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Conserved domains on  [gi|1034581235|ref|XP_016875334|]
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sodium- and chloride-dependent GABA transporter 2 isoform X3 [Homo sapiens]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
1-332 0e+00

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member cd11507:

Pssm-ID: 444915  Cd Length: 544  Bit Score: 661.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11507   213 MLVVLLIRGVSLPGALQGIQFYLYPDLSRLQDPQVWMDAGTQIFFSYAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11507   293 TSFVAGFAIFSILGFMAEEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACFFFFMVVLLGLDSQFVCVESLVTALV 372
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11507   373 DMYPTIFRKKNRRELLILAVSIVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFETLCVAWVYGADRFYDNIEDM 452
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11507   453 IGYRPWAIIKYCWLFITPAVCMATFLFSLIKYTPLTYNKKYVYPWWGDALGWLLALSSMVCIPLWVGYKLSTIKGSLRER 532
                         330
                  ....*....|..
gi 1034581235 321 IRQLMCPAEDLP 332
Cdd:cd11507   533 FRQLTCPDEDLP 544
 
Name Accession Description Interval E-value
SLC6sbd_GAT2 cd11507
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes ...
1-332 0e+00

Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271396  Cd Length: 544  Bit Score: 661.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11507   213 MLVVLLIRGVSLPGALQGIQFYLYPDLSRLQDPQVWMDAGTQIFFSYAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11507   293 TSFVAGFAIFSILGFMAEEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACFFFFMVVLLGLDSQFVCVESLVTALV 372
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11507   373 DMYPTIFRKKNRRELLILAVSIVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFETLCVAWVYGADRFYDNIEDM 452
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11507   453 IGYRPWAIIKYCWLFITPAVCMATFLFSLIKYTPLTYNKKYVYPWWGDALGWLLALSSMVCIPLWVGYKLSTIKGSLRER 532
                         330
                  ....*....|..
gi 1034581235 321 IRQLMCPAEDLP 332
Cdd:cd11507   533 FRQLTCPDEDLP 544
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
1-310 1.60e-179

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 507.98  E-value: 1.60e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:pfam00209 211 VLLVLLVRGVTLPGAADGILFYLTPDWSKLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSA 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:pfam00209 291 TSFLAGFVIFSVLGFMAQEQGVPISEVAESGPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQFGGVEGIITALV 370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKknRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:pfam00209 371 DEFPILLRK--RRELFTLIVCVASFLLGLILVTEGGIYVFTLFDYYAAS-FSLLFVAFFECIAIAWVYGIDRFYDDIKEM 447
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRL 310
Cdd:pfam00209 448 LGFRPGLFWRLCWKFVSPLILLFLFIFSIVQYQPLTYN-NYVYPNWANALGWLMALSSMLCIPLYSIYKL 516
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
1-269 8.99e-50

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 172.59  E-value: 8.99e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:COG0733   182 LLIILVIRALTLPGAAEGLKFLFTPDFSKLTDPEVWLAALGQAFFSLSLGMGIMITYGSYLPKDEDLPRSALIVALLDTL 261
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILgFMSqeqGVPISevaeSGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:COG0733   262 VALLAGLAIFPAV-FAF---GLEPA----AGPGLAFVTLPAVFAQMPGGRLFGVLFFLLLLFAALTSAISLLEVVVAALI 333
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DmyphvfRKKNRREVLILGVSVVSFLVGLIMLT------EGGMYVFQLFDYYAASGMcLLFVAIFESLCVAWVYGAKRFY 234
Cdd:COG0733   334 D------KFGLSRKKATLIVGLLIFLLGIPSALsfnvsvTIGLTFFDLVDFLVSNIL-LPLGGLLIAIFVGWVLGKEKLR 406
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1034581235 235 DNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSL 269
Cdd:COG0733   407 EELNAGSDIKLGKWWRFLIRYVAPVALLIIFLNGL 441
 
Name Accession Description Interval E-value
SLC6sbd_GAT2 cd11507
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes ...
1-332 0e+00

Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271396  Cd Length: 544  Bit Score: 661.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11507   213 MLVVLLIRGVSLPGALQGIQFYLYPDLSRLQDPQVWMDAGTQIFFSYAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11507   293 TSFVAGFAIFSILGFMAEEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACFFFFMVVLLGLDSQFVCVESLVTALV 372
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11507   373 DMYPTIFRKKNRRELLILAVSIVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFETLCVAWVYGADRFYDNIEDM 452
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11507   453 IGYRPWAIIKYCWLFITPAVCMATFLFSLIKYTPLTYNKKYVYPWWGDALGWLLALSSMVCIPLWVGYKLSTIKGSLRER 532
                         330
                  ....*....|..
gi 1034581235 321 IRQLMCPAEDLP 332
Cdd:cd11507   533 FRQLTCPDEDLP 544
SLC6sbd-TauT-like cd11496
Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding ...
1-327 0e+00

Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain; This subgroup represents the solute-binding domain of TauT-like Na(+)- and Cl(-)-dependent transporters. Family members include: human TauT which transports taurine, human GAT1, GAT2, and GAT3, and BGT1, which transport gamma-aminobutyric acid (GABA), and human CT1 which transports creatine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271387  Cd Length: 543  Bit Score: 608.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11496   217 MLIILLIRGVTLPGASDGIKFYLKPDLTKLLDPQVWIDAGTQIFFSYGIGLGSLTALGSYNKFNNNCYKDSIILCFLNSG 296
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11496   297 TSFFAGFAIFSILGFMAQEQGVPISEVAESGPGLAFIAYPRAVSLLPLPQLWAVLFFIMLLLLGLDSQFVGVEGFVTAIV 376
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11496   377 DLYPRVLRRRYRREIFVAIVCLVSFLIGLPMVTEGGIYVFQLFDYYAASGICLLWLAFFECIAISWVYGADRFYDNIKDM 456
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11496   457 IGYRPGPWWKYCWLFGTPAICLGIFIFSLVKYTPLTYGNTYVYPWWAEAIGWFLALSSMLCIPLYAIYELLRTPGTFKER 536

                  ....*..
gi 1034581235 321 IRQLMCP 327
Cdd:cd11496   537 LRKLTTP 543
SLC6sbd_BGT1 cd11511
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding ...
1-327 0e+00

Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding domain; BGT1 is a relatively low-affinity transporter of gamma-aminobutyric acid (GABA), and can also transport betaine. GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human BGT1 is encoded by the SLC6A12 gene, and is similar to mouse GAT2. Mouse GAT2 plays a role in transporting GABA across the blood-brain barrier. In addition to being expressed in cells of the central nervous system, BGT1 is expressed in peripheral tissues, including kidney, liver, and heart. An association has been shown between the SLC6A12 gene and the occurrence of aspirin-intolerant asthma, and BGT1 is a drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212080  Cd Length: 541  Bit Score: 546.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11511   215 MLVILLVRGVTLPGAAEGIIFYLKPDLSRLADPQVWMDAGTQILFSYAICQGCLTALGSYNKYTNNCYRDCIMLCFLNSA 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11511   295 TSFVAGFAIFSVLGFMAREQGVPISEVAESGPGLAFIAYPTAVTMMPVSQLWSCLFFLMLIFLGLDSQFVCVESMVTASI 374
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11511   375 DMFPGVFRKKGRRELLILAIAVICYLLGLLLVTEGGMYIFQLFDYYAASGTCLLFLAIFEVICIGWVYGANRFYDNIEDM 454
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11511   455 IGYRPWPLIKICWLVFTPGLCLAVFLFSLIKYTPLKYNNSYVYPPWGYVLGWLMALSSMVCIPLYAIFILLKTKGSLKQR 534

                  ....*..
gi 1034581235 321 IRQLMCP 327
Cdd:cd11511   535 LMQLISP 541
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
1-310 1.60e-179

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 507.98  E-value: 1.60e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:pfam00209 211 VLLVLLVRGVTLPGAADGILFYLTPDWSKLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSA 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:pfam00209 291 TSFLAGFVIFSVLGFMAQEQGVPISEVAESGPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQFGGVEGIITALV 370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKknRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:pfam00209 371 DEFPILLRK--RRELFTLIVCVASFLLGLILVTEGGIYVFTLFDYYAAS-FSLLFVAFFECIAIAWVYGIDRFYDDIKEM 447
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRL 310
Cdd:pfam00209 448 LGFRPGLFWRLCWKFVSPLILLFLFIFSIVQYQPLTYN-NYVYPNWANALGWLMALSSMLCIPLYSIYKL 516
SLC6sbd_GAT3 cd11508
Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes ...
1-327 3.36e-176

Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes human GAT3 (hGAT3) a high-affinity transporter of gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT3 is encoded by the SLC6A11 gene, and is similar to mouse GAT4, and rat GAT3/GATB. GAT3 is expressed primarily in the glia of the brain, and is a potential drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family


Pssm-ID: 212077  Cd Length: 542  Bit Score: 500.28  E-value: 3.36e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11508   216 MLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSG 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11508   296 TSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVV 375
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11508   376 DMYPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDM 455
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11508   456 IGYRPLSLIKWCWMVITPGICAGIFIFFLVKYKPLKYNNVYTYPDWGYGIGWLMALSSMICIPLWICIKMWKTEGTFPEK 535

                  ....*..
gi 1034581235 321 IRQLMCP 327
Cdd:cd11508   536 LQKLTTP 542
SLC6sbd_TauT cd11510
Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl ...
1-327 1.11e-166

Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl(-)-dependent, high-affinity, low-capacity transporter of taurine and beta-alanine. Human TauT is encoded by the SLC6A6 gene. TauT is expressed in brain, retina, liver, kidney, heart, spleen, and pancreas. It may play a part in the supply of taurine to the intestinal epithelium and in the between-meal-capture of taurine. It may also participate in re-absorbing taurine that has been deconjugated from bile acids in the distal lumen. Functional TauT protects kidney cells from nephrotoxicity caused by the chemotherapeutic agent cisplatin; cisplatin down-regulates TauT in a p53-dependent manner. In mice, TauT has been shown to be important for the maintenance of skeletal muscle function and total exercise capacity. TauT-/- mice develop additional clinically important diseases, some of which are characterized by apoptosis, including vision loss, olfactory dysfunction, and chronic liver disease. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271398  Cd Length: 542  Bit Score: 476.27  E-value: 1.11e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11510   216 MLIVLLIRGVTLPGAAEGIKFYLYPDITRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGCLNSG 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11510   296 TSFVSGFAIFSVLGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLV 375
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11510   376 DLYPSFLRKGYRREIFIAIVCFISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYGGDNMYDAIEDM 455
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11510   456 IGYRPGPWMKYSWIVITPVLCVGCFIFSLVKYEPLTYNKVYVYPEWAIGLGWVLALSSMICIPMVAVIRIIQTDGPLIER 535

                  ....*..
gi 1034581235 321 IRQLMCP 327
Cdd:cd11510   536 IKALTTP 542
SLC6sbd_CT1 cd11509
Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called ...
1-327 4.95e-149

Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called CRTR, CRT) transports creatine. Human CT1 is encoded by the SLC6A8 gene. CT1 is ubiquitously expressed, with highest levels found in skeletal muscle and kidney. Creatine is absorbed from food or synthesized from arginine and plays an important role in energy metabolism. Deficiency in human CT1 leads to X-linked cerebral creatine transporter deficiency. In males, this disorder is characterized by language and speech delays, autistic-like behavior, seizures in about 50% of cases, and can also involve midfacial hypoplasia, and short stature. In females, it is characterized by mild cognitive impairment with behavior and learning problems. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271397  Cd Length: 589  Bit Score: 433.12  E-value: 4.95e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11509   225 VLVVLLVRGVTLPGALDGIIYYLKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFHNNCYKDAFILALINSG 304
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11509   305 TSFFAGFVVFSILGFMASEQGVDISKVAESGPGLAFIAYPKAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGIL 384
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11509   385 DLLPAKYYFRYQREVVVALCCLLCFLIDLSMVTEGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIARM 464
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11509   465 IGYRPLPWMKWCWSVITPLVCMGIFLFHVVNYKPLTYNKTYVYPWWGEAIGWCLALSSMLCIPLTVLYKLLRAKGSLKER 544

                  ....*..
gi 1034581235 321 IRQLMCP 327
Cdd:cd11509   545 WQKLTTP 551
SLC6sbd_GAT1 cd11506
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports ...
1-341 7.44e-142

Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212075 [Multi-domain]  Cd Length: 598  Bit Score: 415.15  E-value: 7.44e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11506   249 MLFILFFRGVTLPGAKEGILFYITPNFSKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNPFHNNVYRDSIIVCCINSC 328
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11506   329 TSMFAGFVIFSIVGFMAHVTKRPIADVAASGPGLAFLAYPEAVTQLPISPLWAVLFFSMLLMLGIDSQFCTVEGFITALV 408
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRkkNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11506   409 DEFPRLLR--NRREIFIAVVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIEEM 486
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11506   487 VGYRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMG-NYVFPKWGQGVGWFMALSSMVLIPGYMAYMFLTLKGSLKQR 565
                         330       340
                  ....*....|....*....|....*..
gi 1034581235 321 IRQLMCPAEDL------PQRNPAGPSA 341
Cdd:cd11506   566 LQVMIQPTEDIvtpengPEQQQQSNSA 592
SLC6sbd_PROT cd11500
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a ...
1-330 2.22e-117

Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a high-affinity L-proline transporter that transports L-proline, and may have a role in excitatory neurotransmission. Human PROT is encoded by the SLC6A7 gene, a potential susceptible gene for asthma. PROT is expressed in the brain. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271390  Cd Length: 541  Bit Score: 350.59  E-value: 2.22e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11500   213 ILIVLLVRGVTLEGALKGIQFYLTPDFHRLASSQVWYDAASQIFYSLGIGFGGLLTMASYNKFNNNIYRDTLIITLGNCI 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11500   293 TSVFAGFAIFSVLGHMAHELGVPVKDVADAGPGLAFVAYPEALTLLPVSPFWSILFFFMLLTLGLDSQFAMLETIVTAVT 372
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKknRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAAsGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11500   373 DEFPYLLRK--YKTWFLGLICVGMYLLGLLLVTDGGMYWLTLMDWYSA-SFGLMVLALFMCLAISWVYGIQRFCRDIKMM 449
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11500   450 IGFEPNLYFKACWMFISPALLLFILVYSIVKYQPSEYG-SYRYPPWAELLGILMGLLSCLMIPIGAIVAILREEGSLWER 528
                         330
                  ....*....|
gi 1034581235 321 IRQLMCPAED 330
Cdd:cd11500   529 LKQACRPAMD 538
SLC6sbd_SERT-like cd11497
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; ...
2-327 1.00e-116

Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain; This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271388  Cd Length: 537  Bit Score: 348.53  E-value: 1.00e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   2 LVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGT 81
Cdd:cd11497   216 LSILLIRGLTLPGASDGIKYYLTPDFSKLKDPEVWIDAATQIFFSLGPGFGVLLALSSYNKFHNNCYRDALVTSSINCAT 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  82 SFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVD 161
Cdd:cd11497   296 SFFSGFVIFSVLGYMAHKQNVPIEDVATEGPGLVFIVYPEAIATLPGSTFWAIIFFLMLITLGLDSTFGGLEAVITGLCD 375
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 162 MYPHVFRkknRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAAsGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMI 241
Cdd:cd11497   376 EFPFLSR---RRELFVLGLVIICFLLALPTVTYGGIYVVTLLDRYAA-GISILFIVFFEAVAVSWFYGVDRFSDDIEEML 451
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 242 GYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYnKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERI 321
Cdd:cd11497   452 GFRPGLYWRVCWKFISPIFLLFIVIFSLVSYEPLQY-QDYVYPPWANVVGWVIACSSIVLIPIYAIYKLISTPGTFRQRI 530

                  ....*.
gi 1034581235 322 RQLMCP 327
Cdd:cd11497   531 AYCITP 536
SLC6sbd cd10324
Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family ...
1-269 2.45e-109

Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family represents the solute-binding domain of SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family). These use sodium and chloride electrochemical gradients to catalyze the thermodynamically uphill movement of a variety of substrates, and include neurotransmitter transporters (NTTs). The latter are Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, through facilitating the uptake of released neurotransmitters from the extracellular space into neurons and glial cells. NTTs are the target of a range of therapeutic drugs for the treatment of psychiatric diseases, such as major depression, anxiety disorders, attention deficit hyperactivity disorder and epilepsy. In addition, they are the primary targets of cocaine, amphetamines and other psychostimulants. This family also includes Drosophila Blot which is expressed primarily in epithelial tissues of ectodermal origin and in the nervous system of the embryo and larvae, but in addition found in the developing oocyte and the freshly laid egg. A lack or reduction of Blot function during oogenesis results in early arrest of embryonic development. 12 transmembrane helices (TMs) appears to be common for eukaryotic and some prokaryotic and archaeal SLC6s, (a core inverted topology repeat, TM1-5 and TM6-10, plus TMs11-12; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT), although a majority of bacterial, and some archaeal SLC6s lack TM12, for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271359 [Multi-domain]  Cd Length: 415  Bit Score: 325.63  E-value: 2.45e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd10324   151 LLLFLLIRGVTLPGAGDGILFYLTPDWSKLLDPKVWIAAATQIFFSLGIGFGGLITYASYNKFKNNIYRDALIVAILNTL 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd10324   231 TSLLAGFVIFSILGFLAHEPGTPVEDVVASGPGLAFIVYPEAIAQMPGPQLWSVLFFLMLFLLGLDSQFAMVEVIVTALA 310
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPhvfRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMcLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd10324   311 DEFP---KLRKRRWLVTLGVCVVGFLLGLPYTTPGGIYVLDLFDYYAAGFS-LLVIALLELIAIAWIYGVDRFLEDIEFM 386
                         250       260
                  ....*....|....*....|....*....
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSL 269
Cdd:cd10324   387 LGIRPSIYWRICWKFITPVVLLIILVFSL 415
SLC6sbd_SERT-like_u1 cd11556
uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter ...
2-327 2.83e-109

uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter subfamily; solute binding domain; SERT-like Na(+)- and Cl(-)-dependent monoamine transporters, transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: the norepinephrine transporter NET, the serotonin transporter SERT , and the dopamine transporter DAT1. These latter may play a role in diseases or disorders including depression, anxiety disorders, and attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. They belongs to the solute carrier 6 (SLC6) transporter family. Members of this subgroup are uncharacterized.


Pssm-ID: 271405  Cd Length: 552  Bit Score: 330.20  E-value: 2.83e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   2 LVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGT 81
Cdd:cd11556   231 LFILLIRGVTLPGSFNGIQYYLTPNFEALKKAEVWVDAATQVFFSLGPGFGVLLAYASYNKFHNNVYKDALLTSFINCAT 310
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  82 SFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVD 161
Cdd:cd11556   311 SFLSGFVIFSVLGYMAHRSGVPIEDVATEGPGLVFVVYPEALSTMPGSTFWSLIFFMMLMTLGLDSSFGGSEAIITALSD 390
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 162 MYPHVfrkKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAAsGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMI 241
Cdd:cd11556   391 EFPII---KRHRELFVGCLFSFYFVIGLASCTQGGFYFFHLLDRYAA-GYSILIAVLFEAIAVSWIYGTDRFCQDIKEML 466
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 242 GYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERI 321
Cdd:cd11556   467 GFPPGIYWKVCWKFIAPIFLLFIITYGLIGYQPLTYD-DYVYPTWANALGWCIAGSSISMIPIVAIYKLLSTPGTLRQRF 545

                  ....*.
gi 1034581235 322 RQLMCP 327
Cdd:cd11556   546 KILTTP 551
SLC6sbd_GlyT2 cd11499
Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also ...
1-330 4.84e-101

Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also called NET1) is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT2 is encoded by the SLC6A5 gene. GlyT2 is expressed in brain and spinal cord. GlyT2 may play a role in pain, and in spasticity. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271389  Cd Length: 597  Bit Score: 310.40  E-value: 4.84e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11499   242 VLVILLIRGVTLPGAGSGIWYFITPKWEKLNDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSA 321
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11499   322 TSIFAGFVIFSVIGFMAHELKVPIESVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSVS 401
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKknRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11499   402 DEFPKYLRT--HKPQFTLVCCLSFFIMGFPMITQGGIYMLQLVDTYAAS-YSLVIIAIFELVGISYIYGLQRFCEDIEMM 478
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11499   479 IGFQPNKFWKVCWAFVTPTILTFILAFSFYQWEPMTYG-SYTYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGSFIER 557
                         330
                  ....*....|
gi 1034581235 321 IRQLMCPAED 330
Cdd:cd11499   558 LKLVCSPQPD 567
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
1-330 1.73e-96

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212083  Cd Length: 555  Bit Score: 297.23  E-value: 1.73e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11514   217 VLTALLLRGVTLPGAIDGIKAYLSVDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSL 296
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11514   297 TSFFSGFVVFSFLGYMAQKHNVPIGDVAKDGPGLIFIIYPEAIATLPLSSVWAVIFFIMLLTLGIDSAMGGMESVITGLI 376
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRkknRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAAsGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11514   377 DEFKFLHR---HRELFTLFIVLSTFLISLFCVTNGGIYVFTLLDHFAA-GTSILFGVLIEAIGIAWFYGVGRFSDDIEEM 452
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11514   453 IGQRPGLYWRLCWKFVSPCFLLFVVVVSIVTFRPPKYG-SYIFPDWANMVGWCLAISSMAMVPLYAIYKFCSLPGSFREK 531
                         330
                  ....*....|
gi 1034581235 321 IRQLMCPAED 330
Cdd:cd11514   532 LAYAITPEKE 541
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
1-330 2.46e-95

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212067  Cd Length: 585  Bit Score: 295.29  E-value: 2.46e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11498   244 VLTILFIRGITLEGAISGIMYYLTPQWDKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISITNCA 323
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11498   324 TSVYAGFVIFSILGFMANHLGVDVSEVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAVV 403
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYPHVFRKKNRREVlILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11498   404 DEIGNDWIIRNKTYV-TLGVAIIGFLLGIPLTTQAGIYWLLLMDNYAAS-FSLVIISCIMCIAIMYIYGHRNYFKDIEMM 481
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKG-PFRE 319
Cdd:cd11498   482 LGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYN-DYVYPGWAIVIGFLMALSSVICIPIYAIFKICMSEGdTFLE 560
                         330
                  ....*....|.
gi 1034581235 320 RIRQLMCPAED 330
Cdd:cd11498   561 RLKNAVKPSKD 571
SLC6sbd_NET cd11512
Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also ...
1-327 3.81e-94

Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also called NAT1, NET1), is a transmembrane transporter that transports the neurotransmitter norepinephrine from synaptic spaces into presynaptic neurons. Human NET is encoded by the SLC6A2 gene. NET is expressed in brain, peripheral nervous system, adrenal gland, and placenta. NET may play a role in diseases or disorders including depression, orthostatic intolerance, anorexia nervosa, cardiovascular diseases, alcoholism, and attention-deficit hyperactivity disorder. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212081  Cd Length: 560  Bit Score: 291.48  E-value: 3.81e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11512   218 VLFVLLIHGVTLPGAFNGINAYLHIDFKRLKEATVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCV 297
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd11512   298 TSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLA 377
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYpHVFRKknRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAAsGMCLLFVAIFESLCVAWVYGAKRFYDNIEDM 240
Cdd:cd11512   378 DDF-SILKK--HRKLFTFGVAFITFLLALFCITNGGIYVLTLLDTFAA-GTSILFAVLMEAIGVSWFYGVDRFSDDIQQM 453
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 241 IGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 320
Cdd:cd11512   454 MGFRPGLYWRLCWKFVSPAFLLFVVIVSIINFKPLTYD-DYNFPPWANRTGWGIALSSMLLVPIYVIYKFFTVPGTFEER 532

                  ....*..
gi 1034581235 321 IRQLMCP 327
Cdd:cd11512   533 LAYCITP 539
SLC6sbd-B0AT-like cd10332
System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding ...
2-309 4.23e-92

System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of transmembrane transporters, which transport, i) neutral amino acids: NTT4 (also called XT1), SBAT1 (also called B0AT2, v7-3, NTT7-3), and B0AT1 (also called HND); the human genes encoding these are SLC6A17, SLC6A15, and SLC6A19 respectively, ii) glycine: B0AT3 (also called Xtrp2, XT2), iii) imino acids, such as proline, pipecolate, MeAIB, and sarcosine: SIT1 (also called XTRP3, XT3, IMINO). The human genes encoding B0AT3 and SIT1 are SLC6A18 and SLC6A20 respectively. Transporters in this subgroup may play a role in disorders including major depression, Hartnup disorder, increased susceptibility to myocardial infarction, and iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271364  Cd Length: 531  Bit Score: 285.32  E-value: 4.23e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   2 LVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGT 81
Cdd:cd10332   203 LIIFFIRGLTLKGAGDGLKHMFTPKFEKLLDPQVWLDAATQIFFSLGLGFGSLIAFSSYNPPKNNCQRDAVLVSLINCFT 282
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  82 SFVAGFAIFSILGFMS------QEQGVPISEV--------AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDS 147
Cdd:cd10332   283 SIFASIVVFSVLGFKInnvtltENQTLGLTNCsledeldeAVQGTGLAFIVFTEAITKMPGAPFWSVLFFLMLLTLGLGS 362
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 148 QFVCVESLVTALVDMYphvFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWV 227
Cdd:cd10332   363 MFGTLEGVVTPLFDSK---ILPKVPKEYLTGLVCLVCFLIGLIFTQRSGNYWVQMFDSYAGT-LPLLIIALFEMIAVSYV 438
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 228 YGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKY--TPLTY---NKKYT------YPWWGDALGWLLAL 296
Cdd:cd10332   439 YGLDRFEEDIEYMTGKRPGWYWKITWRYVSPLLMLVILVASIIQLitKPPTYsawNAELAkteslpYPNWGLAVIILLIL 518
                         330
                  ....*....|...
gi 1034581235 297 SSMVCIPAWSLYR 309
Cdd:cd10332   519 LSILPIPGVALLR 531
SLC6sbd_ATB0 cd11501
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also ...
1-330 2.29e-91

Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also known as the beta-alanine carrier) is a transmembrane transporter with a broad substrate specificity; it can transport non-alpha-amino acids such as beta-alanine with low affinity, and can transport dipolar and cationic amino acids such as leucine and lysine, with a higher affinity. It may have a role in the absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract. Human ATB0+ is encoded by the SLC6A14 gene. ATB0+ is expressed in the lung, trachea, salivary gland, mammary gland, stomach, and pituitary gland. ATB0+ may play a role in obesity, and its upregulation may have a pathogenic role in colorectal cancer. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271391  Cd Length: 602  Bit Score: 285.24  E-value: 2.29e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYL--YPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLN 78
Cdd:cd11501   236 VLLILLVRGATLEGASDGIEYYIgaQSNITKLMEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFHNNCYSDAIVVCVTN 315
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  79 SGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTA 158
Cdd:cd11501   316 CLTSVFAGFAIFSVLGHMAHVSGRPVSEVVDSGFDLAFIAYPEALSKLPISPLWSILFFFMLLTLGLDSQFASIETITTT 395
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 159 LVDMYPHVFRKKnrREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAAsGMCLLFVAIFESLCVAWVYGAKRFYDNIE 238
Cdd:cd11501   396 IQDAYPKVMKKM--RIPITLGVCVILFLLGLVCVTQAGIYWVNLIDHFCA-GWGILFAAVLELVGIIWIYGGNRFIEDIE 472
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 239 DMIGYRPWPL---IKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKG 315
Cdd:cd11501   473 MMIGAKSWIFwlwWRACWFFITPVLLIAILIWSLVTFHSPTYG-SVPYPDWGTALGWCMIIFCLIWIPIVAVIKIIKAKG 551
                         330
                  ....*....|....*
gi 1034581235 316 PFRERIRQLMCPAED 330
Cdd:cd11501   552 NLFQRIKSCCRPTSN 566
SLC6sbd_SERT cd11513
Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also ...
1-327 2.54e-83

Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also called 5-HTT), is a transmembrane transporter that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The antiport of a K+ ion is believed to follow the transport of serotonin and promote the reorientation of SERT for another transport cycle. Human SERT is encoded by the SLC6A4 gene. SERT is expressed in brain, peripheral nervous system, placenta, epithelium, and platelets. SERT may play a role in diseases or disorders including anxiety, depression, autism, gastrointestinal disorders, premature ejaculation, and obesity. It may also have a role in social cognition. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271399  Cd Length: 537  Bit Score: 262.84  E-value: 2.54e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11513   213 VLFILLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLALASYNKFNNNCYQDALVTSVVNCL 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVA-ESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTAL 159
Cdd:cd11513   293 TSFVSGFVIFTVLGYMAEMRNEDVSEVAkDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAV 372
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 160 VDMYPHVFRKknRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYaASGMCLLFVAIFESLCVAWVYGAKRFYDNIED 239
Cdd:cd11513   373 LDEFPHVWSK--RREKFVLGLVIVCFLGSLATLTFGGAYVVKLLEEY-ATGPAVLTVVLLEAVAVSWFYGITQFCNDVKE 449
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 240 MIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRE 319
Cdd:cd11513   450 MLGFSPGWFWRVCWVAISPLFLLFIICSFLMNPPQLRLF-DYNYPYWSIVVGYCIGTSSIICIPIYMAYRLIITPGTLKE 528

                  ....*...
gi 1034581235 320 RIRQLMCP 327
Cdd:cd11513   529 RIIKSITP 536
SLC6sbd_u1 cd10334
uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 ...
1-300 2.19e-62

uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 271366 [Multi-domain]  Cd Length: 480  Bit Score: 206.58  E-value: 2.19e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd10334   183 LFLILVIRALTLPGAADGLNALFTPDWSALLDPKVWIAAYGQIFFSLSLGFGIMITYASYLPKKSDLTNNALITAFANSG 262
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAV-VMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTAL 159
Cdd:cd10334   263 FEILAGIGVFSILGFMAQAQGVPVSEVVSSGIGLAFVAFPKAInLMPPLGALFGVLFFLSLVFAGLTSLISLVEVVISAV 342
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 160 VDMYpHVFRKKnrrevLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIED 239
Cdd:cd10334   343 QDKF-GLSRKK-----AVTIVCLVGFLVSLLFATGAGLYLLDIVDHFINN-YGIVLVGLVEVIVVGWVFGAEKLREHLNA 415
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034581235 240 MIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNkkyTYPWWGD-ALGWLLALSSMV 300
Cdd:cd10334   416 VSDFKVGKWWDFLIKVVTPLVLGYMLILGLIGLLTEPYG---GYPVWALlLFGWGIVALILV 474
SLC6sbd_NTT4-like cd11515
Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; ...
1-303 1.07e-57

Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of NTT4 (also called XT1) and SBAT1 (also called B0AT2, v7-3, NTT7-3); both these proteins can transport neutral amino acids. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons, and may play an important role in synaptic transmission. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271400 [Multi-domain]  Cd Length: 530  Bit Score: 195.55  E-value: 1.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11515   204 VLICFLIRALLLNGSVDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFF 283
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQ---EQGVPISEV-----------AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLD 146
Cdd:cd11515   284 TSVLATLVVFAVLGFKIQkvkEEEFPALHLnpcliedelnkAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLG 363
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 147 SQFVCVESLVTALVDMYphvfrkKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAW 226
Cdd:cd11515   364 SMFGTIEGITTPIVDTF------KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVAF 436
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 227 VYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKY--TPLTYN---------KKYTYPWWGDALGWLLA 295
Cdd:cd11515   437 VYGIDKFMEDLKDMLGFRPYRYYYYMWKYISPLMLLSLLIASIVNMglSPPGYNawiedkaseRFLSYPTWGMVLCISLI 516

                  ....*...
gi 1034581235 296 LSSMVCIP 303
Cdd:cd11515   517 VVAILPIP 524
SLC6sbd_B0AT3 cd11517
glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports ...
1-310 2.30e-56

glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports glycine. Human B0AT3 is encoded by the SLC6A18 gene. B0AT3 is expressed in the kidney. Mutations in the SLC6A18 gene may contribute to the autosomal recessive disorder iminoglycinuria and its related disorder hyperglycinuria. SLC6A18 or its neighboring genes are associated with increased susceptibility to myocardial infarction. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212086 [Multi-domain]  Cd Length: 576  Bit Score: 193.11  E-value: 2.30e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11517   203 VLTIFLIRGLTLPGATEGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNPPRNDCEKDAVTIALVNSM 282
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQ---------------------EQGVPISEV-------------------------------A 108
Cdd:cd11517   283 TSLYASIPVFSVLGFKATndyehcldrnilslinefdfpEQSISRDNYpsvlmhlnatwpervaqlplkaclledfldkS 362
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 109 ESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMypHVFRKKNRREVLILGVSVVSFLVG 188
Cdd:cd11517   363 ASGPGLAFIVFTEAVLHMPGAQVWAVLFFGMLFTLGLSSMFGNVEGVITPLLDV--GVLPRWVPKEALTGLVCLVCFLSA 440
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 189 LIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFL-- 266
Cdd:cd11517   441 LCFTLQSGNYWLEIFDSFAAS-LNLLVIAFFEVVGVVYVYGIKRFCDDIEWMTGRRPSLYWRLTWRVVSPLLLLTIFVay 519
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034581235 267 FSLIKYTPLTY---NKKY---------TYPWWGDALGWLLALSSMVCIPAWSLYRL 310
Cdd:cd11517   520 IILLFQKPPSYkawNPKYelfpsreekLYPGWVQAICVLLSLLPVLWVPVVALAQL 575
SLC6sbd_B0AT1 cd11516
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also ...
1-310 7.21e-52

Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also called HND) transports neutral amino acids. Human B0AT1 is encoded by the SLC6A19 gene. B0AT1 is expressed primarily in the kidney and intestine; it requires collectrin for expression in the kidney, and angiotensin-converting enzyme 2 for expression in the intestine. Interaction with these two proteins implicates B0AT1 in more complex processes such as glomerular structure, exocytosis, and blood pressure control. The autosomal recessive disorder, Hartnup disorder, is caused by mutations in B0AT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212085 [Multi-domain]  Cd Length: 581  Bit Score: 181.24  E-value: 7.21e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11516   202 VLTIFLIRGLTLKGSVNGIKFLFTPDINELANPVTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEKDAVIISVINGF 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQEQ----------------GVPISEVAES---------------------------------- 110
Cdd:cd11516   282 TSIYAATVIYSIIGFRATERfddcfdgniltlinafDLPEGNITQDnyqdmqqslnstdpdiisslslqtcdlnnflseg 361
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 111 --GPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMypHVFRKKNRREVLILGVSVVSFLVG 188
Cdd:cd11516   362 veGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVLVPLQDL--KVIPKSWPKEIITGLICLVSFLIG 439
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 189 LIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFS 268
Cdd:cd11516   440 LIFVLGSGNYWLALFDSFAGS-IPLLIIAFCEMFSVVYVYGIDRFNKDIEFMIGHKPNIFWQATWRVISPLIMLVIFLFY 518
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034581235 269 LI--------------KYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRL 310
Cdd:cd11516   519 FVvkvsqelfysawdpEYEEFPKSQKISYPTWIYVIIVILAGVPSLAIPGYAIYKA 574
SLC6sbd_u2 cd11554
uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins ...
1-232 1.72e-50

uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, and are the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 212092 [Multi-domain]  Cd Length: 406  Bit Score: 173.66  E-value: 1.72e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPN-LTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNS 79
Cdd:cd11554   149 LIIILLGRGASLPNAGDGIRLYFATWrGDKLASGEIWQAAAGQVFFSTGVGFGYMTAYASYNSKFSNAVQDALIIAGSNS 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  80 GTSFVAGFAIFSILGFMSQEQGVpiSEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTAL 159
Cdd:cd11554   229 LFEIIAGFAVFGIVGYLGMTPGV--EGEALGGFVLGFVTYPEAIAQMPGSNFFAVLFFLTLFLLGISSAFALLEAVVTLI 306
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034581235 160 VDMYphvFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYaASGMCLLFVAIFESLCVAWVYGAKR 232
Cdd:cd11554   307 CDSG---WGRKVKRWWIATVVCFVSFLLSLPYCTRFGYYLLDAVDAW-ISNVALVFVVWAECVAATTVYRFED 375
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
1-269 8.99e-50

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 172.59  E-value: 8.99e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:COG0733   182 LLIILVIRALTLPGAAEGLKFLFTPDFSKLTDPEVWLAALGQAFFSLSLGMGIMITYGSYLPKDEDLPRSALIVALLDTL 261
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILgFMSqeqGVPISevaeSGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:COG0733   262 VALLAGLAIFPAV-FAF---GLEPA----AGPGLAFVTLPAVFAQMPGGRLFGVLFFLLLLFAALTSAISLLEVVVAALI 333
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DmyphvfRKKNRREVLILGVSVVSFLVGLIMLT------EGGMYVFQLFDYYAASGMcLLFVAIFESLCVAWVYGAKRFY 234
Cdd:COG0733   334 D------KFGLSRKKATLIVGLLIFLLGIPSALsfnvsvTIGLTFFDLVDFLVSNIL-LPLGGLLIAIFVGWVLGKEKLR 406
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1034581235 235 DNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSL 269
Cdd:COG0733   407 EELNAGSDIKLGKWWRFLIRYVAPVALLIIFLNGL 441
SLC6sbd_SBAT1 cd11522
Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also ...
1-303 1.59e-48

Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also called B0AT2, v7-3, NTT7-3) is a high-affinity Na(+)-dependent transporter for large neutral amino acids, including leucine, isoleucine, valine, proline and methionine. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212091 [Multi-domain]  Cd Length: 580  Bit Score: 172.03  E-value: 1.59e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11522   204 VLICFLIRALLLNGSVDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFF 283
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGF-------------------------MSQE-----------------------QGVPISEV----- 107
Cdd:cd11522   284 TSVLATLVVFAVLGFkanvinekciiqnsekiikllkmgnLSQDiiphhinfssitaedynlvydiiQKVKEEEFpalgl 363
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 108 -----------AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYphvfrkKNRREVL 176
Cdd:cd11522   364 kscqiedelnkAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIITPIVDTF------KVRKEIL 437
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 177 ILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFL 256
Cdd:cd11522   438 TVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVSFVYGIDKFMEDLKDMLGFTPNRYYYYMWKYI 516
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034581235 257 TPAVCTATFLFSLIKY--TPLTYN---------KKYTYPWWGDALGWLLALSSMVCIP 303
Cdd:cd11522   517 SPLVLLSLLVASVVQMglSPPGYNawiedkateEFLSYPTWGLVVCISLVVLAILPVP 574
SLC6sbd_NTT4 cd11521
Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) ...
1-303 6.29e-48

Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) transports the neutral amino acids, proline, glycine, leucine, and alanine, and may play an important role in synaptic transmission. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271403 [Multi-domain]  Cd Length: 589  Bit Score: 170.55  E-value: 6.29e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11521   204 VLVCFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFF 283
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGF----MSQEQGVPISE---------------------------------------VAE-------- 109
Cdd:cd11521   284 TSVLATLVVFAVLGFkaniMNEKCVVENAEkilgylntnvlshdlipphvnfshlttkdynemyrvimtVKEdhfkelgl 363
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 110 -------------SGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYphvfrkKNRREVL 176
Cdd:cd11521   364 daclledeldksvQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMSGITTPIIDTF------KVRKEVF 437
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 177 ILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFL 256
Cdd:cd11521   438 TVGCCIFAFLVGLIFVQRSGNYFVTMFDDYSAT-LPLTVVVILENIAVAWIYGTKKFMQELTEMLGFRPYQFYFYTWKYV 516
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034581235 257 TPaVCTATFLFSLI---KYTPLTYN---------KKYTYPWWgdALGWLLALSSMVCIP 303
Cdd:cd11521   517 SP-ICMAVLMTASIiqlGVSPPGYSawireeaaeKFLFYPTW--AMALLITLIILASLP 572
SLC6sbd_SIT1 cd11518
Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also ...
1-303 2.41e-45

Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also called XTRP3, XT3, IMINO) transports imino acids, such as proline, pipecolate, MeAIB, and sarcosine. It has weak affinity for neutral amino acids such as phenylalanine. Human SIT1 is encoded by the SLC6A20 gene. SIT1 is expressed in brain, kidney, small intestine, thymus, spleen, ovary, and lung. SLC6A20 is a candidate gene for the rare disorder iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271401 [Multi-domain]  Cd Length: 576  Bit Score: 163.21  E-value: 2.41e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11518   205 VLLIYLIRGLTLHGAANGLAYMFTPKLEQLANPKTWINAATQIFFSLGLGFGSLIAFASYNEPSNNCERHAIIVSLINSG 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQ--------------------EQGVPISE---------------------------------- 106
Cdd:cd11518   285 TSIFASIVTFSIYGFKATfnyencmkkvillltntfdlEEGSVTTEnlgdmknylasafpqeyssivpqikncslekeld 364
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 107 VAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDmyPHVFRKKNRREVLILGVSVVSFL 186
Cdd:cd11518   365 TAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFLMLLMLGIGSMLGNTAAILTPLTD--SKFISSHLPKEAISGLLCFTNCI 442
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 187 VGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFL 266
Cdd:cd11518   443 IGLVFTMEAGNYWFDIFNDYAAT-LSLLLIVLVETIAVCYVYGLRRFENDLEAMTGHKLSWYWKIMWAFVSPLLIVSLFI 521
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034581235 267 FSLIKYTpLTYNKKYT-------------YPWWGDALGWLLALSSMVCIP 303
Cdd:cd11518   522 FYLTDYI-MTGTLQYQawdatlgqlvtkdYPPYALAVIGLLVAASTCCIP 570
SLC6sbd_NTT5 cd11502
Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 ...
1-303 7.19e-42

Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 gene. NTT5 is expressed in testis, pancreas, and prostate; its expression is predominantly intracellular, indicative of a vesicular location. Its substrates are unknown. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271392  Cd Length: 535  Bit Score: 153.36  E-value: 7.19e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd11502   202 ILLCFLIRTLFLEGAKFGLKHLLVAKVSALYSLSVWRQAGGQVLYSLGLGFGTIISFSSYMPRSNNCLKDAFLVALVNLV 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILGFMSQE--------QGVP-------ISEV-----------AESGPGLAFIAYPRAVVMLPFSPLWAC 134
Cdd:cd11502   282 TSLLTTPFIFAVLGFWATPasiylswlNNLPqhiksqvLSKVpecsiqkqkekIMEGPGFAFLAFSEAISLFPGSSFWSI 361
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 135 CFFFMVVLLGLDSQFVCVESLVTALVDMYPhVFRKKNRreVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLL 214
Cdd:cd11502   362 LFFLMLLILGLSTMLGIMQGIITPLQDTFS-FFRKHPK--LLTVGVCLLMFLCSLIFTRPSGSYYVSLLDDYWVP-MPII 437
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 215 FVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYT--PLTY---------NKKYTY 283
Cdd:cd11502   438 FIVICENLAVAWAYGAKRFLADLMILLGHPISPIFTWLWCYLTPVVLLVLFTITLIQLYvkPITYlawdsstshEVTRPY 517
                         330       340
                  ....*....|....*....|
gi 1034581235 284 PWWgdALGWLLALSSMVCIP 303
Cdd:cd11502   518 PSW--ALGLVIFLSVIVLLP 535
SLC6sbd_Tyt1-Like cd10336
solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 ...
1-269 6.86e-33

solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271367 [Multi-domain]  Cd Length: 440  Bit Score: 127.17  E-value: 6.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLPGAAQGIQFYLYPNLTRLwDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 80
Cdd:cd10336   178 LLIILAIRSLTLPGAGEGLKFLLKPDFSKL-TPEVVLAALGQAFFSLSLGMGVMITYGSYLSKDENLPKSALIVAVLDTL 256
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  81 TSFVAGFAIFSILgFmsqEQGVPisevAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALV 160
Cdd:cd10336   257 VALLAGLVIFPAV-F---AFGLD----PAAGPGLLFITLPAVFAQMPGGRLFGILFFLLLLFAALTSAISLLEVVVAYLI 328
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 161 DMYpHVFRKKNRReVLILGVSVVSFLVGL-----IMLTEGGMYVFQLFDyYAASGMCLLFVAIFESLCVAWVYGAKRFYD 235
Cdd:cd10336   329 DEF-GWSRKKATL-IVGIIIFLLGIPSALsfgvlSDVTIFGKTFFDLLD-FLVSNILLPLGGLLIAIFVGWVLGKEALLE 405
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1034581235 236 NIE-DMIGYRPWPLIKYCWLFLTPAVCTATFLFSL 269
Cdd:cd10336   406 ELNkGGLGKKLFKIWLFLLRYVAPVAILIIFLLGL 440
SLC5-6-like_sbd cd06857
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
1-267 6.37e-22

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


Pssm-ID: 271356 [Multi-domain]  Cd Length: 407  Bit Score: 95.89  E-value: 6.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   1 MLVVLLIRGVTLP--GAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLN 78
Cdd:cd06857   144 LLLVLTVRALFLEgaGASEGLNKGGTPDFMELNNSGIWTAATIQVFFSLGAGWGSVITIASFCLFKKNAQRDALIAAFLN 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  79 SGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTA 158
Cdd:cd06857   224 LIASIIFVGLIGIAAGVLSFDPQNMVVLGLLNSLYLTFIASPQAISSLAGSNLWAFLYYAALLLAGLSSMATITNTVAQS 303
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 159 LVDmyphVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGmcLLFVAIFESLCVAWVYGAKRFYDNIE 238
Cdd:cd06857   304 LFD----EFRRKLKTGVIDTALIVVLLVAAVIFLVLGLRILFLTDKQLVGTS--VVPLLLILLLVVFWIYGRERIQRDIE 377
                         250       260
                  ....*....|....*....|....*....
gi 1034581235 239 DMIGYRPWPLIKYCWlFLTPAVCTATFLF 267
Cdd:cd06857   378 FMLGPVGSIVWFWLW-VIAPAILVIILVW 405
LeuT-like_sbd cd10333
Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino ...
3-296 3.50e-18

Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino acid transporter with specificity for the hydrophobic amino acids glycine, alanine, methionine, and leucine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family; LeuT has been used as a structural template for understanding fundamental aspects of SLC6 function. It has an arrangement of 12 transmembrane helices (TMs), which appears to be a common motif for eukaryotic and some prokaryotic and archaeal SLC6s: an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12.


Pssm-ID: 271365 [Multi-domain]  Cd Length: 496  Bit Score: 85.44  E-value: 3.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235   3 VVLLIRGVTLP-------GAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALC 75
Cdd:cd10333   187 IILLIRVLTLGspvnpnwTALKGLNFLWNPDFSKLKNPKVWLAAAGQIFFTLSLGMGIIQNYASYLKKDDDVVLSGLTAA 266
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235  76 FLNSGTSFVAG--FAIFSILGFMsqeqGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVE 153
Cdd:cd10333   267 SLNEFAEVILGgsIAIPAAFAFL----GVAVAIAKAGGFGLGFIALPNVFSQMPGGQFFGFLWFLLLFFAGITSSIAMYQ 342
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581235 154 SLVTALVDMyphvFRKKNRREVLIlgVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMcLLFVAIFESLCVAWVYGAKRF 233
Cdd:cd10333   343 PLIAFLEEE----LGISRKHAAWV--VFAIVFFLGLPVVLEFDLKALDELDFWVGTIL-LVILGLIEIIVFGWIFGAKKG 415
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034581235 234 YDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLAL 296
Cdd:cd10333   416 WEEINRGALIKVPRFYKYVMKYITPAFLAVVLVFWTISYIPKGYFKMNLIPTVWIARFVIIGL 478
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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