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Conserved domains on  [gi|1034648897|ref|XP_016865887|]
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protein broad-minded isoform X2 [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 10633145)

TBC (Tre-2, BUB2p, Cdc16p) domain-containing protein may perform a GTP-activator activity on Rab-like GTPases

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BROMI pfam14961
Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase ...
 12-1295 0e+00

Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth.


:

Pssm-ID: 464406  Cd Length: 1292  Bit Score: 2239.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897   12 LQAMLRRLFQSVKEKITGAPSLECAEEILLHLEETDENFHNYEFVKYLRQHIGNTLGSMIEEEMEKCTSDRNQGEECGYD 91
Cdd:pfam14961    1 LQSLLRQLLQSVKEKISGAPSVECAEEILLHLEETDENFHNYEFVKYLRQYIESTLGSVIEEETEKCTSEEGQGEGSGQD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897   92 TVVQQVTKRTQESKEYKEMMHYLKNIMIAVVESMINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKF-C 170
Cdd:pfam14961   81 TLVQAVTKRTRESKEYKEMMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSQHEQLSSHYTDNCSDSDSSFNQSYTFmS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  171 QGKLQLILDQLDPGQPKEVRYEALQTLCSAPPSDVLNCENWTTLCEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTK 250
Cdd:pfam14961  161 QEQLQLIAEKLDPRQPKEVRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  251 EIYTSLAKYLESYFLSRENHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLTVKHN 330
Cdd:pfam14961  241 EIYTSLAKHLESYFLSSKLSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  331 QS--HVVSQKILDPIYFFALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEMCKTRKAD----ETL 404
Cdd:pfam14961  321 QGlnSPGSDKVLDPIYFLALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKtteiSHS 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  405 GHSKHCRNKQKTFYyLGQELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTS 484
Cdd:pfam14961  401 SHQQHIGNKQRTFY-TGKELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETP 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  485 AAHSENYSPASMVTEVLWILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLI 564
Cdd:pfam14961  480 HVGSDNYSPASLVMEVLQILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLS 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  565 LLLYGANMNSSEE-SPTGAHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAW 643
Cdd:pfam14961  560 LLLYGGNLSSAEEeSISAAHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAW 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  644 KKTSLLSERIPTPVEGSDSVSSVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRH 723
Cdd:pfam14961  640 KKASLLSERVPTPVPGADCSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRC 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  724 KKFGYGVLVTRVASTAAGGIALKKSGFINELITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLL-SYPAI 802
Cdd:pfam14961  720 EKFGYGVMVTQVAATAPGAVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAV 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  803 YELVRNQDLPNKTEYSLREVPTCVIDIIDRLIILNSEAKIRSLFNYEQSHIFGLRLLSVICCDLDTLLLLEAQYQVSEML 882
Cdd:pfam14961  800 YELLGNQELPNKTEYSLREMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLLSVLCCNLDSLLLLESQYNISEVL 879

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  883 LNAQEENILEISESHRDFIIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAG 962
Cdd:pfam14961  880 LQAQKENVTEPSGSEGEFIIDGLSVERNHILVRINLIGGPSERILPPRALQKGEDPYPWPMFSSYPLPKCYLPDVPRITD 959

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  963 IKQDNDLDKLLLCLKISDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDANVK 1042
Cdd:pfam14961  960 TKQDSELSKFLSSSKNPEKQAEWMENCRRQFCKIMKTKPDTISGGVLAELLEKFVLHLSESPSECYFSSTEYKAADADVK 1039

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1043 NESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIMLGDK 1122
Cdd:pfam14961 1040 NASLSSVQQLGVKMTIRYGKYLNLLKEDAENDLCLVLKHCEQFLKQQQVKVSSSLRCLQGGYPGHDWFASSVFLIMSGDK 1119

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1123 EKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICLQWI 1202
Cdd:pfam14961 1120 ERSLSFLLRFSHLLVSAFLWPPRLHASIHLPADTAESGIHPVYSCTAHYVEMLLKAEVPLVFSAFRMSGFTPSQICLQWL 1199

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1203 TQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILEQNY 1282
Cdd:pfam14961 1200 TQCFWNYLDWTEICHYIATCIFMGPDYQVYMCISILKHLQQEILQHTQTQDLQVFLKEEPIHGFRVSNYLEYMESLEQTY 1279

                         1290
                   ....*....|...
gi 1034648897 1283 RTVLLRDMRNIRL 1295
Cdd:pfam14961 1280 RPMVLTDMRNIRV 1292
 
Name Accession Description Interval E-value
BROMI pfam14961
Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase ...
 12-1295 0e+00

Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth.


Pssm-ID: 464406  Cd Length: 1292  Bit Score: 2239.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897   12 LQAMLRRLFQSVKEKITGAPSLECAEEILLHLEETDENFHNYEFVKYLRQHIGNTLGSMIEEEMEKCTSDRNQGEECGYD 91
Cdd:pfam14961    1 LQSLLRQLLQSVKEKISGAPSVECAEEILLHLEETDENFHNYEFVKYLRQYIESTLGSVIEEETEKCTSEEGQGEGSGQD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897   92 TVVQQVTKRTQESKEYKEMMHYLKNIMIAVVESMINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKF-C 170
Cdd:pfam14961   81 TLVQAVTKRTRESKEYKEMMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSQHEQLSSHYTDNCSDSDSSFNQSYTFmS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  171 QGKLQLILDQLDPGQPKEVRYEALQTLCSAPPSDVLNCENWTTLCEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTK 250
Cdd:pfam14961  161 QEQLQLIAEKLDPRQPKEVRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  251 EIYTSLAKYLESYFLSRENHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLTVKHN 330
Cdd:pfam14961  241 EIYTSLAKHLESYFLSSKLSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  331 QS--HVVSQKILDPIYFFALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEMCKTRKAD----ETL 404
Cdd:pfam14961  321 QGlnSPGSDKVLDPIYFLALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKtteiSHS 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  405 GHSKHCRNKQKTFYyLGQELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTS 484
Cdd:pfam14961  401 SHQQHIGNKQRTFY-TGKELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETP 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  485 AAHSENYSPASMVTEVLWILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLI 564
Cdd:pfam14961  480 HVGSDNYSPASLVMEVLQILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLS 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  565 LLLYGANMNSSEE-SPTGAHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAW 643
Cdd:pfam14961  560 LLLYGGNLSSAEEeSISAAHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAW 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  644 KKTSLLSERIPTPVEGSDSVSSVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRH 723
Cdd:pfam14961  640 KKASLLSERVPTPVPGADCSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRC 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  724 KKFGYGVLVTRVASTAAGGIALKKSGFINELITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLL-SYPAI 802
Cdd:pfam14961  720 EKFGYGVMVTQVAATAPGAVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAV 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  803 YELVRNQDLPNKTEYSLREVPTCVIDIIDRLIILNSEAKIRSLFNYEQSHIFGLRLLSVICCDLDTLLLLEAQYQVSEML 882
Cdd:pfam14961  800 YELLGNQELPNKTEYSLREMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLLSVLCCNLDSLLLLESQYNISEVL 879

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  883 LNAQEENILEISESHRDFIIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAG 962
Cdd:pfam14961  880 LQAQKENVTEPSGSEGEFIIDGLSVERNHILVRINLIGGPSERILPPRALQKGEDPYPWPMFSSYPLPKCYLPDVPRITD 959

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  963 IKQDNDLDKLLLCLKISDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDANVK 1042
Cdd:pfam14961  960 TKQDSELSKFLSSSKNPEKQAEWMENCRRQFCKIMKTKPDTISGGVLAELLEKFVLHLSESPSECYFSSTEYKAADADVK 1039

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1043 NESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIMLGDK 1122
Cdd:pfam14961 1040 NASLSSVQQLGVKMTIRYGKYLNLLKEDAENDLCLVLKHCEQFLKQQQVKVSSSLRCLQGGYPGHDWFASSVFLIMSGDK 1119

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1123 EKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICLQWI 1202
Cdd:pfam14961 1120 ERSLSFLLRFSHLLVSAFLWPPRLHASIHLPADTAESGIHPVYSCTAHYVEMLLKAEVPLVFSAFRMSGFTPSQICLQWL 1199

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1203 TQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILEQNY 1282
Cdd:pfam14961 1200 TQCFWNYLDWTEICHYIATCIFMGPDYQVYMCISILKHLQQEILQHTQTQDLQVFLKEEPIHGFRVSNYLEYMESLEQTY 1279

                         1290
                   ....*....|...
gi 1034648897 1283 RTVLLRDMRNIRL 1295
Cdd:pfam14961 1280 RPMVLTDMRNIRV 1292
 
Name Accession Description Interval E-value
BROMI pfam14961
Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase ...
 12-1295 0e+00

Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth.


Pssm-ID: 464406  Cd Length: 1292  Bit Score: 2239.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897   12 LQAMLRRLFQSVKEKITGAPSLECAEEILLHLEETDENFHNYEFVKYLRQHIGNTLGSMIEEEMEKCTSDRNQGEECGYD 91
Cdd:pfam14961    1 LQSLLRQLLQSVKEKISGAPSVECAEEILLHLEETDENFHNYEFVKYLRQYIESTLGSVIEEETEKCTSEEGQGEGSGQD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897   92 TVVQQVTKRTQESKEYKEMMHYLKNIMIAVVESMINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKF-C 170
Cdd:pfam14961   81 TLVQAVTKRTRESKEYKEMMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSQHEQLSSHYTDNCSDSDSSFNQSYTFmS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  171 QGKLQLILDQLDPGQPKEVRYEALQTLCSAPPSDVLNCENWTTLCEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTK 250
Cdd:pfam14961  161 QEQLQLIAEKLDPRQPKEVRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  251 EIYTSLAKYLESYFLSRENHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLTVKHN 330
Cdd:pfam14961  241 EIYTSLAKHLESYFLSSKLSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  331 QS--HVVSQKILDPIYFFALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEMCKTRKAD----ETL 404
Cdd:pfam14961  321 QGlnSPGSDKVLDPIYFLALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKtteiSHS 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  405 GHSKHCRNKQKTFYyLGQELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTS 484
Cdd:pfam14961  401 SHQQHIGNKQRTFY-TGKELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETP 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  485 AAHSENYSPASMVTEVLWILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLI 564
Cdd:pfam14961  480 HVGSDNYSPASLVMEVLQILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLS 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  565 LLLYGANMNSSEE-SPTGAHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAW 643
Cdd:pfam14961  560 LLLYGGNLSSAEEeSISAAHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAW 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  644 KKTSLLSERIPTPVEGSDSVSSVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRH 723
Cdd:pfam14961  640 KKASLLSERVPTPVPGADCSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRC 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  724 KKFGYGVLVTRVASTAAGGIALKKSGFINELITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLL-SYPAI 802
Cdd:pfam14961  720 EKFGYGVMVTQVAATAPGAVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAV 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  803 YELVRNQDLPNKTEYSLREVPTCVIDIIDRLIILNSEAKIRSLFNYEQSHIFGLRLLSVICCDLDTLLLLEAQYQVSEML 882
Cdd:pfam14961  800 YELLGNQELPNKTEYSLREMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLLSVLCCNLDSLLLLESQYNISEVL 879

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  883 LNAQEENILEISESHRDFIIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAG 962
Cdd:pfam14961  880 LQAQKENVTEPSGSEGEFIIDGLSVERNHILVRINLIGGPSERILPPRALQKGEDPYPWPMFSSYPLPKCYLPDVPRITD 959

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897  963 IKQDNDLDKLLLCLKISDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDANVK 1042
Cdd:pfam14961  960 TKQDSELSKFLSSSKNPEKQAEWMENCRRQFCKIMKTKPDTISGGVLAELLEKFVLHLSESPSECYFSSTEYKAADADVK 1039

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1043 NESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIMLGDK 1122
Cdd:pfam14961 1040 NASLSSVQQLGVKMTIRYGKYLNLLKEDAENDLCLVLKHCEQFLKQQQVKVSSSLRCLQGGYPGHDWFASSVFLIMSGDK 1119

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1123 EKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICLQWI 1202
Cdd:pfam14961 1120 ERSLSFLLRFSHLLVSAFLWPPRLHASIHLPADTAESGIHPVYSCTAHYVEMLLKAEVPLVFSAFRMSGFTPSQICLQWL 1199

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1203 TQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILEQNY 1282
Cdd:pfam14961 1200 TQCFWNYLDWTEICHYIATCIFMGPDYQVYMCISILKHLQQEILQHTQTQDLQVFLKEEPIHGFRVSNYLEYMESLEQTY 1279

                         1290
                   ....*....|...
gi 1034648897 1283 RTVLLRDMRNIRL 1295
Cdd:pfam14961 1280 RPMVLTDMRNIRV 1292
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 1110-1246 4.77e-04

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 42.63  E-value: 4.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648897 1110 FVSSLFMIMLGDKEKTFQFlhqFSRLLTsaflwlpRLHISSYLPNDTveSGIHpvyfCSTHYIEMLLKAELPLVFSAFHM 1189
Cdd:pfam00566   57 FIAAPLLLVYLDEEDAFWC---FVSLLE-------NYLLRDFYTPDF--PGLK----RDLYVFEELLKKKLPKLYKHLKE 120

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648897 1190 SGFAPSQICLQWITQCFWNYLDWIEICHYIATCVFLGPDYQVY-ICIAVFKHLQQDIL 1246
Cdd:pfam00566  121 LGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLFrVALAILKRFREELL 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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