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F-box DNA helicase 1 isoform X4 [Homo sapiens]
F-box DNA helicase 1( domain architecture ID 17778258)
F-box DNA helicase 1 (FBH1) is a 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||||||||
F-box_FBXO18 | cd22095 | F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ... |
211-258 | 1.33e-25 | ||||||||||
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. : Pssm-ID: 438867 Cd Length: 48 Bit Score: 100.04 E-value: 1.33e-25
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UvrD super family | cl33806 | Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
440-949 | 1.83e-23 | ||||||||||
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; The actual alignment was detected with superfamily member COG0210: Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 106.94 E-value: 1.83e-23
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Name | Accession | Description | Interval | E-value | ||||||||||
F-box_FBXO18 | cd22095 | F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ... |
211-258 | 1.33e-25 | ||||||||||
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438867 Cd Length: 48 Bit Score: 100.04 E-value: 1.33e-25
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UvrD | COG0210 | Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
440-949 | 1.83e-23 | ||||||||||
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 106.94 E-value: 1.83e-23
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SF1_C | cd18786 | C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
836-950 | 6.03e-19 | ||||||||||
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC. Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 82.49 E-value: 6.03e-19
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UvrD_C | pfam13361 | UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
888-953 | 3.17e-12 | ||||||||||
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold. Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 69.36 E-value: 3.17e-12
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F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
212-259 | 1.06e-11 | ||||||||||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 60.57 E-value: 1.06e-11
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PRK13909 | PRK13909 | RecB-like helicase; |
846-954 | 3.56e-07 | ||||||||||
RecB-like helicase; Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 54.59 E-value: 3.56e-07
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FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
215-258 | 3.29e-05 | ||||||||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 42.04 E-value: 3.29e-05
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recB | TIGR00609 | exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
888-951 | 1.91e-04 | ||||||||||
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 45.50 E-value: 1.91e-04
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Name | Accession | Description | Interval | E-value | ||||||||||
F-box_FBXO18 | cd22095 | F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ... |
211-258 | 1.33e-25 | ||||||||||
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438867 Cd Length: 48 Bit Score: 100.04 E-value: 1.33e-25
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UvrD | COG0210 | Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
440-949 | 1.83e-23 | ||||||||||
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 106.94 E-value: 1.83e-23
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SF1_C | cd18786 | C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
836-950 | 6.03e-19 | ||||||||||
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC. Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 82.49 E-value: 6.03e-19
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DEXQc_UvrD | cd17932 | DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
444-702 | 4.15e-16 | ||||||||||
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 77.56 E-value: 4.15e-16
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COG3972 | COG3972 | Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
439-961 | 7.12e-13 | ||||||||||
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 72.56 E-value: 7.12e-13
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SF1_C_UvrD | cd18807 | C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
886-949 | 1.57e-12 | ||||||||||
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC. Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 66.10 E-value: 1.57e-12
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RecB | COG1074 | 3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
641-949 | 2.22e-12 | ||||||||||
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair]; Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 71.53 E-value: 2.22e-12
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UvrD_C | pfam13361 | UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
888-953 | 3.17e-12 | ||||||||||
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold. Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 69.36 E-value: 3.17e-12
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F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
212-259 | 1.06e-11 | ||||||||||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 60.57 E-value: 1.06e-11
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UvrD_C_2 | pfam13538 | UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
888-949 | 7.05e-10 | ||||||||||
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold. Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 55.27 E-value: 7.05e-10
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UvrD-helicase | pfam00580 | UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
441-685 | 1.71e-09 | ||||||||||
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family. Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 59.95 E-value: 1.71e-09
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F-box_FBXO6-like | cd22168 | F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ... |
211-261 | 3.14e-08 | ||||||||||
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438939 [Multi-domain] Cd Length: 82 Bit Score: 51.90 E-value: 3.14e-08
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HelD | COG3973 | DNA helicase IV [Replication, recombination and repair]; |
644-949 | 3.97e-08 | ||||||||||
DNA helicase IV [Replication, recombination and repair]; Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 57.57 E-value: 3.97e-08
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F-box_SF | cd09917 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
214-248 | 4.21e-08 | ||||||||||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. Pssm-ID: 438852 Cd Length: 35 Bit Score: 49.75 E-value: 4.21e-08
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SF1_C_RecD | cd18809 | C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
883-948 | 5.29e-08 | ||||||||||
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC. Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 51.02 E-value: 5.29e-08
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F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
212-252 | 1.16e-07 | ||||||||||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 49.08 E-value: 1.16e-07
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RecD | COG0507 | ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
888-948 | 3.42e-07 | ||||||||||
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair]; Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 54.21 E-value: 3.42e-07
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PRK13909 | PRK13909 | RecB-like helicase; |
846-954 | 3.56e-07 | ||||||||||
RecB-like helicase; Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 54.59 E-value: 3.56e-07
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F-box_FBXO33 | cd22104 | F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ... |
214-258 | 1.31e-06 | ||||||||||
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438876 Cd Length: 48 Bit Score: 46.09 E-value: 1.31e-06
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F-box_FBXL4 | cd22117 | F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ... |
215-261 | 7.06e-06 | ||||||||||
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438889 Cd Length: 47 Bit Score: 44.15 E-value: 7.06e-06
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FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
215-258 | 3.29e-05 | ||||||||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 42.04 E-value: 3.29e-05
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F-box_FBXO10 | cd22090 | F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called ... |
211-259 | 4.07e-05 | ||||||||||
F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438862 Cd Length: 50 Bit Score: 41.95 E-value: 4.07e-05
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F-box_FBXO45 | cd22111 | F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ... |
215-243 | 1.81e-04 | ||||||||||
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438883 Cd Length: 36 Bit Score: 39.57 E-value: 1.81e-04
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recB | TIGR00609 | exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
888-951 | 1.91e-04 | ||||||||||
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 45.50 E-value: 1.91e-04
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recB | TIGR00609 | exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
641-683 | 3.43e-04 | ||||||||||
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 44.73 E-value: 3.43e-04
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F-box_FBXO42 | cd22110 | F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ... |
212-249 | 3.59e-04 | ||||||||||
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438882 Cd Length: 38 Bit Score: 38.86 E-value: 3.59e-04
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F-box_4 | pfam15966 | F-box; |
211-248 | 3.86e-04 | ||||||||||
F-box; Pssm-ID: 464958 Cd Length: 116 Bit Score: 41.12 E-value: 3.86e-04
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DExxQc_SF1-N | cd17914 | DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
637-684 | 3.92e-04 | ||||||||||
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 41.32 E-value: 3.92e-04
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F-box_FBXO4 | cd22085 | F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ... |
212-261 | 5.57e-04 | ||||||||||
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438857 Cd Length: 50 Bit Score: 38.93 E-value: 5.57e-04
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F-box_FBXO3 | cd22084 | F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ... |
212-262 | 5.74e-04 | ||||||||||
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438856 Cd Length: 49 Bit Score: 38.78 E-value: 5.74e-04
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F-box_FBXL8 | cd22121 | F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also ... |
214-248 | 9.49e-04 | ||||||||||
F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438893 Cd Length: 35 Bit Score: 37.72 E-value: 9.49e-04
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F-box_FBXL12 | cd22123 | F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ... |
212-249 | 9.53e-04 | ||||||||||
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438895 Cd Length: 42 Bit Score: 37.71 E-value: 9.53e-04
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F-box_FBXW5 | cd22132 | F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ... |
215-260 | 1.29e-03 | ||||||||||
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438904 [Multi-domain] Cd Length: 46 Bit Score: 37.59 E-value: 1.29e-03
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F-box_FBXO13 | cd22092 | F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ... |
211-258 | 1.98e-03 | ||||||||||
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438864 Cd Length: 49 Bit Score: 37.01 E-value: 1.98e-03
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F-box_AtSKIP31-like | cd22166 | F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar ... |
214-259 | 2.04e-03 | ||||||||||
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438937 Cd Length: 46 Bit Score: 37.05 E-value: 2.04e-03
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recD | TIGR01447 | exodeoxyribonuclease V, alpha subunit; This family describes the exodeoxyribonuclease V alpha ... |
888-946 | 3.13e-03 | ||||||||||
exodeoxyribonuclease V, alpha subunit; This family describes the exodeoxyribonuclease V alpha subunit, RecD. RecD is part of a RecBCD complex. A related family in the Gram-positive bacteria separates in a phylogenetic tree, has an additional N-terminal extension of about 200 residues, and is not supported as a member of a RecBCD complex by neighboring genes. The related family is consequently described by a different model. [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273631 [Multi-domain] Cd Length: 582 Bit Score: 41.28 E-value: 3.13e-03
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F-box_FBXW9 | cd22135 | F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, ... |
214-249 | 3.61e-03 | ||||||||||
F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438907 Cd Length: 45 Bit Score: 36.49 E-value: 3.61e-03
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recB | PRK10876 | exonuclease V subunit beta; Provisional |
646-683 | 5.86e-03 | ||||||||||
exonuclease V subunit beta; Provisional Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 40.72 E-value: 5.86e-03
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F-box_FBXL6 | cd22119 | F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ... |
214-256 | 6.02e-03 | ||||||||||
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438891 Cd Length: 47 Bit Score: 35.69 E-value: 6.02e-03
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F-box_FBXO30-like | cd22101 | F-box domain found in F-box only protein 30 (FBXO30), F-box only protein 40 (FBXO40) and ... |
212-248 | 6.17e-03 | ||||||||||
F-box domain found in F-box only protein 30 (FBXO30), F-box only protein 40 (FBXO40) and similar proteins; FBXO30, also called FBX30, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It is required for muscle atrophy following denervation. FBXO30 regulates mammopoiesis by targeting the bipolar mitotic kinesin Eg5. FBXO40, also called FBX40, or muscle disease-related protein, is a probable substrate-recognition component of an SCF-type E3 ubiquitin ligase complex that may function in myogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438873 Cd Length: 45 Bit Score: 35.81 E-value: 6.17e-03
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F-box_FBXO15 | cd22093 | F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ... |
212-259 | 6.81e-03 | ||||||||||
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438865 Cd Length: 46 Bit Score: 35.69 E-value: 6.81e-03
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F-box_AtSKIP19-like | cd22164 | F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ... |
215-259 | 7.09e-03 | ||||||||||
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438935 [Multi-domain] Cd Length: 47 Bit Score: 35.65 E-value: 7.09e-03
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F-box_FBXO31 | cd22102 | F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ... |
212-247 | 8.52e-03 | ||||||||||
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438874 Cd Length: 48 Bit Score: 35.48 E-value: 8.52e-03
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F-box_AtFBW1-like | cd22157 | F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ... |
214-252 | 8.68e-03 | ||||||||||
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438928 Cd Length: 39 Bit Score: 35.13 E-value: 8.68e-03
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F-box_FBA | cd22083 | F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ... |
214-248 | 8.98e-03 | ||||||||||
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438855 Cd Length: 37 Bit Score: 35.06 E-value: 8.98e-03
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F-box_FBXO17-like | cd22169 | F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ... |
215-257 | 9.63e-03 | ||||||||||
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438940 Cd Length: 48 Bit Score: 35.09 E-value: 9.63e-03
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