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Conserved domains on  [gi|1034661254|ref|XP_016869237|]
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sodium-dependent phosphate transporter 2 isoform X1 [Homo sapiens]

Protein Classification

inorganic phosphate transporter( domain architecture ID 10475700)

inorganic phosphate transporter is involved in phosphate transport, such as bacterial low-affinity inorganic phosphate transporter and vertebrate sodium-dependent phosphate transporters, which play fundamental housekeeping roles in phosphate transport

Gene Ontology:  GO:0005315|GO:0006817|GO:0016020
TCDB:  2.A.20

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
486-637 1.32e-71

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


:

Pssm-ID: 460184  Cd Length: 322  Bit Score: 234.32  E-value: 1.32e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 486 LFHFLQVLTACFGSFAHGGNDVSNAIGPLV-ALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLT 564
Cdd:pfam01384 170 LFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGWRIIKTVGNKIT 249
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034661254 565 PITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFS 637
Cdd:pfam01384 250 KLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVAALLS 322
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
25-224 5.10e-61

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


:

Pssm-ID: 460184  Cd Length: 322  Bit Score: 206.20  E-value: 5.10e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254  25 GANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLyneTVETLMAGEVSAMVGSAVWQLI 104
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALLGAAIWLLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 105 ASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDP--------- 175
Cdd:pfam01384  78 ATYLGLPVSSTHALVGALIGAGLAAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034661254 176 ---------VPNGLRALPVFYAATIAIN----------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 224
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVSFAhgandvqnamgpltaaLYAIGTTGEVASKAPVPLWVLLLGALAIAL 231
 
Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
486-637 1.32e-71

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 234.32  E-value: 1.32e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 486 LFHFLQVLTACFGSFAHGGNDVSNAIGPLV-ALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLT 564
Cdd:pfam01384 170 LFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGWRIIKTVGNKIT 249
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034661254 565 PITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFS 637
Cdd:pfam01384 250 KLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVAALLS 322
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
25-224 5.10e-61

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 206.20  E-value: 5.10e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254  25 GANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLyneTVETLMAGEVSAMVGSAVWQLI 104
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALLGAAIWLLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 105 ASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDP--------- 175
Cdd:pfam01384  78 ATYLGLPVSSTHALVGALIGAGLAAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034661254 176 ---------VPNGLRALPVFYAATIAIN----------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 224
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVSFAhgandvqnamgpltaaLYAIGTTGEVASKAPVPLWVLLLGALAIAL 231
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
483-645 1.15e-45

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 164.95  E-value: 1.15e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 483 VHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIykqGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKD 562
Cdd:COG0306   168 VNRGFRRLQIVSAALMAFSHGANDAQKAMGIITLALLA---AGLLSGFEVPLWVILLCALAIALGTLLGGWRIIKTLGKK 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 563 LTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMA 642
Cdd:COG0306   245 ITKLDPLQGFAAETSSAATVLLASLLGIPVSTTHVITGSIMGVGAARRLSAVRWGVAGRIVLAWVLTLPAAALLAALLYL 324

                  ...
gi 1034661254 643 LLM 645
Cdd:COG0306   325 LLS 327
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
7-224 1.49e-41

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 153.78  E-value: 1.49e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254   7 LWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYneTVET 86
Cdd:COG0306     4 LLLLIVVILLALFFDFNNGFHDAANAIATAVGTRALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVDPGIL--TLEV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254  87 LMAgevsAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIR 166
Cdd:COG0306    82 VLA----ALLGAILWNLITWYLGIPSSSSHALVGGLVGAGLAAAGFGAVNWGVLLKIVLPWVLSPLIGFLLGFLLMRLLY 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034661254 167 -IFILKKEDPVPNGLRALPVFYAATIAIN------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 224
Cdd:COG0306   158 wLFRRANPRRVNRGFRRLQIVSAALMAFShgandaqkamgiITLALLAAGLLSGFEVPLWVILLCALAIAL 228
 
Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
486-637 1.32e-71

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 234.32  E-value: 1.32e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 486 LFHFLQVLTACFGSFAHGGNDVSNAIGPLV-ALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLT 564
Cdd:pfam01384 170 LFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGWRIIKTVGNKIT 249
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034661254 565 PITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFS 637
Cdd:pfam01384 250 KLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVAALLS 322
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
25-224 5.10e-61

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 206.20  E-value: 5.10e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254  25 GANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLyneTVETLMAGEVSAMVGSAVWQLI 104
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALLGAAIWLLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 105 ASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDP--------- 175
Cdd:pfam01384  78 ATYLGLPVSSTHALVGALIGAGLAAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034661254 176 ---------VPNGLRALPVFYAATIAIN----------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 224
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVSFAhgandvqnamgpltaaLYAIGTTGEVASKAPVPLWVLLLGALAIAL 231
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
483-645 1.15e-45

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 164.95  E-value: 1.15e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 483 VHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIykqGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKD 562
Cdd:COG0306   168 VNRGFRRLQIVSAALMAFSHGANDAQKAMGIITLALLA---AGLLSGFEVPLWVILLCALAIALGTLLGGWRIIKTLGKK 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 563 LTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMA 642
Cdd:COG0306   245 ITKLDPLQGFAAETSSAATVLLASLLGIPVSTTHVITGSIMGVGAARRLSAVRWGVAGRIVLAWVLTLPAAALLAALLYL 324

                  ...
gi 1034661254 643 LLM 645
Cdd:COG0306   325 LLS 327
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
7-224 1.49e-41

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 153.78  E-value: 1.49e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254   7 LWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYneTVET 86
Cdd:COG0306     4 LLLLIVVILLALFFDFNNGFHDAANAIATAVGTRALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVDPGIL--TLEV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254  87 LMAgevsAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIR 166
Cdd:COG0306    82 VLA----ALLGAILWNLITWYLGIPSSSSHALVGGLVGAGLAAAGFGAVNWGVLLKIVLPWVLSPLIGFLLGFLLMRLLY 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034661254 167 -IFILKKEDPVPNGLRALPVFYAATIAIN------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 224
Cdd:COG0306   158 wLFRRANPRRVNRGFRRLQIVSAALMAFShgandaqkamgiITLALLAAGLLSGFEVPLWVILLCALAIAL 228
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
503-649 3.02e-15

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 77.15  E-value: 3.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 503 GGNDVSNAIGPLVAlwliykqggvTQeAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIE------L 576
Cdd:pfam01384   1 GANDVANAFATSVG----------SR-ALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSFDPGVLMLgmlaalL 69
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034661254 577 ASAFTVVIASNIGLPVSTTHCKVGSVVAVGW-IRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGIL 649
Cdd:pfam01384  70 GAAIWLLIATYLGLPVSSTHALVGALIGAGLaAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLIL 143
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
14-169 8.14e-14

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 72.89  E-value: 8.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254  14 FIIAFILAFSVGANDVANSFGTAVGSGVVTLRQAC--------ILASIFETTGSVLLGAKVGETIRKGIIDVNLYNEtve 85
Cdd:COG0306   177 IVSAALMAFSHGANDAQKAMGIITLALLAAGLLSGfevplwviLLCALAIALGTLLGGWRIIKTLGKKITKLDPLQG--- 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254  86 tlmageVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLvAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLI 165
Cdd:COG0306   254 ------FAAETSSAATVLLASLLGIPVSTTHVITGSIMGVGA-ARRLSAVRWGVAGRIVLAWVLTLPAAALLAALLYLLL 326

                  ....
gi 1034661254 166 RIFI 169
Cdd:COG0306   327 SLLG 330
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
15-158 6.51e-13

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 70.22  E-value: 6.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254  15 IIAFILAFSVGANDVANSFG------------TAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVnlyne 82
Cdd:pfam01384 177 LSAALVSFAHGANDVQNAMGpltaalyaigttGEVASKAPVPLWVLLLGALAIALGTWTGGWRIIKTVGNKITKL----- 251
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034661254  83 tveTLMAGeVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAiGTKGVQWMELVKIVASWFISPLLSGFMS 158
Cdd:pfam01384 252 ---TPSRG-FAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLAR-GLSAVNWGVVGNIVLAWVLTLPVAALLS 322
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
492-646 7.14e-13

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 70.19  E-value: 7.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661254 492 VLTACFGSFAHGGNDVSNAIGPLVAlwliykqggvTQeAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTP---ITP 568
Cdd:COG0306    11 ILLALFFDFNNGFHDAANAIATAVG----------TR-ALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVDpgiLTL 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034661254 569 SSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGW-IRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMY 646
Cdd:COG0306    80 EVVLAALLGAILWNLITWYLGIPSSSSHALVGGLVGAGLaAAGFGAVNWGVLLKIVLPWVLSPLIGFLLGFLLMRLLYW 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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