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Conserved domains on  [gi|1034648921|ref|XP_016865895|]
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BEN domain-containing protein 6 isoform X1 [Homo sapiens]

Protein Classification

BEN domain-containing protein( domain architecture ID 10660010)

BEN domain-containing protein similar to Homo sapiens protein BANP that controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function; the BEN domain mediates DNA-binding

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BEN smart01025
The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP ...
 190-271 2.87e-14

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.


:

Pssm-ID: 214981  Cd Length: 80  Bit Score: 66.62  E-value: 2.87e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648921  190 QKFINDLMQVLYTNEYMATHSLTGAKSSTSRDKavKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNCTKKPNL 269
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSG--KKPLDPNKVQAIREYLEERFPSVDLDEDWKVCIQAINNKCRRLRR 78


                   ..
gi 1034648921  270 SK 271
Cdd:smart01025  79 RK 80
 
Name Accession Description Interval E-value
BEN smart01025
The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP ...
 190-271 2.87e-14

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.


Pssm-ID: 214981  Cd Length: 80  Bit Score: 66.62  E-value: 2.87e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648921  190 QKFINDLMQVLYTNEYMATHSLTGAKSSTSRDKavKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNCTKKPNL 269
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSG--KKPLDPNKVQAIREYLEERFPSVDLDEDWKVCIQAINNKCRRLRR 78


                   ..
gi 1034648921  270 SK 271
Cdd:smart01025  79 RK 80
BEN pfam10523
BEN domain; The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and ...
 191-263 2.05e-12

BEN domain; The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The BEN domain-containing protein 3 (BEND3) is shown to interact (via BEN domains 1 and 3) with ERCC6L (via N-terminal TPR repeat and SNF2 HeliC region of ERCC6L) which stimulates the ERCC6L translocase and ATPase activities.


Pssm-ID: 463133  Cd Length: 76  Bit Score: 61.24  E-value: 2.05e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034648921 191 KFINDLMQVLYTNEYMATHSLTGAKSSTSRDKavKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNC 263
Cdd:pfam10523   1 KLARKLLVKLFPEDTLANHSGTGKRSPAFPPN--KKGLDPLKVQLIRNYVEERFPENKNEEWWNECVPRINKT 71
 
Name Accession Description Interval E-value
BEN smart01025
The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP ...
 190-271 2.87e-14

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.


Pssm-ID: 214981  Cd Length: 80  Bit Score: 66.62  E-value: 2.87e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648921  190 QKFINDLMQVLYTNEYMATHSLTGAKSSTSRDKavKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNCTKKPNL 269
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSG--KKPLDPNKVQAIREYLEERFPSVDLDEDWKVCIQAINNKCRRLRR 78


                   ..
gi 1034648921  270 SK 271
Cdd:smart01025  79 RK 80
BEN pfam10523
BEN domain; The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and ...
 191-263 2.05e-12

BEN domain; The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The BEN domain-containing protein 3 (BEND3) is shown to interact (via BEN domains 1 and 3) with ERCC6L (via N-terminal TPR repeat and SNF2 HeliC region of ERCC6L) which stimulates the ERCC6L translocase and ATPase activities.


Pssm-ID: 463133  Cd Length: 76  Bit Score: 61.24  E-value: 2.05e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034648921 191 KFINDLMQVLYTNEYMATHSLTGAKSSTSRDKavKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNC 263
Cdd:pfam10523   1 KLARKLLVKLFPEDTLANHSGTGKRSPAFPPN--KKGLDPLKVQLIRNYVEERFPENKNEEWWNECVPRINKT 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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