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Conserved domains on  [gi|1039792428|ref|XP_017168719|]
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semaphorin-3F isoform X4 [Mus musculus]

Protein Classification

semaphorin( domain architecture ID 10336824)

semaphorin, containing Sema, PSI, and Ig domains, is a regulatory molecule that functions in the development of the nervous system and in axonal guidance; similar to Bos taurus semaphorin-4A, the cell surface receptor for plexins PLXNB1, PLXNB2, PLXNB3 and PLXND1, that plays an important role in cell-cell signaling

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sema super family cl15693
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
1-322 0e+00

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


The actual alignment was detected with superfamily member cd11254:

Pssm-ID: 472829 [Multi-domain]  Cd Length: 470  Bit Score: 700.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQNPAVYARIGRICLNDDGG 80
Cdd:cd11254   149 MGTDAAIFRTMGKQPAMRTDQYNSRWLNDPAFVHAHLIPDSSEKNDDKLYFFFREKSLEAPQSPAVLSRIGRVCLNDDGG 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  81 HCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGP 160
Cdd:cd11254   229 HCCLVNKWSTFLKARLVCSVPGADGIETHFDELRDVFIQPTQDTKNPVIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGP 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 161 FAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTTV 240
Cdd:cd11254   309 FAHKEGPNYQWMPYTGKIPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYNAVYPVHRRPLVVRTNVNYRFTTI 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 241 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSLH 320
Cdd:cd11254   389 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDLETEELTLEEVEVFKVPAPIKTMKISSKRQQLYVSSAVGVTHLSLH 468

                  ..
gi 1039792428 321 RC 322
Cdd:cd11254   469 RC 470
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
382-426 3.80e-15

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05871:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 70.84  E-value: 3.80e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1039792428 382 NAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPSDRRREVSS 426
Cdd:cd05871     1 NAEEKVVYGVEGNSTFLECLPKSPQATVKWLFQRGGDQRKEEVKS 45
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
321-358 1.47e-06

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.23  E-value: 1.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039792428  321 RCQAYGAaCADCCLARDPYCAWD--GQACSRYTASSKRRS 358
Cdd:smart00423   1 RCSKYTS-CSECLLARDPYCAWCssQGRCTSGERCDSRRQ 39
 
Name Accession Description Interval E-value
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
1-322 0e+00

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 700.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQNPAVYARIGRICLNDDGG 80
Cdd:cd11254   149 MGTDAAIFRTMGKQPAMRTDQYNSRWLNDPAFVHAHLIPDSSEKNDDKLYFFFREKSLEAPQSPAVLSRIGRVCLNDDGG 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  81 HCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGP 160
Cdd:cd11254   229 HCCLVNKWSTFLKARLVCSVPGADGIETHFDELRDVFIQPTQDTKNPVIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGP 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 161 FAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTTV 240
Cdd:cd11254   309 FAHKEGPNYQWMPYTGKIPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYNAVYPVHRRPLVVRTNVNYRFTTI 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 241 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSLH 320
Cdd:cd11254   389 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDLETEELTLEEVEVFKVPAPIKTMKISSKRQQLYVSSAVGVTHLSLH 468

                  ..
gi 1039792428 321 RC 322
Cdd:cd11254   469 RC 470
Sema smart00630
semaphorin domain;
1-295 8.66e-111

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 337.03  E-value: 8.66e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428    1 MGTDAAIFRTLG----KQTA---MRTDQYNSRWLNDPSFIHAELIpdsaernDDKLYFFFRERSAEA-PQNPAVYARIGR 72
Cdd:smart00630 103 SGSDPAIPRSLSvrrlKGTSgvsLRTVLYDSKWLNEPNFVYAFES-------GDFVYFFFRETAVEDdNCGKAVHSRVAR 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   73 ICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGieTHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMAD 152
Cdd:smart00630 176 VCKNDVGGPRSLDKKWTSFLKARLECSVPGEDP--FYFNELQAAFLLPPGSESDDVLYGVFSTSSNPIPGSAVCAFSLSD 253
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  153 IRMVFNGPFAHKEGPNYQWMPFS-GKMPYPRPGTCPGGTFtpsmkSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRT 231
Cdd:smart00630 254 INAVFNGPFKECETSTSQWLPYSrGKVPYPRPGTCPNKPP-----SSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKT 328
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039792428  232 GAPYRLTTVAVDQVdAADGRYEVLFLGTDRGTVQKVIVLPKDDQeVEELMLEEVEVFKEPAPVK 295
Cdd:smart00630 329 DSNYLLTSIAVDRV-ATDGNYTVLFLGTSDGRILKVVLSESSSS-SESVVLEEISVFPDGSPIS 390
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
113-301 1.15e-74

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 236.01  E-value: 1.15e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 113 LQDVFVQQ--TQDVRNPVIYAVFTSS-GSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGG 189
Cdd:pfam01403   1 LQDVFVLKpgAGDALDTVLYGVFTTQwSNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYTGKVPYPRPGTCIND 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 190 TFtpsmksTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGapYRLTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIV 269
Cdd:pfam01403  81 PL------RLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTG--VRLTSIAVDRVQALDGNYTVLFLGTDDGRLHKVVL 152
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1039792428 270 LPKDD-------QeveelmleeveVFKEPAPVKTMTISS 301
Cdd:pfam01403 153 VGSEEshiieeiQ-----------VFPEPQPVLNLLLSS 180
Ig_Sema3 cd05871
Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed ...
382-426 3.80e-15

Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed of the immunoglobulin (Ig)-like domain of Sema3 and similar proteins. Semaphorins are classified based on structural features additional to the Sema domain. Sema3 is a Class III semaphorin that is secreted. It is a vertebrate class having a Sema domain, an Ig domain, a short basic domain. They have been shown to be axonal guidance cues and have a part in the regulation of the cardiovascular, immune, and respiratory systems. Sema3A, the prototype member of this class III subfamily, induces growth cone collapse and is an inhibitor of axonal sprouting. In perinatal rat cortex, it acts as a chemoattractant and functions to direct the orientated extension of apical dendrites. It may play a role, prior to the development of apical dendrites, in signaling the radial migration of newborn cortical neurons towards the upper layers. Sema3A selectively inhibits vascular endothelial growth factor receptor (VEGF)-induced angiogenesis and induces microvascular permeability. This group also includes Sema3B, -C, -D, -E, -G.


Pssm-ID: 409455  Cd Length: 92  Bit Score: 70.84  E-value: 3.80e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1039792428 382 NAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPSDRRREVSS 426
Cdd:cd05871     1 NAEEKVVYGVEGNSTFLECLPKSPQATVKWLFQRGGDQRKEEVKS 45
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
321-358 1.47e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.23  E-value: 1.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039792428  321 RCQAYGAaCADCCLARDPYCAWD--GQACSRYTASSKRRS 358
Cdd:smart00423   1 RCSKYTS-CSECLLARDPYCAWCssQGRCTSGERCDSRRQ 39
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
321-362 4.18e-03

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 35.76  E-value: 4.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1039792428 321 RCQAYGAaCADCCLARDPYCAWD--GQACSRYTASSKRRSRRQD 362
Cdd:pfam01437   1 RCSQYTS-CSSCLAARDPYCGWCssEGRCVRRSACGAPEGNCEE 43
 
Name Accession Description Interval E-value
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
1-322 0e+00

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 700.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQNPAVYARIGRICLNDDGG 80
Cdd:cd11254   149 MGTDAAIFRTMGKQPAMRTDQYNSRWLNDPAFVHAHLIPDSSEKNDDKLYFFFREKSLEAPQSPAVLSRIGRVCLNDDGG 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  81 HCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGP 160
Cdd:cd11254   229 HCCLVNKWSTFLKARLVCSVPGADGIETHFDELRDVFIQPTQDTKNPVIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGP 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 161 FAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTTV 240
Cdd:cd11254   309 FAHKEGPNYQWMPYTGKIPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYNAVYPVHRRPLVVRTNVNYRFTTI 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 241 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSLH 320
Cdd:cd11254   389 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDLETEELTLEEVEVFKVPAPIKTMKISSKRQQLYVSSAVGVTHLSLH 468

                  ..
gi 1039792428 321 RC 322
Cdd:cd11254   469 RC 470
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
1-322 0e+00

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 614.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQN-PAVYARIGRICLNDDG 79
Cdd:cd11239   149 MGRDAAIFRSLGHRHYIRTEQYDSRWLNEPKFVGAYLIPDSDNPDDDKVYFFFREKAVEAEGSgKAIYSRVGRICKNDVG 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNG 159
Cdd:cd11239   229 GQRSLVNKWSTFLKARLVCSVPGPDGIDTYFDELEDVFLLPTRDPKNPLIYGVFTTSSNVFKGSAVCVYSMADIRAAFNG 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 160 PFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTT 239
Cdd:cd11239   309 PFAHKEGPNYQWVEYQGKVPYPRPGTCPSKTYGPLYKSTKDFPDDVISFARSHPLMYNPVYPLHGRPLLIRTNVPYRLTQ 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 240 VAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSL 319
Cdd:cd11239   389 IAVDRVEAEDGQYDVLFIGTDSGTVLKVVSLPKENWEMEEVILEELQVFKHPSPITSMEISSKRQQLYVGSAEGVVQLPL 468

                  ...
gi 1039792428 320 HRC 322
Cdd:cd11239   469 HRC 471
Sema_3C cd11251
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted ...
1-322 2.14e-169

The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted semaphorin expressed in and adjacent to cardiac neural crest cells, and causes impaired migration of neural crest cells to the developing cardiac outflow tract, resulting in the interruption of the aortic arch and persistent truncus arteriosus. It has been proposed that Sema3C acts as a guidance molecule, regulating migration of neural crest cells that express semaphorin receptors such as plexin A2. Sema3C may also participate in tumor progression. The cleavage of Sema3C induced by ADAMTS1 promotes the migration of breast cancer cells. Sema3C is a member of the class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200512 [Multi-domain]  Cd Length: 470  Bit Score: 489.79  E-value: 2.14e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQNP-AVYARIGRICLNDDG 79
Cdd:cd11251   148 MGTDAAIFRSLTKRNAVRTDQHNSKWLSEPIFVDAHLIPDGTDPNDAKLYFFLKERLTDNSGSTkQIHSMIARVCPNDTG 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNG 159
Cdd:cd11251   228 GQRSLVNKWTTFLKARLVCSVMDEDGTETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHMSDIQTVFNG 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 160 PFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTT 239
Cdd:cd11251   308 PFAHKEGPNHQLIAYQGRIPYPRPGTCPGGAFTPNMQSTKEFPDDVVTFIRNHPLMFNPIYPIGRRPLLVRTGTDYKYTK 387
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 240 VAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSL 319
Cdd:cd11251   388 IAVDRVNAADGRYHVLFLGTDKGTVQKVVVLPTNGSLSGELILEELEVFKNHAPITNMKISSKKQQLYVSSEEGISQVSL 467

                  ...
gi 1039792428 320 HRC 322
Cdd:cd11251   468 HRC 470
Sema_3A cd11249
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been ...
1-322 1.39e-155

The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been reported to inhibit the growth of certain experimental tumors and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response. Sema3A is a member of the Class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200510 [Multi-domain]  Cd Length: 493  Bit Score: 455.61  E-value: 1.39e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDG 79
Cdd:cd11249   170 MGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKIYFFFRENAIDGEHtGKATHARIGQLCKNDFG 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNG 159
Cdd:cd11249   250 GHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYAVFTTSSNIFKGSAVCMYSMTDIRRVFLG 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 160 PFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTpSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTT 239
Cdd:cd11249   330 PYAHRDGPNYQWVPFQGRVPYPRPGTCPSKTFG-GFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIIIKTDVDYQFTQ 408
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 240 VAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDD-QEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLS 318
Cdd:cd11249   409 IVVDRVEAEDGQYDVMFIGTDMGTVLKVVSIPKETwHDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSAIGVSQLP 488

                  ....
gi 1039792428 319 LHRC 322
Cdd:cd11249   489 LHRC 492
Sema_3B cd11250
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is ...
1-322 2.80e-153

The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is coexpressed with semaphorin 3F and both proteins are candidate tumor suppressors. Both Sema3B and Sema3F show high levels of expression in normal tissues and low-grade tumors but are down-regulated in highly metastatic tumors in the lung, melanoma cells, bladder carcinoma cells and prostate carcinoma. They are upregulated by estrogen and inhibit cell motility and invasiveness through decreased FAK phosphorylation and inhibition of MMP-2 and MMP-9 expression. Two receptor families, the neuropilins (NP) and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3B is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200511 [Multi-domain]  Cd Length: 471  Bit Score: 448.98  E-value: 2.80e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQNPAV-YARIGRICLNDDG 79
Cdd:cd11250   149 MGRDFTIFRSLGQRPSLRTEQHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAGLGKQsYSRIGQICRNDMG 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNG 159
Cdd:cd11250   229 GQRSLVNKWTTFLKARLVCSVPGNEGGDTHFDELRDVFLLQTRDKRNPLIYAVFSTSSSVFQGSAVCVYTMNDVRRAFLG 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 160 PFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTpSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTT 239
Cdd:cd11250   309 PFAHKEGPNYQWVSYQGKVPYPRPGMCPSKTFG-SFESTKDFPDDVIQFARNHPLMFNPVLPLGGRPLFLRTGIPYTFTQ 387
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 240 VAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDD-QEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLS 318
Cdd:cd11250   388 IAVDRVAAADGHYDVMFIGTDVGSVLKVISVPKGSwPSNEELLLEELHVFKDSSPITSMQISSKRQQLYVGSRSGVSQLP 467

                  ....
gi 1039792428 319 LHRC 322
Cdd:cd11250   468 LHRC 471
Sema_3G cd11255
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is ...
1-322 2.35e-145

The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200516 [Multi-domain]  Cd Length: 474  Bit Score: 428.56  E-value: 2.35e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQyNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ--NPAVYARIGRICLNDD 78
Cdd:cd11255   148 LGRDSVIFRGFGTRSPLRTET-DQRLLHEPRFVAAHLIPDNADRDNDKVYFFFTERATETAEddDGAIHSRVGRLCANDA 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  79 GGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFN 158
Cdd:cd11255   227 GGQRVLVNKWSTFIKARLVCSVPGPHGIQTHFDQLEDVFLLRTKDGKSPEIYALFSTISNVFQGFAVCVYSMADIWEVFN 306
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 159 GPFAHKEGPNYQWMPFSGKMPYPRPGTCPGG-TFTPS--MKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPY 235
Cdd:cd11255   307 GPFAHKDGPDHQWGPYEGKVPYPRPGVCPSKiTAQPGraFRSTKDYPDEVLQFARAHPLMWRPVYPSHRRPVLVKTGLPY 386
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 236 RLTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELML-EEVEVFKEPAPVKTMTISSKRQQLYVASAVGV 314
Cdd:cd11255   387 RLTQIVVDRVEAEDGYYDVMFIGTDSGSVLKVIVLQKGNSAAGEEVTlEELQVFKVPTPITEMEISVKRQMLYVGSRTGV 466

                  ....*...
gi 1039792428 315 THLSLHRC 322
Cdd:cd11255   467 AQVPLHRC 474
Sema_3D cd11252
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted ...
1-322 3.85e-144

The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200513 [Multi-domain]  Cd Length: 474  Bit Score: 425.48  E-value: 3.85e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLG---KQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAP-QNPAVYARIGRICLN 76
Cdd:cd11252   149 LGKDTTFTRSLGptpDHHYIRTDISEHYWLNGAKFIGTFPIPDTYNPDDDKIYFFFREASQDGStSDKSVLSRVGRVCKN 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  77 DDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMV 156
Cdd:cd11252   229 DVGGQRSLINKWTTFLKARLVCSIPGPDGADTHFDELQDIFLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAV 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 157 FNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYR 236
Cdd:cd11252   309 FNGPYAHKESPDHRWVQYEGRIPYPRPGTCPSKTYDPLIKSTKDFPDEVISFIKRHPLMYKSVYPLTGGPVFTRINVDYR 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 237 LTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTH 316
Cdd:cd11252   389 LTQIVVDHVAAEDGQYDVMFLGTDIGTVLKVVSITKEKWTMEEVVLEELQIFKHPSPILNMELSLKQQQLYIGSRDGLVQ 468

                  ....*.
gi 1039792428 317 LSLHRC 322
Cdd:cd11252   469 LSLHRC 474
Sema_3E cd11253
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted ...
2-322 2.38e-135

The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200514 [Multi-domain]  Cd Length: 471  Bit Score: 403.08  E-value: 2.38e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDGG 80
Cdd:cd11253   149 GRDAAIFRTMNHLAHIRTEHDDERLLKEPKFVGSYMIPDNEDPDDNKVYFFFTEKALEAEGgNHAIYTRVGRVCANDQGG 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  81 HCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGP 160
Cdd:cd11253   229 QRMLVNKWSTFLKTRLICSVPGPNGIDTHFDELEDVFLLRTRDNKNPEIFGLFSTTSNIFKGYAICVYHMASIRAAFNGP 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 161 FAHKEGPNYQWMPFSGKMPYPRPGTCP----GGTFTpsmkSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYR 236
Cdd:cd11253   309 FAHKEGPEYHWSVYEGKVPYPRPGSCAskvnGGHYG----TTKDYPDEALRFARSHPLMYQAVKPVHKRPILVKTDGKYN 384
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 237 LTTVAVDQVDAADGRYEVLFLGTDRGTVQKVI-VLPKDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVT 315
Cdd:cd11253   385 LKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVItIYNQETETMEEVILEELQVFKVPVPIISMEISSKRQQLYIGSESGVA 464

                  ....*..
gi 1039792428 316 HLSLHRC 322
Cdd:cd11253   465 QIRFHQC 471
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
1-320 2.56e-111

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 340.16  E-value: 2.56e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDsaernddKLYFFFRERSAE-APQNPAVYARIGRICLNDDG 79
Cdd:cd11235   133 LGTDPVIYRTLGHNPPLRTEYHDSKWLNEPQFVGAFDIGD-------YVYFFFREIAVEyINCGKAVYSRVARVCKNDQG 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNKWSTFLKARLVCSVPGEDGieTHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNG 159
Cdd:cd11235   206 GSRSLEKKWTTFLKARLNCSVPGEFP--FYFNELQDVFDLPSPSNKEKIFYAVFTTPYNSIPGSAVCAYSLSDIEAVFNG 283
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 160 PFAHKEGPNYQWMPFSG-KMPYPRPGTCPGgtftpsmkSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLT 238
Cdd:cd11235   284 PFKEQHSSNSAWLPVPDeRVPEPRPGTCVD--------DSSPLPDDTLNFIKSHPLMDEAVTPILNRPLFIKTDVNYRFT 355
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 239 TVAVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDQeVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHL 317
Cdd:cd11235   356 KIAVDRVQAKLGQtYDVLFVGTDRGIILKVVSLPEQGL-QASNILEEMPVGPPPEPIQTMQLSRKRRSLYVGSETGVLQV 434

                  ...
gi 1039792428 318 SLH 320
Cdd:cd11235   435 PLA 437
Sema smart00630
semaphorin domain;
1-295 8.66e-111

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 337.03  E-value: 8.66e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428    1 MGTDAAIFRTLG----KQTA---MRTDQYNSRWLNDPSFIHAELIpdsaernDDKLYFFFRERSAEA-PQNPAVYARIGR 72
Cdd:smart00630 103 SGSDPAIPRSLSvrrlKGTSgvsLRTVLYDSKWLNEPNFVYAFES-------GDFVYFFFRETAVEDdNCGKAVHSRVAR 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   73 ICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGieTHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMAD 152
Cdd:smart00630 176 VCKNDVGGPRSLDKKWTSFLKARLECSVPGEDP--FYFNELQAAFLLPPGSESDDVLYGVFSTSSNPIPGSAVCAFSLSD 253
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  153 IRMVFNGPFAHKEGPNYQWMPFS-GKMPYPRPGTCPGGTFtpsmkSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRT 231
Cdd:smart00630 254 INAVFNGPFKECETSTSQWLPYSrGKVPYPRPGTCPNKPP-----SSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKT 328
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039792428  232 GAPYRLTTVAVDQVdAADGRYEVLFLGTDRGTVQKVIVLPKDDQeVEELMLEEVEVFKEPAPVK 295
Cdd:smart00630 329 DSNYLLTSIAVDRV-ATDGNYTVLFLGTSDGRILKVVLSESSSS-SESVVLEEISVFPDGSPIS 390
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
2-319 8.43e-85

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 271.98  E-value: 8.43e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDqYNSRWLNDPSFIHAELIP---DSAERNDDKLYFFFRERSAE-APQNPAVYARIGRICLND 77
Cdd:cd11240   144 GSEPVISRNHSEGNVLKTE-NTLRWLNEPAFVGSAHIResiDSPDGDDDKIYFFFTETAVEyDFYEKVTVSRVARVCKGD 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  78 DGGHCCLVNKWSTFLKARLVCSVPGEdgiETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVF 157
Cdd:cd11240   223 LGGQRTLQKKWTTFLKAQLVCSQPDS---GLPFNVLRDVFVLSPDSWDATIFYGVFTSQWNVSGLSAVCAYSLEDIKKVF 299
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 158 NGPFAHKEGPNYQWMPFSGKMPYPRPGTC-PGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQrRPLVVRTGAPYr 236
Cdd:cd11240   300 SGKYKEFNRETSKWSRYTGPVPDPRPGACiTNSARSQGITSSLNLPDNVLTFVKDHPLMDEQVHPIN-RPLLVKSGVNY- 377
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 237 lTTVAVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKddqevEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVT 315
Cdd:cd11240   378 -TRIAVHRVQALDGQtYTVLFLGTEDGFLHKAVSLDG-----GMHIIEEIQLFDQPQPVKNLLLSSSKGVLYVGSSSGVV 451

                  ....
gi 1039792428 316 HLSL 319
Cdd:cd11240   452 QVPL 455
Sema_4G cd11262
The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and ...
14-319 2.57e-80

The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex. Sema4G and Sema4C proteins specifically bind to Plexin B2 expressed in the cerebellar granule cells. Sema4G and Sema4C are involved in neural tube closure and cerebellar granule cell development through Plexin B2.Sema4G belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200523 [Multi-domain]  Cd Length: 457  Bit Score: 260.08  E-value: 2.57e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  14 QTAMRTDQYNSRWLNDPSFIHAELIP---DSAERNDDKLYFFFRERSAEAPQNPAVY--ARIGRICLNDDGGHCCLVNKW 88
Cdd:cd11262   154 QPTLRTEEAPTRWLNDADFVGSVLVResmNSSVGDDDKIYFFFTERSQEETAYFSQSrvARVARVCKGDRGGKKTLQRKW 233
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  89 STFLKARLVCSVPGedgIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPN 168
Cdd:cd11262   234 TSFLKARLVCYIPE---YEFLFNVLRSVFVLWGSTPQDTVFYGIFGLEWKNVKASAICRYSLSDIQTAFEGPYMEYQDSS 310
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 169 YQWMPFSGKMPYPRPGTCPGGTF-TPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYrlTTVAVDQVDA 247
Cdd:cd11262   311 SKWSRYTGKVPEPRPGSCITDEHrSQGINSSQDLPDNVLDFVRRHPLMAEQVLPVEGRPLLFKRNVIY--TKIAVQTVRG 388
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039792428 248 ADGR-YEVLFLGTDRGTVQKVIVLpkddqEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSL 319
Cdd:cd11262   389 LDGRvYDVLFLGTDEGWLHKAVVI-----GSAVHIIEELQVFREPQPVENLVISKKQNSLYVGARSGVVQVPL 456
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
2-322 3.15e-76

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 249.17  E-value: 3.15e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTlgkqtAMRTDQYNSRWLNDPSFIHaelipdSAERNDdKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDGG 80
Cdd:cd11237   137 GADPLIYRE-----PLRTERYDLKQLNAPNFVS------SFAYGD-YVYFFFRETAVEYINcGKAIYSRVARVCKNDKGG 204
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  81 HCCLVNKWSTFLKARLVCSVPGEdgIETHFDELQ---DVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVF 157
Cdd:cd11237   205 PHPFRDRWTSFLKARLNCSVPGE--YPFYFNEIQstsDIVEGGYGGKSAKLIYGVFTTPVNSISGSAVCAFSLQDILEVF 282
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 158 NGPFAHKEGPNYQWMPFSG-KMPYPRPGTCpggtftpsMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYR 236
Cdd:cd11237   283 DGSFKEQQDINSNWLPVPSnKVPEPRPGQC--------VNDSRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSLQYR 354
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 237 LTTVAVD-QVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDQEVEELML--EEVEVFKEPAPVKTMTISSKRQQ--LYVAS 310
Cdd:cd11237   355 FTQIAVDpQVKALDGKyYDVLFIGTDDGKVLKAVNIASADTVDKVSPVviEETQVFPRGVPIRNLLIVRGKDDgrLVVVS 434
                         330
                  ....*....|..
gi 1039792428 311 AVGVTHLSLHRC 322
Cdd:cd11237   435 DDEIVSIPLHRC 446
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
113-301 1.15e-74

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 236.01  E-value: 1.15e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 113 LQDVFVQQ--TQDVRNPVIYAVFTSS-GSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGG 189
Cdd:pfam01403   1 LQDVFVLKpgAGDALDTVLYGVFTTQwSNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYTGKVPYPRPGTCIND 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 190 TFtpsmksTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGapYRLTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIV 269
Cdd:pfam01403  81 PL------RLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTG--VRLTSIAVDRVQALDGNYTVLFLGTDDGRLHKVVL 152
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1039792428 270 LPKDD-------QeveelmleeveVFKEPAPVKTMTISS 301
Cdd:pfam01403 153 VGSEEshiieeiQ-----------VFPEPQPVLNLLLSS 180
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
1-271 1.37e-68

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 229.71  E-value: 1.37e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAElipdsaeRNDDKLYFFFRERSAE-APQNPAVYARIGRICLNDDG 79
Cdd:cd11242   144 LASDAVIYRSLGDSPTLRTVKYDSKWLKEPHFVHAV-------EYGDYVYFFFREIAVEyNTLGKVVFSRVARVCKNDMG 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNK-WSTFLKARLVCSVPGEDGIetHFDELQDVfvqqTQDVR---NPVIYAVFTSSGSVFRGSAVCVYSMADIRM 155
Cdd:cd11242   217 GSPRVLEKqWTSFLKARLNCSVPGDSHF--YFDVLQAV----TDVIRingRPVVLGVFTTQYNSIPGSAVCAFDMDDIEK 290
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 156 VFNGPFAHKEGPNYQWMPFS-GKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAP 234
Cdd:cd11242   291 VFEGRFKEQKSPDSAWTPVPeDRVPKPRPGCCAGSGSAEKYKTSNDFPDDTLNFIKTHPLMDEAVPSIINRPWFTRTMVR 370
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1039792428 235 YRLTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIVLP 271
Cdd:cd11242   371 YRLTQIAVDNAAGPYQNYTVVFLGSEAGTVLKFLARI 407
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
1-268 2.19e-64

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 218.36  E-value: 2.19e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAElipdsaeRNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDG 79
Cdd:cd11269   144 LASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNlGKAVYSRVARICKNDMG 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNK-WSTFLKARLVCSVPGEDGIetHFDELQDVfvQQTQDVRN-PVIYAVFTSSGSVFRGSAVCVYSMADIRMVF 157
Cdd:cd11269   217 GSQRVLEKhWTSFLKARLNCSVPGDSFF--YFDVLQSI--TDIIEINGiPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVF 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 158 NGPFAHKEGPNYQWMPF-SGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYR 236
Cdd:cd11269   293 KGRFKEQKTPDSVWTAVpEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYR 372
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1039792428 237 LTTVAVDQVDAADGRYEVLFLGTDRGTVQKVI 268
Cdd:cd11269   373 LTAIAVDHAAGPHQNYTVIFVGSEAGVVLKIL 404
Sema_4E cd11260
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed ...
1-319 1.95e-63

The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200521 [Multi-domain]  Cd Length: 456  Bit Score: 215.54  E-value: 1.95e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTlgKQTAMRTdQYNSRWLNDPSFIHAELIP---DSAERNDDKLYFFFRERSAEAP-QNPAVYARIGRICLN 76
Cdd:cd11260   143 LGSEPVIMRS--SPITIRT-EFKSSWLNEPNFIYMAAVPeseDSPEGDDDKIYLFFSETAVEYDfYNKLVVSRVARVCKG 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  77 DDGGHCCLVNKWSTFLKARLVCSVPgedgiETHFDEL-QDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRM 155
Cdd:cd11260   220 DLGGQRTLQKKWTSFLKARLDCSVP-----EPSLPYViQDVFHVCHQDWRKCVFYAVFTSQSDSSQSSAVCAYNVTDISN 294
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 156 VFN-----GPFAhKEGPNYQWMPFSGKMPYPRPGTC-PGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVV 229
Cdd:cd11260   295 VFSrgkfkTPVA-VETSFVKWVMYSGELPVPRPGACiNNAARTSGIKKSLNLPDKTLQFVKDKPLMDQAVHPITGKPLLV 373
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 230 RTGAPyrLTTVAVDQVDAADG-RYEVLFLGTDRGTVQKVIvlpkdDQEVEELMLEEVEVFKEPAPVKTMTISSKrqQLYV 308
Cdd:cd11260   374 KRGAL--FTRIVVDMVTAADGqSYPVMFIGTANGYVLKAV-----NYDGEMHIIEEVQLFEPEEPIDILRLSQN--QLYA 444
                         330
                  ....*....|.
gi 1039792428 309 ASAVGVTHLSL 319
Cdd:cd11260   445 GSASGVVQMPV 455
Sema_6A cd11266
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, ...
1-269 1.13e-60

The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, Sema6A-plexin A2 signaling modulates granule cell migration by controlling centrosome positioning. Besides plexin A2, plexin A4 is also found to be a receptor of Sema6A. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. It is required for the clustering of boundary cap cells at the PNS/CNS interface and thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site, it organizes the segregation of dorsal roots. Sema6A may also be involved in axonal pathfinding processes in the periinfarct and homotopic contralateral cortex. Sema6A is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200527 [Multi-domain]  Cd Length: 466  Bit Score: 208.73  E-value: 1.13e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAElipdsaeRNDDKLYFFFRERSAE-APQNPAVYARIGRICLNDDG 79
Cdd:cd11266   144 LAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAV-------DYGDYIYFFFREIAVEyNSMGKVVFPRVAQVCKNDMG 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNK-WSTFLKARLVCSVPGEDGIetHFDELQDVFVQQTQDVRNpVIYAVFTSSGSVFRGSAVCVYSMADIRMVFN 158
Cdd:cd11266   217 GSQRVLEKqWTSFLKARLNCSVPGDSHF--YFNILQAVTDVIHINGRD-VVLATFSTPYNSIPGSAVCAYDMLDIASVFT 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 159 GPFAHKEGPNYQWMPFSG-KMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRL 237
Cdd:cd11266   294 GRFKEQKSPDSTWTPVPDeRVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRL 373
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1039792428 238 TTVAVDQVDAADGRYEVLFLGTDRGTVQKVIV 269
Cdd:cd11266   374 TKIAVDNAAGPYQNHTVVFLGSEKGIILKFLA 405
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
1-314 1.91e-60

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 208.17  E-value: 1.91e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLgKQTAMRTdQYNSRWLNDPSFIHAELI---PDSAERNDDKLYFFFRERSAEAP-QNPAVYARIGRICLN 76
Cdd:cd11259   152 LGSEPIISRNS-SQSPLRT-EYAIPWLNEPSFVFADVIradPDSPDGEDDKIYFFFTEVSVEYEfVGKLLIPRIARVCKG 229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  77 DDGGHCCLVNKWSTFLKARLVCSVPGEDGIethFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMV 156
Cdd:cd11259   230 DQGGLRTLQKKWTSFLKARLICSIPDKNLV---FNVVNDVFILKSPTLKEPVIYGVFTPQLNNVGLSAVCAYNLSTVEEV 306
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 157 FN-GPFAHK---EGPNYQWMPFSGKMPYPRPGTCPGGTFTPS-MKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRT 231
Cdd:cd11259   307 FSkGKYMQSatvEQSHTKWVRYNGEVPKPRPGACINNEARAAnYTSSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKK 386
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 232 GAPYrlTTVAVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKDdqeveELMLEEVEVFKEPAPVKTMTISSK--RQQLYV 308
Cdd:cd11259   387 DVNY--TQIVVDRVQALDGTiYDVMFISTDRGALHKAISLENE-----VHIIEETQLFPDFEPVQTLLLSSKkgRRFLYA 459

                  ....*.
gi 1039792428 309 ASAVGV 314
Cdd:cd11259   460 GSNSGV 465
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
4-274 9.61e-60

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 206.22  E-value: 9.61e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   4 DAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHA-ELIPdsaernddKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDGGH 81
Cdd:cd11267   147 DAVIYRSLGDSPALRTVKHDSKWFKEPYFVHAvEWGS--------HVYFFFREIAMEFNYlEKVVVSRVARVCKNDMGGS 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  82 CCLVNK-WSTFLKARLVCSVPGEdgieTHFdelqdVF--VQQTQDVRN----PVIYAVFTSSGSVFRGSAVCVYSMADIR 154
Cdd:cd11267   219 QRVLEKqWTSFLKARLNCSVPGD----SHF-----YFnvLQAVSDILNlggrPVVLAVFSTPTNSIPGSAVCAFDMTQVA 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 155 MVFNGPFAHKEGPNYQWMPFSGKM-PYPRPGTCPGgtftPSMK--STKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRT 231
Cdd:cd11267   290 AVFEGRFREQKSPESIWTPVPEELvPRPRPGCCAA----PGMRynSSSTLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRT 365
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1039792428 232 GAPYRLTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDD 274
Cdd:cd11267   366 MTRYQLTHMVVDTEAGPHGNHTVVFLGSTRGTVLKFLIIPNAS 408
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
2-319 1.29e-57

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 199.70  E-value: 1.29e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIhaelipdSAERNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDGG 80
Cdd:cd11241   140 GRDPAIYRSLGGKPPLRTAQYNSKWLNEPNFV-------GSYEIGNHTYFFFRENAVEHQDcGKTVYSRIARVCKNDIGG 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  81 HCCLVNKWSTFLKARLVCSVPGEdgIETHFDELQDVFVQQTQDvrnpVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGP 160
Cdd:cd11241   213 RFLLEDTWTTFMKARLNCSLPGE--FPFYYNEIQGTFYLPETD----LIYAVFTTNVNGIAGSAICAFNLSAINQAFNGP 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 161 FAHKEGPNYQWMPFsgkmPYPRPGTCPGGTFTPSMKSTKDyPDEVINFMRtHPLMYQAVYPLQRRPLVVRTGApyRLTTV 240
Cdd:cd11241   287 FKYQENNGSAWLPT----PNPHPNFQCTTSIDRGQPANTT-ERDLQDAQK-YQLMAEVVQPVTKIPLVTMDDV--RFSKL 358
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 241 AVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKdDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSL 319
Cdd:cd11241   359 AVDVVQGRGTQlVHIFYVGTDYGTILKMYQPHR-SQKSCTLEEIKILPAMKGEPITSLQFLKSEKSLFVGLETGVLRIPL 437
Sema_4B cd11257
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in ...
2-319 2.76e-56

The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in T and B cells, is an immune semaphorin. It functions as a negative regulatory of basophils through T cell-basophil contacts and it significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. In addition, T cell-derived Sema4B suppresses basophil-mediated Th2 skewing and humoral memory responses. Sema4B may be also involved in lung cancer cell mobility by inducing the degradation of CLCP1 (CUB, LCCL-homology, coagulation factor V/VIII homology domains protein). Sema4B is characterized by a PDZ-binding motif at the carboxy-terminus, which mediates interaction with the post-synaptic density protein PSD-95/SAP90, which is thought to play a central role during synaptogenesis and in the structure and function of post-synaptic specializations of excitatory synapses. Sema4B belongs to class 4 transmembrane semaphorin family proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200518 [Multi-domain]  Cd Length: 464  Bit Score: 196.62  E-value: 2.76e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDqyNS-RWLNDPSFIHAELIPDS---AERNDDKLYFFFRERSAEAP--QNPAVyARIGRICL 75
Cdd:cd11257   151 GNDPIIYRSLGSGTPLKTE--NSlNWLQDPAFVGSAYIQESlpkLVGDDDKIYFFFSETGKEFDffENTIV-SRIARVCK 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  76 NDDGGHCCLVNKWSTFLKARLVCSVPGeDGIEthFDELQDVFV--QQTQDVRNPVIYAVFTS--SGSVFRGSAVCVYSMA 151
Cdd:cd11257   228 GDEGGERVLQKRWTTFLKAQLLCSLPD-DGFP--FNVLQDVFVltPSPEDWKDTLFYGVFTSqwHKGTAGSSAVCVFTMD 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 152 DIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTP-SMKSTKDYPDEVINFMRTHPLMYQAVyplQRRPLVVR 230
Cdd:cd11257   305 QVQRAFNGLYKEVNRETQQWYTYTHPVPEPRPGACITNSARErKINSSLHMPDRVLNFVKDHFLMDGQV---RSQPLLLQ 381
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 231 TGAPYrlTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKddqevEELMLEEVEVFKEPAPVKTMTISSKRQQLYVAS 310
Cdd:cd11257   382 PQVRY--TQIAVHRVKGLHKTYDVLFLGTDDGRLHKAVSVGP-----MVHIIEELQIFSEGQPVQNLLLDTHKGLLYASS 454

                  ....*....
gi 1039792428 311 AVGVTHLSL 319
Cdd:cd11257   455 HSGVVQVPV 463
Sema_7A cd11243
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); ...
7-319 3.29e-56

The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); Sema7A plays regulatory roles in both immune and nervous systems. Unlike other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Sema7A also plays a critical role in the negative regulation of T cell activation and function. Sema7A is a membrane-anchored member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200504 [Multi-domain]  Cd Length: 414  Bit Score: 195.06  E-value: 3.29e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   7 IFRTLGKQTAMRTDqynSRWLNDPSFIHAELIPdSAERNDDKLYFFFRERSAEA-PQNPAVYARIGRICLNDDGGHCCL- 84
Cdd:cd11243   131 RFRRYGGKKELYTS---DTVMQKPQFVKATLLP-EDEQYQDKIYYFFREDNEDKgPEAEPNISRVARLCKEDQGGTSSLs 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  85 VNKWSTFLKARLVCSVPGEDGietHFDELQDVFVQQTQDVRNPVIYAVFTSSgsvFRGSAVCVYSMADIRMVFNgpfahk 164
Cdd:cd11243   207 TSKWSTFLKARLVCGDPATPM---NFNRLQDVFLLPKEEWREAVVYGVFSNT---WGSSAVCSYSLGDIDKVFR------ 274
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 165 egpNYQWMPFSGKMPYPRPGTC-PGGTFTPSmkstkdypdEVINFMRTHPLMYQAVYPLQRRPLVVRTGApYRLTTVAVD 243
Cdd:cd11243   275 ---TSSLKGYSGSLPNPRPGTCvPPEQTHPS---------ETFSFADEHPELDDRIEPDEPRKLPVFQNK-DHYQKVVVD 341
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039792428 244 QVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDqeveeLMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSL 319
Cdd:cd11243   342 EVRASDGVsYDVLYLATDKGKIHKVVESKGQT-----HNIMEIQPFKEQEPIQSMILDAERSHLYVGTKAEVTRLPL 413
Sema_6E cd11270
The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed ...
2-268 3.67e-55

The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200531 [Multi-domain]  Cd Length: 462  Bit Score: 193.79  E-value: 3.67e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQT-AMRTDQYNSRWLNDPSFIHAElipdsaeRNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDG 79
Cdd:cd11270   142 ASDAVIYRSLGESSpVLRTVKYDSKWLREPHFLHAI-------EYGNYVYFFLSEIAVEYTTlGKVVFSRVARVCKNDNG 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNK-WSTFLKARLVCSVPGEDGIetHFDELQDVFVQQTQDVRnPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFN 158
Cdd:cd11270   215 GSPRVLERyWTSFLKARLNCSVPGDSFF--YFDVLQSLTNVMQINHR-PAVLGVFTTQANSITGSAVCAFYMDDIEKVFN 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 159 GPFAHKEGPNYQWMPF-SGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRL 237
Cdd:cd11270   292 GKFKEQRNSESAWTPVpDEAVPKPRPGSCAGDGPAAGYKSSTNFPDETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFKL 371
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1039792428 238 TTVAVDQVDAADGRYEVLFLGTDRGTVQKVI 268
Cdd:cd11270   372 TQIAVDTAAGPYKNYTVVFLGSENGHVLKVL 402
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
2-319 2.03e-54

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 191.48  E-value: 2.03e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRT----LGKQ---TAMRTDQYNSRWLNDPSFIHAELIpdsaernDDKLYFFFRERSAEAPQ-NPAVYARIGRI 73
Cdd:cd11238   150 KANTVIYRPplynNTKGrheSFMRTLKYDSKWLDEPNFVGSFDI-------GDYVYFFFRETAVEYINcGKVVYSRVARV 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  74 CLNDDGGHCCLVNKWSTFLKARLVCSVPGEdgIETHFDELQDVF-VQQTQDVRnpvIYAVFTSSGSVFRGSAVCVYSMAD 152
Cdd:cd11238   223 CKKDTGGKNVLRQNWTTFLKARLNCSISGE--FPFYFNEIQSVYkVPGRDDTL---FYATFTTSENGFTGSAVCVFTLSD 297
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 153 IRMVFN-GPFAHKEGPNYQWMPF-SGKMPYPRPGTCPGgtftpsmkSTKDYPDEVINFMRTHPLMYQAVYplQRRPLVVR 230
Cdd:cd11238   298 INAAFDtGKFKEQASSSSAWLPVlSSEVPEPRPGTCVN--------DSATLSDTVLHFARTHPLMDDAVS--HGPPLLYL 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 231 tgAPYRLTTVAVDQVDAADGRYEVLFLGTDRGTVQKvIVLPKDDQeVEELMLEEVEVFKEPAPVKTMTIsSKRQQLYVAS 310
Cdd:cd11238   368 --RDVVFTHLVVDKLRIDDQEYVVFYAGSNDGKVYK-IVHWKDAG-ESKSNLLDVFELTPGEPIRAMEL-LPGEFLYVAS 442

                  ....*....
gi 1039792428 311 AVGVTHLSL 319
Cdd:cd11238   443 DHRVSQIDL 451
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
2-268 4.59e-53

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 187.50  E-value: 4.59e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAernddklYFFFRERSAEAPQNPAVYARIGRICLNDDGGH 81
Cdd:cd11264   140 GRDPAIYRSLGSVPPLRTAQYNSKWLNEPNFIAAYDIGLFT-------YFFFRENAVEHDCGKTVYSRVARVCKNDIGGR 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  82 CCLVNKWSTFLKARLVCSVPGEdgIETHFDELQDVFVQQTQDvrnpVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPF 161
Cdd:cd11264   213 FLLEDTWTTFMKARLNCSRPGE--IPFYYNELQSTFYLPEQD----LIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPF 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 162 AHKEGPNYQWMPFSGKMPYPRPGTCPggtftpsmkstKDYPDE-----VINFMRTHPLMYQAVYPLQRRPLVvrTGAPYR 236
Cdd:cd11264   287 RYQENPRSAWLPTANPIPNFQCGTLS-----------DDSPNEnlterSLQDAQRLFLMNDVVQPVTVDPLV--TQDSVR 353
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1039792428 237 LTTVAVDQVDAADGRYEVLFLGTDRGTVQKVI 268
Cdd:cd11264   354 FSKLVVDIVQGKDTLYHVMYIGTEYGTILKAL 385
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
1-319 9.45e-53

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 186.93  E-value: 9.45e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGKQTAMRTdQYNSRWLNDPSFIHAELIPDSAER---NDDKLYFFFRERSAEAP-QNPAVYARIGRICLN 76
Cdd:cd11258   144 LGTEPVILRNLGQHYSMKT-EYLAFWLNEPHFVGSAFVPESVGSftgDDDKIYFFFSERAVEYDcDSEQVVARVARVCKG 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  77 DDGGHCCLVNKWSTFLKARLVCSVPgedGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMV 156
Cdd:cd11258   223 DLGGARTLQKKWTTFLKARLLCSIP---EWQLYFNQLKAVFTLEGASWRNTTFFAVFQARWGDMDVSAVCEYQLGEIQQV 299
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 157 FNGPFAHKEGPNYQWMPFSGKMPYPRPGTC-PGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGApy 235
Cdd:cd11258   300 FEGPYKEYSEQAQKWGRYTDPVPSPRPGSCiNNWHRDHGYTSSLELPDNTLNFVKKHPLMEDRVKPRLGRPLLVPCNS-- 377
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 236 RLTTVAVDQVDAADGR-YEVLFLGTDRGTVQKVIVLpkddqEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGV 314
Cdd:cd11258   378 NFTHVVWTRVLGLDGEtYSVLFIGTLDGWLIKAVSL-----GSWVHMIEELQVFDQEPPESLVVSQSSKKLLFAGSRSEL 452

                  ....*
gi 1039792428 315 THLSL 319
Cdd:cd11258   453 LQLPW 457
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
2-342 1.13e-52

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 186.65  E-value: 1.13e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDQYNsRWLN-DPSFIHAELIPDsaernDDKLYFFFRERSAEAPQNPAVY-ARIGRICLNDDG 79
Cdd:cd11256   150 GNEPIIFRNLGTKVSLKTDGFL-RWLNaDAVFVASFNPQG-----DSKVYFFFEETAREFDFFEKLTvARVARVCKNDVG 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  80 GHCCLVNKWSTFLKARLVCSVPGEdgieTHFDELQDVFVQQTQDVRNPVIYAVFTSSGSV--FRGSAVCVYSMADIRMVF 157
Cdd:cd11256   224 GEKLLQKKWTTFLKAQLTCSQQGH----FPFNVIHHVALLNQPDPNNSVFYAVFTSQWQLggRRSSAVCAYKLNDIEKVF 299
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 158 NGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTpsmkstkdypDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYrl 237
Cdd:cd11256   300 NGKYKELNKESSRWTRYMGPVSDPRPGSCSGGKSS----------DKALNFMKDHFLMDEVVLPGAGRPLLVKSNVQY-- 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 238 TTVAVDQVDAADGR-YEVLFLGTDRGTVQKVIVlpkddqeveelmleevevfkepapvktmtisSKRQQLYVASAVGVTH 316
Cdd:cd11256   368 TRIAVDSVQGVSGHnYTVMFLGTDKGFLHKAVL-------------------------------MGGSESHIIEEIELLT 416
                         330       340
                  ....*....|....*....|....*.
gi 1039792428 317 LSLHRCQAYGAACADCCLARDPYCAW 342
Cdd:cd11256   417 PPEPVENLLLAANEGVVYIGYSAGVW 442
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
2-308 4.34e-52

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 184.85  E-value: 4.34e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAernddklYFFFRERSAEAPQNPAVYARIGRICLNDDGGH 81
Cdd:cd11263   140 GRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFT-------YFFFRENAVEHDCGKTVFSRAARVCKNDIGGR 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  82 CCLVNKWSTFLKARLVCSVPGEdgIETHFDELQDVFVQQTQDvrnpVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPF 161
Cdd:cd11263   213 FLLEDTWTTFMKARLNCSRPGE--IPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPF 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 162 AHKEGPNYQWMPFSGKMPYPRPGTCPGGTFtpsMKSTKDYPDEVINFMrthpLMYQAVYPLQRRPLVVRTGApyRLTTVA 241
Cdd:cd11263   287 KYQENSRSAWLPYPNPNPNFQCGTMDQGLY---VNLTERNLQDAQKFI----LMHEVVQPVTPVPYFMEDNS--RFSHVA 357
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039792428 242 VDQVDAADGRYEVLFLGTDRGTVQKviVLPKDDQEVEELMLEEVEVF--KEPAPVKTMTISSKRQQLYV 308
Cdd:cd11263   358 VDVVQGKDMLFHIIYLATDYGTIKK--VLAPLNQSSSSCLLEEIELFpkRQREPIRSLQILHSQSVLFV 424
Sema_4F cd11261
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in ...
1-317 1.73e-49

The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200522 [Multi-domain]  Cd Length: 460  Bit Score: 178.15  E-value: 1.73e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   1 MGTDAAIFRTLGK-QTAMRTDQYNSrWLNDPSFIHAELIPDSA---ERNDDKLYFFFRERSAEAPQ-NPAVYARIGRICL 75
Cdd:cd11261   145 LGTEPIISRAVGRaEEWIRTETLPS-WLNAPAFVAAVFLSPAEwgdEDGDDEIYFFFTETAREYDSyERIKVPRVARVCA 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  76 NDDGGHCCLVNKWSTFLKARLVCSVPgEDGieTHFDELQDVFVQQTQDVRN-PVIYAVFTSSGSVFRGSAVCVYSMADIR 154
Cdd:cd11261   224 GDLGGRKTLQQRWTTFLKADLLCPGP-EHG--RASSILQDVTTLRPLPGAGtPIFYGIFSSQWEGASISAVCAFRPQDIR 300
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 155 MVFNGPFAHKEGPNYQWMPFS-GKMPYPRPGTCpggtFTPSMK-----STKDYPDEVINFMRTHPLMYQAVYPLQRRPLV 228
Cdd:cd11261   301 RVMNGPFREFKHDCNRGLPVMdSDVPQPRPGEC----ITNNMKllgfgSSLSLPDRVLTFVRDHPLMDRPVFPADGHPLL 376
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 229 VRTGAPYrlTTVAVDQVDAADGR-YEVLFLGTDRGTVQKVIVLpkddqEVEELMLEEVEVFKEPAPVKTMTIssKRQQLY 307
Cdd:cd11261   377 VTTDTAY--LRVAAHRVTSLSGKeYDVLYLGTEDGHLHRAVRI-----GAQLSVLEDLALFPEPQPVENLQL--HHNWLL 447
                         330
                  ....*....|
gi 1039792428 308 VASAVGVTHL 317
Cdd:cd11261   448 VGSDTEVTQI 457
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
2-317 6.76e-49

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 175.74  E-value: 6.76e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTA--MRTDQYNSRWLNDPSFIhaelipDSAErNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDD 78
Cdd:cd11265   140 GSDSAIYRTLGTSNKsfLRTKQYNSKWLNEPQFV------GSFE-TGNFVYFLFRESAVEYMNcGKVIYSRIARVCKNDV 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  79 GGHCCLV-NKWSTFLKARLVCSVPGEdgIETHFDELQDVFVQQTQDVrnpvIYAVFTSSGSVFRGSAVCVYSMADIRMVF 157
Cdd:cd11265   213 GGGTMLLkDNWTTFLKARLNCSLPGE--YPFYFDEIQGMTYLPDEGI----LYATFTTPENSIAGSAVCAFNLSSINAAF 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 158 NGPFAHKEGPNYQWmpfsGKMPYP---RPGTCPGGTFTPSMKSTKdypdevinfmrtHPLMYQAVYPLQRRPLVVRTGAp 234
Cdd:cd11265   287 DGPFKHQESSGAAW----ERVNVNhrdHFNQCSSSSSSHLLESSR------------YQLMDEAVQPITLEPLHHAKLE- 349
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 235 yRLTTVAVDQVDAA-DGRYEVLFLGTDRGTVQKVIVLPKDDQeveELMLEEVEVFKEPA-PVKTMTISSKRQQLYVASAV 312
Cdd:cd11265   350 -RFSHIAVDVIPTKiHQSVHVLYVATTGGLIKKISVLPRTQE---TCLVEIWQPLPTPDsPIKTMQYLKVTDSLYVGTEL 425

                  ....*
gi 1039792428 313 GVTHL 317
Cdd:cd11265   426 ALMRI 430
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
2-268 6.04e-48

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 174.12  E-value: 6.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAElipdsaeRNDDKLYFFFRERSAEAPQNPAV-YARIGRICLNDDGG 80
Cdd:cd11268   144 ASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQAL-------EHGDHVYFFFREVSVEDARLGRVqFSRVARVCKRDMGG 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  81 HCCLVNK-WSTFLKARLVCSVPGEDGIetHFDELQDVFVQQTQDVRNpVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNG 159
Cdd:cd11268   217 SPRALDRhWTSFLKLRLNCSVPGDSTF--YFDVLQALTGPVNLHGRS-ALFGVFTTQTNSIPGSAVCAFYLDEIERGFEG 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 160 PFAHKEGPNYQWMPFS-GKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYrLT 238
Cdd:cd11268   294 KFKEQRSLDGAWTPVSeDRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRAL-LT 372
                         250       260       270
                  ....*....|....*....|....*....|
gi 1039792428 239 TVAVDQVDAADGRYEVLFLGTDRGTVQKVI 268
Cdd:cd11268   373 QVAVDGMAGPHSNITVMFLGSNDGTVLKVL 402
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
2-315 3.66e-29

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 119.62  E-value: 3.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428   2 GTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSaernDDKLYFFFRERSAEAPQNPAVY-ARIGRICLNDDGG 80
Cdd:cd09295   142 GDRPALSRRSSNVHYLRIVVDSSTGLDEITFVYAFVSGDD----DDEVYFFFRQEPVEYLKKGMVYvPRIARVCKLDVGG 217
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  81 HCCLVNKWSTFLKARLVCSVPGEDgieTHFDELQDVFVQQTQDVRNpVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGP 160
Cdd:cd09295   218 CHRLKKKLTSFLKADLNCSRPQSG---FAFNLLQDATGDTKNLIQD-VKFAIFSSCLNKSVESAVCAYLFTDINNVFDDP 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 161 fahkegpnyqwmpfsgkmpyprpgtcpggtftpsmkstkdypdevinfmrthplmyqaVYPLQRRPLVVRTGAPYRLTTV 240
Cdd:cd09295   294 ----------------------------------------------------------VEAINNRPLYAHQNQRSRLTSI 315
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039792428 241 AVDQVDAADGRYEVLFLGTDRGTVQKVIVlpkDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVT 315
Cdd:cd09295   316 AVDATKQKSVGYQVVFLGLKLGSLGKALA---FFFLYKGHIIEEWKVFKDSSRITNLDLSRPPLYLYVGSESGVL 387
Ig_Sema3 cd05871
Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed ...
382-426 3.80e-15

Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed of the immunoglobulin (Ig)-like domain of Sema3 and similar proteins. Semaphorins are classified based on structural features additional to the Sema domain. Sema3 is a Class III semaphorin that is secreted. It is a vertebrate class having a Sema domain, an Ig domain, a short basic domain. They have been shown to be axonal guidance cues and have a part in the regulation of the cardiovascular, immune, and respiratory systems. Sema3A, the prototype member of this class III subfamily, induces growth cone collapse and is an inhibitor of axonal sprouting. In perinatal rat cortex, it acts as a chemoattractant and functions to direct the orientated extension of apical dendrites. It may play a role, prior to the development of apical dendrites, in signaling the radial migration of newborn cortical neurons towards the upper layers. Sema3A selectively inhibits vascular endothelial growth factor receptor (VEGF)-induced angiogenesis and induces microvascular permeability. This group also includes Sema3B, -C, -D, -E, -G.


Pssm-ID: 409455  Cd Length: 92  Bit Score: 70.84  E-value: 3.80e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1039792428 382 NAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPSDRRREVSS 426
Cdd:cd05871     1 NAEEKVVYGVEGNSTFLECLPKSPQATVKWLFQRGGDQRKEEVKS 45
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
236-362 1.23e-07

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 54.55  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 236 RLTTVAVDQVDAadgrYEVLFLGTDRGTVQKVIVlpkDDQEVEELMLEEVEVFKEPAPV-KTMTISSKRQQLYVASAVGV 314
Cdd:cd11272   394 RLTSVASYVYNG----YSVVFVGTKSGKLKKIRA---DGPPHGGVQYEMVSVFKDGSPIlRDMAFSIDHKYLYVMSERQV 466
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1039792428 315 THLSLHRCQAYgAACADCCLARDPYCAWdgqaCSRYTASSKR-RSRRQD 362
Cdd:cd11272   467 SRVPVESCEQY-TTCGECLSSGDPHCGW----CALHNMCSRRdKCQRAW 510
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
50-272 7.08e-07

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 51.95  E-value: 7.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  50 YFFFRERSAEAPQNPaVYARIGRICLNDdgghcclvNKWSTFLKARLVCSvpGEDGieTHFDELQDVFV---------QQ 120
Cdd:cd11236   196 YFVTVQRKSVDDESP-YISRLVRVCQSD--------SNYYSYTEVPLQCT--GGDG--TNYNLLQAAYVgkagsdlarSL 262
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 121 TQDVRNPVIYAVF----TSSGSVFRGSAVCVYSMADIRMVFNgpfahkegpnyqwmpfsgkmpyprpgtcpggtftpsmk 196
Cdd:cd11236   263 GISTDDDVLFGVFskskGPSAEPSSKSALCVFSMKDIEAAFN-------------------------------------- 304
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039792428 197 stkdypdevinfmRTHPLmyQAVYPLQRRPLVVRTgapyRLTTVAVDQVDaadgRYEVLFLGTDRGTVQKVIVLPK 272
Cdd:cd11236   305 -------------DNCPL--GGGVPITTSAVLSDS----LLTSVAVTTTR----NHTVAFLGTSDGQLKKVVLESS 357
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
321-358 1.47e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.23  E-value: 1.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039792428  321 RCQAYGAaCADCCLARDPYCAWD--GQACSRYTASSKRRS 358
Cdd:smart00423   1 RCSKYTS-CSECLLARDPYCAWCssQGRCTSGERCDSRRQ 39
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
41-275 1.95e-06

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 50.70  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  41 SAERNDDKLYFFFRERSAEAPQNPAVYarIGRICLNDdgghcclvNKWSTFLKARLVCsvpgEDGIETHFDELQDVFVQQ 120
Cdd:cd11245   188 YAFADNGYIYFLFSRRPGTADSTKRTY--ISRLCEND--------HHYYSYVELPLNC----TVNQENTYNLVQAAYLAK 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 121 TQDVRN-PVIYAVFTSSGSVFRG----SAVCVYSMADIRMVFN--------GPFAHKEGPNYQWMPFSGK-----MPYPR 182
Cdd:cd11245   254 PGKVLNgKVLFGVFSADEASTAApdgrSALCMYPLSSVDARFErtrescytGEGLEDDKPETAYIEYNVKsicktLPDKN 333
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 183 PGTCP-GGTFTPSmkstkdypdevinfmrthPLMYQavYPLQRRPLVVRtgaPYRLTTVAVdqvdAADGRYEVLFLGTDR 261
Cdd:cd11245   334 VKAYPcGAEHTPS------------------PLASR--YPLAAKPILTR---NDMLTAVAV----AVENGHTIAFLGDSG 386
                         250
                  ....*....|....
gi 1039792428 262 GTVQKVIVLPKDDQ 275
Cdd:cd11245   387 GQLHKVYLDPNHTD 400
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
46-267 2.50e-05

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 47.08  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428  46 DDKLYFFFRERSAEAPQNPAVYarIGRICLNDDGGHcclvnkwsTFLKARLVCSVPgedgiETHFDELQDVFV------- 118
Cdd:cd11276   198 DNNYVYFLFNQQLGHPDKNRTL--IARLCENDHHYY--------SYTEMDLNCRDG-----ANAYNKCQAAYVstpgkel 262
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792428 119 -QQTQDVR--NPVIYAVFTSSGSVFRGSAVCVYSMADI--RMVFNGPFAH---KEGPNYQWMPFSGKMPyprpgtCPGGT 190
Cdd:cd11276   263 aQNYGNSIlsDKVLFAVFSRDEKDSGESALCMFPLKSInaKMEANREACYtgtIDDRDVFYKPFHSQKD------IICGS 336
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039792428 191 FTPsmKSTKDYP--DEVInfmrTHPLMYQAVYPLqRRPLVVRTGApyRLTTVAVdqvdAADGRYEVLFLGTDRGTVQKV 267
Cdd:cd11276   337 HQQ--KNSKSFPcgSEHL----PYPLGSRDELAL-TAPVLQRGGL--NLTAVTV----AVENGHTVAFLGTSDGRILKV 402
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
321-362 4.18e-03

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 35.76  E-value: 4.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1039792428 321 RCQAYGAaCADCCLARDPYCAWD--GQACSRYTASSKRRSRRQD 362
Cdd:pfam01437   1 RCSQYTS-CSSCLAARDPYCGWCssEGRCVRRSACGAPEGNCEE 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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