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Conserved domains on  [gi|1034675168|ref|XP_016885288|]
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zinc finger X-chromosomal protein isoform X6 [Homo sapiens]

Protein Classification

Zfx_Zfy_act and COG5048 domain-containing protein( domain architecture ID 12057222)

protein containing domains Zfx_Zfy_act, COG5048, zf-C2H2, and zf-H2C2_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 70-357 1.82e-149

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 439.30  E-value: 1.82e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168  70 DVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTGDSIHVSDVGHVGH 149
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 150 VGHvehvvhdsVVEAEIVTDPLTTDVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSG 229
Cdd:pfam04704  81 VIH--------DSEREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 230 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 309
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1034675168 310 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMP 357
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMP 275
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-633 1.85e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 496 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 573
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034675168 574 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKH 633
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
zf-H2C2_2 pfam13465
Zinc-finger double domain;
686-710 9.45e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.45e-04
                          10        20
                  ....*....|....*....|....*
gi 1034675168 686 ELKKHMKTHSGRKVYQCEYCEYSTT 710
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 672-694 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 1034675168 672 FRCKRCRKGFRQQSELKKHMKTH 694
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ROS_MUCR super family cl19880
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 380-410 3.19e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


The actual alignment was detected with superfamily member pfam05443:

Pssm-ID: 473244  Cd Length: 122  Bit Score: 38.21  E-value: 3.19e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1034675168 380 CMICGKKFKSrgfLKRHMKNHpeHLAKKKYR 410
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAH--GLTPEEYR 92
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 70-357 1.82e-149

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 439.30  E-value: 1.82e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168  70 DVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTGDSIHVSDVGHVGH 149
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 150 VGHvehvvhdsVVEAEIVTDPLTTDVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSG 229
Cdd:pfam04704  81 VIH--------DSEREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 230 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 309
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1034675168 310 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMP 357
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMP 275
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-633 1.85e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 496 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 573
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034675168 574 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKH 633
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-539 5.44e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.44e-05
                          10        20
                  ....*....|....*....|....*
gi 1034675168 515 ELKKHMRIHTGEKPYQCQYCEYRSA 539
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
686-710 9.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.45e-04
                          10        20
                  ....*....|....*....|....*
gi 1034675168 686 ELKKHMKTHSGRKVYQCEYCEYSTT 710
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 672-694 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 1034675168 672 FRCKRCRKGFRQQSELKKHMKTH 694
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 380-410 3.19e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 38.21  E-value: 3.19e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1034675168 380 CMICGKKFKSrgfLKRHMKNHpeHLAKKKYR 410
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAH--GLTPEEYR 92
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 70-357 1.82e-149

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 439.30  E-value: 1.82e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168  70 DVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTGDSIHVSDVGHVGH 149
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 150 VGHvehvvhdsVVEAEIVTDPLTTDVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSG 229
Cdd:pfam04704  81 VIH--------DSEREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 230 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 309
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1034675168 310 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMP 357
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMP 275
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-633 1.85e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 496 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 573
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034675168 574 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKH 633
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-539 5.44e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.44e-05
                          10        20
                  ....*....|....*....|....*
gi 1034675168 515 ELKKHMRIHTGEKPYQCQYCEYRSA 539
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
464-607 2.37e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 464 KEKGANKMHKCKFCEYETAEQGLLNRHLLAVH---SKNFPHICVE--CGKGFRHPSELKKHMRIHTGEKPYQCQYC---- 534
Cdd:COG5048   282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsss 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675168 535 ------------------------EYRSADSSNLKTHVKTKHSKEMP----------FKCDICLLTFSDTKEVQQHALIH 580
Cdd:COG5048   362 kfspllnneppqslqqykdlkndkKSETLSNSCIRNFKRDSNLSLHIithlsfrpynCKNPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*..
gi 1034675168 581 QESKTHQCLHCDhKSSNSSDLKRHIIS 607
Cdd:COG5048   442 TNHAPLLCSILK-SFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
686-710 9.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.45e-04
                          10        20
                  ....*....|....*....|....*
gi 1034675168 686 ELKKHMKTHSGRKVYQCEYCEYSTT 710
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 501-523 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 1034675168 501 HICVECGKGFRHPSELKKHMRIH 523
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 672-694 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 1034675168 672 FRCKRCRKGFRQQSELKKHMKTH 694
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 380-410 3.19e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 38.21  E-value: 3.19e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1034675168 380 CMICGKKFKSrgfLKRHMKNHpeHLAKKKYR 410
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAH--GLTPEEYR 92
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 378-400 8.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.56e-03
                          10        20
                  ....*....|....*....|...
gi 1034675168 378 YPCMICGKKFKSRGFLKRHMKNH 400
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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