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Conserved domains on  [gi|1034673893|ref|XP_016884874|]
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bromodomain and WD repeat-containing protein 3 isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
178-496 4.27e-61

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 4.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
Cdd:COG2319   118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 258 AVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRdrpvkfTERSRPGVQISCSSFSSGGMFITTGS 337
Cdd:COG2319   198 RTLTGHTGAVRSVAFSPD----GKLLASGSADGTVRL--WDLATGKLL------RTLTGHSGSVRSVAFSPDGRLLASGS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 338 TDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPSG 417
Cdd:COG2319   266 ADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSPDGKLL--ASGSDDGTVRLW------------DLATGKLLRTLTGH 329

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034673893 418 EDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLD 496
Cdd:COG2319   330 TG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
178-496 4.27e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 4.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
Cdd:COG2319   118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 258 AVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRdrpvkfTERSRPGVQISCSSFSSGGMFITTGS 337
Cdd:COG2319   198 RTLTGHTGAVRSVAFSPD----GKLLASGSADGTVRL--WDLATGKLL------RTLTGHSGSVRSVAFSPDGRLLASGS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 338 TDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPSG 417
Cdd:COG2319   266 ADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSPDGKLL--ASGSDDGTVRLW------------DLATGKLLRTLTGH 329

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034673893 418 EDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLD 496
Cdd:COG2319   330 TG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-494 4.59e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.78  E-value: 4.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 172 MHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISD-MAVNYeNTLIAAGSCDKVVRVWC 250
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASAD-GTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 251 LRTCAPVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFWQwhvktmkFRDRPVKFTERSRPGvQISCSSFSSGG 330
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPD----GRILSSSSRDKTIKVWD-------VETGKCLTTLRGHTD-WVNSVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 331 MFITTGSTDHVIRIYYLGSEVPekIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIWqyqqqewksivlDMATKMT 410
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGKC--VATLTGHTGEVNSVAFSPDGE--KLLSSSSDGTIKLW------------DLSTGKC 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 411 GNNLPSGEDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIIlSAGHDGNI 490
Cdd:cd00200   212 LGTLRGHEN-----GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA-SGSADGTI 285


                  ....
gi 1034673893 491 FIWD 494
Cdd:cd00200   286 RIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 181-391 2.75e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 2.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 181 SSVYC-VAFDRSGRRIFTGSDDCLVKIWATD----DGRLL----ATLRGHSaEISDMAVN-YENTLIAAGSCDKVVRVWC 250
Cdd:PLN00181  483 SNLVCaIGFDRDGEFFATAGVNKKIKIFECEsiikDGRDIhypvVELASRS-KLSGICWNsYIKSQVASSNFEGVVQVWD 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 251 LRTCAPVAVLQGHSASITSIQFcpsTKGTNRYLTSTGADGTICFWQWH----VKTMKFRdrpvkftersrpgVQISCSSF 326
Cdd:PLN00181  562 VARSQLVTEMKEHEKRVWSIDY---SSADPTLLASGSDDGSVKLWSINqgvsIGTIKTK-------------ANICCVQF 625

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034673893 327 -SSGGMFITTGSTDHviRIYYLGSEVPE-KIAELESHTDKVVAVQFCnngDSLRFVSGSRDGTARIW 391
Cdd:PLN00181  626 pSESGRSLAFGSADH--KVYYYDLRNPKlPLCTMIGHSKTVSYVRFV---DSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-494 6.17e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.17e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034673893  454 TGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWD 494
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
212-249 1.53e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.53e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034673893 212 GRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVW 249
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
178-496 4.27e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 4.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
Cdd:COG2319   118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 258 AVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRdrpvkfTERSRPGVQISCSSFSSGGMFITTGS 337
Cdd:COG2319   198 RTLTGHTGAVRSVAFSPD----GKLLASGSADGTVRL--WDLATGKLL------RTLTGHSGSVRSVAFSPDGRLLASGS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 338 TDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPSG 417
Cdd:COG2319   266 ADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSPDGKLL--ASGSDDGTVRLW------------DLATGKLLRTLTGH 329

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034673893 418 EDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLD 496
Cdd:COG2319   330 TG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
177-529 2.39e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.76  E-value: 2.39e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAP 256
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 257 VAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRDRpvkFTERSRPgvqISCSSFSSGGMFITTG 336
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPD----GKLLASGSDDGTVRL--WDLATGKLLRT---LTGHTGA---VRSVAFSPDGKLLASG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 337 STDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPS 416
Cdd:COG2319   223 SADGTVRLWDLAT--GKLLRTLTGHSGSVRSVAFSPDGRLL--ASGSADGTVRLW------------DLATGELLRTLTG 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 417 GEDKITKlkvtmVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLD 496
Cdd:COG2319   287 HSGGVNS-----VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLA 360

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1034673893 497 RGTKIRNYfnmiegQGH-GAVFDCKFSPDGNHFA 529
Cdd:COG2319   361 TGELLRTL------TGHtGAVTSVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-494 4.59e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.78  E-value: 4.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 172 MHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISD-MAVNYeNTLIAAGSCDKVVRVWC 250
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASAD-GTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 251 LRTCAPVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFWQwhvktmkFRDRPVKFTERSRPGvQISCSSFSSGG 330
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPD----GRILSSSSRDKTIKVWD-------VETGKCLTTLRGHTD-WVNSVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 331 MFITTGSTDHVIRIYYLGSEVPekIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIWqyqqqewksivlDMATKMT 410
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGKC--VATLTGHTGEVNSVAFSPDGE--KLLSSSSDGTIKLW------------DLSTGKC 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 411 GNNLPSGEDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIIlSAGHDGNI 490
Cdd:cd00200   212 LGTLRGHEN-----GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA-SGSADGTI 285


                  ....
gi 1034673893 491 FIWD 494
Cdd:cd00200   286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
175-539 1.08e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 1.08e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 175 RILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTC 254
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 255 APVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRDRpvkFTERSRPgvqISCSSFSSGGMFIT 334
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPD----GKTLASGSADGTVRL--WDLATGKLLRT---LTGHSGA---VTSVAFSPDGKLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 335 TGSTDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIWqyqqqewksivlDMATKMTGNNL 414
Cdd:COG2319   179 SGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRLW------------DLATGKLLRTL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 415 PSGEDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWD 494
Cdd:COG2319   243 TGHSG-----SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWD 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1034673893 495 LDRGTKIRNYfnmiegQGH-GAVFDCKFSPDGNHFACTDSHGHLLL 539
Cdd:COG2319   317 LATGKLLRTL------TGHtGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
187-540 1.98e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 1.98e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 187 AFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSAS 266
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 267 ITSIQFCPSTkgtnRYLTSTGADGTICFWQwhVKTMKFRDRPVKFTERsrpgvqISCSSFSSGGMFITTGSTDHVIRIYY 346
Cdd:COG2319    81 VLSVAFSPDG----RLLASASADGTVRLWD--LATGLLLRTLTGHTGA------VRSVAFSPDGKTLASGSADGTVRLWD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 347 LGSevPEKIAELESHTDKVVAVQFcnNGDSLRFVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPSGEDkitklKV 426
Cdd:COG2319   149 LAT--GKLLRTLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLW------------DLATGKLLRTLTGHTG-----AV 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 427 TMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLDRGTKIRNYfn 506
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTL-- 284

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1034673893 507 miegQGH-GAVFDCKFSPDGNHFACTDSHGHLLLF 540
Cdd:COG2319   285 ----TGHsGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-392 9.32e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.94  E-value: 9.32e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 171 KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWC 250
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 251 LRTCAPVAVLQGHSASITSIQFCPstkgTNRYLTSTGADGTICFW----QWHVKTMKFRDRPVkftersrpgvqiSCSSF 326
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSP----DGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENGV------------NSVAF 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034673893 327 SSGGMFITTGSTDHVIRIYYLGSEVPekIAELESHTDKVVAVQFCNNGdsLRFVSGSRDGTARIWQ 392
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVWDLRTGEC--VQTLSGHTNSVTSLAWSPDG--KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
178-349 8.46e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 8.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
Cdd:COG2319   244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 258 AVLQGHSASITSIQFCPstkgTNRYLTSTGADGTICFWQWHVKTmkfrdRPVKFTERSRPgvqISCSSFSSGGMFITTGS 337
Cdd:COG2319   324 RTLTGHTGAVRSVAFSP----DGKTLASGSDDGTVRLWDLATGE-----LLRTLTGHTGA---VTSVAFSPDGRTLASGS 391

                         170
                  ....*....|..
gi 1034673893 338 TDHVIRIYYLGS 349
Cdd:COG2319   392 ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-540 1.79e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 1.79e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 321 ISCSSFSSGGMFITTGSTDHVIRIYYLgsEVPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWQYQQQEwKS 400
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYL--ASGSSDKTIRLWDLETGE-CV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 401 IVLDMATKMtgnnlpsgedkitklkVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRI 480
Cdd:cd00200    87 RTLTGHTSY----------------VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTF 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034673893 481 ILSAGHDGNIFIWDLDRGTKIRNYfnmiegQGH-GAVFDCKFSPDGNHFACTDSHGHLLLF 540
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATL------TGHtGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 355-525 1.42e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 1.42e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 355 IAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIWQYQQQEWKsivldmaTKMTGNNLPsgedkitklkVTMVAWDRY 434
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGELL-------RTLKGHTGP----------VRDVAASAD 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 435 DTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLDRGTKIRNYfnmiegQGH- 513
Cdd:cd00200    63 GTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTL------RGHt 135

                         170
                  ....*....|..
gi 1034673893 514 GAVFDCKFSPDG 525
Cdd:cd00200   136 DWVNSVAFSPDG 147
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 457-531 6.45e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 6.45e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034673893 457 LLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLDRGTKIRnyfnmiEGQGH-GAVFDCKFSPDGNHFACT 531
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR------TLKGHtGPVRDVAASADGTYLASG 69
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 181-391 2.75e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 2.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 181 SSVYC-VAFDRSGRRIFTGSDDCLVKIWATD----DGRLL----ATLRGHSaEISDMAVN-YENTLIAAGSCDKVVRVWC 250
Cdd:PLN00181  483 SNLVCaIGFDRDGEFFATAGVNKKIKIFECEsiikDGRDIhypvVELASRS-KLSGICWNsYIKSQVASSNFEGVVQVWD 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 251 LRTCAPVAVLQGHSASITSIQFcpsTKGTNRYLTSTGADGTICFWQWH----VKTMKFRdrpvkftersrpgVQISCSSF 326
Cdd:PLN00181  562 VARSQLVTEMKEHEKRVWSIDY---SSADPTLLASGSDDGSVKLWSINqgvsIGTIKTK-------------ANICCVQF 625

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034673893 327 -SSGGMFITTGSTDHviRIYYLGSEVPE-KIAELESHTDKVVAVQFCnngDSLRFVSGSRDGTARIW 391
Cdd:PLN00181  626 pSESGRSLAFGSADH--KVYYYDLRNPKlPLCTMIGHSKTVSYVRFV---DSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-494 6.17e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.17e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034673893  454 TGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWD 494
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 171-207 1.39e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.39e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034673893  171 KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIW 207
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
212-249 1.53e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.53e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034673893 212 GRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVW 249
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 211-249 1.68e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.68e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1034673893  211 DGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVW 249
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
174-207 1.86e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034673893 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIW 207
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-295 3.64e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.64e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034673893  253 TCAPVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFW 295
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 353-391 5.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 5.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1034673893  353 EKIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIW 391
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
455-494 1.42e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034673893 455 GQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWD 494
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 197-390 2.43e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 197 TGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCA-PVAVLQGHSASITSIQFCPS 275
Cdd:PLN00181  593 SGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDS 672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034673893 276 TKgtnryLTSTGADGTICFWQWHVKTMKFRDRPV-KFTERSRPGVQISCsSFSSGgmFITTGSTDHVIRIYYLGSEVP-- 352
Cdd:PLN00181  673 ST-----LVSSSTDNTLKLWDLSMSISGINETPLhSFMGHTNVKNFVGL-SVSDG--YIATGSETNEVFVYHKAFPMPvl 744

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1034673893 353 -------EKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARI 390
Cdd:PLN00181  745 sykfktiDPVSGLEVDDASQFISSVCWRGQSSTLVAANSTGNIKI 789
WD40 pfam00400
WD domain, G-beta repeat;
256-295 4.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034673893 256 PVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFW 295
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
174-211 1.23e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034673893 174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDD 211
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
353-391 1.23e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034673893 353 EKIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIW 391
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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