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Conserved domains on  [gi|1039734088|ref|XP_017169565|]
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myoregulin isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myoregulin cd20260
Myoregulin; Myoregulin (MLN) is encoded by a skeletal muscle-specific RNA Linc-RAM, which is ...
 2-46 4.56e-17

Myoregulin; Myoregulin (MLN) is encoded by a skeletal muscle-specific RNA Linc-RAM, which is annotated as a putative long noncoding RNA (lncRNA). It is a single-pass transmembrane alpha-helix that interacts directly with sarcoplasmic reticulum (SR) calcium transporting ATPase (SERCA) and impedes Ca(2+) uptake into the SR. SERCA is the membrane pump that controls muscle relaxation by regulating Ca(2+) uptake into the SR. MLN is the dominant regulator of SERCA1 activity in adult skeletal muscle and is a promising drug target for improving muscle performance.


:

Pssm-ID: 380769  Cd Length: 45  Bit Score: 65.89  E-value: 4.56e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1039734088  2 SGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVITS 46
Cdd:cd20260    1 TCKNWILISTTTPTSLEDEIVGRLLKILFVIFVDLMSIIYVVITS 45
 
Name Accession Description Interval E-value
Myoregulin cd20260
Myoregulin; Myoregulin (MLN) is encoded by a skeletal muscle-specific RNA Linc-RAM, which is ...
 2-46 4.56e-17

Myoregulin; Myoregulin (MLN) is encoded by a skeletal muscle-specific RNA Linc-RAM, which is annotated as a putative long noncoding RNA (lncRNA). It is a single-pass transmembrane alpha-helix that interacts directly with sarcoplasmic reticulum (SR) calcium transporting ATPase (SERCA) and impedes Ca(2+) uptake into the SR. SERCA is the membrane pump that controls muscle relaxation by regulating Ca(2+) uptake into the SR. MLN is the dominant regulator of SERCA1 activity in adult skeletal muscle and is a promising drug target for improving muscle performance.


Pssm-ID: 380769  Cd Length: 45  Bit Score: 65.89  E-value: 4.56e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1039734088  2 SGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVITS 46
Cdd:cd20260    1 TCKNWILISTTTPTSLEDEIVGRLLKILFVIFVDLMSIIYVVITS 45
 
Name Accession Description Interval E-value
Myoregulin cd20260
Myoregulin; Myoregulin (MLN) is encoded by a skeletal muscle-specific RNA Linc-RAM, which is ...
 2-46 4.56e-17

Myoregulin; Myoregulin (MLN) is encoded by a skeletal muscle-specific RNA Linc-RAM, which is annotated as a putative long noncoding RNA (lncRNA). It is a single-pass transmembrane alpha-helix that interacts directly with sarcoplasmic reticulum (SR) calcium transporting ATPase (SERCA) and impedes Ca(2+) uptake into the SR. SERCA is the membrane pump that controls muscle relaxation by regulating Ca(2+) uptake into the SR. MLN is the dominant regulator of SERCA1 activity in adult skeletal muscle and is a promising drug target for improving muscle performance.


Pssm-ID: 380769  Cd Length: 45  Bit Score: 65.89  E-value: 4.56e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1039734088  2 SGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVITS 46
Cdd:cd20260    1 TCKNWILISTTTPTSLEDEIVGRLLKILFVIFVDLMSIIYVVITS 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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