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Conserved domains on  [gi|1034643849|ref|XP_016864611|]
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tetratricopeptide repeat protein 23-like isoform X1 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 18649383)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes; similar to TPR repeat-containing protein MJ1345 in the archaeon Methanococcus jannaschii

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
253-332 6.00e-04

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 253 DLISLYEEAAQIEQLRRNHNQAIQYLQQAHSVCVSLFTEVSPKTAEMSALLAKAYAMSGeaQHRDAVEiYFIRSINAYRA 332
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELG--RYEEALE-LLERALALAEK 77
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
152-322 7.79e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 7.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 152 SNKEKEEILEALVKLYYTLGvawllqnrgreayfNLQKAERNMKELKELYKGGVcelqvsenDLTLALGRASLAIHRLNL 231
Cdd:COG2956    71 RDPDRAEALLELAQDYLKAG--------------LLDRAEELLEKLLELDPDDA--------EALRLLAEIYEQEGDWEK 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 232 ALAYFEKAIgdviaakgDRTSDLISLYEEAAQIEQLRRNHNQAIQYLQQAHsvcvslftEVSPKTAEMSALLAKAYAMSG 311
Cdd:COG2956   129 AIEVLERLL--------KLGPENAHAYCELAELYLEQGDYDEAIEALEKAL--------KLDPDCARALLLLAELYLEQG 192
                         170
                  ....*....|.
gi 1034643849 312 eaQHRDAVEIY 322
Cdd:COG2956   193 --DYEEAIAAL 201
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
253-332 6.00e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 253 DLISLYEEAAQIEQLRRNHNQAIQYLQQAHSVCVSLFTEVSPKTAEMSALLAKAYAMSGeaQHRDAVEiYFIRSINAYRA 332
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELG--RYEEALE-LLERALALAEK 77
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
152-322 7.79e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 7.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 152 SNKEKEEILEALVKLYYTLGvawllqnrgreayfNLQKAERNMKELKELYKGGVcelqvsenDLTLALGRASLAIHRLNL 231
Cdd:COG2956    71 RDPDRAEALLELAQDYLKAG--------------LLDRAEELLEKLLELDPDDA--------EALRLLAEIYEQEGDWEK 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 232 ALAYFEKAIgdviaakgDRTSDLISLYEEAAQIEQLRRNHNQAIQYLQQAHsvcvslftEVSPKTAEMSALLAKAYAMSG 311
Cdd:COG2956   129 AIEVLERLL--------KLGPENAHAYCELAELYLEQGDYDEAIEALEKAL--------KLDPDCARALLLLAELYLEQG 192
                         170
                  ....*....|.
gi 1034643849 312 eaQHRDAVEIY 322
Cdd:COG2956   193 --DYEEAIAAL 201
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
253-332 6.00e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 253 DLISLYEEAAQIEQLRRNHNQAIQYLQQAHSVCVSLFTEVSPKTAEMSALLAKAYAMSGeaQHRDAVEiYFIRSINAYRA 332
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELG--RYEEALE-LLERALALAEK 77
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
152-322 7.79e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 7.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 152 SNKEKEEILEALVKLYYTLGvawllqnrgreayfNLQKAERNMKELKELYKGGVcelqvsenDLTLALGRASLAIHRLNL 231
Cdd:COG2956    71 RDPDRAEALLELAQDYLKAG--------------LLDRAEELLEKLLELDPDDA--------EALRLLAEIYEQEGDWEK 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 232 ALAYFEKAIgdviaakgDRTSDLISLYEEAAQIEQLRRNHNQAIQYLQQAHsvcvslftEVSPKTAEMSALLAKAYAMSG 311
Cdd:COG2956   129 AIEVLERLL--------KLGPENAHAYCELAELYLEQGDYDEAIEALEKAL--------KLDPDCARALLLLAELYLEQG 192
                         170
                  ....*....|.
gi 1034643849 312 eaQHRDAVEIY 322
Cdd:COG2956   193 --DYEEAIAAL 201
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
155-322 1.17e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 155 EKEEILEALVKLYYTLGVAWLLQNRGREAYFNLQKAernmkelkelykggvCELQVSENDLTLALGRASLAIHRLNLALA 234
Cdd:COG3914    69 AAAAALLLLAALLELAALLLQALGRYEEALALYRRA---------------LALNPDNAEALFNLGNLLLALGRLEEALA 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 235 YFEKAigdvIAAKGDRTSDLISLyeeaAQIEQLRRNHNQAIQYLQQAhsvcvslfTEVSPKTAEMSALLAKAYAMSGeaQ 314
Cdd:COG3914   134 ALRRA----LALNPDFAEAYLNL----GEALRRLGRLEEAIAALRRA--------LELDPDNAEALNNLGNALQDLG--R 195

                  ....*...
gi 1034643849 315 HRDAVEIY 322
Cdd:COG3914   196 LEEAIAAY 203
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
112-314 6.84e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 112 ARALANLAYGYLTLrGLPVQAKKHATSAKNTlltwkanttsNKEKEEILEALVKLYytlgvawLLQNRGREAYFNLQKAE 191
Cdd:COG2956    76 AEALLELAQDYLKA-GLLDRAEELLEKLLEL----------DPDDAEALRLLAEIY-------EQEGDWEKAIEVLERLL 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643849 192 RNMKELKELYkggvCELqvsendltlalGRASLAIHRLNLALAYFEKAIgdviaakgDRTSDLISLYEEAAQIEQLRRNH 271
Cdd:COG2956   138 KLGPENAHAY----CEL-----------AELYLEQGDYDEAIEALEKAL--------KLDPDCARALLLLAELYLEQGDY 194
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034643849 272 NQAIQYLQQAhsvcvslfTEVSPKTAEMSALLAKAYAMSGEAQ 314
Cdd:COG2956   195 EEAIAALERA--------LEQDPDYLPALPRLAELYEKLGDPE 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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