeipdpssintktmellinaIAINSAYttkilpPEKEgalprqvgnktecgLLGFVLDLkqdyepvrsqmp 561
Cdd:cd07550    304 AI---------------------------ITFDGRL------SEED--------------LLYLAASA------------ 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  562 EEKLYKVYTFNSVRKSMSTVIKLPDESFRMY--SKG-ASEIVLKKcckILngAGEPRVFRPRDRD--EMVKKVIEPMACD 636
Cdd:cd07550    325 EEHFPHPVARAIVREAEERGIEHPEHEEVEYivGHGiASTVDGKR---IR--VGSRHFMEEEEIIliPEVDELIEDLHAE 399
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  637 GLRTICVAYrdfpsspepdwDNEndilneltCICVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAikcg 715
Cdd:cd07550    400 GKSLLYVAI-----------DGR--------LIGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA---- 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  716 iihpgedflclegkefnrrirnekgeiEQERIDkiwpklRVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGP 795
Cdd:cd07550    457 ---------------------------EQLGID------RYHAEALPEDKAEIVEKLQAEGRT-----VAFVGDGINDSP 498
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  796 ALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 865
Cdd:cd07550    499 ALSYADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGVFG 567
E1-E2_ATPase pfam00122
E1-E2 ATPase;
193-445 1.26e-30

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 119.21  E-value: 1.26e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKsvDKDPMLLSGTHVMEGSGRML 272
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  273 VTAVGVNSQTGIIFTLLgaggeeeekkdkkgkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkaSMHKKEK 352
Cdd:pfam00122   85 VTATGEDTELGRIARLV--------------------------------------------------------EEAKSKK 108
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  353 SVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVvnkkpwlpectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAV 432
Cdd:pfam00122  109 TPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRA---------------------LLRALAVLVAACPCALPLAT 167
                          250
                   ....*....|...
gi 1034633540  433 TISLAYSVKKMMK 445
Cdd:pfam00122  168 PLALAVGARRLAK 180
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
194-865 1.43e-30

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 128.91  E-value: 1.43e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLV 273
Cdd:cd07551    117 IQRDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRV 193
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  274 TAVGVNSQTGIIFTLLGaggeeeekkdkkgkmqdgnvDASQSKAKQQdgaaamemQPLKSAEGGdaddrkkasmhkkeks 353
Cdd:cd07551    194 TKLSSDTVFAKIVQLVE--------------------EAQSEKSPTQ--------SFIERFERI---------------- 229
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  354 vlqgkltklavqigKAGLVMSAITVIILVLYFtvdtfvVNKKPWLPEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVT 433
Cdd:cd07551    230 --------------YVKGVLLAVLLLLLLPPF------LLGWTWADS------------FYRAMVFLVVASPCALVASTP 277
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  434 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSSINT--KTMELLIN-- 509
Cdd:cd07551    278 PATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVT-----DVIPAEGVDEEELLQvaAAAESQSEhp 352
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  510 -AIAINSAYTTKILPPekegALPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklpdes 588
Cdd:cd07551    353 lAQAIVRYAEERGIPR----LPAIEVEAVTGKGVTATV---------------DGQTYRI-------------------- 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  589 frmyskgaseivlkkcckilngaGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDfpsspepdwdnendilnelTC 668
Cdd:cd07551    394 -----------------------GKPGFFGEVGIPSEAAALAAELESEGKTVVYVARDD-------------------QV 431
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  669 ICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeriD 748
Cdd:cd07551    432 VGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI-------------------------------D 480
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  749 KIWPKLRvlarssPTDKhtlVKgIIDSTHTEQRQVvAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFS 828
Cdd:cd07551    481 EVVANLL------PEDK---VA-IIRELQQEYGTV-AMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLS 548
                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 1034633540  829 SIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 865
Cdd:cd07551    549 KLPYAIRLSRKMRRIIKQNLIFALAVIALLIVANLFG 585
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
157-941 1.73e-30

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 129.68  E-value: 1.73e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  157 ILLSVICVVLVTafndWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY-GDLLPADGLFIQGNDLk 235
Cdd:cd07542     58 VIISVISIFLSL----YETRKQSKRLREMVHFTCPVRVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCI- 132
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  236 IDESSLTGESDQVRKS--VDKDPMLLSGTHVMEGSGR-MLVtavgvnSQTGIIftllgaggeeeekkdkkgkmqdgnvda 312
Cdd:cd07542    133 VNESMLTGESVPVTKTplPDESNDSLWSIYSIEDHSKhTLF------CGTKVI--------------------------- 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  313 sQSKAKQQDGAAAMEMQP-LKSAEGgdadDRKKASMHKKEKSVlqgKLTK-----LAVQIGKAGLVMsAITVIILVLYFT 386
Cdd:cd07542    180 -QTRAYEGKPVLAVVVRTgFNTTKG----QLVRSILYPKPVDF---KFYRdsmkfILFLAIIALIGF-IYTLIILILNGE 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  387 vdtfvvnkkpwlpectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC---ETMGNAT 463
Cdd:cd07542    251 ---------------------SLGEIIIRALDIITIVVPPALPAALTVGIIYAQSR------LKKKGIFCispQRINICG 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  464 AI---CSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILppekegalpRQVGNKtec 540
Cdd:cd07542    304 KInlvCFDKTGTLTEDGLDLWGVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSL---------TLIDGE--- 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  541 gLLGFVLDLKQ------DYEPVRSqmpeeklykvYTFNSVRKSMSTVIKLP-DESFRMYSKGASEIVLKKCckilngagE 613
Cdd:cd07542    372 -LVGDPLDLKMfeftgwSLEILRQ----------FPFSSALQRMSVIVKTPgDDSMMAFTKGAPEMIASLC--------K 432
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  614 PRVFrPRDRDEMVKKviepMACDGLRTICVAYRDFPSSPEPDWDNENDIL-NELTCICVVGIEDPVRPEVPEAIRKCQRA 692
Cdd:cd07542    433 PETV-PSNFQEVLNE----YTKQGFRVIALAYKALESKTWLLQKLSREEVeSDLEFLGLIVMENRLKPETAPVINELNRA 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  693 GITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEfnrrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGI 772
Cdd:cd07542    508 NIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAVK-------PEDDDSASLTWTLLLKGTVFARMSPDQKSELVEEL 580
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  773 --IDSThteqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVakeASDIILTDDNFSSIVKAVMWGRNVYD---SISKF 847
Cdd:cd07542    581 qkLDYT-------VGMCGDGANDCGALKAADVGISLSEAEASV---AAPFTSKVPDISCVPTVIKEGRAALVtsfSCFKY 650
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  848 LqfqltvnVVAVIVAFTGACI--TQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRnkpLISRTMMKNIL 925
Cdd:cd07542    651 M-------ALYSLIQFISVLIlySINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS---LVSPPVLVSLL 720
                          810
                   ....*....|....*.
gi 1034633540  926 GHAVYQLALIFTLLFV 941
Cdd:cd07542    721 GQIVLILLFQVIGFLI 736
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
151-892 2.30e-30

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 128.31  E-value: 2.30e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  151 WIEGAAIllsVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKF-TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:cd07545     59 WPEAAMV---VFLFAISEALEAYSMDRARRSIRSLMDIAPKTaLVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIV 135
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  230 QGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkdkkgkmqdgn 309
Cdd:cd07545    136 RGESS-VNQAAITGESLPVEKGVGDE--VFAGTLNGEGALEVRVTKPAEDSTIARIIHL--------------------- 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  310 VDASQSkakqqdgaaamemqplksaeggdaddrkkasmhkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT 389
Cdd:cd07545    192 VEEAQA-----------------------------------ERAPTQAFVDRFARYYTPVVMAIAALVAIVPPLFFGGAW 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  390 FvvnkkPWlpectpVYVqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 469
Cdd:cd07545    237 F-----TW------IYR---------GLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDK 296
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  470 TGTLTTNRMTVVQAYVgdvhykeipdpssintktmellinaiainsayttkilppekegalprqVGNKTECGLLGFVLDL 549
Cdd:cd07545    297 TGTLTKGKPVVTDVVV------------------------------------------------LGGQTEKELLAIAAAL 328
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  550 KQdyepvRSQMPEEKLYkvytfnsVRKSMSTVIKLPD-ESFR-MYSKGASEIVLKKCCKIlngaGEPRVFRPRDRDEMV- 626
Cdd:cd07545    329 EY-----RSEHPLASAI-------VKKAEQRGLTLSAvEEFTaLTGRGVRGVVNGTTYYI----GSPRLFEELNLSESPa 392
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  627 -KKVIEPMACDGlRTICVayrdfpsspepdwdnendILNELTCICVVGIEDPVRPEVPEAIRKCQRAGI--TVrMVTGDN 703
Cdd:cd07545    393 lEAKLDALQNQG-KTVMI------------------LGDGERILGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLTGDN 452
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  704 INTARAIAIKCGIihpgedflclegkefnrrirnekGEIEQERIdkiwpklrvlarssPTDKHTLVKGIidsthTEQRQV 783
Cdd:cd07545    453 PQTAQAIAAQVGV-----------------------SDIRAELL--------------PQDKLDAIEAL-----QAEGGR 490
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  784 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAF 863
Cdd:cd07545    491 VAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALLLVI 570
                          730       740
                   ....*....|....*....|....*....
gi 1034633540  864 TGacitqdsplkaVQMLWVNLIMDTFASL 892
Cdd:cd07545    571 PG-----------WLTLWMAVFADMGASL 588
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
190-865 4.46e-28

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 120.89  E-value: 4.46e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSG 269
Cdd:cd07544    110 RIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKRPGDR--VMSGAVNGDSAL 186
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  270 RMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkgkmqdgnvdasqsKAKQQDGAAAMEMqplksaeggdADdrkkasmhk 349
Cdd:cd07544    187 TMVATKLAADSQYAGIVRLV--------------------------KEAQANPAPFVRL----------AD--------- 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  350 keksvlqgkltKLAVqigkaglvmsaitviilvlYFTVDTFVVNKKPWLPECTPVYVqyfvkffiigVTVLVVAVPEGLP 429
Cdd:cd07544    222 -----------RYAV-------------------PFTLLALAIAGVAWAVSGDPVRF----------AAVLVVATPCPLI 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  430 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeIPDPssiNTKTMELL-- 507
Cdd:cd07544    262 LAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDV---------VPAP---GVDADEVLrl 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  508 ----------INAIAINSAYTTKILPPekegALPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVYTFNSVRKS 577
Cdd:cd07544    330 aasveqysshVLARAIVAAARERELQL----SAVTELTEVPGAGVTGTV---------------DGHEVKVGKLKFVLAR 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  578 MSTviklpDESFRMYSKGASEIVLkkcckilngageprvfrprdrdemvkkviepmACDGlrTICVAYRdfpsspepdwd 657
Cdd:cd07544    391 GAW-----APDIRNRPLGGTAVYV--------------------------------SVDG--KYAGAIT----------- 420
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  658 nendilneltcicvvgIEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrir 736
Cdd:cd07544    421 ----------------LRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGIDE------------------ 466
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  737 nekgeieqeridkiwpklrVLARSSPTDKHTLVKgiidsTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAGTDVAKE 816
Cdd:cd07544    467 -------------------VRAELLPEDKLAAVK-----EAPKAGPTIMV-GDGVNDAPALAAADVGIAMGARGSTAASE 521
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034633540  817 ASDIILTDDNFSSIVKAVMWGRnvyDSISKFLQFQL---TVNVVAVIVAFTG 865
Cdd:cd07544    522 AADVVILVDDLDRVVDAVAIAR---RTRRIALQSVLigmALSIIGMLIAAFG 570
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
411-814 4.13e-25

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 112.68  E-value: 4.13e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  411 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYVGDVHY 490
Cdd:cd02082    252 FIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKL-DLIGYQLKGQN 330
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  491 KEIPDPSSINTKTMELLINAIAINSAyTTKIlppekEGALprqVGNKTECGLLGFV-LDLKQDYE----PVRSQMPEEKL 565
Cdd:cd02082    331 QTFDPIQCQDPNNISIEHKLFAICHS-LTKI-----NGKL---LGDPLDVKMAEAStWDLDYDHEakqhYSKSGTKRFYI 401
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  566 YKVYTFNSVRKSMSTV---IKLPDESFRMYS--KGASEIVLKKCCKIlngageprvfrPRDRdemvKKVIEPMACDGLRT 640
Cdd:cd02082    402 IQVFQFHSALQRMSVVakeVDMITKDFKHYAfiKGAPEKIQSLFSHV-----------PSDE----KAQLSTLINEGYRV 466
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  641 ICVAYRDFPSSPEPDWDN--ENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIH 718
Cdd:cd02082    467 LALGYKELPQSEIDAFLDlsREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEIIN 546
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  719 PGEDFLCLEGkefnrrIRNEKGEIEQERIDKIwPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALK 798
Cdd:cd02082    547 RKNPTIIIHL------LIPEIQKDNSTQWILI-IHTNVFARTAPEQKQTIIRLL-----KESDYIVCMCGDGANDCGALK 614
                          410
                   ....*....|....*.
gi 1034633540  799 KADVGFAMGIAGTDVA 814
Cdd:cd02082    615 EADVGISLAEADASFA 630
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
189-861 1.44e-23

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 107.69  E-value: 1.44e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  189 EQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK----IDESSLTGESD-QVRKSVDKDPMLLSGTH 263
Cdd:cd07536     82 KKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDlKLRVAVSCTQQLPALGD 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  264 VMEGSGRML--VTAVGVNSQTGIiFTLLGAGGEEEEKKDKKGKMqdgnVDASQSKAKQQDGAAAMemqplksAEGGDADD 341
Cdd:cd07536    162 LMKISAYVEcqKPQMDIHSFEGN-FTLEDSDPPIHESLSIENTL----LRASTLRNTGWVIGVVV-------YTGKETKL 229
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  342 RKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMsAITVIILVLYFTvDTFVVNKKPWLPECTPVYVQYFVKF-FIIGVTVL 420
Cdd:cd07536    230 VMNTSNAKNKVGLLDLELNRLTKALFLALVVL-SLVMVTLQGFWG-PWYGEKNWYIKKMDTTSDNFGRNLLrFLLLFSYI 307
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  421 VvavpeglPLAVTISL----AYSVKKMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVG 486
Cdd:cd07536    308 I-------PISLRVNLdmvkAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCHIG 380
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  487 DVHYKeipdpssintktmellinaiainsayttkilppekegalprqvGNKTECGLLgfvldlkqdyepvrsqmpeekly 566
Cdd:cd07536    381 GVSYG-------------------------------------------GQVLSFCIL----------------------- 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  567 KVYTFNSVRKSMSTVIKLPDES-FRMYSKGASEIVLkkcckilngagePRVfRPRDRDEMVKKVIEPMACDGLRTICVAY 645
Cdd:cd07536    395 QLLEFTSDRKRMSVIVRDESTGeITLYMKGADVAIS------------PIV-SKDSYMEQYNDWLEEECGEGLRTLCVAK 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  646 RDFPSSPEPDW------------DNE-------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINT 706
Cdd:cd07536    462 KALTENEYQEWesryteaslslhDRSlrvaevvESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQET 541
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  707 ARAIAIKCGIIHP-------------GED-----FLCLEGKEFNRR------IRNEKGEI-----EQERID-KIWPKLRV 756
Cdd:cd07536    542 AICIAKSCHLVSRtqdihllrqdtsrGERaaitqHAHLELNAFRRKhdvalvIDGDSLEValkyyRHEFVElACQCPAVI 621
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  757 LARSSPTDKHTLVKgiIDSTHTEQRQVvaVTGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNFSSIVKAV 834
Cdd:cd07536    622 CCRVSPTQKARIVT--LLKQHTGRRTL--AIGDGGNDVSMIQAADCG--VGISGKEgkQASLAADYSIT--QFRHLGRLL 693
                          730       740
                   ....*....|....*....|....*...
gi 1034633540  835 M-WGRNVYDSISKFLQFQLTVNVVAVIV 861
Cdd:cd07536    694 LvHGRNSYNRSAALGQYVFYKGLIISTI 721
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
193-896 2.21e-22

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 103.25  E-value: 2.21e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSvdkdpmllSGTHVMEGSgrml 272
Cdd:cd07546    102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKA--------AGDKVFAGS---- 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  273 vtavgVNSqtgiiftllgaggeeeekkdkkgkmqdgnvdasqskakqqDGAAAMEmqpLKSAEGGDADDRKKASMHKKE- 351
Cdd:cd07546    169 -----INV----------------------------------------DGVLRIR---VTSAPGDNAIDRILHLIEEAEe 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  352 -KSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTfvvnkKPWLPEctpvyvqyfvkffiiGVTVLVVAVPEGL-- 428
Cdd:cd07546    201 rRAPIERFIDRFSRWYTPAIMAVALLVIVVPPLLFGADW-----QTWIYR---------------GLALLLIGCPCALvi 260
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  429 --PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSsintktmEL 506
Cdd:cd07546    261 stPAAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVT-----DVVPLTGISEA-------EL 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  507 LINAIAINSAYT----TKILP-PEKEGALPRQVGNKTecGLLGFVLDLKQDYEPVRsqmpeeklykvytfnsvrksmstv 581
Cdd:cd07546    325 LALAAAVEMGSShplaQAIVArAQAAGLTIPPAEEAR--ALVGRGIEGQVDGERVL------------------------ 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  582 iklpdesfrmyskgaseivlkkcckilngAGEPRVFRPRDRDEmVKKVIEPMACDGlRTICVAYRdfpsspepdwdnEND 661
Cdd:cd07546    379 -----------------------------IGAPKFAADRGTLE-VQGRIAALEQAG-KTVVVVLA------------NGR 415
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  662 ILNeltcicVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgeDFlclegkefnrrirneKGE 741
Cdd:cd07546    416 VLG------LIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGL-----DF---------------RAG 469
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  742 IeqeridkiwpklrvlarsSPTDKhtlVKGIidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDII 821
Cdd:cd07546    470 L------------------LPEDK---VKAV---RELAQHGPVAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAA 524
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034633540  822 LTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacITQdsplkavqmLWVNLIMDTFASlALAT 896
Cdd:cd07546    525 LTHNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVTTLLG--ITG---------LWLAVLADTGAT-VLVT 587
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
411-806 3.07e-22

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 103.62  E-value: 3.07e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  411 KFFIIGVTVLVVAVPEGLP----LAVTISLAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTTNRMtVV 481
Cdd:cd07543    260 KLFLECTLILTSVVPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VV 329
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  482 QAYVGDVHYKE-IPDPSSINTKTmellINAIAinSAYTtkiLPPEKEGALprqVGNKTECGLLGFV---LDLKQDYEPVR 557
Cdd:cd07543    330 EGVAGLNDGKEvIPVSSIEPVET----ILVLA--SCHS---LVKLDDGKL---VGDPLEKATLEAVdwtLTKDEKVFPRS 397
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  558 SQMPEEKLYKVYTFNSVRKSMSTV--IKLP---DESFRMYSKGASEIV---LKKCckilngageprvfrPRDRDEMVKKv 629
Cdd:cd07543    398 KKTKGLKIIQRFHFSSALKRMSVVasYKDPgstDLKYIVAVKGAPETLksmLSDV--------------PADYDEVYKE- 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  630 iepMACDGLRTICVAYRDFPS---SPEPDWDNEnDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINT 706
Cdd:cd07543    463 ---YTRQGSRVLALGYKELGHltkQQARDYKRE-DVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLT 538
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  707 ARAIAIKCGIIhpgedflclegkeFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVkgiidSTHTEQRQVVAV 786
Cdd:cd07543    539 ACHVAKELGIV-------------DKPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFII-----TTLKELGYVTLM 600
                          410       420
                   ....*....|....*....|
gi 1034633540  787 TGDGTNDGPALKKADVGFAM 806
Cdd:cd07543    601 CGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
164-850 8.54e-20

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 95.55  E-value: 8.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  164 VVLVT----AFNDWSkekqfRGLQSRIEQEQKFTVVraGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGND------ 233
Cdd:cd07541     58 VLAVTmakeAVDDIR-----RRRRDKEQNYEKLTVR--GETVEIPSSDIKVGDLIIVEKNQRIPADMVLLRTSEksgscf 130
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  234 LKIDEssLTGESD-QVRKSVDKDPMLLSGTHVMEgsgrmlVTAVGVNSQTGIIFTLLGaggeeeekkdkKGKMQDGNVDA 312
Cdd:cd07541    131 IRTDQ--LDGETDwKLRIAVPCTQKLPEEGILNS------ISAVYAEAPQKDIHSFYG-----------TFTINDDPTSE 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  313 SQS---KAKQQDGAAAMEMQPLKSAEGGDAddrkKASMHKKEKSVLQGKLTKlavQIGKAGLVMSAITVIILVLYFTVDT 389
Cdd:cd07541    192 SLSvenTLWANTVVASGTVIGVVVYTGKET----RSVMNTSQPKNKVGLLDL---EINFLTKILFCAVLALSIVMVALQG 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  390 FvvnKKPWLpectpVYVQYFVKFF--IIGVTvlvvavpeglpLAVTISLAYSV--KKMMKDNNL----VRHLDACETMGN 461
Cdd:cd07541    265 F---QGPWY-----IYLFRFLILFssIIPIS-----------LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGR 325
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  462 ATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipdpsSINTKTMELLinaiainsayttkilppekegalprqvgnktecg 541
Cdd:cd07541    326 IEYLLSDKTGTLTQNEMVFKKLHLGTVSY-------GGQNLNYEIL---------------------------------- 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  542 llgfvldlkqdyepvrsqmpeeklyKVYTFNSVRKSMSTVIKLP-DESFRMYSKGAseivlkkcckilngageprvfrpr 620
Cdd:cd07541    365 -------------------------QIFPFTSESKRMGIIVREEkTGEITFYMKGA------------------------ 395
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  621 drDEMVKKVIEP----------MACDGLRTICVAYRDFPSSPEPDWDNEND-------------------ILNELTCICV 671
Cdd:cd07541    396 --DVVMSKIVQYndwleeecgnMAREGLRTLVVAKKKLSEEEYQAFEKRYNaaklsihdrdlkvaevvesLERELELLCL 473
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  672 VGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGI------IH-------PGEDFLCLEgkeFNRRIRNE 738
Cdd:cd07541    474 TGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLvsrgqyIHvfrkvttREEAHLELN---NLRRKHDC 550
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  739 K------------GEIEQERIDKIWPKLRVLA-RSSPTDKHTLVKGIIDSThteQRQVVAVtGDGTNDGPALKKADVGfa 805
Cdd:cd07541    551 AlvidgeslevclKYYEHEFIELACQLPAVVCcRCSPTQKAQIVRLIQKHT---GKRTCAI-GDGGNDVSMIQAADVG-- 624
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 1034633540  806 MGIAGTDvAKEAS---DIILTDdnFSSIVKAVMW-GRNVYDSISKFLQF 850
Cdd:cd07541    625 VGIEGKE-GKQASlaaDFSITQ--FSHIGRLLLWhGRNSYKRSAKLAQF 670
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
511-607 1.01e-19

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 84.96  E-value: 1.01e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  511 IAINSAyttkILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKlykVYTFNSVRKSMSTVIKLPDES-F 589
Cdd:pfam13246    1 ALCNSA----AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVA---EIPFNSDRKRMSTVHKLPDDGkY 73
                           90
                   ....*....|....*...
gi 1034633540  590 RMYSKGASEIVLKKCCKI 607
Cdd:pfam13246   74 RLFVKGAPEIILDRCTTI 91
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
671-838 2.53e-18

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 90.40  E-value: 2.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  671 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLclegkefnrrirnekgeieqeridki 750
Cdd:cd02078    430 VIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL-------------------------- 479
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  751 wpklrvlARSSPTDKHTLVKgiidsthTEQRQ--VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFS 828
Cdd:cd02078    480 -------AEAKPEDKLELIR-------KEQAKgkLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPT 544
                          170
                   ....*....|
gi 1034633540  829 SIVKAVMWGR 838
Cdd:cd02078    545 KLIEVVEIGK 554
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
674-838 1.88e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 84.21  E-value: 1.88e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  674 IEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeriDKIWP 752
Cdd:cd07548    426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI-------------------------------DEVYA 474
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  753 KLrvlarsSPTDKHTLVKGIIDsthtEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 832
Cdd:cd07548    475 EL------LPEDKVEKVEELKA----ESKGKVAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                   ....*.
gi 1034633540  833 AVMWGR 838
Cdd:cd07548    545 AIKIAR 550
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
194-876 1.57e-15

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 81.25  E-value: 1.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRksVDKDPMLLSGTHVMEGSGRMLV 273
Cdd:cd02092    131 LQADGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPVT--VAPGDLVQAGAMNLSGPLRLRA 207
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  274 TAVGVNsqtgiifTLLGAGgeeeekkdkkgkmqdgnvdasqskakqqdgAAAMEMqplksAEGGDAddrkkasmhkkeks 353
Cdd:cd02092    208 TAAGDD-------TLLAEI------------------------------ARLMEA-----AEQGRS-------------- 231
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  354 vlqgKLTKLAVQIgkAGLVMSAITVIILVlyftvdTFVVnkkpWLPECTPVYVQyfvkfFIIGVTVLVVAVPEGLPLAVT 433
Cdd:cd02092    232 ----RYVRLADRA--ARLYAPVVHLLALL------TFVG----WVAAGGDWRHA-----LLIAVAVLIITCPCALGLAVP 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  434 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipdpSSINTKTMELLiNAIAI 513
Cdd:cd02092    291 AVQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGA-------------HAISADLLALA-AALAQ 356
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  514 NSAYTTKILPPEKEGALPRQVGNKTE---CGLLGFVLDLkqdyePVRSQMPEeklykvytFNSVRKSMSTviklpdesfr 590
Cdd:cd02092    357 ASRHPLSRALAAAAGARPVELDDAREvpgRGVEGRIDGA-----RVRLGRPA--------WLGASAGVST---------- 413
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  591 myskgASEIVLKKcckilnGAGEPRVFRprdrdemvkkviepmacdglrticvayrdfpsspepdwdnendilneltcic 670
Cdd:cd02092    414 -----ASELALSK------GGEEAARFP---------------------------------------------------- 430
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  671 vvgIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrirnekgeieqeridki 750
Cdd:cd02092    431 ---FEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGIED-------------------------------- 475
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  751 wpklrVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSI 830
Cdd:cd02092    476 -----WRAGLTPAEKVARIEEL-----KAQGRRVLMVGDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPV 544
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*.
gi 1034633540  831 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 876
Cdd:cd02092    545 PEAIEIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
197-866 9.80e-15

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 79.16  E-value: 9.80e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  197 AGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNdLKIDESSLTGESDQVRKSVDKD-PMLLSGTHVMEGSgrmLVTA 275
Cdd:TIGR01497  113 DGAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIKESGGDfASVTGGTRILSDW---LVVE 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  276 VGVNSQTGIIftllgaggeeeekkdkkgkmqdgnvdasqskakqqDGAAAMemqplksAEGGdaddrkkasmhKKEKSVL 355
Cdd:TIGR01497  189 CTANPGETFL-----------------------------------DRMIAL-------VEGA-----------QRRKTPN 215
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  356 QGKLTKLAVqigkaglVMSAITVIILVLYFTVDTFVVNKKPwlpectpvyvqyfvkfFIIGVTVLVVAVPE---GLPLAV 432
Cdd:TIGR01497  216 EIALTILLI-------ALTLVFLLVTATLWPFAAYGGNAIS----------------VTVLVALLVCLIPTtigGLLSAI 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  433 TISlaySVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT-NRMTVvqayvgdvhyKEIPdpssINTKTMELLINAI 511
Cdd:TIGR01497  273 GIA---GMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTITLgNRLAS----------EFIP----AQGVDEKTLADAA 335
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  512 AINSAYTTKilpPEKEGALprqvgnktecgLLGFVLDLKQDYEPVRSQMPEEklykvytfNSVRKSMSTvIKLPDEsfRM 591
Cdd:TIGR01497  336 QLASLADDT---PEGKSIV-----------ILAKQLGIREDDVQSLHATFVE--------FTAQTRMSG-INLDNG--RM 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  592 YSKGASEiVLKKCCKILNGageprVFrPRDRDEMVKKVIE----PMAcdglrtICVayrdfpsspepdwdnENDILNelt 667
Cdd:TIGR01497  391 IRKGAVD-AIKRHVEANGG-----HI-PTDLDQAVDQVARqggtPLV------VCE---------------DNRIYG--- 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  668 cicVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLclegkefnrrirnekgeieqeri 747
Cdd:TIGR01497  440 ---VIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI----------------------- 489
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  748 dkiwpklrvlARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNF 827
Cdd:TIGR01497  490 ----------AEATPEDKIALIR-----QEQAEGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDP 553
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 1034633540  828 SSIVKAVMWGRNVYDSISKFLQFQLTVNVV---AVI-VAFTGA 866
Cdd:TIGR01497  554 TKLIEVVHIGKQLLITRGALTTFSIANDVAkyfAIIpAIFAAA 596
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
669-823 5.06e-14

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 76.96  E-value: 5.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  669 ICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgeDFlclegkefnrrirnekgeieqerid 748
Cdd:PRK11033   560 LGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF------------------------- 609
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034633540  749 kiwpklrvlaRSS--PTDKhtlVKGIidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 823
Cdd:PRK11033   610 ----------RAGllPEDK---VKAV---TELNQHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALT 669
copA PRK10671
copper-exporting P-type ATPase CopA;
194-834 7.88e-14

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 76.32  E-value: 7.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSgrMLV 273
Cdd:PRK10671   327 VVTDEGEKSVPLADVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGEGDS--VHAGTVVQDGS--VLF 401
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  274 TAVGVNSQTG---IIftllgaggeeeekkdkkgkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkasmhkk 350
Cdd:PRK10671   402 RASAVGSHTTlsrII----------------------------------------------------------------- 416
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  351 eKSVLQGKLTKlaVQIGKAGLVMSAI---TVIILVLYFTVDTFVVNKKPWLpectpVYVqyfvkfFIIGVTVLVVAVPEG 427
Cdd:PRK10671   417 -RMVRQAQSSK--PEIGQLADKISAVfvpVVVVIALVSAAIWYFFGPAPQI-----VYT------LVIATTVLIIACPCA 482
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  428 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgdvhykEIPDPSSINTKTMELL 507
Cdd:PRK10671   483 LGLATPMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLTEGKPQVV----------AVKTFNGVDEAQALRL 552
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  508 INAIAINSAY--TTKILPPEKEGALPRQVGNKTECGLlgfvlDLKQDYEPVRSQMPEEKLYKVYTFNSvrKSMSTVIKlp 585
Cdd:PRK10671   553 AAALEQGSSHplARAILDKAGDMTLPQVNGFRTLRGL-----GVSGEAEGHALLLGNQALLNEQQVDT--KALEAEIT-- 623
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  586 desfRMYSKGASEIVLkkcckilngageprvfrprdrdemvkkviepmACDGlrticvayrdfpsspepdwdnendilne 665
Cdd:PRK10671   624 ----AQASQGATPVLL--------------------------------AVDG---------------------------- 639
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  666 lTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqe 745
Cdd:PRK10671   640 -KAAALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGID---------------------------- 690
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  746 ridkiwpklRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDD 825
Cdd:PRK10671   691 ---------EVIAGVLPDGKAEAIKRL-----QSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRH 755

                   ....*....
gi 1034633540  826 NFSSIVKAV 834
Cdd:PRK10671   756 SLMGVADAL 764
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
205-876 3.13e-12

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 70.62  E-value: 3.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  205 VAEIVVGDIAQVKYGDLLPADGLFIQGNdLKIDESSLTGESDQVrkSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGI 284
Cdd:cd07553    143 ADQIKSGDVYLVASGQRVPVDGKLLSEQ-ASIDMSWLTGESLPR--IVERGDKVPAGTSLENQAFEIRVEHSLAESWSGS 219
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  285 IftllgaggeeeekkdkkgkmqdgnvdasqskakqqdgaaameMQPLKSAEggdaddrkkasmHKKEKSVLqgkLTKlav 364
Cdd:cd07553    220 I------------------------------------------LQKVEAQE------------ARKTPRDL---LAD--- 239
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  365 qigKAGLVMSAITVIILVLYFTVdtfvvnkkpWLPECTPVYVQYFVkffiigvTVLVVAVPEGLPLAVTISLAYSVKKMM 444
Cdd:cd07553    240 ---KIIHYFTVIALLIAVAGFGV---------WLAIDLSIALKVFT-------SVLIVACPCALALATPFTDEIALARLK 300
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  445 KDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipDPSSINTKtmellinaiAINSAYTTkilpp 524
Cdd:cd07553    301 KKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSFVMV-----------NPEGIDRL---------ALRAISAI----- 355
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  525 ekegalprqvgnktecgllgfvldLKQDYEPVrSQMPEEKLYKVytfNSVRKSMSTVIKLPDESFRMYSKGaSEIVLKKC 604
Cdd:cd07553    356 ------------------------EAHSRHPI-SRAIREHLMAK---GLIKAGASELVEIVGKGVSGNSSG-SLWKLGSA 406
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  605 CkilngageprvfrprdrdemvkkviepMACDGLRTICVAYRDfpsspepdwdnendilneLTCICVVGIEDPVRPEVPE 684
Cdd:cd07553    407 P---------------------------DACGIQESGVVIARD------------------GRQLLDLSFNDLLRPDSNR 441
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  685 AIRKCQRAGITVRMVTGDNINTARAIAikcgiihpgeDFLCLEGKEfnrrirnekgeieqeridkiwpklrVLARSSPTD 764
Cdd:cd07553    442 EIEELKKGGLSIAILSGDNEEKVRLVG----------DSLGLDPRQ-------------------------LFGNLSPEE 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  765 KHTLVKgiidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 844
Cdd:cd07553    487 KLAWIE-------SHSPENTLMVGDGANDALALASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAI 558
                          650       660       670
                   ....*....|....*....|....*....|..
gi 1034633540  845 SKFLQFQLTVNVVAVIVAFTGACitqdSPLKA 876
Cdd:cd07553    559 KGLFAFSLLYNLVAIGLALSGWI----SPLVA 586
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1095-1137 5.39e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 61.27  E-value: 5.39e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633540 1095 GQILWFRGLNRIQTQIEVVNTFKSGA--SFQGALRRQS--SVTSQSQ 1137
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLreGIQKPYLRNSihSFMSHPE 47
PLN03190 PLN03190
aminophospholipid translocase; Provisional
413-710 3.75e-11

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 67.62  E-value: 3.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  413 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMT 479
Cdd:PLN03190   394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  480 VVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILP---------PEKEGA----------------LPRQV 534
Cdd:PLN03190   471 FQCASIWGVDYSDGRTPTQNDHAGYSVEVDGKILRPKMKVKVDPqllelsksgKDTEEAkhvhdfflalaacntiVPIVV 550
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  535 GNKTE---------------------CGLLGFVLDLKQDYEPVRSQMPEEKLYKV---YTFNSVRKSMSTVIKLPDESFR 590
Cdd:PLN03190   551 DDTSDptvklmdyqgespdeqalvyaAAAYGFMLIERTSGHIVIDIHGERQRFNVlglHEFDSDRKRMSVILGCPDKTVK 630
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  591 MYSKGASEIVLKKCCKILNgagePRVFRPrdrdemVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNE----------- 659
Cdd:PLN03190   631 VFVKGADTSMFSVIDRSLN----MNVIRA------TEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFSfeaastaligr 700
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034633540  660 --------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 710
Cdd:PLN03190   701 aallrkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
671-856 9.96e-10

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 62.80  E-value: 9.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  671 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridki 750
Cdd:PRK14010   435 VIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------------------- 481
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  751 wpklRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 830
Cdd:PRK14010   482 ----RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAANLIDLDSNPTKL 551
                          170       180
                   ....*....|....*....|....*.
gi 1034633540  831 VKAVMWGRNVYDSISKFLQFQLTVNV 856
Cdd:PRK14010   552 MEVVLIGKQLLMTRGSLTTFSIANDI 577
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
662-801 4.96e-08

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 54.51  E-value: 4.96e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  662 ILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFnrrirnekge 741
Cdd:pfam00702   83 VLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV---------- 152
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  742 ieqeridkiwpklrvlARSSPTDKHTLVKGIIDSTHteqrQVVAVtGDGTNDGPALKKAD 801
Cdd:pfam00702  153 ----------------GKPKPEIYLAALERLGVKPE----EVLMV-GDGVNDIPAAKAAG 191
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
50-112 6.01e-07

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 47.94  E-value: 6.01e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034633540   50 YGDTEAICRRLKTSPVEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILE 112
Cdd:pfam00690    3 ALSVEEVLKKLGTDLEKGL--TEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILL 63
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
680-826 3.82e-06

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 48.59  E-value: 3.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  680 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPgedFLCLEGKEfnrrIRNEKGE------IEQERIDKIWPK 753
Cdd:COG0561     22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGAL----IYDPDGEvlyerpLDPEDVREILEL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  754 LR-------VLARSSPT---------DKHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEA 817
Cdd:COG0561     95 LRehglhlqVVVRSGPGfleilpkgvSKGSALKKLAERLGIPPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PPEVKAA 172

                   ....*....
gi 1034633540  818 SDIIlTDDN 826
Cdd:COG0561    173 ADYV-TGSN 180
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
735-833 5.68e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 43.00  E-value: 5.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633540  735 IRNEKGEIEQ--ERIDKIWPKLRVLARSSP---------TDKHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVG 803
Cdd:pfam08282  147 ILLDEEDLDEleKELKELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLG 225
                           90       100       110
                   ....*....|....*....|....*....|
gi 1034633540  804 FAMGIAgTDVAKEASDIILTDDNFSSIVKA 833
Cdd:pfam08282  226 VAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
784-826 8.38e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 42.64  E-value: 8.38e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034633540  784 VAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 826
Cdd:TIGR00099  207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
765-836 8.75e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 39.13  E-value: 8.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034633540  765 KHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAGTDVaKEASDIIlTDDNFSS-IVKAVMW 836
Cdd:cd07517    142 KAKGIQKVIEHLGIKKEETMAF-GDGLNDIEMLEAVGIGIAMGNAHEEL-KEIADYV-TKDVDEDgILKALKH 211
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
779-826 9.43e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.12  E-value: 9.43e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034633540  779 EQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 826
Cdd:cd07516    198 SLEEVIAF-GDNENDLSMLEYAGLGVAMGNA-IDEVKEAADYV-TLTN 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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