NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034570288|ref|XP_016872401|]
View 

leucine-rich glioma-inactivated protein 1 isoform X2 [Homo sapiens]

Protein Classification

EPTP domain-containing protein( domain architecture ID 10509911)

EPTP domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 98-173 1.34e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 63.95  E-value: 1.34e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034570288   98 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV---EDIYCEGPPEYKKRKINSLSSKDFDC 173
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 177-217 6.45e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.07  E-value: 6.45e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034570288 177 EFAKSQDLP-YQSLSIDTFSYLNDEYVVIAqPFTGKCIFLEW 217
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
 
Name Accession Description Interval E-value
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 98-173 1.34e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 63.95  E-value: 1.34e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034570288   98 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV---EDIYCEGPPEYKKRKINSLSSKDFDC 173
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
LRR_8 pfam13855
Leucine rich repeat;
71-127 1.90e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.90e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034570288  71 SLSFVRSGFTEISEGSFLFTPSLQLLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 127
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
125-173 7.98e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 7.98e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034570288  125 NSFNCDCKLKWLVEWL---GHTNaTVEDIYCEGPPEYKKRKINSLSSkDFDC 173
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQ-DPVDLRCASPSSLRGPLLELLHS-EFKC 50
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 177-217 6.45e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.07  E-value: 6.45e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034570288 177 EFAKSQDLP-YQSLSIDTFSYLNDEYVVIAqPFTGKCIFLEW 217
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-127 2.83e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 2.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1034570288  91 PSLQLLSLANNNLQTLPKDIfKGLDSLTNVDLRGNSF 127
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQL 240
 
Name Accession Description Interval E-value
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 98-173 1.34e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 63.95  E-value: 1.34e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034570288   98 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV---EDIYCEGPPEYKKRKINSLSSKDFDC 173
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
LRR_8 pfam13855
Leucine rich repeat;
71-127 1.90e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.90e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034570288  71 SLSFVRSGFTEISEGSFLFTPSLQLLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 127
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
125-173 7.98e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 7.98e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034570288  125 NSFNCDCKLKWLVEWL---GHTNaTVEDIYCEGPPEYKKRKINSLSSkDFDC 173
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQ-DPVDLRCASPSSLRGPLLELLHS-EFKC 50
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 177-217 6.45e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.07  E-value: 6.45e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034570288 177 EFAKSQDLP-YQSLSIDTFSYLNDEYVVIAqPFTGKCIFLEW 217
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
LRR_8 pfam13855
Leucine rich repeat;
91-128 3.45e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 3.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034570288  91 PSLQLLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
LRR smart00370
Leucine-rich repeats, outliers;
91-113 4.80e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 4.80e-04
                           10        20
                   ....*....|....*....|...
gi 1034570288   91 PSLQLLSLANNNLQTLPKDIFKG 113
Cdd:smart00370   2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
91-113 4.80e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 4.80e-04
                           10        20
                   ....*....|....*....|...
gi 1034570288   91 PSLQLLSLANNNLQTLPKDIFKG 113
Cdd:smart00369   2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 91-125 1.84e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 1.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034570288  91 PSLQLLSLANNNLQTLPkdIFKGLDSLTNVDLRGN 125
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-127 2.83e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 2.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1034570288  91 PSLQLLSLANNNLQTLPKDIfKGLDSLTNVDLRGNSF 127
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-125 7.41e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.22  E-value: 7.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034570288  91 PSLQLLSLANNNLQTLPKDIfKGLDSLTNVDLRGN 125
Cdd:COG4886   136 TNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNN 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH