NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034663447|ref|XP_016869660|]
View 

WASH complex subunit 1 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WASH_WAHD super family cl13393
WAHD domain of WASH complex; This domain forms part of the WASH-complex of domains and ...
 130-200 5.42e-33

WAHD domain of WASH complex; This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see pfam04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.


The actual alignment was detected with superfamily member pfam11945:

Pssm-ID: 463408  Cd Length: 286  Bit Score: 124.49  E-value: 5.42e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034663447 130 PVPENYFYVPDLGQVPEIHVPSYLPDLPGIANDLMYSADLGPGIAPSAPGT-IPELPTFHTEVAEPLKVDLQ 200
Cdd:pfam11945 215 KPAENLFYVPDLGQVPEIDVPSDLPDLPGIADDLMYSVDLGPGIAPSAPLVqIPELPTFETNPAEPSSQDQQ 286
 
Name Accession Description Interval E-value
WASH_WAHD pfam11945
WAHD domain of WASH complex; This domain forms part of the WASH-complex of domains and ...
 130-200 5.42e-33

WAHD domain of WASH complex; This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see pfam04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.


Pssm-ID: 463408  Cd Length: 286  Bit Score: 124.49  E-value: 5.42e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034663447 130 PVPENYFYVPDLGQVPEIHVPSYLPDLPGIANDLMYSADLGPGIAPSAPGT-IPELPTFHTEVAEPLKVDLQ 200
Cdd:pfam11945 215 KPAENLFYVPDLGQVPEIDVPSDLPDLPGIADDLMYSVDLGPGIAPSAPLVqIPELPTFETNPAEPSSQDQQ 286
 
Name Accession Description Interval E-value
WASH_WAHD pfam11945
WAHD domain of WASH complex; This domain forms part of the WASH-complex of domains and ...
 130-200 5.42e-33

WAHD domain of WASH complex; This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see pfam04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.


Pssm-ID: 463408  Cd Length: 286  Bit Score: 124.49  E-value: 5.42e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034663447 130 PVPENYFYVPDLGQVPEIHVPSYLPDLPGIANDLMYSADLGPGIAPSAPGT-IPELPTFHTEVAEPLKVDLQ 200
Cdd:pfam11945 215 KPAENLFYVPDLGQVPEIDVPSDLPDLPGIADDLMYSVDLGPGIAPSAPLVqIPELPTFETNPAEPSSQDQQ 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH