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Conserved domains on  [gi|1034588736|ref|XP_016877329|]
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disks large-associated protein 5 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GKAP super family cl24154
Guanylate-kinase-associated protein (GKAP) protein;
414-601 5.18e-20

Guanylate-kinase-associated protein (GKAP) protein;


The actual alignment was detected with superfamily member pfam03359:

Pssm-ID: 460897  Cd Length: 341  Bit Score: 92.48  E-value: 5.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 414 PSLERNEGRIAQPHHGVP-------YFRNILQSETEKLTSHCFEWDRKL-ELDIPDDAKDLIRTAVGQTRLLMKERFKQF 485
Cdd:pfam03359 131 PWLEDGPRSLPDSGRASPvcrrdgeWFLKLLQAETERMEGWCQQMEREAeENDLPEEILGKIRSAVGSAQLLMSQKFQQF 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 486 EGLvddCE-------YKRgikeTTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNknvfrKKVVSGI 558
Cdd:pfam03359 211 RGL---CEqnlnpnaNPR----PTSQDLAGFWDLLQLSIEDISMKFDELHQLKANNWKLEDPPEKKEN-----KKLPPPV 278
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034588736 559 ASKP----------KQDDAG---RIAARNRLAAIKNAmrERIRQEECAETAVSV---IP 601
Cdd:pfam03359 279 PKKPskgrpplvreRSLDSVdrqRQEARKRLMAAKRA--ASVRQNSATESADSIeiyIP 335
PspC_subgroup_1 super family cl41462
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
24-196 7.46e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


The actual alignment was detected with superfamily member NF033838:

Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.08  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736  24 AHRKSLSQKENRHKEYERNRHfglkdvniPTLEGRIL---VELDETSQGLVPEKTNvKPRAMKTIlgDQRKQMLQKYKEE 100
Cdd:NF033838  151 AEKKAKDQKEEDRRNYPTNTY--------KTLELEIAesdVEVKKAELELVKEEAK-EPRDEEKI--KQAKAKVESKKAE 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 101 -KQLQKLKEQREKAKRGifkvGRYRPDMPCFLLSNQNAVKAEPKKaiPSSvRITRSKAKDQMEQTKIDNESDVRAIRPG- 178
Cdd:NF033838  220 aTRLEKIKTDREKAEEE----AKRRADAKLKEAVEKNVATSEQDK--PKR-RAKRGVLGEPATPDKKENDAKSSDSSVGe 292
                         170       180
                  ....*....|....*....|...
gi 1034588736 179 -----PRQTSEKKVSDKEKKVVQ 196
Cdd:NF033838  293 etlpsPSLKPEKKVAEAEKKVEE 315
 
Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
414-601 5.18e-20

Guanylate-kinase-associated protein (GKAP) protein;


Pssm-ID: 460897  Cd Length: 341  Bit Score: 92.48  E-value: 5.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 414 PSLERNEGRIAQPHHGVP-------YFRNILQSETEKLTSHCFEWDRKL-ELDIPDDAKDLIRTAVGQTRLLMKERFKQF 485
Cdd:pfam03359 131 PWLEDGPRSLPDSGRASPvcrrdgeWFLKLLQAETERMEGWCQQMEREAeENDLPEEILGKIRSAVGSAQLLMSQKFQQF 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 486 EGLvddCE-------YKRgikeTTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNknvfrKKVVSGI 558
Cdd:pfam03359 211 RGL---CEqnlnpnaNPR----PTSQDLAGFWDLLQLSIEDISMKFDELHQLKANNWKLEDPPEKKEN-----KKLPPPV 278
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034588736 559 ASKP----------KQDDAG---RIAARNRLAAIKNAmrERIRQEECAETAVSV---IP 601
Cdd:pfam03359 279 PKKPskgrpplvreRSLDSVdrqRQEARKRLMAAKRA--ASVRQNSATESADSIeiyIP 335
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
24-196 7.46e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.08  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736  24 AHRKSLSQKENRHKEYERNRHfglkdvniPTLEGRIL---VELDETSQGLVPEKTNvKPRAMKTIlgDQRKQMLQKYKEE 100
Cdd:NF033838  151 AEKKAKDQKEEDRRNYPTNTY--------KTLELEIAesdVEVKKAELELVKEEAK-EPRDEEKI--KQAKAKVESKKAE 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 101 -KQLQKLKEQREKAKRGifkvGRYRPDMPCFLLSNQNAVKAEPKKaiPSSvRITRSKAKDQMEQTKIDNESDVRAIRPG- 178
Cdd:NF033838  220 aTRLEKIKTDREKAEEE----AKRRADAKLKEAVEKNVATSEQDK--PKR-RAKRGVLGEPATPDKKENDAKSSDSSVGe 292
                         170       180
                  ....*....|....*....|...
gi 1034588736 179 -----PRQTSEKKVSDKEKKVVQ 196
Cdd:NF033838  293 etlpsPSLKPEKKVAEAEKKVEE 315
 
Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
414-601 5.18e-20

Guanylate-kinase-associated protein (GKAP) protein;


Pssm-ID: 460897  Cd Length: 341  Bit Score: 92.48  E-value: 5.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 414 PSLERNEGRIAQPHHGVP-------YFRNILQSETEKLTSHCFEWDRKL-ELDIPDDAKDLIRTAVGQTRLLMKERFKQF 485
Cdd:pfam03359 131 PWLEDGPRSLPDSGRASPvcrrdgeWFLKLLQAETERMEGWCQQMEREAeENDLPEEILGKIRSAVGSAQLLMSQKFQQF 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 486 EGLvddCE-------YKRgikeTTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNknvfrKKVVSGI 558
Cdd:pfam03359 211 RGL---CEqnlnpnaNPR----PTSQDLAGFWDLLQLSIEDISMKFDELHQLKANNWKLEDPPEKKEN-----KKLPPPV 278
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034588736 559 ASKP----------KQDDAG---RIAARNRLAAIKNAmrERIRQEECAETAVSV---IP 601
Cdd:pfam03359 279 PKKPskgrpplvreRSLDSVdrqRQEARKRLMAAKRA--ASVRQNSATESADSIeiyIP 335
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
24-196 7.46e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.08  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736  24 AHRKSLSQKENRHKEYERNRHfglkdvniPTLEGRIL---VELDETSQGLVPEKTNvKPRAMKTIlgDQRKQMLQKYKEE 100
Cdd:NF033838  151 AEKKAKDQKEEDRRNYPTNTY--------KTLELEIAesdVEVKKAELELVKEEAK-EPRDEEKI--KQAKAKVESKKAE 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588736 101 -KQLQKLKEQREKAKRGifkvGRYRPDMPCFLLSNQNAVKAEPKKaiPSSvRITRSKAKDQMEQTKIDNESDVRAIRPG- 178
Cdd:NF033838  220 aTRLEKIKTDREKAEEE----AKRRADAKLKEAVEKNVATSEQDK--PKR-RAKRGVLGEPATPDKKENDAKSSDSSVGe 292
                         170       180
                  ....*....|....*....|...
gi 1034588736 179 -----PRQTSEKKVSDKEKKVVQ 196
Cdd:NF033838  293 etlpsPSLKPEKKVAEAEKKVEE 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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