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Conserved domains on  [gi|1034625670|ref|XP_016883505|]
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N-terminal EF-hand calcium-binding protein 3 isoform X4 [Homo sapiens]

Protein Classification

antibiotic biosynthesis monooxygenase family protein( domain architecture ID 10512581)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces tetracenomycin-F1 monooxygenase and deoxynogalonate monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0017000|GO:0016491
SCOP:  4000637

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 101-173 4.00e-12

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


:

Pssm-ID: 427635  Cd Length: 74  Bit Score: 59.21  E-value: 4.00e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034625670 101 LMAQRQVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVSA-QKMLDGASFTLYEFWQDEASWRRHQQSPGSKAFQ 173
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELlRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
 
Name Accession Description Interval E-value
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 101-173 4.00e-12

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 59.21  E-value: 4.00e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034625670 101 LMAQRQVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVSA-QKMLDGASFTLYEFWQDEASWRRHQQSPGSKAFQ 173
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELlRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
106-189 3.79e-08

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 49.18  E-value: 3.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625670 106 QVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVS-AQKMLDGASFTLYEFWQDEASWRRHQQSPGSKAFQRILIDHLRAPD 184
Cdd:COG1359     6 KLTVKPGKRDEFLAALRELVEATRAEPGCLSYElYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLLAEPP 85


                  ....*
gi 1034625670 185 TLTTV 189
Cdd:COG1359    86 EVRVY 90
 
Name Accession Description Interval E-value
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 101-173 4.00e-12

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 59.21  E-value: 4.00e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034625670 101 LMAQRQVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVSA-QKMLDGASFTLYEFWQDEASWRRHQQSPGSKAFQ 173
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELlRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
106-189 3.79e-08

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 49.18  E-value: 3.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625670 106 QVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVS-AQKMLDGASFTLYEFWQDEASWRRHQQSPGSKAFQRILIDHLRAPD 184
Cdd:COG1359     6 KLTVKPGKRDEFLAALRELVEATRAEPGCLSYElYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLLAEPP 85


                  ....*
gi 1034625670 185 TLTTV 189
Cdd:COG1359    86 EVRVY 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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