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Conserved domains on  [gi|1034581668|ref|XP_016875474|]
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transcription termination factor 2, mitochondrial isoform X1 [Homo sapiens]

Protein Classification

mTERF domain-containing protein( domain architecture ID 139977)

mTERF (mitochondrial transcription termination factor) domain-containing protein may function as a transcription termination factor that binds promoter DNA and regulates mitochondrial replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mTERF super family cl47744
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 58-360 2.28e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


The actual alignment was detected with superfamily member pfam02536:

Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 81.88  E-value: 2.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668  58 DIRKIRRLKGWVLLED-ETYVEEIANILQELGADETAVASILERCPEAIVCSPtaVNTQRKLWQLV--CKNEEELIKLIE 134
Cdd:pfam02536  13 QISKILTRYPPVLHADvEKDLAPKLQFLLSLGASSSDLGKILSKYPRILGFKL--EETMSTSVDFLkeIGVDKSSIGGAL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 135 QFPESFFTIKDQENQKLNVQFFQELGLKNVVISRLLTAAPNVFHNPVEKNKQMVRILQ--ESYLDVGGSEANmkVWllKL 212
Cdd:pfam02536  91 RSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKPKTFEEkvEFLKELGFSVED--VW--KI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 213 LSQNPFILLNSPTA-IKETLEFLQEQGFTSFEILQLLSKLKGFLfQLCPRSIQNSISFSKNaFKCTDHDLKQLVLKCPAL 291
Cdd:pfam02536 167 IKKCPEILGLSIEKkLKKKIEFLKKCGLSEEELPRVIKKYPQIL-SLSERTILNRVEFLLG-LGFSKEEVAKMVKRFPQL 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034581668 292 LYYSVPVLEERMQGLLRE-GISIAQIRETPMVL--ELTPQIVQyRIRKLNSSGYR--IKDGhlanLNGSKKEFE 360
Cdd:pfam02536 245 LGLSIEVLKPKLEFLVKEmKWPLKEVVEYPRVFgySLEKRIKP-RIKALVSKGLEcsLSWM----LACSDERFL 313
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 58-360 2.28e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 81.88  E-value: 2.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668  58 DIRKIRRLKGWVLLED-ETYVEEIANILQELGADETAVASILERCPEAIVCSPtaVNTQRKLWQLV--CKNEEELIKLIE 134
Cdd:pfam02536  13 QISKILTRYPPVLHADvEKDLAPKLQFLLSLGASSSDLGKILSKYPRILGFKL--EETMSTSVDFLkeIGVDKSSIGGAL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 135 QFPESFFTIKDQENQKLNVQFFQELGLKNVVISRLLTAAPNVFHNPVEKNKQMVRILQ--ESYLDVGGSEANmkVWllKL 212
Cdd:pfam02536  91 RSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKPKTFEEkvEFLKELGFSVED--VW--KI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 213 LSQNPFILLNSPTA-IKETLEFLQEQGFTSFEILQLLSKLKGFLfQLCPRSIQNSISFSKNaFKCTDHDLKQLVLKCPAL 291
Cdd:pfam02536 167 IKKCPEILGLSIEKkLKKKIEFLKKCGLSEEELPRVIKKYPQIL-SLSERTILNRVEFLLG-LGFSKEEVAKMVKRFPQL 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034581668 292 LYYSVPVLEERMQGLLRE-GISIAQIRETPMVL--ELTPQIVQyRIRKLNSSGYR--IKDGhlanLNGSKKEFE 360
Cdd:pfam02536 245 LGLSIEVLKPKLEFLVKEmKWPLKEVVEYPRVFgySLEKRIKP-RIKALVSKGLEcsLSWM----LACSDERFL 313
PLN03196 PLN03196
MOC1-like protein; Provisional
 127-304 3.45e-03

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 39.31  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 127 EELIKLIEQFPEsFFTIKDQENQKLNVQFFQELGLKNVVISRLLTAAPNVFHNPVEKNKQMVRILQESYLDVGGSEanmk 206
Cdd:PLN03196  247 LAVARILEKRPY-ILGFDLEETVKPNVECLLEFGVRKEALPSVIAQYPDILGLDLKAKLAEQQYWLTSKLKIDPED---- 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 207 vwLLKLLSQNPFILLNSPTAIKETLEFLQEQGFTSFEILQLLSKLKGFLfQLCPRSIQNSISFSKNAFKctdHDLKQLVl 286
Cdd:PLN03196  322 --FGRVIEKLPQIVSLNRNVALKHVEFLRGRGFSAQDVAKMVVRCPQIL-ALNLEIMKPSLEFFKKEMK---RPLKELV- 394

                         170
                  ....*....|....*...
gi 1034581668 287 KCPALLYYSvpvLEERMQ 304
Cdd:PLN03196  395 EFPAYFTYG---LESRIK 409
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 58-360 2.28e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 81.88  E-value: 2.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668  58 DIRKIRRLKGWVLLED-ETYVEEIANILQELGADETAVASILERCPEAIVCSPtaVNTQRKLWQLV--CKNEEELIKLIE 134
Cdd:pfam02536  13 QISKILTRYPPVLHADvEKDLAPKLQFLLSLGASSSDLGKILSKYPRILGFKL--EETMSTSVDFLkeIGVDKSSIGGAL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 135 QFPESFFTIKDQENQKLNVQFFQELGLKNVVISRLLTAAPNVFHNPVEKNKQMVRILQ--ESYLDVGGSEANmkVWllKL 212
Cdd:pfam02536  91 RSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKPKTFEEkvEFLKELGFSVED--VW--KI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 213 LSQNPFILLNSPTA-IKETLEFLQEQGFTSFEILQLLSKLKGFLfQLCPRSIQNSISFSKNaFKCTDHDLKQLVLKCPAL 291
Cdd:pfam02536 167 IKKCPEILGLSIEKkLKKKIEFLKKCGLSEEELPRVIKKYPQIL-SLSERTILNRVEFLLG-LGFSKEEVAKMVKRFPQL 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034581668 292 LYYSVPVLEERMQGLLRE-GISIAQIRETPMVL--ELTPQIVQyRIRKLNSSGYR--IKDGhlanLNGSKKEFE 360
Cdd:pfam02536 245 LGLSIEVLKPKLEFLVKEmKWPLKEVVEYPRVFgySLEKRIKP-RIKALVSKGLEcsLSWM----LACSDERFL 313
PLN03196 PLN03196
MOC1-like protein; Provisional
 127-304 3.45e-03

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 39.31  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 127 EELIKLIEQFPEsFFTIKDQENQKLNVQFFQELGLKNVVISRLLTAAPNVFHNPVEKNKQMVRILQESYLDVGGSEanmk 206
Cdd:PLN03196  247 LAVARILEKRPY-ILGFDLEETVKPNVECLLEFGVRKEALPSVIAQYPDILGLDLKAKLAEQQYWLTSKLKIDPED---- 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581668 207 vwLLKLLSQNPFILLNSPTAIKETLEFLQEQGFTSFEILQLLSKLKGFLfQLCPRSIQNSISFSKNAFKctdHDLKQLVl 286
Cdd:PLN03196  322 --FGRVIEKLPQIVSLNRNVALKHVEFLRGRGFSAQDVAKMVVRCPQIL-ALNLEIMKPSLEFFKKEMK---RPLKELV- 394

                         170
                  ....*....|....*...
gi 1034581668 287 KCPALLYYSvpvLEERMQ 304
Cdd:PLN03196  395 EFPAYFTYG---LESRIK 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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