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Conserved domains on  [gi|1034596142|ref|XP_016879218|]
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phagosome assembly factor 1 isoform X1 [Homo sapiens]

Protein Classification

UPF0183 family protein( domain architecture ID 10508485)

UPF0183 family protein similar to Homo sapiens protein C16orf70

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHAF1 pfam03676
Phagosome assembly factor 1; PHAF1 and BCAS3 form a complex that affects the recruitment of ...
15-504 0e+00

Phagosome assembly factor 1; PHAF1 and BCAS3 form a complex that affects the recruitment of several core autophagy proteins to the phagophore assembly site.


:

Pssm-ID: 461013  Cd Length: 392  Bit Score: 600.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142  15 EQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLMFDAFNQRLKVIEVCDLTKVKLKYCGV 94
Cdd:pfam03676   1 EQGEFTLGMPISQAIAIIQSQVRIIKNVQVLYSDKNPLNSDIIINLPQDGIRLIFDPVSQRLKLIEVYDMKKVKLKYCGV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142  95 HFNSQAIAPTIEQIDQSFGATHPGgkpspsdssghqwqfiainlpgsaipphflesgshrivglvlgcegnilplvfnlv 174
Cdd:pfam03676  81 VFNSPSVLPTIEQIYNSFGPTHPG-------------------------------------------------------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 175 gqfrnkpqgrccqsllparlvyvshfrcqstmlfsspppptVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGL 254
Cdd:pfam03676 105 -----------------------------------------VYDAEKQIYTLNYPGLSFSFPIPSEYSYSKGEPGYAHGL 143
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 255 ASLQIPHGAT--VKRMYIYSGNSLQDTKAPMMPLSCFLGNVYAESVDVLRDGTGPAGLRLRLLAAGCGPglladAKMRVF 332
Cdd:pfam03676 144 LSLEFPNGTSpvVSKMSIYDGSSLSDAKAPSLPLSCYHGQLYLEEVEVLLDEGNTTGLKLQFYTEGSGR-----VRRSTL 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 333 ERSVYFGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPSPHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPG 412
Cdd:pfam03676 219 KREINFGDSTQDVLSELGAPSRVFYKSEDKMKIHSPSDHRPLPTKCSDYFFNYFTLGLDILFDGSTHRVKKFVLHTNFPG 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 413 HYNFNIYHRCEFKIPLAIKK--ENADGQTETCTTYSKWDNIQELLGHPVEKPVVLHRSSSPNNTNPFGSTFCFGLQRMIF 490
Cdd:pfam03676 299 HYNFNIYHRCNFRIPLSSGAaqTKSSENKDFITPYTKWDEVKKALGGPSERPVVLNRGSSTNTTNPFGSTFCYGYQNIIF 378
                         490
                  ....*....|....
gi 1034596142 491 EVMQNNHIASVTLY 504
Cdd:pfam03676 379 EVMKNGHIASVTLY 392
 
Name Accession Description Interval E-value
PHAF1 pfam03676
Phagosome assembly factor 1; PHAF1 and BCAS3 form a complex that affects the recruitment of ...
15-504 0e+00

Phagosome assembly factor 1; PHAF1 and BCAS3 form a complex that affects the recruitment of several core autophagy proteins to the phagophore assembly site.


Pssm-ID: 461013  Cd Length: 392  Bit Score: 600.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142  15 EQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLMFDAFNQRLKVIEVCDLTKVKLKYCGV 94
Cdd:pfam03676   1 EQGEFTLGMPISQAIAIIQSQVRIIKNVQVLYSDKNPLNSDIIINLPQDGIRLIFDPVSQRLKLIEVYDMKKVKLKYCGV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142  95 HFNSQAIAPTIEQIDQSFGATHPGgkpspsdssghqwqfiainlpgsaipphflesgshrivglvlgcegnilplvfnlv 174
Cdd:pfam03676  81 VFNSPSVLPTIEQIYNSFGPTHPG-------------------------------------------------------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 175 gqfrnkpqgrccqsllparlvyvshfrcqstmlfsspppptVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGL 254
Cdd:pfam03676 105 -----------------------------------------VYDAEKQIYTLNYPGLSFSFPIPSEYSYSKGEPGYAHGL 143
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 255 ASLQIPHGAT--VKRMYIYSGNSLQDTKAPMMPLSCFLGNVYAESVDVLRDGTGPAGLRLRLLAAGCGPglladAKMRVF 332
Cdd:pfam03676 144 LSLEFPNGTSpvVSKMSIYDGSSLSDAKAPSLPLSCYHGQLYLEEVEVLLDEGNTTGLKLQFYTEGSGR-----VRRSTL 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 333 ERSVYFGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPSPHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPG 412
Cdd:pfam03676 219 KREINFGDSTQDVLSELGAPSRVFYKSEDKMKIHSPSDHRPLPTKCSDYFFNYFTLGLDILFDGSTHRVKKFVLHTNFPG 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 413 HYNFNIYHRCEFKIPLAIKK--ENADGQTETCTTYSKWDNIQELLGHPVEKPVVLHRSSSPNNTNPFGSTFCFGLQRMIF 490
Cdd:pfam03676 299 HYNFNIYHRCNFRIPLSSGAaqTKSSENKDFITPYTKWDEVKKALGGPSERPVVLNRGSSTNTTNPFGSTFCYGYQNIIF 378
                         490
                  ....*....|....
gi 1034596142 491 EVMQNNHIASVTLY 504
Cdd:pfam03676 379 EVMKNGHIASVTLY 392
 
Name Accession Description Interval E-value
PHAF1 pfam03676
Phagosome assembly factor 1; PHAF1 and BCAS3 form a complex that affects the recruitment of ...
15-504 0e+00

Phagosome assembly factor 1; PHAF1 and BCAS3 form a complex that affects the recruitment of several core autophagy proteins to the phagophore assembly site.


Pssm-ID: 461013  Cd Length: 392  Bit Score: 600.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142  15 EQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLMFDAFNQRLKVIEVCDLTKVKLKYCGV 94
Cdd:pfam03676   1 EQGEFTLGMPISQAIAIIQSQVRIIKNVQVLYSDKNPLNSDIIINLPQDGIRLIFDPVSQRLKLIEVYDMKKVKLKYCGV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142  95 HFNSQAIAPTIEQIDQSFGATHPGgkpspsdssghqwqfiainlpgsaipphflesgshrivglvlgcegnilplvfnlv 174
Cdd:pfam03676  81 VFNSPSVLPTIEQIYNSFGPTHPG-------------------------------------------------------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 175 gqfrnkpqgrccqsllparlvyvshfrcqstmlfsspppptVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGL 254
Cdd:pfam03676 105 -----------------------------------------VYDAEKQIYTLNYPGLSFSFPIPSEYSYSKGEPGYAHGL 143
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 255 ASLQIPHGAT--VKRMYIYSGNSLQDTKAPMMPLSCFLGNVYAESVDVLRDGTGPAGLRLRLLAAGCGPglladAKMRVF 332
Cdd:pfam03676 144 LSLEFPNGTSpvVSKMSIYDGSSLSDAKAPSLPLSCYHGQLYLEEVEVLLDEGNTTGLKLQFYTEGSGR-----VRRSTL 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 333 ERSVYFGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPSPHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPG 412
Cdd:pfam03676 219 KREINFGDSTQDVLSELGAPSRVFYKSEDKMKIHSPSDHRPLPTKCSDYFFNYFTLGLDILFDGSTHRVKKFVLHTNFPG 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596142 413 HYNFNIYHRCEFKIPLAIKK--ENADGQTETCTTYSKWDNIQELLGHPVEKPVVLHRSSSPNNTNPFGSTFCFGLQRMIF 490
Cdd:pfam03676 299 HYNFNIYHRCNFRIPLSSGAaqTKSSENKDFITPYTKWDEVKKALGGPSERPVVLNRGSSTNTTNPFGSTFCYGYQNIIF 378
                         490
                  ....*....|....
gi 1034596142 491 EVMQNNHIASVTLY 504
Cdd:pfam03676 379 EVMKNGHIASVTLY 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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