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Conserved domains on  [gi|1034595528|ref|XP_016879025|]
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nucleotide-binding oligomerization domain-containing protein 2 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 71-241 4.05e-44

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 156.70  E-value: 4.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528  71 DTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPD 150
Cdd:pfam05729   1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 151 RVLLTFDGFDEFKFRFtdrerhCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAfLRKYIRTE--FNLKGFSEQ 228
Cdd:pfam05729  81 RLLLILDGLDELVSDL------GQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRD-LRRGLEEPryLEVRGFSES 153

                         170
                  ....*....|...
gi 1034595528 229 GIELYLRKRHHEP 241
Cdd:pfam05729 154 DRKQYVRKYFSDE 166
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 535-809 1.86e-42

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 160.34  E-value: 1.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 535 KAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVaLQLDYNSVGDIGVEQLLPCLGVCKA---LYLRDNNISDRGIC 611
Cdd:COG5238   148 KDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVET-VYLGCNQIGDEGIEELAEALTQNTTvttLWLKRNPIGDEGAE 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 612 KLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGD 691
Cdd:COG5238   227 ILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGD 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 692 EGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNN 771
Cdd:COG5238   307 EGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKN 386

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1034595528 772 CITYLGAEALLQALERNdTILEVWLRGNTFSLEEVDKL 809
Cdd:COG5238   387 NIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRL 423
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
66-409 1.40e-21

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 100.65  E-value: 1.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528  66 LNDDADTVLVVGEAGSGKSTLLQRL-HLLWAAGQDFQEFLFVFpFSCRQLqcmAKPLSVRTLLFEHCCWPDVGQEDIFQL 144
Cdd:COG5635   176 LEAKKKRLLILGEPGSGKTTLLRYLaLELAERYLDAEDPIPIL-IELRDL---AEEASLEDLLAEALEKRGGEPEDALER 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 145 LLDHpDRVLLTFDGFDEFKFRfTDRERhcsptdptsVQTLLFNLLQGnlLKNARKVVTSRPAAV-SAFLRKYirTEFNLK 223
Cdd:COG5635   252 LLRN-GRLLLLLDGLDEVPDE-ADRDE---------VLNQLRRFLER--YPKARVIITSRPEGYdSSELEGF--EVLELA 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 224 GFSEQGIELYLRKRH-HEPGVADRLIRLLQETSALHGLCHLPVFSWMVSkchqeLLLQEGGS-PKTTTDMYLLILQHFLl 301
Cdd:COG5635   317 PLSDEQIEEFLKKWFeATERKAERLLEALEENPELRELARNPLLLTLLA-----LLLRERGElPDTRAELYEQFVELLL- 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 302 hATPPDSASQGLGPSLLRGRLPTLlhLGRLALWGLGMCCYVFSAQQLQ-------AAQVSPDDI------SLGFLV-RAK 367
Cdd:COG5635   391 -ERWDEQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEeilreylGRRKDAEALldelllRTGLLVeRGE 467

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1034595528 368 GVVpgstaplEFLHITFQCFFAAFYLA--LSADVPPALLRHLFN 409
Cdd:COG5635   468 GRY-------SFAHRSFQEYLAARALVeeLDEELLELLAEHLED 504
NLRC4_HD2 super family cl39284
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 381-535 3.45e-14

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


The actual alignment was detected with superfamily member pfam17776:

Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 69.63  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 381 HITFQCFFAAFYLALSADV-PPALLRHLFNCGRpgnspmarllptmciqaSEGKDSSVAALLQKAEPHnLQITAAFLAGL 459
Cdd:pfam17776   1 HLSFQEFFAALFYVLSFKEeKSNPLKEFFGLRK-----------------RESLKSLLDKALKSKNGH-LDLFLRFLFGL 62

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034595528 460 LSREHWGLLAECQTSEKALLRRQAcARWCLARSLRKHFHSippaapgeaksvhamPGFIWLIRSLYEMQEERLARK 535
Cdd:pfam17776  63 LNEENQRLLEGLLGCKLSSEIKQE-LLQWIKSLIQKELSS---------------ERFLNLFHCLYELQDESFVKE 122
 
Name Accession Description Interval E-value
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 71-241 4.05e-44

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 156.70  E-value: 4.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528  71 DTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPD 150
Cdd:pfam05729   1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 151 RVLLTFDGFDEFKFRFtdrerhCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAfLRKYIRTE--FNLKGFSEQ 228
Cdd:pfam05729  81 RLLLILDGLDELVSDL------GQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRD-LRRGLEEPryLEVRGFSES 153

                         170
                  ....*....|...
gi 1034595528 229 GIELYLRKRHHEP 241
Cdd:pfam05729 154 DRKQYVRKYFSDE 166
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 535-809 1.86e-42

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 160.34  E-value: 1.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 535 KAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVaLQLDYNSVGDIGVEQLLPCLGVCKA---LYLRDNNISDRGIC 611
Cdd:COG5238   148 KDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVET-VYLGCNQIGDEGIEELAEALTQNTTvttLWLKRNPIGDEGAE 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 612 KLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGD 691
Cdd:COG5238   227 ILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGD 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 692 EGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNN 771
Cdd:COG5238   307 EGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKN 386

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1034595528 772 CITYLGAEALLQALERNdTILEVWLRGNTFSLEEVDKL 809
Cdd:COG5238   387 NIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRL 423
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 545-810 3.21e-30

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 122.08  E-value: 3.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 545 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDI--GVEQLLPCLGVCKAL---YLRDNNISDRGiCKLIECALH 619
Cdd:cd00116    28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLqelDLSDNALGPDG-CGVLESLLR 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 620 CEQLQKLALFNNKLTD-GCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALA 698
Cdd:cd00116   107 SSSLQELKLNNNGLGDrGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 699 EALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKK-NSSLKILKLSNNCITYLG 777
Cdd:cd00116   187 EGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDG 266

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1034595528 778 AEALLQALERNDTILEVWLRGNTFSLEEVDKLG 810
Cdd:cd00116   267 AKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
66-409 1.40e-21

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 100.65  E-value: 1.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528  66 LNDDADTVLVVGEAGSGKSTLLQRL-HLLWAAGQDFQEFLFVFpFSCRQLqcmAKPLSVRTLLFEHCCWPDVGQEDIFQL 144
Cdd:COG5635   176 LEAKKKRLLILGEPGSGKTTLLRYLaLELAERYLDAEDPIPIL-IELRDL---AEEASLEDLLAEALEKRGGEPEDALER 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 145 LLDHpDRVLLTFDGFDEFKFRfTDRERhcsptdptsVQTLLFNLLQGnlLKNARKVVTSRPAAV-SAFLRKYirTEFNLK 223
Cdd:COG5635   252 LLRN-GRLLLLLDGLDEVPDE-ADRDE---------VLNQLRRFLER--YPKARVIITSRPEGYdSSELEGF--EVLELA 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 224 GFSEQGIELYLRKRH-HEPGVADRLIRLLQETSALHGLCHLPVFSWMVSkchqeLLLQEGGS-PKTTTDMYLLILQHFLl 301
Cdd:COG5635   317 PLSDEQIEEFLKKWFeATERKAERLLEALEENPELRELARNPLLLTLLA-----LLLRERGElPDTRAELYEQFVELLL- 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 302 hATPPDSASQGLGPSLLRGRLPTLlhLGRLALWGLGMCCYVFSAQQLQ-------AAQVSPDDI------SLGFLV-RAK 367
Cdd:COG5635   391 -ERWDEQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEeilreylGRRKDAEALldelllRTGLLVeRGE 467

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1034595528 368 GVVpgstaplEFLHITFQCFFAAFYLA--LSADVPPALLRHLFN 409
Cdd:COG5635   468 GRY-------SFAHRSFQEYLAARALVeeLDEELLELLAEHLED 504
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 381-535 3.45e-14

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 69.63  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 381 HITFQCFFAAFYLALSADV-PPALLRHLFNCGRpgnspmarllptmciqaSEGKDSSVAALLQKAEPHnLQITAAFLAGL 459
Cdd:pfam17776   1 HLSFQEFFAALFYVLSFKEeKSNPLKEFFGLRK-----------------RESLKSLLDKALKSKNGH-LDLFLRFLFGL 62

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034595528 460 LSREHWGLLAECQTSEKALLRRQAcARWCLARSLRKHFHSippaapgeaksvhamPGFIWLIRSLYEMQEERLARK 535
Cdd:pfam17776  63 LNEENQRLLEGLLGCKLSSEIKQE-LLQWIKSLIQKELSS---------------ERFLNLFHCLYELQDESFVKE 122
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 324-379 8.13e-08

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 49.49  E-value: 8.13e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034595528 324 TLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEF 379
Cdd:pfam17779   2 LLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEKVYSF 57
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 72-171 8.60e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.74  E-value: 8.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528   72 TVLVVGEAGSGKSTLLQRLhllwaAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQ--EDIFQLLLDHP 149
Cdd:smart00382   4 VILIVGPPGSGKTTLARAL-----ARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELrlRLALALARKLK 78

                           90       100
                   ....*....|....*....|..
gi 1034595528  150 DRVLLtfdgFDEFkFRFTDRER 171
Cdd:smart00382  79 PDVLI----LDEI-TSLLDAEQ 95
 
Name Accession Description Interval E-value
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 71-241 4.05e-44

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 156.70  E-value: 4.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528  71 DTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPD 150
Cdd:pfam05729   1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 151 RVLLTFDGFDEFKFRFtdrerhCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAfLRKYIRTE--FNLKGFSEQ 228
Cdd:pfam05729  81 RLLLILDGLDELVSDL------GQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRD-LRRGLEEPryLEVRGFSES 153

                         170
                  ....*....|...
gi 1034595528 229 GIELYLRKRHHEP 241
Cdd:pfam05729 154 DRKQYVRKYFSDE 166
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 535-809 1.86e-42

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 160.34  E-value: 1.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 535 KAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVaLQLDYNSVGDIGVEQLLPCLGVCKA---LYLRDNNISDRGIC 611
Cdd:COG5238   148 KDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVET-VYLGCNQIGDEGIEELAEALTQNTTvttLWLKRNPIGDEGAE 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 612 KLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGD 691
Cdd:COG5238   227 ILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGD 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 692 EGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNN 771
Cdd:COG5238   307 EGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKN 386

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1034595528 772 CITYLGAEALLQALERNdTILEVWLRGNTFSLEEVDKL 809
Cdd:COG5238   387 NIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRL 423
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 581-810 2.97e-37

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 145.32  E-value: 2.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 581 GDIGVEQLLPCLGVCKAL--------YLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFL 652
Cdd:COG5238   160 GLAARLGLLAAISMAKALqnnsvetvYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLT 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 653 ALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKN 732
Cdd:COG5238   240 TLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGN 319

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034595528 733 VMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLG 810
Cdd:COG5238   320 KTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALI 397
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 583-810 1.88e-33

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 134.15  E-value: 1.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 583 IGVEQLLPCLGVCKALYLRDNNIS-DRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYI 661
Cdd:COG5238   141 INLIQVLKDPLGGNAVHLLGLAARlGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 662 TAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLE 741
Cdd:COG5238   221 GDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS 300

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034595528 742 ENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLG 810
Cdd:COG5238   301 VNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALA 369
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 545-810 3.21e-30

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 122.08  E-value: 3.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 545 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDI--GVEQLLPCLGVCKAL---YLRDNNISDRGiCKLIECALH 619
Cdd:cd00116    28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLqelDLSDNALGPDG-CGVLESLLR 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 620 CEQLQKLALFNNKLTD-GCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALA 698
Cdd:cd00116   107 SSSLQELKLNNNGLGDrGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 699 EALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKK-NSSLKILKLSNNCITYLG 777
Cdd:cd00116   187 EGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDG 266

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1034595528 778 AEALLQALERNDTILEVWLRGNTFSLEEVDKLG 810
Cdd:cd00116   267 AKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 558-786 5.61e-29

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 118.23  E-value: 5.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 558 AALAFVLQHLRRPVALQ-LDY--NSVGDIGVEQLLPCL--GVCKALYLRDNNISDRGIcKLIECAL--HCEQLQKLALFN 630
Cdd:cd00116    68 RGLQSLLQGLTKGCGLQeLDLsdNALGPDGCGVLESLLrsSSLQELKLNNNGLGDRGL-RLLAKGLkdLPPALEKLVLGR 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 631 NKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWL 710
Cdd:cd00116   147 NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVL 226

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034595528 711 SLVGNNIGSVGAQALAL-MLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALE 786
Cdd:cd00116   227 NLGDNNLTDAGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLL 303
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 573-799 7.45e-25

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 106.29  E-value: 7.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 573 LQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGiCKLIECALHCEQLQKLALFNNKLTdgcAHSMAKLLACRQNFL 652
Cdd:cd00116     3 LSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEA-AKALASALRPQPSLKELCLSLNET---GRIPRGLQSLLQGLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 653 A------LRLGNNYITAAGAQVLaEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNIGSVGAQAL 725
Cdd:cd00116    79 KgcglqeLDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEAL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034595528 726 ALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGN 799
Cdd:cd00116   158 AKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDN 231
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
66-409 1.40e-21

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 100.65  E-value: 1.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528  66 LNDDADTVLVVGEAGSGKSTLLQRL-HLLWAAGQDFQEFLFVFpFSCRQLqcmAKPLSVRTLLFEHCCWPDVGQEDIFQL 144
Cdd:COG5635   176 LEAKKKRLLILGEPGSGKTTLLRYLaLELAERYLDAEDPIPIL-IELRDL---AEEASLEDLLAEALEKRGGEPEDALER 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 145 LLDHpDRVLLTFDGFDEFKFRfTDRERhcsptdptsVQTLLFNLLQGnlLKNARKVVTSRPAAV-SAFLRKYirTEFNLK 223
Cdd:COG5635   252 LLRN-GRLLLLLDGLDEVPDE-ADRDE---------VLNQLRRFLER--YPKARVIITSRPEGYdSSELEGF--EVLELA 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 224 GFSEQGIELYLRKRH-HEPGVADRLIRLLQETSALHGLCHLPVFSWMVSkchqeLLLQEGGS-PKTTTDMYLLILQHFLl 301
Cdd:COG5635   317 PLSDEQIEEFLKKWFeATERKAERLLEALEENPELRELARNPLLLTLLA-----LLLRERGElPDTRAELYEQFVELLL- 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 302 hATPPDSASQGLGPSLLRGRLPTLlhLGRLALWGLGMCCYVFSAQQLQ-------AAQVSPDDI------SLGFLV-RAK 367
Cdd:COG5635   391 -ERWDEQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEeilreylGRRKDAEALldelllRTGLLVeRGE 467

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1034595528 368 GVVpgstaplEFLHITFQCFFAAFYLA--LSADVPPALLRHLFN 409
Cdd:COG5635   468 GRY-------SFAHRSFQEYLAARALVeeLDEELLELLAEHLED 504
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 381-535 3.45e-14

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 69.63  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 381 HITFQCFFAAFYLALSADV-PPALLRHLFNCGRpgnspmarllptmciqaSEGKDSSVAALLQKAEPHnLQITAAFLAGL 459
Cdd:pfam17776   1 HLSFQEFFAALFYVLSFKEeKSNPLKEFFGLRK-----------------RESLKSLLDKALKSKNGH-LDLFLRFLFGL 62

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034595528 460 LSREHWGLLAECQTSEKALLRRQAcARWCLARSLRKHFHSippaapgeaksvhamPGFIWLIRSLYEMQEERLARK 535
Cdd:pfam17776  63 LNEENQRLLEGLLGCKLSSEIKQE-LLQWIKSLIQKELSS---------------ERFLNLFHCLYELQDESFVKE 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
596-809 1.14e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 596 KALYLRDNNISDrgickLIECALHCEQLQKLALFNNKLTDgcahsMAKLLACRQNFLALRLGNNYITaagaqVLAEGLRG 675
Cdd:COG4886   116 ESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLT-----DLPEELGN 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 676 NTSLQFLGFWGNRVGDegaqaLAEALGDHQSLRWLSLVGNNIGSVGAQalalmLAKNVMLEELCLEENHLQDegvcslAE 755
Cdd:COG4886   181 LTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPEP-----LANLTNLETLDLSNNQLTD------LP 244

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034595528 756 GLKKNSSLKILKLSNNCITYLGAEALLQALErndtilEVWLRGNTFSLEEVDKL 809
Cdd:COG4886   245 ELGNLTNLEELDLSNNQLTDLPPLANLTNLK------TLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
619-802 1.54e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 1.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 619 HCEQLQKLALFNNKLTDgcahsMAKLLACRQNFLALRLGNNYITAagaqvLAEGLRGNTSLQFLGFWGNRVGDegaqaLA 698
Cdd:COG4886   111 NLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LP 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 699 EALGDHQSLRWLSLVGNNIGSvgaqaLALMLAKNVMLEELCLEENHLQDegvcsLAEGLKKNSSLKILKLSNNCITYLGA 778
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDLPE 245

                         170       180
                  ....*....|....*....|....
gi 1034595528 779 EALLQALErndtilEVWLRGNTFS 802
Cdd:COG4886   246 LGNLTNLE------ELDLSNNQLT 263
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 541-701 2.38e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 66.74  E-value: 2.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 541 NVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKA---LYLRDNNISDRGICKLIECA 617
Cdd:COG5238   265 TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTlhtLNLAYNGIGAQGAIALAKAL 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 618 LHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTsLQFLGFWGNRVGDEGAQAL 697
Cdd:COG5238   345 QENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRL 423


                  ....
gi 1034595528 698 AEAL 701
Cdd:COG5238   424 EQLL 427
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 324-379 8.13e-08

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 49.49  E-value: 8.13e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034595528 324 TLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEF 379
Cdd:pfam17779   2 LLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEKVYSF 57
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 589-774 1.02e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 589 LPCLGVCKA---LYLRDNNISdrgickLIECALHCEQLQKLALFNNKLTdgcahsmaKLlacrQNFLALR------LGNN 659
Cdd:cd21340    17 IDNLSLCKNlkvLYLYDNKIT------KIENLEFLTNLTHLYLQNNQIE--------KI----ENLENLVnlkklyLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 660 YITaagaqVLaEGLRGNTSLQFLgfwgnrvgDEGAQALAE------------ALGDhqSLRWLSLVGNNIGSVgaQALAL 727
Cdd:cd21340    79 RIS-----VV-EGLENLTNLEEL--------HIENQRLPPgekltfdprslaALSN--SLRVLNISGNNIDSL--EPLAP 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034595528 728 MlaKNvmLEELCLEENHLQD-EGVCSLaegLKKNSSLKILKLSNNCIT 774
Cdd:cd21340   141 L--RN--LEQLDASNNQISDlEELLDL---LSSWPSLRELDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
564-796 2.45e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 2.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 564 LQHLRRpvaLQLDYNSVGDIGVE-QLLPCLgvcKALYLRDNNISD--RGICKLiecalhcEQLQKLALFNNKLTDgcahs 640
Cdd:COG4886   135 LTNLKE---LDLSNNQLTDLPEPlGNLTNL---KSLDLSNNQLTDlpEELGNL-------TNLKELDLSNNQITD----- 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 641 MAKLLACRQNFLALRLGNNYITAagaqvLAEGLRGNTSLQFLGFWGNRVGD----EGAQALAE------------ALGDH 704
Cdd:COG4886   197 LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDlpelGNLTNLEEldlsnnqltdlpPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 705 QSLRWLSLVGNNIGSVGAQALA--LMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALL 782
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELEllLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250
                  ....*....|....
gi 1034595528 783 QALERNDTILEVWL 796
Cdd:COG4886   352 LLLLLNLLSLLLTL 365
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
564-797 1.37e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 564 LQHLRRpvaLQLDYNSVGDIGVEqllpcLGVCKAL---YLRDNNISDrgicklIECAL-HCEQLQKLALFNNKLTDgcah 639
Cdd:COG4886   181 LTNLKE---LDLSNNQITDLPEP-----LGNLTNLeelDLSGNQLTD------LPEPLaNLTNLETLDLSNNQLTD---- 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 640 smAKLLACRQNFLALRLGNNYITAAGAqvlaegLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGS 719
Cdd:COG4886   243 --LPELGNLTNLEELDLSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034595528 720 VGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLR 797
Cdd:COG4886   315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 530-650 1.99e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528 530 ERLARKAARGL----NVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGV----EQLLPCLGVCKALYLR 601
Cdd:cd00116   179 DAGIRALAEGLkancNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAaalaSALLSPNISLLTLSLS 258

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1034595528 602 DNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQN 650
Cdd:cd00116   259 CNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 72-171 8.60e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.74  E-value: 8.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595528   72 TVLVVGEAGSGKSTLLQRLhllwaAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQ--EDIFQLLLDHP 149
Cdd:smart00382   4 VILIVGPPGSGKTTLARAL-----ARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELrlRLALALARKLK 78

                           90       100
                   ....*....|....*....|..
gi 1034595528  150 DRVLLtfdgFDEFkFRFTDRER 171
Cdd:smart00382  79 PDVLI----LDEI-TSLLDAEQ 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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