|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
6-750 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1426.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 85
Cdd:cd00764 17 GMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFREREGRLQAAYNLIQR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 86 GITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 165
Cdd:cd00764 97 GITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTDMTIGTDSALHRICEV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 166 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAID 245
Cdd:cd00764 177 VDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRSRGKRLNIIIVAEGAID 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 246 RNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPL 325
Cdd:cd00764 257 DQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPACVVSLNGNKAVRLPL 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 326 MECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPK--EKSNFSLAILNVGAPAAGMNAAVRSAVRTGI 403
Cdd:cd00764 337 MECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPlpEKTNLNIAIVNVGAPAAGMNAAVRSAVRYGL 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 404 SHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQ 483
Cdd:cd00764 417 AHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGIDGLIIVGGFEAYKGLLQ 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 484 LVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIA 563
Cdd:cd00764 497 LREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVETMGGYCGYLATMTGLA 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 564 VGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGA 643
Cdd:cd00764 577 VGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGVFDCRTNVLGHVQQGGA 656
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 644 PTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTdFEHRMPREQWWLSLRL 723
Cdd:cd00764 657 PSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT-FEHRIPKEQWWLSLRP 735
|
730 740
....*....|....*....|....*..
gi 1034627277 724 MLKMLAQYRISMAAYVSGELEHVTRRT 750
Cdd:cd00764 736 LLKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
6-732 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1183.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 85
Cdd:TIGR02478 14 GMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRERPGRLKAARNLVSN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 86 GITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 165
Cdd:TIGR02478 94 GIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMTIGADSALHRICEA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 166 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAID 245
Cdd:TIGR02478 174 IDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGKRKTIVIVAEGAID 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 246 RNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPL 325
Cdd:TIGR02478 254 RDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPVISLRGNKIVRKPL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 326 MECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPK-----EKSNFSLAILNVGAPAAGMNAAVRSAVR 400
Cdd:TIGR02478 334 VEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKklvpsEASRLRIAIIHVGAPAGGMNAATRSAVR 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 401 TGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEG 480
Cdd:TIGR02478 414 YALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKIDGLIIIGGFEAFEA 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 481 VLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVT 560
Cdd:TIGR02478 494 LYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVETMGGYSGYLATMA 573
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 561 GIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQ 640
Cdd:TIGR02478 574 GLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGRFDARTAVLGHMQQ 653
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 641 GGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANaPDSACVIGLKKKAVAFSPV-TELKKDTDFEHRMPREQWWL 719
Cdd:TIGR02478 654 GGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVkQLLANETDFEHRRPKNQWWL 732
|
730
....*....|...
gi 1034627277 720 SLRLMLKMLAQYR 732
Cdd:TIGR02478 733 QLRPLVRILAGRD 745
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
6-360 |
4.06e-179 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 515.31 E-value: 4.06e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 85
Cdd:cd00363 14 GMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRAKAAENLKKH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 86 GITNLCVIGGDGSLTGANIFRSEWGSlleelvaegkisettarTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 165
Cdd:cd00363 92 GIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 166 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAID 245
Cdd:cd00363 155 IDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGKRHGIVIVAEGAID 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 246 RNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPL 325
Cdd:cd00363 235 FIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNLNENQVVRHPL 314
|
330 340 350
....*....|....*....|....*....|....*
gi 1034627277 326 MECVQMTKEVQkamddkrfdeaTQLRGGSFENNWN 360
Cdd:cd00363 315 TEAVNMTKRVG-----------VDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
5-298 |
2.03e-131 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 390.55 E-value: 2.03e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 5 GGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQ 84
Cdd:pfam00365 12 PGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGREKIAENLKK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 85 HGITNLCVIGGDGSLTGANIFRSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIME 164
Cdd:pfam00365 90 LGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 165 VIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgwENFMCERLgETRSRGSRLNIIIIAEGAI 244
Cdd:pfam00365 148 AIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKI-KELRKGKRFSIIVVAEGAS 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1034627277 245 DrngkpisSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAV 298
Cdd:pfam00365 224 D-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
379-660 |
2.42e-121 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 364.74 E-value: 2.42e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 379 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLES-- 456
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGre 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 457 -IVENIRIYGIHALLVVGGFEAYEGVLQLVEARGryeelcIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQS 535
Cdd:pfam00365 82 kIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 536 ASGTkRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTeKMKTDIqrgLVLRNEKCHDyytTEF 615
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFS---IIVVAEGASD---GEF 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1034627277 616 LYNLYssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAM 660
Cdd:pfam00365 228 LAKLI--EEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
6-335 |
3.09e-112 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 343.98 E-value: 3.09e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 85
Cdd:COG0205 15 GLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTEEGREKALENLKKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 86 GITNLCVIGGDGSLTGANIFRSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 165
Cdd:COG0205 93 GIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 166 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgwENFMCERLGETRSRGSRLNIIIIAEGAID 245
Cdd:COG0205 151 IDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGKGYSIIVVAEGAGD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 246 RNGKPISSS---------------YVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEatpDTPA 310
Cdd:COG0205 228 EDGEAVLEAdtdafghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE---GKTG 304
|
330 340
....*....|....*....|....*
gi 1034627277 311 CVVTLSGNQSVRLPLMECVQMTKEV 335
Cdd:COG0205 305 VMVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
6-342 |
7.68e-111 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 339.36 E-value: 7.68e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 85
Cdd:PRK03202 15 GMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGRAKAIENLKKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 86 GITNLCVIGGDGSLTGANIFrSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 165
Cdd:PRK03202 93 GIDALVVIGGDGSYMGAKRL-TEHG----------------------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 166 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDgwenfMCERLGETRSRGSRLNIIIIAEGA 243
Cdd:PRK03202 150 IDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPfdIEE-----LCAKIKKGRERGKKHAIIVVAEGV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 244 IDRNGkpisssyVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTpacVVTLSGNQSVRL 323
Cdd:PRK03202 225 MPAEE-------LAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---MVGIQNNKIVHV 294
|
330 340
....*....|....*....|
gi 1034627277 324 PLMECV-QMTKEVQKAMDDK 342
Cdd:PRK03202 295 PIEEAVeNMKHPFDKDLYEL 314
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
6-327 |
5.44e-102 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 315.83 E-value: 5.44e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 85
Cdd:TIGR02482 13 GMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVREKAVENLKKL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 86 GITNLCVIGGDGSLTGANIfrsewgslleeLVAEGKIsettartyshlNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 165
Cdd:TIGR02482 91 GIEGLVVIGGDGSYTGAQK-----------LYEEGGI-----------PVIGLPGTIDNDIPGTDYTIGFDTALNTIIDA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 166 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEA--PPEDgwenfMCERLGETRSRGSRLNIIIIAEGA 243
Cdd:TIGR02482 149 VDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFdyDIDE-----LIQRLKEQHEAGKKHSIIIVAEGN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 244 IDRNGKPISSSyVKDlvvqRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEatpDTPACVVTLSGNQSVRL 323
Cdd:TIGR02482 224 IVGSAKEVAKK-IEE----KTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLE---GKGGVMIGIQNNKIVTH 295
|
....
gi 1034627277 324 PLME 327
Cdd:TIGR02482 296 PIEE 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
6-339 |
1.83e-88 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 281.22 E-value: 1.83e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQH 85
Cdd:cd00763 14 GMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEGQAKAIEQLKKH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 86 GITNLCVIGGDGSLTGAnifrsewgsllEELVAEGkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEV 165
Cdd:cd00763 92 GIDALVVIGGDGSYMGA-----------MRLTEHG------------FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 166 IDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDgwenfMCERLGETRSRGSRLNIIIIAEGA 243
Cdd:cd00763 149 IDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEfdREE-----VANRIKAGIERGKKHAIVVVAEGV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 244 IDRNGkpisssyVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEAtpdTPACVVTLSGNQSVRL 323
Cdd:cd00763 224 YDVDE-------LAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLAVGIQNEQLVHH 293
|
330
....*....|....*.
gi 1034627277 324 PLMECVQMTKEVQKAM 339
Cdd:cd00763 294 DIIDAIENMKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
6-329 |
1.75e-70 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 233.73 E-value: 1.75e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYV-GAKVFLIYEGYEGLVEGGEnIKQANWLSVSNIIQLGGTIIGSARCKAFTT-REGRRAAAYNLV 83
Cdd:TIGR02483 13 GLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKYeEDGDDKIVANLK 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 84 QHGITNLCVIGGDGSLTGANifrsewgslleELVAEGkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIM 163
Cdd:TIGR02483 92 ELGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPKTIDNDLEATDYTFGFDTAVEIAT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 164 EVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgWENfMCERLGETRSRGSRLNIIIIAEGA 243
Cdd:TIGR02483 149 EALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD--IDS-VCEKVRERFARGKRFAIVVVAEGA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 244 IDRNGKPISSSYVKD----------------LVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPD 307
Cdd:TIGR02483 226 KPKGGEMVVQEGVKDafghvrlggignwlaeEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVAAVDLVHEGQFG 305
|
330 340
....*....|....*....|..
gi 1034627277 308 TpacVVTLSGNQSVRLPLMECV 329
Cdd:TIGR02483 306 H---MVALRGTDIVYVPIAEAV 324
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
379-665 |
1.56e-67 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 226.49 E-value: 1.56e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 379 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPK---GQLE 455
Cdd:COG0205 4 IGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFkteEGRE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 456 SIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQ 534
Cdd:COG0205 84 KALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG-------IPVVgIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 535 SASGTkRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLkvnVEHMTEKMKTDIQRGLVL--------RNEK 606
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDGEA 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034627277 607 CHDYYTTEFLYNLYSSEGKGV---------FDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSE 665
Cdd:COG0205 233 VLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
379-659 |
2.60e-66 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 222.26 E-value: 2.60e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 379 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRT----LPKGQL 454
Cdd:PRK03202 4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFpefkDEEGRA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 455 EsIVENIRIYGIHALLVVGGFEAYEGVLQLVEARgryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIK 533
Cdd:PRK03202 84 K-AIENLKKLGIDALVVIGGDGSYMGAKRLTEHG--------IPVIgLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 534 QSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLkvnVEHMTEKMKTDIQRGLVLRNEKCHD--YY 611
Cdd:PRK03202 155 DTAS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEEL---CAKIKKGRERGKKHAIIVVAEGVMPaeEL 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1034627277 612 TTEFlynlyssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 659
Cdd:PRK03202 231 AKEI-------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
378-702 |
2.43e-60 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 207.15 E-value: 2.43e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 378 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRT----LPKGQ 453
Cdd:cd00363 2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCkefrTEEGR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 454 LESIvENIRIYGIHALLVVGGFEAYEGVLQLVE-ARGRYEELCIVMCviPATISNNVPGTDFSLGSDTAVNAAMESCDRI 532
Cdd:cd00363 82 AKAA-ENLKKHGIDALVVIGGDGSYTGADLLTEeWPSKYQGFNVIGL--PGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 533 KQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNihdlKVNVEHMTEKMKTDIQRG----LVLRNEKCH 608
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAA----DEWEEEMVDVIKKRRERGkrhgIVIVAEGAI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 609 DYY----TTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVyrkgrvfanapdSA 684
Cdd:cd00363 234 DFIpkpiTEKLLAKLVEERLG--FDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGT------------PV 299
|
330
....*....|....*...
gi 1034627277 685 CVIGLKKKAVAFSPVTEL 702
Cdd:cd00363 300 GIQNLNENQVVRHPLTEA 317
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
379-659 |
7.00e-58 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 199.56 E-value: 7.00e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 379 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKR----TLPKGQL 454
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARfpefKDEEGQA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 455 ESIvENIRIYGIHALLVVGGFEAYEGVLQLVEARgryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIK 533
Cdd:cd00763 83 KAI-EQLKKHGIDALVVIGGDGSYMGAMRLTEHG--------FPCVgLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 534 QSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKtdiQRGLVLRNEkcHDYYTT 613
Cdd:cd00763 154 DTSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAE--GVYDVD 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1034627277 614 EFLYNLyssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 659
Cdd:cd00763 228 ELAKEI---EEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
5-319 |
2.06e-51 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 191.78 E-value: 2.06e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 5 GGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGenIKQANWLSVSNIIQLGGTIIGSARCkafTTREGRRAAAYNLVQ 84
Cdd:TIGR02478 402 GGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELGTNRS---LPGDDLGTIAYYFQQ 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 85 HGITNLCVIGGDGSLTGANIFRsewgslleelvaegkisetTART-YSHLNI--AGLVGSIDNDFCGTDMTIGTDSALHR 161
Cdd:TIGR02478 477 HKIDGLIIIGGFEAFEALYQLD-------------------AAREkYPAFRIpmVVIPATISNNVPGTEYSLGSDTALNE 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 162 IMEVIDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP-PEDGWEN---FMCERLGETRSRGsrlnI 236
Cdd:TIGR02478 538 ITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGiSLKDLQEdieHLKETFAEGRAGK----L 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 237 IIIAEGAIdrngKPISSSYVKDLVVQ--RLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATP-------- 306
Cdd:TIGR02478 614 ILRNEKAS----KVYTTDFIARIISEegKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKankhadkl 689
|
330
....*....|....*.
gi 1034627277 307 ---DTPACVVTLSGNQ 319
Cdd:TIGR02478 690 sadDTSAVVIGIRGSN 705
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
5-336 |
4.10e-49 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 176.80 E-value: 4.10e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 5 GGMNAAVRAVTR--MGIYvGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARcK----AFTTREG---- 74
Cdd:PRK14071 17 AGLNAVIRAVVHraRGTY-GWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTN-KgdpfAFPMPDGslrd 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 75 RRA---AAYNlvQHGITNLCVIGGDGSLtganifrsewgSLLEELVAEGKIsettartyshlNIAGLVGSIDNDFCGTDM 151
Cdd:PRK14071 95 RSQeiiDGYH--SLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGIPKTIDNDVGATEV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 152 TIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgWENfMCERLGETRSRG 231
Cdd:PRK14071 151 SIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT--LEN-VCKKIRERQEEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 232 SRLNIIIIAEGAIDRNGKPIS-------------SSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAV 298
Cdd:PRK14071 228 KNFCLVVVSEAVRTEEGEQVTktqalgedryggiGQYLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAV 307
|
330 340 350
....*....|....*....|....*....|....*...
gi 1034627277 299 MALLEATPDTpacVVTLSGNQSVRLPLMECVQMTKEVQ 336
Cdd:PRK14071 308 DLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAVD 342
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
379-712 |
6.21e-49 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 184.47 E-value: 6.21e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 379 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQ--VQEVGWHDVAGWLGRGGSMLGTKRTLP----KG 452
Cdd:TIGR02478 3 IAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGdnIEEAQWEDVRGILSLGGTIIGTARCKEfrerPG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 453 QLESiVENIRIYGIHALLVVGGFEAYEG-----------VLQLV-------EARGRYEELCIVMCVipATISNNVPGTDF 514
Cdd:TIGR02478 83 RLKA-ARNLVSNGIDALVVIGGDGSLTGadlfreewpslLEELVdtgkitaEQAEEHRHLTIVGLV--GSIDNDMCGTDM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 515 SLGSDTAVNAAMESCDRIKQSASGTKrRVFIVETMGGYCGYLATVTGIAVGADaaYVF--EDPfnihdLKVN-VEHMTEK 591
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQ-RAFVVEVMGRHCGYLALMAAIATGAD--YVFipERP-----PEEGwEDQLCHK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 592 MKTDIQRG----LVLRNEKCHD----YYTTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWL 663
Cdd:TIGR02478 232 LKRNRKAGkrktIVIVAEGAIDrdlnPITSEDVKDVLVERLG--LDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1034627277 664 SEKLREvyrkgrvfanAPdsACVIGLKK---------KAVAFS-PVTELKKDTDFEHRM 712
Cdd:TIGR02478 310 LESTPE----------TP--SPVISLRGnkivrkplvEAVAQTkTVAKAIEEKDFDEAM 356
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
378-722 |
1.52e-44 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 171.54 E-value: 1.52e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 378 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKG--QVQEVGWHDVAGWLGRGGSMLGTKR----TLPK 451
Cdd:cd00764 5 AIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARckefRERE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 452 GQLESIVeNIRIYGIHALLVVGGFEAYEG-----------VLQLV-------EARGRYEELCIVMCVipATISNNVPGTD 513
Cdd:cd00764 85 GRLQAAY-NLIQRGITNLCVIGGDGSLTGadlfrsewpslLEELVkdgkiteEEVAKYQHLNIVGMV--GSIDNDFCGTD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 514 FSLGSDTAVNAAMESCDRIKQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADaaYVF------EDPFNIHDLKVNVEH 587
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSGLATGAD--WIFiperppEDGWEDQMCRRLSEH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 588 MTEKMKTDI---QRGLVLRNEKChdyYTTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLS 664
Cdd:cd00764 239 RSRGKRLNIiivAEGAIDDQLKP---ITSEDVKDLVVERLG--LDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034627277 665 EklrevyrkgrvfaNAPDS-ACVIGLKKKAVAFSPVTE---LKKDTDFEHRMPREQWWLSLR 722
Cdd:cd00764 314 E-------------ATPDTpACVVSLNGNKAVRLPLMEcvqLTKDVQKAMDEKRFDEAAALR 362
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
5-298 |
9.38e-44 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 169.23 E-value: 9.38e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 5 GGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGenIKQANWLSVSNIIQLGGTIIGSARCkafTTREGRRAAAYNLVQ 84
Cdd:cd00764 402 AGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQ--IVELGWIDVGGWTGRGGSELGTKRT---LPKKDLETIAYNFQK 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 85 HGITNLCVIGGDGSLTGanifrsewgsLLEELVAEGKisettartYSHLNIAGLV--GSIDNDFCGTDMTIGTDSALHRI 162
Cdd:cd00764 477 YGIDGLIIVGGFEAYKG----------LLQLREAREQ--------YEEFCIPMVLipATVSNNVPGTDFSLGSDTALNAL 538
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 163 MEVIDAITTTAQS-HQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDGWENF--MCERLGETRSRGSRLNII 237
Cdd:cd00764 539 MKYCDRIKQSASGtKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPfnIRDLQENVehLTEKMKTTIGRGLVLRNE 618
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034627277 238 IIAEGAIDRNGKPISSSYVKDLvvqrlgFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAV 298
Cdd:cd00764 619 KCNENYTTVFTYELYSEEGKGV------FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAM 673
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
381-659 |
1.15e-30 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 124.03 E-value: 1.15e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 381 ILNVGAPAAGMNAAVRSAVRTGISH-GHTVYVVHDGFEGLAKG--QVQEVGWHDVAGWLGRGGSMLGTKRT-------LP 450
Cdd:PRK14071 9 ILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNKgdpfafpMP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 451 KGQL----ESIVENIRIYGIHALLVVGGfeayEGVLQLVEargryeELC----IVMCVIPATISNNVPGTDFSLGSDTAV 522
Cdd:PRK14071 89 DGSLrdrsQEIIDGYHSLGLDALIGIGG----DGSLAILR------RLAqqggINLVGIPKTIDNDVGATEVSIGFDTAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 523 NAAMESCDRIKQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIhdlkvnvEHMTEKMKTDIQRG--- 599
Cdd:PRK14071 159 NIATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknf 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034627277 600 -LVLRNEKCHDY------YTTEFLYNLYSSEGKGVFD---------CRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 659
Cdd:PRK14071 231 cLVVVSEAVRTEegeqvtKTQALGEDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAA 306
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
6-243 |
1.86e-24 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 107.44 E-value: 1.86e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTRMGIYV-GAK-VFLIYEGYEGLVEggENIKQANWLSVSNIIQLGGTIIGSARcKAFTTREgrraAAYNLV 83
Cdd:PTZ00286 101 GLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYK--EDWIKLDPKDVKTIHRLGGTILGSSR-GGFDPKV----MVDTLI 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 84 QHGITNLCVIGGDGSLTGANifrsewgSLLEELVAEG-KISettartyshlnIAGLVGSIDNDFCGTDMTIGTDSALHRI 162
Cdd:PTZ00286 174 RHGINILFTLGGDGTHRGAL-------AIYKELRRRKlNIS-----------VVGIPKTIDNDIPIIDESFGFQTAVEEA 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 163 MEVIDAITTTAQSHQRTF-VLEVMGRHCGYLALVSALASG-ADWLFIPEAP-PEDGWENFMCERLGETRSRgsrlnIIII 239
Cdd:PTZ00286 236 QNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFDiPLEGVLEYIEQRLQKKGHC-----VIVV 310
|
....
gi 1034627277 240 AEGA 243
Cdd:PTZ00286 311 AEGA 314
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
371-578 |
5.59e-18 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 87.41 E-value: 5.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 371 PKEKSNFS-----LAILNVGAPAAGMNAAVRSAVRTGIS--HGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSML 443
Cdd:PTZ00286 77 PRKHLYFNpkevkAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTIL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 444 GTKRTlpkGQ-LESIVENIRIYGIHALLVVGGFEAYEGVLQL-VEARGRYEELCIvmCVIPATISNNVPGTDFSLGSDTA 521
Cdd:PTZ00286 157 GSSRG---GFdPKVMVDTLIRHGINILFTLGGDGTHRGALAIyKELRRRKLNISV--VGIPKTIDNDIPIIDESFGFQTA 231
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034627277 522 VNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVG-ADAAYVFEDPFNI 578
Cdd:PTZ00286 232 VEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIPL 289
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
6-243 |
1.18e-17 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 86.46 E-value: 1.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRAVTR--MGIYVGAKVFLIYEGYEGLV-EGGENIKQANWLSVSNIIQLGGTIIGSARckafttreGRRAAAY-- 80
Cdd:PRK06830 94 GLNDVIRAIVLelHHHYGVRRILGIRYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR--------GPQDPEEiv 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 81 -NLVQHGITNLCVIGGDGSLTGANifrsewgslleelvaegKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSAL 159
Cdd:PRK06830 166 dTLERMNINILFVIGGDGTLRGAS-----------------AIAEEIERRGLKISVIGIPKTIDNDINFIQKSFGFETAV 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 160 HRIMEVIDAITTTAQSHQRTFVL-EVMGRHCGYLALVSALASG-ADWLFIPEAPPE-DGWENFMcERLgETRSRGSRLNI 236
Cdd:PRK06830 229 EKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDlEGPNGLL-AAL-EKRLAERGHAV 306
|
....*..
gi 1034627277 237 IIIAEGA 243
Cdd:PRK06830 307 IVVAEGA 313
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
24-243 |
3.15e-15 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 79.02 E-value: 3.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 24 KVFLIYEGYEGLVegGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTRegrraAAYNLVQHGITNLCVIGGDGSLTGAN 103
Cdd:PLN02564 121 RILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSRGGHDTSK-----IVDSIQDRGINQVYIIGGDGTQKGAS 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 104 ifrsewgSLLEELVAEG-KISettartyshlnIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQS-HQRTFV 181
Cdd:PLN02564 194 -------VIYEEIRRRGlKVA-----------VAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGL 255
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034627277 182 LEVMGRHCGYLALVSALAS-GADWLFIPEAP----PEDGWENFMCERLGETRSRgsrlnIIIIAEGA 243
Cdd:PLN02564 256 VKLMGRYSGFIAMYATLASrDVDCCLIPESPfyleGKGGLFEFIEKRLKENGHM-----VIVVAEGA 317
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
142-309 |
7.71e-15 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 77.21 E-value: 7.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 142 IDNDFCGTDMTIGTDSALHRI----MEV-IDAITTTAQShqRTFVLEVMGRHCGYLALVSALAS-----GADWLFIPEAP 211
Cdd:PRK14072 142 IDNDLPGTDHCPGFGSAAKYIatsvLEAaLDVAAMANTS--KVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERP 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 212 PEDgwENFMcERLGETRSRGSRLnIIIIAEGAIDRNGKPISSS-----------------YVKDLVVQRLGFDTRVTVLG 274
Cdd:PRK14072 220 FDE--EKFL-ADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAglaedafghaqlggvapVLANLIKEKLGKKVHWAVLD 295
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1034627277 275 HVQR--GGTPSAFDR---ILSSKM-------GMEAVMALLEATPDTP 309
Cdd:PRK14072 296 YLQRaaRHIASKTDVeeaYAVGKAaveyalaGKNGVMPAIRRTSDDP 342
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
6-335 |
1.10e-12 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 70.61 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 6 GMNAAVRA-VTRMGIYVGAKVFLIYEGYEGLVEggENIKQANwLS---VSNIIQLGGTIIGSARCKAFTTRegrraAAYN 81
Cdd:PLN02884 67 GLNDVIRQiVFTLEIYGVKNIVGIPFGYRGFFE--KGLSEMP-LSrkvVQNIHLSGGSLLGVSRGGAKTSD-----IVDS 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 82 LVQHGITNLCVIGGDGSLTGANIfrsewgslleelvaegkISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHR 161
Cdd:PLN02884 139 IEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEE 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 162 IMEVIDAITTTAQSHQRTF-VLEVMGRHCGYLALVSALASG-ADWLFIPEAPPE-DGWENFM--CERLGETRSRGsrlnI 236
Cdd:PLN02884 202 AQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTlDGPNGVLrhLEHLIETKGSA----V 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 237 IIIAEGA-IDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPS-----------------AFDRILSSKMGMEAV 298
Cdd:PLN02884 278 VCVAEGAgQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLGQNAV 357
|
330 340 350
....*....|....*....|....*....|....*..
gi 1034627277 299 MAlleATPDTPACVVTLSGNQSVRLPLMECVQMTKEV 335
Cdd:PLN02884 358 HG---AFAGFSGITVGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
367-591 |
1.07e-11 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 67.53 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 367 HQKPPKEKSNF-----SLAILNVGAPAAGMNAAVRSAVRT----------GISHGHTvyvvhdGF--EGLA-----KGQV 424
Cdd:PLN02884 39 HRAGPRKKIYFepeevKAAIVTCGGLCPGLNDVIRQIVFTleiygvknivGIPFGYR------GFfeKGLSemplsRKVV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 425 QEVGWHdvagwlgrGGSMLGTKRTLPKgqLESIVENIRIYGIHALLVVGGFEAYEGVLQL-VEARGRYEELCIVmCViPA 503
Cdd:PLN02884 113 QNIHLS--------GGSLLGVSRGGAK--TSDIVDSIEARGINMLFVLGGNGTHAGANAIhNECRKRKMKVSVV-GV-PK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 504 TISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVG-ADAAYVFEDPFNIH--- 579
Cdd:PLN02884 181 TIDNDILLMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDgpn 260
|
250
....*....|..
gi 1034627277 580 DLKVNVEHMTEK 591
Cdd:PLN02884 261 GVLRHLEHLIET 272
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
390-579 |
1.98e-10 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 63.73 E-value: 1.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 390 GMNAAVRSAVRTGishgHTVYVVHD------GFEGLakgqVQEVGwHD--------VAGWLGRGGSMLGTKRtlpkGQ-- 453
Cdd:PRK06830 94 GLNDVIRAIVLEL----HHHYGVRRilgiryGYQGL----IPRYG-HDpveltpevVADIHEFGGTILGSSR----GPqd 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 454 LESIVENIRIYGIHALLVVGGFEAYEGVLQLV-EARGRYEELCIVmcVIPATISNNVPGTDFSLGSDTAVNAAMESCDRI 532
Cdd:PRK06830 161 PEEIVDTLERMNINILFVIGGDGTLRGASAIAeEIERRGLKISVI--GIPKTIDNDINFIQKSFGFETAVEKATEAIRCA 238
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1034627277 533 KQSASGTKRRVFIVETMGGYCGYLATVTGIAVgADAAYVF--EDPFNIH 579
Cdd:PRK06830 239 HVEANGAPNGIGLVKLMGRHSGFIAAYAALAS-KDVNFVLipEVPFDLE 286
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
438-576 |
8.64e-10 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 61.69 E-value: 8.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 438 RGGSMLGTKRtlpKGQ-LESIVENIRIYGIHALLVVGGFEAYEG---VLQLVEARGryeeLCIVMCVIPATISNNVPGTD 513
Cdd:PLN02564 151 RGGTILGTSR---GGHdTSKIVDSIQDRGINQVYIIGGDGTQKGasvIYEEIRRRG----LKVAVAGIPKTIDNDIPVID 223
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034627277 514 FSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAV-GADAAYVFEDPF 576
Cdd:PLN02564 224 KSFGFDTAVEEAQRAINAAHVEAESVENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPF 287
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
31-243 |
9.85e-08 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 55.01 E-value: 9.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 31 GYEGLVeGGENI-------KQANWLSvsniiQLGGTIIGSARCKAFTT---------REGR---RAAAYNLVQHGITNLC 91
Cdd:PRK06555 44 GYQGLL-LGDSIeitpavrANAGLLH-----RYGGSPIGNSRVKLTNVadcvkrglvKEGEnplKVAAERLAADGVDILH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 92 VIGGDGSLTGAnifrsewGSLLEELVAEGkisettartYsHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITT 171
Cdd:PRK06555 118 TIGGDDTNTTA-------ADLAAYLAENG---------Y-DLTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVIN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 172 TAQSHQRTFVL-EVMGRHCGYLALVSALA-----SGADWL---------------FIPEAPPEDGWEnfmCERLGETRSR 230
Cdd:PRK06555 181 EHSANPRMLIIhEVMGRNCGWLTAATARAyrewlDRQEYVpgfglsaerwdihavYLPEMAFDLEAE---AERLKAVMDE 257
|
250
....*....|...
gi 1034627277 231 GSRLNiIIIAEGA 243
Cdd:PRK06555 258 VGNVN-IFLSEGA 269
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
385-643 |
7.06e-07 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 52.17 E-value: 7.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 385 GAPAAGMNAAVRSAVRTGISHG--HTVYVVHDGFEGLAKGQV---QEVGWHDVAGWLGRGGSMLGTKRTLPKG------Q 453
Cdd:PRK14072 12 GGPTAVINASAAGVIEEARKHKkiGKVYGARNGIIGILDEDLidlSKESDEALAALAHTPSGALGSCRYKLKSleedraE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 454 LESIVENIRIYGIHALLVVGG---FEAYEGVLQLVEARGrYEELCIVmcvIPATISNNVPGTDFSLGSDTAVN----AAM 526
Cdd:PRK14072 92 YERLLEVFKAHDIGYFFYNGGndsMDTALKVSQLAKKMG-YPIRCIG---IPKTIDNDLPGTDHCPGFGSAAKyiatSVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 527 E-SCDrikQSASGTKRRVFIVETMGGYCGYLATVTGIA-----VGADAAYVFEDPFnihdlkvNVEHMTEKMKTDIQRG- 599
Cdd:PRK14072 168 EaALD---VAAMANTSKVFILEVMGRHAGWLAAAAALAkqnpdDAPHLIYLPERPF-------DEEKFLADVRAIVKRYg 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1034627277 600 --LVLRNEKCHDyytteflynlysSEGKGVFD--CRTNVLGHLQQGGA 643
Cdd:PRK14072 238 ycVVVVSEGIRD------------ADGKFIAEagLAEDAFGHAQLGGV 273
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
18-245 |
2.20e-05 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 48.11 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 18 GIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNII-----QLGG-TIIGSARCKafTTREGRRAAAYNLVQH-GITNL 90
Cdd:PTZ00287 198 GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITDSLmnrfrNLGGfNMLWSGRGK--VRNKDDLIAIENIVAKlKLNGL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 91 CVIGGDGSLTGAnifrsewgSLLEELVAEGKISettartyshLNIAGLVGSIDNDFC--GTDMTIGTDSALHRIMEVIDA 168
Cdd:PTZ00287 276 VIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSEVIGN 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 169 ITTTAQS-HQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE---------NFMCERlgetRSRGSRLNIII 238
Cdd:PTZ00287 339 LCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSlkdivsnivNTILKR----RSLNKNYGVIL 414
|
....*..
gi 1034627277 239 IAEGAID 245
Cdd:PTZ00287 415 IPEGLIE 421
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
50-245 |
3.19e-04 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 44.19 E-value: 3.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 50 VSNIIQLGG-TIIGSARCKaFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIfrsewgslleelvaegkISETTAR 128
Cdd:PTZ00468 160 INGILNQGGfNIICSGRHK-IETEEQMRASLEICEKLKLHGLVVIGGDDSNTNAAV-----------------LAEYFKR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627277 129 TYSHLNIAGLVGSIDNDFCG--TDMTIGTDSALHRIMEVIDAITTTAQSHQ-RTFVLEVMGRHCGYLALVSALASGADWL 205
Cdd:PTZ00468 222 NSSSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMI 301
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1034627277 206 FIPEAPPEDGWE-----NFMCERLGETRSRGSRLNIIIIAEGAID 245
Cdd:PTZ00468 302 LIGEEIKEENRSlmsivDEIVEMILKRDSLGKKHGIVLLPEGLIE 346
|
|
| |
