|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
40-488 |
0e+00 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 599.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17422 161 LVVGALQLNIVVCGALLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17422 179 ------------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAAG 439
Cdd:cd17422 235 RISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSALG 314
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1039735314 440 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 488
Cdd:cd17422 315 VYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
40-488 |
3.65e-110 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 332.21 E-value: 3.65e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17352 179 ------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAG 439
Cdd:cd17352 235 RILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILA--DLVGLEKLSNAYG 312
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1039735314 440 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 488
Cdd:cd17352 313 LVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
33-524 |
4.91e-89 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 281.24 E-value: 4.91e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 33 QVPDGGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMA 112
Cdd:TIGR00892 10 PPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 113 GGLLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEH 192
Cdd:TIGR00892 90 GGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFES 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 193 IGWRYSLLFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelTTSPKNVPSEA 272
Cdd:TIGR00892 170 FGWRGSFLILGGLLLHCCVCGALMRPV------------------------------------------GPSQRVSKSKS 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 273 K--MEQETRAEQQQTLVTAPKHSQmkapLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLS 350
Cdd:TIGR00892 208 KegLPPDGSTKKLSKKSTAEKINR----FLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLS 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 351 TMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASL--FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDV 428
Cdd:TIGR00892 284 IIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLthLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLM--DL 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 429 VGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVRPCkkglCQNSHSGENQTDRQ 508
Cdd:TIGR00892 362 VGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYI----NYRLLAKEQKAALE 437
|
490
....*....|....*...
gi 1039735314 509 RGKAL--QDIPEDFLEMD 524
Cdd:TIGR00892 438 REGARdkKDAEGDSRESE 455
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
40-484 |
7.52e-80 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 255.01 E-value: 7.52e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPIIIQGpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPG-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17423 185 --------DPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVG 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAG 439
Cdd:cd17423 257 RLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPE--LVGVERVLNATG 334
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1039735314 440 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 484
Cdd:cd17423 335 LLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLIL 379
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
40-486 |
2.80e-63 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 211.13 E-value: 2.80e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkaplLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17430 180 --------------------LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNREPIRKIYIELICVILLTASL--FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSA 437
Cdd:cd17430 240 RPACGVVAGLKWVRPRVVYLFSFAMLFNGLtdLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMA--IVGTQKFSSA 317
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1039735314 438 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 486
Cdd:cd17430 318 IGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLAL 366
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
40-486 |
1.04e-59 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 201.54 E-value: 1.04e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRPF------------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkaplldfsvLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17425 181 -------------------------CSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFM 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGfVLNREPI---RKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSS 436
Cdd:cd17425 236 RPLAG-LLSGLPVfkgRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLM--DTVEMDRFPS 312
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1039735314 437 AAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 486
Cdd:cd17425 313 ALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
40-484 |
5.10e-54 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 186.56 E-value: 5.10e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPIiiqGPgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPL---GP------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17427 183 ------------------------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFA 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNREPIR---------KIYIELICVILLtaslfafTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVG 430
Cdd:cd17427 239 RPSMGLVANSKWIRpriqyffsfAVMYNGVCHLLC-------PLAEDYTGLVIYAVFFGFAFGMVSSVLFETLM--DLVG 309
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1039735314 431 IEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 484
Cdd:cd17427 310 AQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
40-484 |
7.23e-51 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 178.53 E-value: 7.23e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPI------------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtAPKhsqmkaPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17426 181 ---------GPK------PFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVA 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNREPIRK--IYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSA 437
Cdd:cd17426 246 RPSMGIVANTKWVRPriQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLM--DLVGAQRFSSA 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1039735314 438 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 484
Cdd:cd17426 324 VGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
40-488 |
1.69e-44 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 161.13 E-value: 1.69e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPIIIQGpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFLLMPD-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkaplldfsvlkeksFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17424 185 ------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNREPIRKI--YIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIgGTHIPMLAEdDVVGIEKMSSA 437
Cdd:cd17424 235 NITFGWLTDRRCLKKYryFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAY-VALIPVVTS-DVVGTSSLSSA 312
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1039735314 438 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 488
Cdd:cd17424 313 LGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
40-487 |
2.14e-43 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 158.06 E-value: 2.14e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAvFAFAPAITALKEHIGWRYSL 199
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLT-FALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI------------------------------------------------------------ 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkapllDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17421 180 ---------------------DFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVA 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAG 439
Cdd:cd17421 239 QLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLV--DLVGVTKVNSSLG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1039735314 440 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 487
Cdd:cd17421 317 FSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLE 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-488 |
2.74e-35 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 136.55 E-value: 2.74e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 41 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 120
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 121 MITASFSQRvYHMYISIGVISGLGYCFSFLPTVTILSQYFDK-RRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:COG2223 84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLrpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveLTTSPKNVPSEAKMEQETR 279
Cdd:COG2223 163 LILGILLLVVAVLAWLF--------------------------------------------LRDPPAGAAAAAKASLRDQ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 AEqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVF 358
Cdd:COG2223 199 LE----------------------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGAL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 359 GRIGAGFVLNREPIRKIYieLICVILLTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSA 437
Cdd:COG2223 257 GRPLGGWLSDRIGGRRVL--LIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVP--DIFPTKNAGAV 332
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1039735314 438 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 488
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
40-488 |
1.15e-33 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 131.62 E-value: 1.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGY-CFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYS 198
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 199 LLFVGLLQLNIMVcgallrpiiiqgpgqspkAVTLEPRREvqymlenektrtsidsidsgvelttspknvPSEAKMEQET 278
Cdd:cd17355 161 LLVLALLALLVLV------------------PVLLLLRRR------------------------------PADLALRAYD 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 279 RAEQQQTLVTAPKhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVF 358
Cdd:cd17355 193 DASPASPGSTLKE------------ALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 359 GRIGAGFVLNRepIRKIYIELICVILLTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSA 437
Cdd:cd17355 261 GRLLSGWLGDR--YSPRRLLAASYALRALGLALLLLLPFpPLALLLFAALFGLGWGATVPLTAALAAR--YFGARSYGTL 336
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1039735314 438 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAgMCLAAVCLALVR 488
Cdd:cd17355 337 FGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVA-LGLIAALLVLPI 386
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
40-489 |
2.84e-32 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 127.25 E-value: 2.84e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF-LLSTMAIAEVF 358
Cdd:cd17429 179 ------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIF 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 359 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggTHIPMLAEdDVVGIEKMSSAA 438
Cdd:cd17429 235 GKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYF--SLMPVVTE-DLVGIKNLANAY 311
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1039735314 439 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLaLVRP 489
Cdd:cd17429 312 GIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICL-LLKP 361
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
40-486 |
1.73e-31 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 124.93 E-value: 1.73e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF-LLSTMAIAEVF 358
Cdd:cd17428 179 ------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAI 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 359 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGgthIPMLAEDDVVGIEKMSSAA 438
Cdd:cd17428 235 GKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS---IFPYVTTKTVGIEKLGHAY 311
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1039735314 439 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 486
Cdd:cd17428 312 GILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
37-489 |
1.53e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 119.59 E-value: 1.53e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 37 GGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLL 116
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 117 ISLGMITASFSQRVYHMYISIgVISGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGW 195
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 196 RYSLLFVGLlqlnIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakme 275
Cdd:COG2271 164 RAAFLILGL----PGLLLALLR---------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 276 qetraeqqqtlvtapkhsqmkaplldfsvlkeksFICYALFGLFATLGFFAPSLYIIP-LGISLGIDPDRAAFLLSTMAI 354
Cdd:COG2271 182 ----------------------------------FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFL 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 355 AEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKM 434
Cdd:COG2271 228 AGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE--LFPKKAR 305
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1039735314 435 SSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRAFYSCAAGMCLAAVCLALVRP 489
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLR 359
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
60-489 |
1.60e-28 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 117.28 E-value: 1.60e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 60 SFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYHMYISIGV 139
Cdd:COG2807 36 SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 140 IsGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAvFAFAPAITA-LKEHIGWRYSLLFVGLLQLNIMVcgaLLRP 218
Cdd:COG2807 116 I-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLG-AALAAGLTVpLAAALGWRGALAVWALLALLALL---LWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 219 IIIQGPGQSPKAVTLEPRRevqymlenektrtsidsidsgvelttspknvpseakmeqetraeqqqtlvtapkhsqmkap 298
Cdd:COG2807 191 LLRRRPAAAAAAPAAASLR------------------------------------------------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 299 lldfSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIe 378
Cdd:COG2807 210 ----SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLL- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 379 LICVILLTASLFAFTFATEFWgLMLCSVFFGSMVG---TIGGTHIPMLAEDDvvgiekmSSAAGVYVFIQSISGL---AG 452
Cdd:COG2807 285 LLLGLLGLAGLLGLLLAPGSL-PWLWAVLLGLGQGglfPLALTLIGLRARTP-------AEAAALSGMAQSVGYLlaaLG 356
|
410 420 430
....*....|....*....|....*....|....*...
gi 1039735314 453 PPLAGLLVDQSKIYSRAFYSCAAGMCLAAVC-LALVRP 489
Cdd:COG2807 357 PLLVGALHDATGSWTAALLLLAALAVLMLVAgLLAGRP 394
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
40-487 |
2.64e-27 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 113.78 E-value: 2.64e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSF-----DESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGG 114
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 115 LLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 194
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 195 WRYSLLFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveLTTSPKNVPSEAKM 274
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRP------------------------------------------LHPSPEDPKSKPGR 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 275 EQETRAeqqqtlvtapKHSQMKApLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAI 354
Cdd:cd17420 199 RTLHSR----------INLFLRK-IFNVEIFKRKRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGI 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 355 AEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEK 433
Cdd:cd17420 268 TSGIGRLIFGVIADMPPgVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFE--LVGPSG 345
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1039735314 434 MSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 487
Cdd:cd17420 346 ASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFI 399
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
40-487 |
1.83e-24 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 105.19 E-value: 1.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 120 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 279
Cdd:cd17314 161 TILGILAAIVLSVVSLLGF------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeQQQTLVTAPKHSQMKAPLLDFSVLKEKSF-ICYALFGLFATlGFFAPSLYIIPLGISLGID-PDRAAFLLSTMAIAEV 357
Cdd:cd17314 180 --KEPPDNQARLHVQKKKTQTMGEIFRDKVFwILFIAIFLVLI-GGFLFIANMASLVRSLQLDaPSFVTKLMSIYGLFNA 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 358 FGRIGAGFVLNREpIRKIYIELICVILLTASLFAFTFATEF--WGLMLCSVFFGSMVGtiGGTHIPMLAEDDVVGIEKMS 435
Cdd:cd17314 257 FGRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSYG--GLFTVYPATVSTVFGTESFA 333
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1039735314 436 SAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 487
Cdd:cd17314 334 TLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
41-487 |
3.54e-24 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 104.61 E-value: 3.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 41 WAVAVSFFFVeVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 120
Cdd:cd17353 3 WLVLLGAVLM-HLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 121 MITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLL 200
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 201 FVGLLQLNIMVCGALLrpIIIQGPGQSPKAVTleprrevqymlenektrtsidsidsgvelttsPKNVPSEAKMEQETRA 280
Cdd:cd17353 162 ILGIIFLIIIVIGAFL--IRDPPKGWVPPGVD--------------------------------PLANNAENSPRDYTPR 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 281 EqqqtlvtapkhsqmkaplldfsVLKEKSFIC-YALFGLFATLGFFAPSlYIIPLGISL-GIDPDRAAFLLSTMAIAEVF 358
Cdd:cd17353 208 E----------------------MLRTPTFWLlWLMFFLNATAGLMLIG-QAKPIGQEFaGLDAGIAALAVSILSIFNGG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 359 GRIGAGFVLNREPIRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAA 438
Cdd:cd17353 265 GRPFWGWLSDKIGRKNTLS-IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTA--DFFGTKNAGTNY 341
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1039735314 439 GVYVFIQSISGLAGPPLAGlLVDQSKIYSRAFYSCAAGMCLAAVCLALV 487
Cdd:cd17353 342 GLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
41-449 |
3.98e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 100.82 E-value: 3.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 41 WAVAVSFFFVeVFTYGIIksfGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 120
Cdd:COG2814 13 LALALGAFLS-GLGIGIV---LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 121 MITASFSQRVYHMYISiGVISGLGYCFSFLPTVTILSQYFD-KRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:COG2814 89 SLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqETR 279
Cdd:COG2814 168 LVNAVLALLALLLLLRLLP----------------------------------------------------------ESR 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 AEQQQTLVTAPKHsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVF 358
Cdd:COG2814 190 PAARARLRGSLRE-----------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 359 GRIGAGFVLNREPIRKIYIelICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAA 438
Cdd:COG2814 259 GALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE--LAPPEARGRAS 334
|
410
....*....|.
gi 1039735314 439 GVYVFIQSISG 449
Cdd:COG2814 335 GLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
47-484 |
4.20e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 98.27 E-value: 4.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 47 FFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASF 126
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 127 SQRVYHMYIsIGVISGLGYCFSFLPTVTILSQYFDKR-RSVVTAVASTGECFAVFAFAPAITALKEHI--GWRYSLLFVG 203
Cdd:cd06174 81 APSFWLLLL-GRFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 204 LLqlnimvcgallrpiiiqgpgqspkavtleprrevqymlenektrtsidsidSGVELTTSPKNVPSEAKMEQETRAEQQ 283
Cdd:cd06174 160 AL---------------------------------------------------ALLAAILLLLVVPDPPESARAKNEEAS 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 284 QTLVTAPKhsqmkaplldFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIG 362
Cdd:cd06174 189 SKSVLKLL----------KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 363 AGFVLNREPIRK--IYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTiggthIPMLAEDDVVGIEKMSSAAGV 440
Cdd:cd06174 259 LGLLSDRLIGRKplLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP-----LSFALIAELFPPEIRGTAFGL 333
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1039735314 441 YVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 484
Cdd:cd06174 334 LNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
47-453 |
2.75e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.10 E-value: 2.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 47 FFFVEVFTYGIIKSFGVFF-NDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITAS 125
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 126 FSQRVYHMYISiGVISGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGL 204
Cdd:pfam07690 81 FASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 205 LQLNIMVCGALLRPiiiqgpgqSPKAVTLEPRREVQYMLenektrtsidsidsgvelttspknvpseakmeqetraeqqq 284
Cdd:pfam07690 160 LSLLAAVLLLLPRP--------PPESKRPKPAEEARLSL----------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 285 tlvtapkhsqmkapLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAG 364
Cdd:pfam07690 191 --------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 365 FVLNR-EPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGThiPMLAEDDVVGIEKMSSAAGVYVF 443
Cdd:pfam07690 257 RLSDRlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA--LNALVSDLAPKEERGTASGLYNT 334
|
410
....*....|
gi 1039735314 444 IQSISGLAGP 453
Cdd:pfam07690 335 AGSLGGALGP 344
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
40-471 |
8.24e-19 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 88.70 E-value: 8.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSF-DESNS----KISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGG 114
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgSKDDAqmrfKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 115 LLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 194
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 195 WRYSLLFVGLLQLNIMVCGALLRPIIiqgpgqspkavtlePRREvqymlenektrtsiDSIDSGVELTTSPKNvpseakm 274
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLV--------------PMKK--------------DKEGKKRKFKCPPLK------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 275 eqetraeqqqtlvtapkhsqmkaPLLDFSVLKEKSFICYAlFGLFATL-GFFAPSLYIIPLGISLGIDPDRAAFLLSTMA 353
Cdd:cd17464 206 -----------------------KIFNFNIWKSTGYRIWA-FGIPAALfGYFVPYVHLMNHVKERFGEDVNKEVLLMCIG 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 354 IAEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIE 432
Cdd:cd17464 262 ITSGIGRLIFGRVADYIPgVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFE--LVGAQ 339
|
410 420 430
....*....|....*....|....*....|....*....
gi 1039735314 433 KMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFY 471
Cdd:cd17464 340 NVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFY 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-488 |
4.27e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.09 E-value: 4.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 48 FFVEVFTYGIIksfGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFS 127
Cdd:cd17325 5 LFLDMLGYGII---IPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 128 QRVYHMYISIgVISGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGEcFAVFAFAPAI-TALKEHIGWRYSLLFVGLL 205
Cdd:cd17325 82 TSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAI-GLGFLIGPLLgGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 206 QLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpsEAKMEQETRAEQQQT 285
Cdd:cd17325 160 ALLALVLALLLLP----------------------------------------------------EPRPPPNKRAVSAAR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 286 LVTAPKHSQMKAPLLdfsvlkeksFICYALFGLFATLGFFAP--SLYIIPLGislGIDPDRAAFLLSTMAIAEVFGRIGA 363
Cdd:cd17325 188 LRSGLRLLLRDRRLL---------ALFLAIFVLAFAFGALEPflPLYAAELG---GLSPAQIGLLFGAQGLASALSQPPA 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 364 GFVLNRePIRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVF 443
Cdd:cd17325 256 GKLSDR-IGRKPLI-LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA--DIVPPEGRGTAMGLFNT 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1039735314 444 IQSISGLAGPPLAGLLVDQSKIYSrAFYSCAAGMCLAAVCLALVR 488
Cdd:cd17325 332 AFSLGMVLGPLLGGFLYDAFGFAT-PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
40-471 |
2.41e-13 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 71.37 E-value: 2.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 40 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNS-----KISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGG 114
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDqavqfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 115 LLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 194
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 195 WRYSLLFVGLLQLnimvcgallrpiiiqgpgqspkavtleprreVQYMLEnektrtsidsidsgvelttspknvpseakm 274
Cdd:cd17465 161 LAHTFQVLSLFMF-------------------------------IQIFLS------------------------------ 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 275 eqetraeqqqtlvtapkhsqmkaplLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAI 354
Cdd:cd17465 180 -------------------------LTYKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGA 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 355 AEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEK 433
Cdd:cd17465 235 SSGIGRLMSGKIGDLIPgLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFE--LVGPMQ 312
|
410 420 430
....*....|....*....|....*....|....*...
gi 1039735314 434 MSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFY 471
Cdd:cd17465 313 ASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFY 350
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
308-489 |
1.15e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 69.23 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 308 KSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTA 387
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--LLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 388 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYS 467
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIA--DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180
....*....|....*....|..
gi 1039735314 468 rAFYSCAAGMCLAAVCLALVRP 489
Cdd:COG2814 166 -VFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
68-485 |
2.46e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 65.34 E-value: 2.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 68 LMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRvYHMYISIGVISGLGYCF 147
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-YPVLLVLLFLVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 148 SFLPTVTILSQYFDKR-RSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGLLqlnIMVCGALlrpiiiqgpgq 226
Cdd:cd17475 101 VQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV---SILAAVL----------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 227 spkavtleprrevqYMLenektrtsidsidsgvelttspknvpseakMEQETRAEQQQTLVTAPKHSQMKAPLLDFSVLK 306
Cdd:cd17475 167 --------------FWL------------------------------FYREPPAASAATESASTLLRSLKEVLRNRDVWL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 307 eksfICYALFGL----FATLGFFapslyIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNR--EPIRKIYIELI 380
Cdd:cd17475 203 ----IAIAGALLvapqFALLTFL-----LLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRRPVLVIT 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 381 -CVILLTASLFAF-TFATEFWGLMLCSVFFGsmVGTIG--GTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLA 456
Cdd:cd17475 274 aAIAAAALLVLSLlSPGTPLWLLVLLLILLG--LFAIGwnGLYLTLVAE--SAGPEQAGTALGLANTINFIGIAIGPPLF 349
|
410 420
....*....|....*....|....*....
gi 1039735314 457 GLLVDQSKIYSRAFYSCAAGMCLAAVCLA 485
Cdd:cd17475 350 GLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
67-483 |
3.34e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 64.88 E-value: 3.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 67 DLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRvYHMYISIGVISGLGYC 146
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 147 FSFLPTVTILSQYFDK-RRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGLLQLNIMVCGALLRPiiiqgPG 225
Cdd:cd17324 103 GFWAIAAAYAADLVPPeKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLP-----SL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 226 QSPKAVTLEPRREVQYMLENEKTRTSIdsidsgvelttspknvpseakmeqetraeqqqtLVTApkhsqmkaplldfsvl 305
Cdd:cd17324 178 PPKKPGSLGLLSSLLLLLRNPRLRLAY---------------------------------LITF---------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 306 keksFICYALFGLFATLGFFAPSLYiiplgislGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIyieLICVILL 385
Cdd:cd17324 209 ----LLFGGFFALYTYLAPFLTDVP--------GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL---LIALLLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 386 TASLFAFTFATEFW-----GLMLCSVFFGSMVgTIGGTHIPMLAEDDVvgiekmSSAAGVYVFIQSISGLAGPPLAGLLV 460
Cdd:cd17324 274 AAALLLLTLLGPSPllllvGLVLWGLGFFAAH-SALQTRVLRLAPEAR------GLASSLYLAAYNLGGALGAALGGLVL 346
|
410 420
....*....|....*....|...
gi 1039735314 461 DQSKiYSRAFYSCAAGMCLAAVC 483
Cdd:cd17324 347 DHGG-WAGVGWVGAALLLLALLL 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
68-487 |
1.29e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.97 E-value: 1.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 68 LMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRvYHMYISIGVISGLGYCF 147
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS-FALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 148 SFLPTVTILSQYF--DKRRSVV---TAVASTGEcfavfAFAPAITALKEHIGWRYSLLFVGLLQLNIMVCGALLRPiiiq 222
Cdd:cd17474 104 LGPLALTLIGDLFegGERAKAMglyEAALGLGI-----AVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLP---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 223 gpgqspkavtlEPRREVQymlenektrtsidsidsgvelttspknvpseakmeqetraEQQQTLVTAPKHSQMKAPLLDF 302
Cdd:cd17474 175 -----------EPKEKAK----------------------------------------SSSATKLRDLKKALRGRGLLTF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 303 SVLkekSFICYalFGLFATLGFFApslyiIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREpIRKIYIELICV 382
Cdd:cd17474 204 LVS---AFLYF--FLYFAFLTYLP-----FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR-FGARRILVIGL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 383 ILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQ 462
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE--LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
|
410 420
....*....|....*....|....*
gi 1039735314 463 SKIYSrAFYSCAAGMCLAAVCLALV 487
Cdd:cd17474 351 FGLSA-PFLVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
310-489 |
1.38e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 62.82 E-value: 1.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 310 FICYALFGLFATLgffAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 389
Cdd:pfam07690 2 FLAAFLAALGRSL---LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 390 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSrA 469
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIA--DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA-A 153
|
170 180
....*....|....*....|
gi 1039735314 470 FYSCAAGMCLAAVCLALVRP 489
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP 173
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-487 |
1.64e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.95 E-value: 1.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 39 WGWAVAVSFFFvevFTYGII-KSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLI 117
Cdd:COG0738 7 RRALIAIYLLF---FLWGFAtALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 118 SLGMITASFSQRVYHMYISIGVIsglGYCFSFL-----PTVTILSQyfDKRRSVVT---AVASTGECFAVFAFApAITAL 189
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLL---GLGLGLLdvaanPYVAALGP--ETAASRLNllhAFFSLGALLGPLLGG-LLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 190 KEHIGWRYSLLFVGLLQLnIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttsPKNVP 269
Cdd:COG0738 158 GLSLSWHLPYLILAVLLL-LLALLFLRSKL---------------------------------------------PEIEE 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 270 SEAKMEQETRAEqqqtlvtapkhsqmkaplldFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFL 348
Cdd:COG0738 192 EEEEAAGSAASL--------------------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALG 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 349 LSTMAIAEVFGRIGAGFVLNREPIRKIYI--ELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTI---GGTHIPML 423
Cdd:COG0738 252 LSLFWGGMTIGRFLGGFLLKRFGPVRLLRlsALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIfslALDGLGKR 331
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039735314 424 AeddvvgiekmSSAAGVYVFIQSISGLAGPPLAGLLVDQskiysrafYSCAAGMCLAAVCLALV 487
Cdd:COG0738 332 T----------AAAVSAVLIMGIVGGAIGPPLIGFLADA--------FGLRAAFLVPLVCYLLI 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
311-489 |
1.75e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 311 ICYALFGLFATLGFFAPslyIIPLGI-SLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 389
Cdd:cd17325 1 LSLALFLDMLGYGIIIP---ILPLYAeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL--LGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 390 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRA 469
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIA--DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAP 152
|
170 180
....*....|....*....|
gi 1039735314 470 FYSCAAGMCLAAVCLALVRP 489
Cdd:cd17325 153 FLVCAALALLALVLALLLLP 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
290-461 |
1.85e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.92 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 290 PKHSQMKAPLLDF--SVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFV 366
Cdd:COG2211 208 PVPEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 367 LNREPIRKIYIelICVILLTASLFAFTFA--TEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVV-------GIEKMSSA 437
Cdd:COG2211 288 AKRFGKKKAFI--IGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLA--DVVdydewktGRRREGLY 363
|
170 180
....*....|....*....|....
gi 1039735314 438 AGVYVFIQSISGLAGPPLAGLLVD 461
Cdd:COG2211 364 FGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-487 |
3.83e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 58.35 E-value: 3.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 41 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 120
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 121 MITASFSQRVYHMYIsIGVISGLGYCFSFLPTVTILSQYFDKR-RSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 200 LFVGLLQLnIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknVPseakmeqetr 279
Cdd:cd17319 161 IIEGLLGL-LLAVLWWFY--------------------------------------------------LR---------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 280 aeqqQTLVTApkhsqmkaplldfsvlkeksFICYALFGLFATLGFFAPSLyiipLGISLGIDPDRAAFLLSTMAIAEVFG 359
Cdd:cd17319 180 ----QVWGLA--------------------LGYFGINYALYGLLTWLPTY----LKQARGFSLKQVGLLAAIPFLAGAIG 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 360 RIGAGFVLNR-EPIRKIYIELICVILLTASLFAFTFATEFWG--LMLCSVFFGSMVGTIGGTHIPMlaedDVVGIEKMSS 436
Cdd:cd17319 232 MILGGRLSDRlLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVavILLSLAGFGIGAASPVFWSLPA----DLLPGEAAAT 307
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1039735314 437 AAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 487
Cdd:cd17319 308 AGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
39-205 |
1.21e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 56.36 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 39 WGWAVAVSF-FFVEVFTYGIIksfGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLI 117
Cdd:COG0477 13 RRALLALALgTFLEGLDFTIV---NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 118 SLGMITASFSQRVYHMYISIgVISGLGYCFSFLPTVTILSQYFDKRR-----SVVTAVASTGecfavFAFAPAIT-ALKE 191
Cdd:COG0477 90 GLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFPARErgralGLWGAAIGLG-----LALGPLLGgLLVA 163
|
170
....*....|....
gi 1039735314 192 HIGWRYSLLFVGLL 205
Cdd:COG0477 164 ALGWRWIFLINAPL 177
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
53-487 |
1.43e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.95 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 53 FTYGIIKSF-GVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVY 131
Cdd:cd17333 6 FSNGLTDALlGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 132 hMYISIGVISGLGY-CFSFLPTVTILSQY---FDKRRSVVTAVASTGECFAVFAFAPAITALkehIGWRYSLLFVGLLQL 207
Cdd:cd17333 86 -LFVVLMFLAGLGAgILDTGANTFVGALFeesSATRLNVLHGFFGLGALIGPLIATSLLTSE---LSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 208 NIMVCgallrpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveltTSPKNVPSEAKMEQETRAEQQQTLV 287
Cdd:cd17333 162 LLAIL--------------------------------------------------ILLTLFPELPSARNPQQSVGAFSAS 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 288 TAPKHSQMKapLLDFSVLkeksFICYAlfGLFATLGFFAPSLYIIPLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVL 367
Cdd:cd17333 192 ASRLLRNPS--IILGALA----LFLYV--GAETAFSSWVPSYLVEKKHVSDGL----AGYLLSGFWVGITIGRLLGGPIS 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 368 NREPIRKiYIELICV---ILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIekmssaaGVYVFI 444
Cdd:cd17333 260 RRIKPHT-LLVLSGSgalLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGT-------SVLLAA 331
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1039735314 445 QSISGLAGPPLAGLLVDQSKIYSraFYSCAAGMCLAAVCLALV 487
Cdd:cd17333 332 GSIGGAIIPFIMGFIAEAVGIQT--AMLLITILYAIIFVLALL 372
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
314-485 |
1.93e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.41 E-value: 1.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 314 ALFGLFATlGFFAPSLY-IIPL-GISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPiRKIYIELICVILLTASLFA 391
Cdd:cd17477 193 ALLGAFVA-GFLEGAFYsLLPLyGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD-RRRVLLGCALLGALAALLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 392 FTFATEFWGLMLCSVFFGSMVG---TIGGTHIpmlaeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiySR 468
Cdd:cd17477 271 PLVPGLPLALLVLLFLWGGAAGplyTLALALA-----GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG--PH 343
|
170
....*....|....*..
gi 1039735314 469 AFYSCAAGMCLAAVCLA 485
Cdd:cd17477 344 GLFLFLAAVALLFLLFL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
313-489 |
8.69e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 54.35 E-value: 8.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 313 YALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAf 392
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 393 tFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSR-AFY 471
Cdd:cd06174 80 -FAPSFWLLLLGRFLLGLGSGLIDPAVLALIA--DLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFL 156
|
170
....*....|....*...
gi 1039735314 472 SCAAGMCLAAVCLALVRP 489
Cdd:cd06174 157 IAAALALLAAILLLLVVP 174
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-207 |
9.11e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 9.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 41 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSfdeSNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 120
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGL---SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 121 MITASFSQRVYHMYISIgVISGLGYCFSFLPTVTILSQYFDKR-RSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17325 279 LLLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPPEgRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
....*...
gi 1039735314 200 LFVGLLQL 207
Cdd:cd17325 358 LAAAALLL 365
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
287-487 |
7.78e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.44 E-value: 7.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 287 VTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDpdRAAFLLSTMAIAEVFGRIGAGFV 366
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 367 LNRepIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggthIPMLAED--DVVGIEKMSSAAGVYVFI 444
Cdd:cd17489 251 SDR--KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLL----FPALQALavDLVPPHRRGAANGTFFIF 324
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1039735314 445 QSISGLAGPPLAGLLVDQSKiYSRAFYSCAagmCLAAVCLALV 487
Cdd:cd17489 325 FDLGIGLGGLLLGLVAELFG-YRAMFLLAA---VVVLLALVLY 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
313-489 |
1.38e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.62 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 313 YALFGLFATLGFFAPSL--YIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLF 390
Cdd:COG0738 11 IAIYLLFFLWGFATALWgpLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL--LGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 391 AFTFATEFWGLMLCSVFFGSMVG---TIGGTHIPMLAEDDvvGIEKMSSAAGVYvfiqSISGLAGPPLAGLLVDQSKIYS 467
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGlldVAANPYVAALGPET--AASRLNLLHAFF----SLGALLGPLLGGLLILLGLSLS 162
|
170 180
....*....|....*....|...
gi 1039735314 468 -RAFYSCAAGMCLAAVCLALVRP 489
Cdd:COG0738 163 wHLPYLILAVLLLLLALLFLRSK 185
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
297-462 |
2.21e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.88 E-value: 2.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 297 APLLDFSVLKEKSFICYALFGLFATLGFFApSLYIIP--LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK 374
Cdd:cd17503 167 APLLDLRLFKDRNFTLGLLLSFLLGLGLFG-AMFLLPlyLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 375 IYIelICVILLTASLFAFTFATE---FWGLMLCSVFFGSMVG-------TIGGTHIPMlaeddvvgiEKMSSAAGVYVFI 444
Cdd:cd17503 246 LLL--AGLLLLALGTLLLAFLTPdtsLWLIILPLFIRGLGMGlvfmplnTLALNSLPP---------EQIGDATALFNTI 314
|
170
....*....|....*...
gi 1039735314 445 QSISGLAGPPLAGLLVDQ 462
Cdd:cd17503 315 RQLGGSIGTALLATLLTN 332
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
315-489 |
2.76e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.47 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 315 LFGLFATLGFFAPSLYII-----PLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASL 389
Cdd:cd17324 1 LLALALAAFAIGTTEYVIqgllpDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLL--LVLLLLFILGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 390 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRA 469
Cdd:cd17324 79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA--DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAA 155
|
170 180
....*....|....*....|
gi 1039735314 470 FYSCAAGMCLAAVCLALVRP 489
Cdd:cd17324 156 FLAIAVLALLAALLLWRLLP 175
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
87-486 |
3.09e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.54 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 87 VFVLTFT--APLSTVLSNRFGHRLVvMAGGLLI-SLGMITASFSQRVYHMYIS-IGVISGLGYCFSFLPTvtILSQYFDK 162
Cdd:cd17328 42 VFIISYMvlSPIFGYLGDRYNRKWI-LAVGILIwSAATLLSSFAPNFWQLLLFrALVGIGEASYSPIAPT--IIADLFPK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 163 -RRSVVTAV---ASTGECFAVFAFAPAITALKehIGWRYSLLFVGLLQLnimVCGALLrpiiiqgpgqspKAVTLEPRRE 238
Cdd:cd17328 119 eKRTRALGVfyfAIPLGSGLGYVVGGLVAQAT--GGWRWAFRVTGVLGV---LLAILL------------LLFVREPPRG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 239 VqymlenektrtsidsIDSGVELTTSPKNVPSEAKMeqetraeqqqtlvtapkhsqmkaplldfsVLKEKSFICYAL--- 315
Cdd:cd17328 182 A---------------AEGGVMAKSTATSFLADLKA-----------------------------LAKNPSFILSTLgft 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 316 FGLFAT--LGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIE-LICVILLTASLFAF 392
Cdd:cd17328 218 AVSFVTgaLAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADpLVCAVGLLAAAPFL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 393 TFATEF--------WGLMLCSVFFGSMvgtiggTHIPMLAEDDVVGIEKM-SSAAGVYVFIQSISGLAGPPLAG-----L 458
Cdd:cd17328 298 FLALVLalsnlllaWVLLFLGEFLLSL------NWAPVFAILLYVVIPTRrSTASAIQILLSHLLGDAGSPYLIglisdL 371
|
410 420
....*....|....*....|....*...
gi 1039735314 459 LVDQSKIYSRAFYSCAAGMCLAAVCLAL 486
Cdd:cd17328 372 LRQNKDSPLAEAASLQYALLLCSFVLVL 399
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
303-488 |
4.71e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.76 E-value: 4.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 303 SVLKEKSFICYALFGLFATLGFFAPSLYI-IPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelIC 381
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLpVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILM--IG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 382 VILLTASLFAFTFATEFWGLMLCSVFFgSMVGTIGGTHIPMLAeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVD 461
Cdd:cd17329 273 ILLFAIGFAVLAFANTLAVLILAMIVL-TLGEMLVFPAVQTLV-AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD 350
|
170 180
....*....|....*....|....*..
gi 1039735314 462 QSkIYSRAFYSCAAGMCLAAVCLALVR 488
Cdd:cd17329 351 LL-GPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
315-484 |
8.10e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 8.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 315 LFGLFATLGFFAPSLYII--PLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKiyieLICVILLTASLF 390
Cdd:cd17471 203 LLFAAFTLLFAANSMYIIamPLYVTneLGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRR----LLLAGFLAGVLF 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 391 --AFTFATEFWGLMLCSVFFGSMVGTIGGthIPMLAEDDVVGiEKMSSAAGVYVFIQSISGLAGPPLAGLLVdQSKIYSR 468
Cdd:cd17471 279 ylGLALATSLWQLIALQLLNAIFIGITAG--LGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIA-QYFGYRA 354
|
170
....*....|....*.
gi 1039735314 469 AFYSCAAGMCLAAVCL 484
Cdd:cd17471 355 VFLVCAVLALLALVLL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
311-491 |
1.06e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 311 ICYALFGLFATLGFFAP--SLYIIPLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTAS 388
Cdd:cd17489 1 ILLANFFFFLSFYLLLPvlPLYAHDLGGSEAV----AGLVVGLFTLAALLARPFAGRLLDRFGRKRLL--LIGLLIFALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 389 LFAFTFATEFWGLMLCSVFFG---SMVGTIGGTHIpmlaeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSkI 465
Cdd:cd17489 75 TLLYLLATSVALLLVLRLIHGigwGAFTTAAATLV-----ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-G 148
|
170 180
....*....|....*....|....*.
gi 1039735314 466 YSRAFYSCAAgmcLAAVCLALVRPCK 491
Cdd:cd17489 149 FAVLFIVAAV---LALLALLLVFLVK 171
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
41-207 |
1.23e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.65 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 41 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 120
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 121 MITASFSQRVYHMYISIGViSGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 199
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGL-NGLFQSMGWPPCVKLLGNWFsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
....*...
gi 1039735314 200 LFVGLLQL 207
Cdd:cd17312 161 LVPGIVGL 168
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
302-463 |
1.68e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.19 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 302 FSVLKEKSFICYALFGLFATLGFF-----APSLYIIPLGISlgidPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY 376
Cdd:cd17320 195 KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQLGLS----PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 377 IE---LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGG--THIPMLAEDDVVGiekmsSAAGVYVFIQSISGLA 451
Cdd:cd17320 271 RLgllLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPnaTSLALEPFPHVAG-----TASALLGFLQFLIGAL 345
|
170
....*....|..
gi 1039735314 452 GPPLAGLLVDQS 463
Cdd:cd17320 346 AGALVGLLPNGT 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
317-482 |
1.93e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 317 GLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLFAFTFAT 396
Cdd:cd06173 218 ALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL--IGALLLGLALLVLGLSP 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 397 EFWGLMLCSVFFGSMVGTIG---GTHIPMLAEDDVVGiekmsSAAGVYVFIQSISGLAGPPLAGLLVDQSKIySRAFYSC 473
Cdd:cd06173 296 SLWLLLAALFLLGLAGGLFNvplNTLLQLRVPDELRG-----RVFSVYNALNSGAMPLGALLAGLLADALGL-SAVFLLA 369
|
....*....
gi 1039735314 474 AAGMCLAAV 482
Cdd:cd06173 370 GALLLLAAL 378
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
58-207 |
2.57e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 46.42 E-value: 2.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 58 IKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQrVYHMYI-- 135
Cdd:cd17339 15 ITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGG-IALLFLgt 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 136 -----SIGVISGLgycfsfLPTVtiLSQYFDKRRSVVTAVASTGECFAVfAFAPAIT---ALKEHIGWRYSLLFVGLLQL 207
Cdd:cd17339 94 alagaGIAVGNVL------LPSL--IKRDFPRRVGLMTGLYTTSMNLGA-ALASGLSvplAQALGGGWRGALAIWALPAL 164
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
297-489 |
2.76e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 297 APLLDFSVLKEKSFICYALFGLFATLGFFA-----PSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP 371
Cdd:cd17504 166 VPLIDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 372 IRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLA 451
Cdd:cd17504 246 PRRVLL-IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVE--SVPPDRTGIATGMNTVLRTIGSAI 322
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1039735314 452 GPPLAGLLVDQSKI------------YSRAFYSCAAgMCLAAVCLALVRP 489
Cdd:cd17504 323 GPAIAGAILTTYTVsitsggvptegaYVLAFLIGAA-LALAALLLSLLIP 371
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
309-490 |
3.00e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 46.45 E-value: 3.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 309 SFICYALFGLFATLGFFAPSLYIIPLGISL---------------------GIDPDRAAFLLSTMAIAEVFGRIGAGFVL 367
Cdd:cd17390 153 ALLCSAIFILNAGLVWFLLSKLWDLLLVRFlmgfsvllfrsnfslyleerfDLSPKTIGYLISYSGVLGALSGFLVGRIL 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 368 NREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFgSMVGTIGGTHIPMLaEDDVVGIEKMSSAAGVYVFIQSI 447
Cdd:cd17390 233 KLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPL-SISSAVLRTCSTSL-LLSRGKSKERGTLLGVGQSVTSL 310
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1039735314 448 SGLAGPPLAGLLVDQSKIYSRAFyscAAGMCLAAVCLALVRPC 490
Cdd:cd17390 311 ARILAPLLSGLLQEFSVSGPGLL---GAVLALAAILLMLARQR 350
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
41-217 |
3.19e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.39 E-value: 3.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 41 WAVAVSFFFVeVFTYGIIKSFGVFFndLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 120
Cdd:COG0738 213 LLGGLAIFLY-VGAEGAIGDWLPLY--LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 121 MITASFSQRVYHMYISIgVISGLGYCFSFlPTV-TILSQYFDKRR----SVVTAVASTGecfavFAFAPAIT-ALKEHIG 194
Cdd:COG0738 290 LLLALLAPGPWLALIGL-ALVGLGLSLMF-PTIfSLALDGLGKRTaaavSAVLIMGIVG-----GAIGPPLIgFLADAFG 362
|
170 180
....*....|....*....|...
gi 1039735314 195 WRYSLLFVGLLQLNIMVCGALLR 217
Cdd:COG0738 363 LRAAFLVPLVCYLLILLLALALK 385
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
92-218 |
3.51e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.79 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 92 FTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYHMYISiGVISGLGYCFsFLPTVTIL--SQYFDKRRSVVTA 169
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAF-ALVAGAALiaDIYPPEERGVALG 90
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1039735314 170 VASTGeCFAVFAFAPAITA-LKEHIGWRYSLLFVGLLQLNIMVCGALLRP 218
Cdd:TIGR00880 91 LMSAG-IALGPLLGPPLGGvLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
67-197 |
4.37e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.01 E-value: 4.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 67 DLMDSFDESNSKISWIISIcvFVLTFTAPLSTV--LSNRFGHRLVVMAGGLLISLGMITASFSQRVYhMYISIGVISGLG 144
Cdd:cd17321 21 TIARDLGASPSQLQWVVNA--YLLAFAALLLLAgrLGDRFGRKRVFLIGLALFGLASLLCALAPSLA-FLIAARALQGIG 97
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039735314 145 YCFSFLPTVTILSQYFDKRR-----SVVTAVASTGecfavFAFAPAIT-ALKEHIGWRY 197
Cdd:cd17321 98 AAAIMPASLALIAATFPGERrgralGLWGAVVGIG-----AALGPLLGgLLLELFGWRW 151
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
77-196 |
8.36e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 45.31 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 77 SKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYhMYISIGVISGLGYCFSFLPTVTIL 156
Cdd:cd06179 32 SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVN-MLIGGQALIGIGAGTQGLGAAVAS 110
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1039735314 157 SQYFDKRRSVVTAVASTGeCFAVFAFAPAIT---ALKEHIGWR 196
Cdd:cd06179 111 ELVPNKYRGLVQGVVNLV-ASPGSALGPLIAgalVEANAAGWR 152
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
308-486 |
8.83e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.90 E-value: 8.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 308 KSFICYALFGLFATLGFFAPSLYIiP--LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILL 385
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFL-PtyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 386 TASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEkmSSAAGVYVFIQSISGLAGPPLAGLLVDQSKI 465
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVR--ATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|.
gi 1039735314 466 YSRAFYScAAGMCLAAVCLAL 486
Cdd:cd17316 334 TGVPALI-LALLAIVALIVAL 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
62-212 |
9.61e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.50 E-value: 9.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 62 GVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVyHMYISIGVIS 141
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSV-LQLALLRFLT 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039735314 142 GLGYCFSfLPTV-TILSQYF-DKRRSVVTAVASTGecfavFAFAPAITA-----LKEHIGWRYSLLFVGLLQLNIMVC 212
Cdd:cd17365 98 GLGLGAA-MPNAiTLVSEYApARRRSLAVTLMFCG-----YPLGAALGGflaaaLIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
58-459 |
1.31e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 44.56 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 58 IKSFGVFFND-LMDSFDE--SNSKISWIISICVFVL----TFTAPLSTVLSNRFGHRLVVMAGGLL--ISLGMITASFSQ 128
Cdd:cd17357 23 QEVFKEFINDtLVDRYGLnlSDSELDLLWSLIVSIFfiggAIGSFISAFLANRFGRKNGLLISNALlvVSSLLMFLSKSA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 129 RVYHMYIS----IGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECF--AVFAFaPAITALKEHigWRYSLLFV 202
Cdd:cd17357 103 KSPELLIFgrflVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILlgQVFGL-PSVLGTETL--WPYLLFFP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 203 GLLqlnIMVCGALLrPIIiqgpGQSPKAVTLEPRREVQYMLENEKTRTSIDSIDsgvelttspknvPSEAKMEQETRAEQ 282
Cdd:cd17357 180 GIP---ALLQLAAL-PFF----PESPKFLLISKGDEEEAEKSLKFLRGIEDDVD------------QELEEIKKESEQMG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 283 QQTLVTapkhsqMKAPLLDFSVLKEKSFICYALFGLfATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIG 362
Cdd:cd17357 240 DQKQVS------LMQLLRDPSLRLPLLLVLVVSASQ-QFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 363 AGFVLNREPIRKIYIE-----LICVILLTASLFAFTFATEF-WGLMLCSVFFGsMVGTIGGTHIPMLAEDDVVGIEKMSS 436
Cdd:cd17357 313 GPFLIEKVGRRPLLLIslsvcAVALLLMSVFLFLSEQNSWMsYGCIVAIFLFI-FFFAIGLGPIPWFIGAELFPQAPRSA 391
|
410 420
....*....|....*....|....*..
gi 1039735314 437 AAGVYVFIQS----ISGLAGPPLAGLL 459
Cdd:cd17357 392 AQSLGSSVNWtsnfIVGMAFPPLQSIG 418
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
68-456 |
1.32e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 44.68 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 68 LMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYHMYIS---IGVISGLG 144
Cdd:TIGR00711 28 IAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFrviQGFGGGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 145 YCFSFlptVTILSQYFDKRRSVVTAVASTGECFAVfAFAPAITA-LKEHIGWRYslLFVGLLQLNIMVCgaLLRPIIIqg 223
Cdd:TIGR00711 108 IPLSF---STLLNIYPPEKRGRAMAIWGLTVLVAP-ALGPTLGGwIIENYHWRW--IFLINVPIGIIVV--VVAFFIL-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 224 PGQSPKAvtLEPRREVQYMLENEKTRTSIDSIDSGVEL-TTSPKNVPSEAKME---------QETRAEQqqtlvtapkhs 293
Cdd:TIGR00711 178 PRDKPAA--SENFDFLGLLLLSVGLGSLLYGLSEGPERgWFDSNEILILSITGlvaiiafvvWELTDDN----------- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 294 qmkaPLLDFSVLKEKSFICYALFGLFATLGFFApSLYIIPLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP 371
Cdd:TIGR00711 245 ----PLVDLRLFKYRNFTIGCVYMSLLGLGLYG-SFYLLPLYLQqvLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKID 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 372 IRKIYIELICVILLTASLFAFTFA--TEFWGLMLCSVF--FGSMVGTIGGTHIPMlaedDVVGIEKMSSAAGVYVFIQSI 447
Cdd:TIGR00711 320 PRKLVTIGLILYAVGFYWRAFTFTpdTPFLAIALPQFIrgFGMGCFFMPLTTIAL----SGLPPHKIARGSSLSNFTRQL 395
|
....*....
gi 1039735314 448 SGLAGPPLA 456
Cdd:TIGR00711 396 GGSIGTALI 404
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
309-488 |
1.79e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 43.71 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 309 SFICYALFGLFATLGFFAPSLYIiPL---GIsLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK--IYIELICVI 383
Cdd:cd17502 168 TILLSSIFGFLFGGALFGLIYYL-PLyfqLV-LGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKplIVIGTILMS 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 384 LLTASLFAFTFATEFWGLMLCSVFFGSMVGTigGTHIPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAgllvdqs 463
Cdd:cd17502 246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGI--GFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT------- 316
|
170 180
....*....|....*....|....*
gi 1039735314 464 kiysRAFYSCAAGMCLAAVCLALVR 488
Cdd:cd17502 317 ----DVFLVALALAALAFLLSLFLP 337
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
287-488 |
2.44e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 287 VTAPKHSQMKAPLLDFSVLkeksFICYALFglfatLGFFApsLYIIPLGISL------GIDPDRAAFLLSTMAIAEVFGR 360
Cdd:cd17473 182 SAASPGAATAAALPWKRVL----PIYFLAF-----LAMLL--FYVIPIQLPFllqergGGSAALIGLALAIASLAGAIGA 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 361 IGAGFVLNRepIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGV 440
Cdd:cd17473 251 LLFGRLKRR--LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS--LVPPELRGRAMGI 326
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1039735314 441 YVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 488
Cdd:cd17473 327 VTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
39-183 |
4.61e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 39 WGWAVAVSFFFVevFTYGIIKSFGVFFndLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLIS 118
Cdd:COG2211 230 FLLLLLAYLLFF--LALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039735314 119 LGMITASFSQR--VYHMYIsIGVISGLGYCFSFLPTVTILSQYFDKRRsVVTAVASTGECFAVFAFA 183
Cdd:COG2211 306 LGLLLLFFLGPgnLWLLLV-LAALAGIGLGAILVLPWAMLADVVDYDE-WKTGRRREGLYFGIFTFA 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
379-489 |
5.15e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.60 E-value: 5.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 379 LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGL 458
Cdd:cd06173 73 LRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPE--LVPKEQLVRANALNSLATQLARIIGPALGGL 150
|
90 100 110
....*....|....*....|....*....|.
gi 1039735314 459 LVDQSKIYSrAFYSCAAGMCLAAVCLALVRP 489
Cdd:cd06173 151 LVALLGPGG-AFAINALSFLLSALLLLFIRR 180
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
308-482 |
6.31e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 6.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 308 KSFICYALFGLFATLGFFAPSLYIIPLGiSLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTA 387
Cdd:cd17370 200 KAFWLYLLAVALFALGNFSFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLI--LGYLSLAL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 388 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYS 467
Cdd:cd17370 277 AYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA--DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PS 353
|
170
....*....|....*
gi 1039735314 468 RAFYSCAAGMCLAAV 482
Cdd:cd17370 354 AAFLFSAVLALIALL 368
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
310-513 |
6.80e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 6.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 310 FICYALFGLfaTLGFFAP--SLYIIPlgiSLGIDPDRAAFLLSTMAIAEV-----FGRIGagfvlNREPIRKIYIeLICV 382
Cdd:cd17471 2 LLATLLTGL--AGAFVLPylSLFLTE---ELGASPLQIGIFMTLSALSGIvvsqwLGRLS-----DRGGDRKPLI-LLAL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 383 ILLTASLFAFTFATEFWGLMLCSVFFGSmvgtIGGTHIPML------------AEDDVVGIEKMSSAAgvyvfiqSISGL 450
Cdd:cd17471 71 LAGALGYLLFAFLRNYWVLLLVGVVLLS----LGAAAFPQLfalareyadrssGRDATLFNSVLRAAF-------SLAWV 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039735314 451 AGPPLAGLLVDQSKiYSRAFYSCAAGMCLAAVCLALVRPCKKGLCQNSHSGENQTDRQRGKAL 513
Cdd:cd17471 140 IGPPLAFLLLDVLG-FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRL 201
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
41-145 |
9.44e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 9.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 41 WAVAVSFFFVEvFTYGIIKSFgvffndLMDSFDESNSKISWIISICV-FVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 119
Cdd:cd17489 197 LPPALILFLAS-IAYGAISTF------LPLYAAERGISNAGLFFTVYaIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL 269
|
90 100
....*....|....*....|....*.
gi 1039735314 120 GMITASFSQRVYHMYISiGVISGLGY 145
Cdd:cd17489 270 GLLLLSFAGSPWMLLLA-AVLYGLGF 294
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
310-487 |
9.44e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 9.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 310 FICYALFGLFATLGFFAPSlyiiplgiSLGIDPDRAAFLLSTMAIAEVFGRIG-AGFVLNREPIRKIYIelICVILLTAS 388
Cdd:cd17330 185 LIALAFAGLESVFSLFLKD--------RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLR--LGLLLAIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 389 LFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLvdQSKIYSR 468
Cdd:cd17330 255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK--SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL--YSFLGPG 330
|
170
....*....|....*....
gi 1039735314 469 AFYSCAAGMCLAAVCLALV 487
Cdd:cd17330 331 VPFLLAAGLLLIALFLLSL 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
49-212 |
9.54e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 9.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 49 FVEVFTYgiiksFGVFfndLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQ 128
Cdd:cd17324 214 FFALYTY-----LAPF---LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGP 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 129 RVYHMYISIgVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTgeCF----AVFAFAPAItaLKEHIGWRYSLLFVGL 204
Cdd:cd17324 286 SPLLLLVGL-VLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLA--AYnlggALGAALGGL--VLDHGGWAGVGWVGAA 360
|
....*...
gi 1039735314 205 LQLNIMVC 212
Cdd:cd17324 361 LLLLALLL 368
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
316-497 |
1.11e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.42 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 316 FGLFATLGFFAP--SLYiiplGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIyIELICVILLTASLFAFT 393
Cdd:cd17335 7 FFFFAALGSLLPflSVY----LKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKA-LLLLSLLAAVLFFLSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 394 F-ATEFWGLMLCSVFFGSMVGTiggthIPMLAEDDVVGIEKMSSAA-GVYVFIQSISGLAGPPLAGLLVDQSKI---YSR 468
Cdd:cd17335 82 FvAQIFWLLLLLVILGAFFSAP-----VVPLVDSITLQYLGEERERyGKQRLWGSIGFGIAALLVGILIDRSSTyknYTI 156
|
170 180
....*....|....*....|....*....
gi 1039735314 469 AFYSCAAGMCLAAVCLALVRPCKKGLCQN 497
Cdd:cd17335 157 AFYVFAVLMLLALLLALKFPFRPKHPEPN 185
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
316-489 |
1.78e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 316 FGLFATLGFFApsLYII-PLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASLFAFTF 394
Cdd:cd17329 13 LGFFMVWPFMA--IYLHqQLGLSASI----VGLVLALSAVAGIVASLIGGRLADRFGRKPVM--LAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 395 ATEFWGLMLCSV---FFGSMVGTIGGThipMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSkiYSRAFY 471
Cdd:cd17329 85 AHSPWLFAIALVltgFGGGLFEPASEA---MIA--DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS--FRLLFL 157
|
170
....*....|....*...
gi 1039735314 472 SCAAGMCLAAVCLALVRP 489
Cdd:cd17329 158 AAAVLFLLAALVLLFLLP 175
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
287-459 |
2.38e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 287 VTAPKHSQMKAPLLD--FSVLKEKSFICYALFGLFATLGFFAP-SLYIIPLGISLGIDPDrAAFLLSTMAIAEVFGRIGA 363
Cdd:cd17332 198 VVPPEEEKSKLPLLKslKALLKNRPFLILLLAYLLYFLAFNIVnTVLVYYFKYVLGGRAE-LVLLLLLILSGALLALLPW 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 364 GFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSS------- 436
Cdd:cd17332 277 PPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLA--DVIDYGELKTgkrregi 354
|
170 180
....*....|....*....|...
gi 1039735314 437 AAGVYVFIQSISGLAGPPLAGLL 459
Cdd:cd17332 355 FYSVMTFFRKLGLALAGALVGLI 377
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
48-211 |
8.30e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 38.75 E-value: 8.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 48 FFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIIS---ICVFVLTFtapLSTVLSNRFGHRLVVMAGGLLISLGMITA 124
Cdd:PRK03699 13 FLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTflnAGILISIF---LNAWLMEIIPLKRQLIFGFALMILAVAGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039735314 125 SFSQRVYHMYIS---IGVISGLGYCfsfLPTVTILSQYFDKRRS---VVTavastgECFavFAFA----PAITA--LKEH 192
Cdd:PRK03699 90 MFSHSLALFSIAmfvLGVVSGITMS---IGTFLITHVYEGKQRGsrlLFT------DSF--FSMAgmifPIIAAylLARS 158
|
170
....*....|....*....
gi 1039735314 193 IGWRYSLLFVGLLQLNIMV 211
Cdd:PRK03699 159 IEWYWVYACIGLVYVAIFI 177
|
|
| |
