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Conserved domains on  [gi|1034649826|ref|XP_016866218|]
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protein FAM50B isoform X1 [Homo sapiens]

Protein Classification

FAM50/XAP5 family protein( domain architecture ID 10522725)

FAM50/XAP5 family protein similar to plant protein XAP5 CIRCADIAN TIMEKEEPER that is involved in light regulation of the circadian clock and photomorphogenesis, and may play a global role in coordinating growth in response to the light environment

Gene Ontology:  GO:0006397|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XAP5 pfam04921
XAP5, circadian clock regulator; This protein is found in a wide range of eukaryotes. It is a ...
 141-324 7.94e-104

XAP5, circadian clock regulator; This protein is found in a wide range of eukaryotes. It is a nuclear protein previously suggested to be DNA binding but recent studies suggest that they play a role in the spliceosome complex. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light.


:

Pssm-ID: 461480  Cd Length: 238  Bit Score: 303.77  E-value: 7.94e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649826 141 NLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGL 220
Cdd:pfam04921  55 KKGKNPNVDTSFLPDKEREEREAAEREALRKEFLALQEAVKAEEIEIPFSFYDGTGHRRPVRVKKGDTIWLFLDKCREQL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649826 221 RKDFLELRSAGVEQLMFIKEDLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSWYEK 300
Cdd:pfam04921 135 RKEFREWARVSVDDLMLVKEDLIIPHHYTFYDFIVNKARGKSGPLFNFDYSDDVRLISDLEGEKDDSHATKVVDRRWYER 214

                         170       180
                  ....*....|....*....|....
gi 1034649826 301 NKHIFPASRWEAYDPEKKWDKYTI 324
Cdd:pfam04921 215 NKHIFPASRWEEFDPEKDYSKYTI 238
 
Name Accession Description Interval E-value
XAP5 pfam04921
XAP5, circadian clock regulator; This protein is found in a wide range of eukaryotes. It is a ...
 141-324 7.94e-104

XAP5, circadian clock regulator; This protein is found in a wide range of eukaryotes. It is a nuclear protein previously suggested to be DNA binding but recent studies suggest that they play a role in the spliceosome complex. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light.


Pssm-ID: 461480  Cd Length: 238  Bit Score: 303.77  E-value: 7.94e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649826 141 NLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGL 220
Cdd:pfam04921  55 KKGKNPNVDTSFLPDKEREEREAAEREALRKEFLALQEAVKAEEIEIPFSFYDGTGHRRPVRVKKGDTIWLFLDKCREQL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649826 221 RKDFLELRSAGVEQLMFIKEDLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSWYEK 300
Cdd:pfam04921 135 RKEFREWARVSVDDLMLVKEDLIIPHHYTFYDFIVNKARGKSGPLFNFDYSDDVRLISDLEGEKDDSHATKVVDRRWYER 214

                         170       180
                  ....*....|....*....|....
gi 1034649826 301 NKHIFPASRWEAYDPEKKWDKYTI 324
Cdd:pfam04921 215 NKHIFPASRWEEFDPEKDYSKYTI 238
 
Name Accession Description Interval E-value
XAP5 pfam04921
XAP5, circadian clock regulator; This protein is found in a wide range of eukaryotes. It is a ...
 141-324 7.94e-104

XAP5, circadian clock regulator; This protein is found in a wide range of eukaryotes. It is a nuclear protein previously suggested to be DNA binding but recent studies suggest that they play a role in the spliceosome complex. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light.


Pssm-ID: 461480  Cd Length: 238  Bit Score: 303.77  E-value: 7.94e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649826 141 NLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGL 220
Cdd:pfam04921  55 KKGKNPNVDTSFLPDKEREEREAAEREALRKEFLALQEAVKAEEIEIPFSFYDGTGHRRPVRVKKGDTIWLFLDKCREQL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649826 221 RKDFLELRSAGVEQLMFIKEDLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSWYEK 300
Cdd:pfam04921 135 RKEFREWARVSVDDLMLVKEDLIIPHHYTFYDFIVNKARGKSGPLFNFDYSDDVRLISDLEGEKDDSHATKVVDRRWYER 214

                         170       180
                  ....*....|....*....|....
gi 1034649826 301 NKHIFPASRWEAYDPEKKWDKYTI 324
Cdd:pfam04921 215 NKHIFPASRWEEFDPEKDYSKYTI 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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