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Conserved domains on  [gi|1039736229|ref|XP_017169863|]
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nuclear receptor corepressor 1 isoform X20 [Mus musculus]

Protein Classification

nuclear receptor corepressor 1( domain architecture ID 15502538)

nuclear receptor corepressor 1 (NCOR1) is a transcriptional coregulatory protein which assists nuclear receptors in the down regulation of gene expression

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580|20084085
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPS2_interact super family cl24372
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 8.46e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


The actual alignment was detected with superfamily member pfam15784:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 106.10  E-value: 8.46e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1039736229  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 636-679 6.24e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.24e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736229  636 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 679
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
MDN1 super family cl34967
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 726-925 7.12e-06

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5271:

Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 51.55  E-value: 7.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  726 DEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAE------LEATTDPAPcASPSSA 799
Cdd:COG5271    454 DEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAeetsadDGADTDAAA-DPEDSD 532

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  800 VPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSS-VLDPPAPTKADSVDPEMQvpENTASKGEGDAKERDLES 878
Cdd:COG5271    533 EDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDEAAEEEEA 610

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039736229  879 TSEKTEArDEDVVVAEQIERPEPQSDDDSS----ATCSADEGVDGEPERQR 925
Cdd:COG5271    611 DDDEADA-DADGAADEEETEEEAAEDEAAEpetdASEAADEDADAETEAEA 660
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 450-492 1.29e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736229  450 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 492
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 8.46e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 106.10  E-value: 8.46e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1039736229  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 636-679 6.24e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.24e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736229  636 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 679
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 636-679 1.35e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.35e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039736229  636 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 679
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
636-681 2.15e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.15e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1039736229   636 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 681
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 726-925 7.12e-06

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 51.55  E-value: 7.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  726 DEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAE------LEATTDPAPcASPSSA 799
Cdd:COG5271    454 DEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAeetsadDGADTDAAA-DPEDSD 532

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  800 VPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSS-VLDPPAPTKADSVDPEMQvpENTASKGEGDAKERDLES 878
Cdd:COG5271    533 EDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDEAAEEEEA 610

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039736229  879 TSEKTEArDEDVVVAEQIERPEPQSDDDSS----ATCSADEGVDGEPERQR 925
Cdd:COG5271    611 DDDEADA-DADGAADEEETEEEAAEDEAAEpetdASEAADEDADAETEAEA 660
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 760-925 6.92e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 48.05  E-value: 6.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  760 EAAKSSEDSSENAASRGNTEPVAELEATT--DPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEEcGAE 837
Cdd:PRK13108   283 GALRGSEYVVDEALEREPAELAAAAVASAasAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGE-STP 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  838 GSSVLDPPAPTKADSVDPEMQVPENTASKGEGDAKErDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSADEGV 917
Cdd:PRK13108   362 AVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAA-PEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDD 440


                   ....*...
gi 1039736229  918 DGEPERQR 925
Cdd:PRK13108   441 PAEPDGIR 448
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 450-492 1.29e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736229  450 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 492
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
448-493 3.98e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 3.98e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1039736229   448 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 493
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 450-489 5.29e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039736229  450 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 489
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 692-920 7.49e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.90  E-value: 7.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  692 KQKVSRAVVASRKPREE---RDVSQCESVAStvSAQEDEDIEASNEEENPEDSEG-AENSSDTES---APSPSPVEAAKS 764
Cdd:TIGR00927  613 KEQLSRRPVAKVMALGDlskGDVAEAEHTGE--RTGEEGERPTEAEGENGEESGGeAEQEGETETkgeNESEGEIPAERK 690

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  765 SEDSSENAASRGNTEPVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDP 844
Cdd:TIGR00927  691 GEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGET 770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  845 PAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSAD---------E 915
Cdd:TIGR00927  771 EAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAEnqgeakqdeK 850


                   ....*
gi 1039736229  916 GVDGE 920
Cdd:TIGR00927  851 GVDGG 855
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 8.46e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 106.10  E-value: 8.46e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1039736229  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 636-679 6.24e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.24e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736229  636 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 679
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 636-679 1.35e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.35e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039736229  636 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 679
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
636-681 2.15e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.15e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1039736229   636 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 681
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 726-925 7.12e-06

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 51.55  E-value: 7.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  726 DEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAE------LEATTDPAPcASPSSA 799
Cdd:COG5271    454 DEEEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAeetsadDGADTDAAA-DPEDSD 532

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  800 VPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSS-VLDPPAPTKADSVDPEMQvpENTASKGEGDAKERDLES 878
Cdd:COG5271    533 EDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD--ESEEAEASEDEAAEEEEA 610

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039736229  879 TSEKTEArDEDVVVAEQIERPEPQSDDDSS----ATCSADEGVDGEPERQR 925
Cdd:COG5271    611 DDDEADA-DADGAADEEETEEEAAEDEAAEpetdASEAADEDADAETEAEA 660
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 701-920 4.02e-05

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 49.24  E-value: 4.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  701 ASRKPREERDVSQCESVASTVSAQEDEDIEAS-----NEEENPEDSEGAENSSDTE------SAPSPSPVEAAKSSEDSS 769
Cdd:COG5271    525 AADPEDSDEDALEDETEGEENAPGSDQDADETdepeaTAEEDEPDEAEAETEDATEnadadeTEESADESEEAEASEDEA 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  770 ENAASRGNTEPVAELEATTDPAPCASPSSAVPTTKP------AERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVL- 842
Cdd:COG5271    605 AEEEEADDDEADADADGAADEEETEEEAAEDEAAEPetdaseAADEDADAETEAEASADESEEEAEDESETSSEDAEEDa 684

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  843 -DPPAPTKADSVDPEM---------QVPENTASKGEGDAKERDLESTSEKTEARDE---------DVVVAEQIERPEPQS 903
Cdd:COG5271    685 dAAAAEASDDEEETEEadedaetasEEADAEEADTEADGTAEEAEEAAEEAESADEeaaslpdeaDAEEEAEEAEEAEED 764

                          250
                   ....*....|....*..
gi 1039736229  904 DDDSSATCSADEGVDGE 920
Cdd:COG5271    765 DADGLEEALEEEKADAE 781
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 760-925 6.92e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 48.05  E-value: 6.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  760 EAAKSSEDSSENAASRGNTEPVAELEATT--DPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEEcGAE 837
Cdd:PRK13108   283 GALRGSEYVVDEALEREPAELAAAAVASAasAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGE-STP 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  838 GSSVLDPPAPTKADSVDPEMQVPENTASKGEGDAKErDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSADEGV 917
Cdd:PRK13108   362 AVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAA-PEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDD 440


                   ....*...
gi 1039736229  918 DGEPERQR 925
Cdd:PRK13108   441 PAEPDGIR 448
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 450-492 1.29e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039736229  450 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 492
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 715-922 2.51e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 46.55  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  715 ESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPApcA 794
Cdd:COG5271    561 ATAEEDEPDEAEAETEDATENADADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEA--A 638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  795 SPSSAVPTtkpAERESVEAQVTDSASAETAEPMDVDHEEcgaegssVLDPPAPTKADSVDPEMQVPENTASKGEGDAKER 874
Cdd:COG5271    639 EPETDASE---AADEDADAETEAEASADESEEEAEDESE-------TSSEDAEEDADAAAAEASDDEEETEEADEDAETA 708

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1039736229  875 DLESTSEKTEArDEDVVVAEQIERPEPQSDDDSSATcSADEGVDGEPE 922
Cdd:COG5271    709 SEEADAEEADT-EADGTAEEAEEAAEEAESADEEAA-SLPDEADAEEE 754
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 729-885 3.19e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 45.74  E-value: 3.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  729 IEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNT------------EPVAELEATTDPAPCASP 796
Cdd:PRK13108   273 ILAPKGREAPGALRGSEYVVDEALEREPAELAAAAVASAASAVGPVGPGEpnqpddvaeavkAEVAEVTDEVAAESVVQV 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  797 SSAVPTTKPAERESVEAQVTDSASAET-AEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQVPENTASKGEGDakeRD 875
Cdd:PRK13108   353 ADRDGESTPAVEETSEADIEREQPGDLaGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPEVPEKAAPIPDPA---KP 429

                          170
                   ....*....|
gi 1039736229  876 LESTSEKTEA 885
Cdd:PRK13108   430 DELAVAGPGD 439
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
448-493 3.98e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 3.98e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1039736229   448 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 493
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 450-489 5.29e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039736229  450 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 489
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 741-941 8.05e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 8.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  741 SEGAENSSDTESAPSPSPVEAAKSSEDSS----------------ENAASRGNTEPVAELEATTDPAPCA-SPSSAVPTT 803
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEAPANESRStptwslstlapasparEGSPTPPGPSSPDPPPPTPPPASPPpSPAPDLSEM 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  804 KPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQVPENT-ASKGEGDAKERDLESTSek 882
Cdd:PHA03307   138 LRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTpPAAASPRPPRRSSPISA-- 215

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039736229  883 tEARDEDVVVAEQIERPEPQSDDDSSATCSADEGVDGEPERQRvfPMDAKPSLLTPPGS 941
Cdd:PHA03307   216 -SASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPL--PRPAPITLPTRIWE 271
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 450-493 9.75e-04

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 9.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039736229  450 WTDHEKEIFKDKFIQHPKNFGLI-ASYLERKSVPDCVLYYYLTKK 493
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 720-922 1.65e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.85  E-value: 1.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  720 TVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPAPCASPSSA 799
Cdd:COG5271    266 GTPDTDDEATDDADGLEAAEDDALDAELTAAQAADPESDDDADDSTLAALEGAAEDTEIATADELAAADDEDDDDSAAED 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  800 VPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQVPENTASKGEGDAKERDLEST 879
Cdd:COG5271    346 AAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEASADGGTSPTSDTDEEEEEADEDAS 425

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039736229  880 SEKTEARDEDVVVAEQIErpepqsDDDSSATCSADEGVDGEPE 922
Cdd:COG5271    426 AGETEDESTDVTSAEDDI------ATDEEADSLADEEEEAEAE 462
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 701-873 1.88e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 43.54  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  701 ASRKPREERDVSQCESVASTVSAQ----EDEDIEASNEEENPEDSEGAENSSDTESAPSPSP-----VEAAKSSEDSSEN 771
Cdd:PRK08691   390 AAKKPQPRPEAETAQTPVQTASAAampsEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsaksIQTASEAETPPEN 469

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  772 AASRgNTEPVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEgssvlDPPAPTkad 851
Cdd:PRK08691   470 QVSK-NKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAEPFYGYGFPDNDCPPEDGAE-----IPPPDW--- 540

                          170       180
                   ....*....|....*....|..
gi 1039736229  852 svdpEMQVPENTASKGEGDAKE 873
Cdd:PRK08691   541 ----EHAAPADTAGGGADEEAE 558
PHA03169 PHA03169
hypothetical protein; Provisional
 689-889 2.01e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.04  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  689 QQHKQKVSRAVVASRKPREERDVS-----QCESVASTVSAQEDEDIEASNEE---ENPEDSEGAENSSDTESAPSPSPVE 760
Cdd:PHA03169    28 GTREQAGRRRGTAARAAKPAPPAPttsgpQVRAVAEQGHRQTESDTETAEESrhgEKEERGQGGPSGSGSESVGSPTPSP 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  761 AAKSSEDSS----ENAASRGNTEPVAELEATTDPAPCASPSSAVPTT---KPAERESVEAQVTDSASAETAEPMDVDHEE 833
Cdd:PHA03169   108 SGSAEELASglspENTSGSSPESPASHSPPPSPPSHPGPHEPAPPEShnpSPNQQPSSFLQPSHEDSPEEPEPPTSEPEP 187

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039736229  834 CGAEGSSVLDP-PAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDED 889
Cdd:PHA03169   188 DSPGPPQSETPtSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPEREG 244
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 637-684 3.17e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.06  E-value: 3.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039736229  637 WTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKnFYFNYKRRHNL 684
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCF-DRWRRKLNPKI 47
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 759-922 3.28e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 42.66  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  759 VEAAKSSEDSsenAASRGNtEPVAELEATTDPAPCA-----SPSSAVPTTKPAEresvEAQVTDSASAETAEPMDVDHEE 833
Cdd:PRK13108   273 ILAPKGREAP---GALRGS-EYVVDEALEREPAELAaaavaSAASAVGPVGPGE----PNQPDDVAEAVKAEVAEVTDEV 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  834 CGAEGSSVLD-----PPAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSS 908
Cdd:PRK13108   345 AAESVVQVADrdgesTPAVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPEVPEKAAPIP 424

                          170
                   ....*....|....
gi 1039736229  909 ATCSADEGVDGEPE 922
Cdd:PRK13108   425 DPAKPDELAVAGPG 438
PHA03169 PHA03169
hypothetical protein; Provisional
 679-925 5.05e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.88  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  679 KRRHNLDNLLQQH-KQKVSRAVVASRKPREERDVSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPS 757
Cdd:PHA03169    10 RSRHTLRSSCRGHcKRHGGTREQAGRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGEKEERGQ 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  758 PVEAAKSSEDSSENAASRGNTEPV----AELEATTDPAPCASPSSAVPTTKPAERESVEaqvtdSASAETAEPMDVDHEE 833
Cdd:PHA03169    90 GGPSGSGSESVGSPTPSPSGSAEElasgLSPENTSGSSPESPASHSPPPSPPSHPGPHE-----PAPPESHNPSPNQQPS 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  834 CGAEGSSVLDPPAPTKADSVDPEmQVPENTASKGEGDAKERDLESTSEKTEARDEdvvvAEQIERPEPQSDDDSSATCSA 913
Cdd:PHA03169   165 SFLQPSHEDSPEEPEPPTSEPEP-DSPGPPQSETPTSSPPPQSPPDEPGEPQSPT----PQQAPSPNTQQAVEHEDEPTE 239

                          250
                   ....*....|..
gi 1039736229  914 DEGVDGEPERQR 925
Cdd:PHA03169   240 PEREGPPFPGHR 251
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 722-922 5.15e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 42.31  E-value: 5.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  722 SAQEDEDIEASNEEENPED---------SEGAENSSDTEsapspSPVEAAKSSEDSSENAASRGNTEpvaelEATTDPAP 792
Cdd:COG5271    645 SEAADEDADAETEAEASADeseeeaedeSETSSEDAEED-----ADAAAAEASDDEEETEEADEDAE-----TASEEADA 714

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  793 CASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDppAPTKADSVDPEMQVPENTASKGEGDAK 872
Cdd:COG5271    715 EEADTEADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEEAEEDD--ADGLEEALEEEKADAEEAATDEEAEAA 792

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039736229  873 ERDLESTSEKTEARDEDVVVAEQIE--------RPEPQSDDDSSATCSADEGVDGEPE 922
Cdd:COG5271    793 AEEKEKVADEDQDTDEDALLDEAEAdeeedldgEDEETADEALEDIEAGIAEDDEEDD 850
rne PRK10811
ribonuclease E; Reviewed
 700-866 5.42e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 42.33  E-value: 5.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  700 VASRKPREERDVSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTE 779
Cdd:PRK10811   847 VVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPVTE 926

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  780 PVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQV 859
Cdd:PRK10811   927 QPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQV 1006


                   ....*..
gi 1039736229  860 PENTASK 866
Cdd:PRK10811  1007 PEATVEH 1013
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 692-920 7.49e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.90  E-value: 7.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  692 KQKVSRAVVASRKPREE---RDVSQCESVAStvSAQEDEDIEASNEEENPEDSEG-AENSSDTES---APSPSPVEAAKS 764
Cdd:TIGR00927  613 KEQLSRRPVAKVMALGDlskGDVAEAEHTGE--RTGEEGERPTEAEGENGEESGGeAEQEGETETkgeNESEGEIPAERK 690

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  765 SEDSSENAASRGNTEPVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDP 844
Cdd:TIGR00927  691 GEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGET 770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  845 PAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSAD---------E 915
Cdd:TIGR00927  771 EAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAEnqgeakqdeK 850


                   ....*
gi 1039736229  916 GVDGE 920
Cdd:TIGR00927  851 GVDGG 855
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 725-923 8.18e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 41.54  E-value: 8.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  725 EDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPAPCASPSSAVpttK 804
Cdd:COG5271    514 TSADDGADTDAAADPEDSDEDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEE---S 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  805 PAERESVEAQVTDSASAETAEPMDVDheecgAEGSSVLDppaptKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTE 884
Cdd:COG5271    591 ADESEEAEASEDEAAEEEEADDDEAD-----ADADGAAD-----EEETEEEAAEDEAAEPETDASEAADEDADAETEAEA 660

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1039736229  885 ARDEDVV-VAEQIERPEPQSDDDSSATcSADEGVDGEPER 923
Cdd:COG5271    661 SADESEEeAEDESETSSEDAEEDADAA-AAEASDDEEETE 699
motB PRK12799
flagellar motor protein MotB; Reviewed
 724-866 9.78e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 40.85  E-value: 9.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736229  724 QEDEDIEASNEEE---NPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVA-------ELEATTDPAPC 793
Cdd:PRK12799   267 QSQHDIEHENLDNralDIEKATGLKQIDTHGTVPVAAVTPSSAVTQSSAITPSSAAIPSPAVipssvttQSATTTQASAV 346

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039736229  794 ASPSSAVPTTKPAERESVEAQVTDSASAEtAEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQVPENTASK 866
Cdd:PRK12799   347 ALSSAGVLPSDVTLPGTVALPAAEPVNMQ-PQPMSTTETQQSSTGNITSTANGPTTSLPAAPASNIPVSPTSR 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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