NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039737316|ref|XP_017170060|]
View 

serine racemase isoform X3 [Mus musculus]

Protein Classification

PALP domain-containing protein( domain architecture ID 751)

PALP domain-containing protein belonging to the tryptophan synthase beta superfamily (fold type II) that consists of pyridoxal phosphate (PLP)-dependent enzymes that catalyze beta-replacement and beta-elimination reactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Trp-synth-beta_II super family cl00342
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 5-322 1.45e-144

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


The actual alignment was detected with superfamily member PLN02970:

Pssm-ID: 444852 [Multi-domain]  Cd Length: 328  Bit Score: 411.38  E-value: 1.45e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   5 YCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEekpKAVVTHSS 84
Cdd:PLN02970    7 YAADLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAE---KGVVTHSS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQG 164
Cdd:PLN02970   84 GNHAAALALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVISGQG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHpPETIADGVKSSI 244
Cdd:PLN02970  164 TIALEFLEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPV-TNTIADGLRASL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 245 GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSP--EVKNVCIVLSGGNVDLTSL 322
Cdd:PLN02970  243 GDLTWPVVRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSDSFRSNPAwkGCKNVGIVLSGGNVDLGVL 322
 
Name Accession Description Interval E-value
PLN02970 PLN02970
serine racemase
 5-322 1.45e-144

serine racemase


Pssm-ID: 215524 [Multi-domain]  Cd Length: 328  Bit Score: 411.38  E-value: 1.45e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   5 YCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEekpKAVVTHSS 84
Cdd:PLN02970    7 YAADLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAE---KGVVTHSS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQG 164
Cdd:PLN02970   84 GNHAAALALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVISGQG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHpPETIADGVKSSI 244
Cdd:PLN02970  164 TIALEFLEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPV-TNTIADGLRASL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 245 GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSP--EVKNVCIVLSGGNVDLTSL 322
Cdd:PLN02970  243 GDLTWPVVRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSDSFRSNPAwkGCKNVGIVLSGGNVDLGVL 322
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 9-318 5.99e-125

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 360.26  E-value: 5.99e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   9 FADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHG 88
Cdd:cd01562     1 LEDILAAAARIKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSL---SEEERAKGVVAASAGNHA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  89 QALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIAL 168
Cdd:cd01562    78 QGVAYAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDVIAGQGTIGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 169 EVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLN 247
Cdd:cd01562   158 EILEQVPDLDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPAMAQSLAAGKPVTLPEVD-TIADGLAvKRPGEL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039737316 248 TWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQtvsPEVKNVCIVLSGGNVD 318
Cdd:cd01562   237 TFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLD---LKGKKVVVVLSGGNID 304
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 7-325 6.07e-109

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 320.45  E-value: 6.07e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:COG1171     6 PTLADIEAAAARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASL---SEEERARGVVAASAGN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTI 166
Cdd:COG1171    83 HAQGVAYAARLLGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPFDDPDVIAGQGTI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 167 ALEVLNQVPLVDALvvpvggggmvagIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVK-SSIG 245
Cdd:COG1171   163 ALEILEQLPDLDAVfvpvggggliagVAAALKALSPDIRVIGVEPEGAAAMYRSLAAGEPVT-LPGVDTIADGLAvGRPG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 246 LNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQtvsPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:COG1171   242 ELTFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKER---LKGKRVVVVLSGGNIDPDRLAEI 318
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 19-314 1.82e-73

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 229.12  E-value: 1.82e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  19 IQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtpEEKPKAVVTHSSGNHGQALTYAAKLE 98
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKE---GEGGKTVVEASSGNHGRALAAAAARL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  99 GIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEG-ILVHPNQEPAVIAGQGTIALEVLNQV-PL 176
Cdd:pfam00291  78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPGaYYINQYDNPLNIEGYGTIGLEILEQLgGD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 177 VDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSSI--GLNTWPIIRD 254
Cdd:pfam00291 158 PDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSLAAGRPVP-VPVADTIADGLGVGDepGALALDLLDE 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 255 LVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEvKNVCIVLSG 314
Cdd:pfam00291 237 YVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGG-DRVVVVLTG 295
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
 26-325 3.02e-67

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 215.76  E-value: 3.02e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGALNKIANL---SEDQRQRGVVAASAGNHAQGVAYAAKKFGIKAVIV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 106 VPQTAPNCKKLAIQAYGASIV-YCDPSDESREKVTqRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPV 184
Cdd:TIGR01127  78 MPESAPPSKVKATKSYGAEVIlHGDDYDEAYAFAT-SLAEEEGRVFVHPFDDEFVMAGQGTIGLEIMEDIPDVDTVIVPV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 185 GGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLNTWPIIRDLVDDVFTVT 263
Cdd:TIGR01127 157 GGGGLISGVASAAKQINPNVKVIGVEAEGAPSMYESLREGKIKAVESVR-TIADGIAvKKPGDLTFNIIKEYVDDVVTVD 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039737316 264 EDEIKYATQLVWGRMKLLIEPTAGVALAAVLSqhfQTVSPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:TIGR01127 236 EEEIANAIYLLLERHKILAEGAGAAGVAALLE---QKVDVKGKKIAVVLSGGNIDLNLLNKI 294
 
Name Accession Description Interval E-value
PLN02970 PLN02970
serine racemase
 5-322 1.45e-144

serine racemase


Pssm-ID: 215524 [Multi-domain]  Cd Length: 328  Bit Score: 411.38  E-value: 1.45e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   5 YCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEekpKAVVTHSS 84
Cdd:PLN02970    7 YAADLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAE---KGVVTHSS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQG 164
Cdd:PLN02970   84 GNHAAALALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVISGQG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHpPETIADGVKSSI 244
Cdd:PLN02970  164 TIALEFLEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPV-TNTIADGLRASL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 245 GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSP--EVKNVCIVLSGGNVDLTSL 322
Cdd:PLN02970  243 GDLTWPVVRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSDSFRSNPAwkGCKNVGIVLSGGNVDLGVL 322
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 9-318 5.99e-125

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 360.26  E-value: 5.99e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   9 FADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHG 88
Cdd:cd01562     1 LEDILAAAARIKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSL---SEEERAKGVVAASAGNHA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  89 QALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIAL 168
Cdd:cd01562    78 QGVAYAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDVIAGQGTIGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 169 EVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLN 247
Cdd:cd01562   158 EILEQVPDLDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPAMAQSLAAGKPVTLPEVD-TIADGLAvKRPGEL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039737316 248 TWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQtvsPEVKNVCIVLSGGNVD 318
Cdd:cd01562   237 TFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLD---LKGKKVVVVLSGGNID 304
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 7-325 6.07e-109

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 320.45  E-value: 6.07e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:COG1171     6 PTLADIEAAAARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASL---SEEERARGVVAASAGN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTI 166
Cdd:COG1171    83 HAQGVAYAARLLGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPFDDPDVIAGQGTI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 167 ALEVLNQVPLVDALvvpvggggmvagIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVK-SSIG 245
Cdd:COG1171   163 ALEILEQLPDLDAVfvpvggggliagVAAALKALSPDIRVIGVEPEGAAAMYRSLAAGEPVT-LPGVDTIADGLAvGRPG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 246 LNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQtvsPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:COG1171   242 ELTFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKER---LKGKRVVVVLSGGNIDPDRLAEI 318
PRK07048 PRK07048
threo-3-hydroxy-L-aspartate ammonia-lyase;
7-320 2.34e-99

threo-3-hydroxy-L-aspartate ammonia-lyase;


Pssm-ID: 235918 [Multi-domain]  Cd Length: 321  Bit Score: 296.16  E-value: 2.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK07048    6 PTYDDVAAAAARLAGVAHRTPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQF---SPEQRRAGVVTFSSGN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK07048   83 HAQAIALSARLLGIPATIVMPQDAPAAKVAATRGYGGEVVTYDRYTEDREEIGRRLAEERGLTLIPPYDHPHVIAGQGTA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADGVKS-SIG 245
Cdd:PRK07048  163 AKELFEEVGPLDALFVCLGGGGLLSGCALAARALSPGCKVYGVEPEAGNDGQQSFRSGEIV-HIDTPRTIADGAQTqHLG 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737316 246 LNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSqhfQTVSPEVKNVCIVLSGGNVDLT 320
Cdd:PRK07048  242 NYTFPIIRRLVDDIVTVSDAELVDAMRFFAERMKIVVEPTGCLGAAAALR---GKVPLKGKRVGVIISGGNVDLA 313
PRK06608 PRK06608
serine/threonine dehydratase;
8-323 6.85e-78

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 241.98  E-value: 6.85e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   8 SFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDtpEEKPKAVVTHSSGNH 87
Cdd:PRK06608    6 NPQNIAAAHNRIKQYLHLTPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKEQ--GKLPDKIVAYSTGNH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  88 GQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGIlvHPNQEPAVIAGQGTIA 167
Cdd:PRK06608   84 GQAVAYASKLFGIKTRIYLPLNTSKVKQQAALYYGGEVILTNTRQEAEEKAKEDEEQGFYYI--HPSDSDSTIAGAGTLC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 168 LEVLNQVPL-VDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKS-SIG 245
Cdd:PRK06608  162 YEALQQLGFsPDAIFASCGGGGLISGTYLAKELISPTSLLIGSEPLNANDAYLSLKNNKIYRLNYSPNTIADGLKTlSVS 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039737316 246 LNTWPIIRDLvDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPevKNVCIVLSGGNVDLTSLN 323
Cdd:PRK06608  242 ARTFEYLKKL-DDFYLVEEYEIYYWTAWLTHLLKVICEPSSAINMVAVVNWLKTQSKP--QKLLVILSGGNIDPILYN 316
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 19-314 1.82e-73

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 229.12  E-value: 1.82e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  19 IQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtpEEKPKAVVTHSSGNHGQALTYAAKLE 98
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKE---GEGGKTVVEASSGNHGRALAAAAARL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  99 GIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEG-ILVHPNQEPAVIAGQGTIALEVLNQV-PL 176
Cdd:pfam00291  78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPGaYYINQYDNPLNIEGYGTIGLEILEQLgGD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 177 VDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSSI--GLNTWPIIRD 254
Cdd:pfam00291 158 PDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSLAAGRPVP-VPVADTIADGLGVGDepGALALDLLDE 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 255 LVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEvKNVCIVLSG 314
Cdd:pfam00291 237 YVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGG-DRVVVVLTG 295
PRK06815 PRK06815
threonine/serine dehydratase;
9-322 5.84e-69

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 218.41  E-value: 5.84e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   9 FADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHG 88
Cdd:PRK06815    4 FDAILEAHQRLRPQVRVTPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLRLL---NEAQRQQGVITASSGNHG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  89 QALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIAL 168
Cdd:PRK06815   81 QGVALAAKLAGIPVTVYAPEQASAIKLDAIRALGAEVRLYGGDALNAELAARRAAEQQGKVYISPYNDPQVIAGQGTIGM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 169 EVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSSI--GL 246
Cdd:PRK06815  161 ELVEQQPDLDAVFVAVGGGGLISGIATYLKTLSPKTEIIGCWPANSPSLYTSLEAGEIVE-VAEQPTLSDGTAGGVepGA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039737316 247 NTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQhfqtvSPEV--KNVCIVLSGGNVDLTSL 322
Cdd:PRK06815  240 ITFPLCQQLIDQKVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKL-----APRYqgKKVAVVLCGKNIVLEKY 312
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
 26-325 3.02e-67

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 215.76  E-value: 3.02e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGALNKIANL---SEDQRQRGVVAASAGNHAQGVAYAAKKFGIKAVIV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 106 VPQTAPNCKKLAIQAYGASIV-YCDPSDESREKVTqRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPV 184
Cdd:TIGR01127  78 MPESAPPSKVKATKSYGAEVIlHGDDYDEAYAFAT-SLAEEEGRVFVHPFDDEFVMAGQGTIGLEIMEDIPDVDTVIVPV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 185 GGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLNTWPIIRDLVDDVFTVT 263
Cdd:TIGR01127 157 GGGGLISGVASAAKQINPNVKVIGVEAEGAPSMYESLREGKIKAVESVR-TIADGIAvKKPGDLTFNIIKEYVDDVVTVD 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039737316 264 EDEIKYATQLVWGRMKLLIEPTAGVALAAVLSqhfQTVSPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:TIGR01127 236 EEEIANAIYLLLERHKILAEGAGAAGVAALLE---QKVDVKGKKIAVVLSGGNIDLNLLNKI 294
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
7-320 1.68e-65

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 209.98  E-value: 1.68e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK08638    9 VAIDDIIEAKQRLAGRIRKTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFNKLSSL---TDAEKRKGVVACSAGN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YCDPSDESREKVTQRImqETEG-ILVHPNQEPAVIAGQG 164
Cdd:PRK08638   86 HAQGVALSCALLGIDGKVVMPKGAPKSKVAATCGYGAEVVlHGDNFNDTIAKVEEIV--EEEGrTFIPPYDDPKVIAGQG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVKSSI 244
Cdd:PRK08638  164 TIGLEILEDLWDVDTVIVPIGGGGLIAGIAVALKSINPTIHIIGVQSENVHGMAASFYAGEITTHRTTG-TLADGCDVSR 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039737316 245 -GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEVKNVCIVlSGGNVDLT 320
Cdd:PRK08638  243 pGNLTYEIVRELVDDIVLVSEDEIRNAMKDLIQRNKVVTEGAGALATAALLSGKLDQYIQNKKVVAII-SGGNVDLS 318
PRK07334 PRK07334
threonine dehydratase; Provisional
 7-318 1.39e-60

threonine dehydratase; Provisional


Pssm-ID: 235994 [Multi-domain]  Cd Length: 403  Bit Score: 199.35  E-value: 1.39e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK07334    5 VTLADIRAAAARLAGQVLRTPCVHSRTLSQITGAEVWLKFENLQFTASFKERGALNKLLLL---TEEERARGVIAMSAGN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YCDPSDESREkvTQRIMQETEG-ILVHPNQEPAVIAGQG 164
Cdd:PRK07334   82 HAQGVAYHAQRLGIPATIVMPRFTPTVKVERTRGFGAEVVlHGETLDEARA--HARELAEEEGlTFVHPYDDPAVIAGQG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQsKLKGELTPNLHppETIADG--VKs 242
Cdd:PRK07334  160 TVALEMLEDAPDLDTLVVPIGGGGLISGMATAAKALKPDIEIIGVQTELYPSMYA-AIKGVALPCGG--STIAEGiaVK- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 243 SIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVwgrmkLLIEPT----AGVA-LAAVLS--QHFQTvspevKNVCIVLSGG 315
Cdd:PRK07334  236 QPGQLTLEIVRRLVDDILLVSEADIEQAVSLL-----LEIEKTvvegAGAAgLAALLAypERFRG-----RKVGLVLSGG 305


                  ...
gi 1039737316 316 NVD 318
Cdd:PRK07334  306 NID 308
eutB PRK07476
threonine dehydratase; Provisional
 7-319 2.94e-56

threonine dehydratase; Provisional


Pssm-ID: 236025 [Multi-domain]  Cd Length: 322  Bit Score: 185.55  E-value: 2.94e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK07476    1 VSLADIYRARRRIAGRVRRTPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALLSL---SAQERARGVVTASTGN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPS-DESREKVtQRIMQETEGILVHPNQEPAVIAGQGT 165
Cdd:PRK07476   78 HGRALAYAARALGIRATICMSRLVPANKVDAIRALGAEVRIVGRSqDDAQAEV-ERLVREEGLTMVPPFDDPRIIAGQGT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 166 IALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGeltpnlHP-----PETIADGV 240
Cdd:PRK07476  157 IGLEILEALPDVATVLVPLSGGGLASGVAAAVKAIRPAIRVIGVSMERGAAMHASLAAG------RPvqveeVPTLADSL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 241 KSSIGLN---TWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSqhfQTVSPEVKNVCIVLSGGNV 317
Cdd:PRK07476  231 GGGIGLDnryTFAMCRALLDDVVLLDEAEIAAGIRHAYREERLVVEGAGAVGIAALLA---GKIAARDGPIVVVVSGANI 307


                  ..
gi 1039737316 318 DL 319
Cdd:PRK07476  308 DM 309
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 26-315 2.00e-53

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 175.78  E-value: 2.00e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDtpEEKPKAVVTH-SSGNHGQALTYAAKLEGIPAYI 104
Cdd:cd00640     1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEE--GKLPKGVIIEsTGGNTGIALAAAAARLGLKCTI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 105 VVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEG-ILVHPNQEPAVIAGQGTIALEVLNQVP--LVDALV 181
Cdd:cd00640    79 VMPEGASPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEDPGaYYVNQFDNPANIAGQGTIGLEILEQLGgqKPDAVV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 182 VPVGGGGMVAGIAITIKALKPSVKVYAAEPsnaddcyqsklkgeltpnlhppetiadgvkssiglntwpiirdlvdDVFT 261
Cdd:cd00640   159 VPVGGGGNIAGIARALKELLPNVKVIGVEP----------------------------------------------EVVT 192

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039737316 262 VTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTvsPEVKNVCIVLSGG 315
Cdd:cd00640   193 VSDEEALEAIRLLAREEGILVEPSSAAALAAALKLAKKL--GKGKTVVVILTGG 244
PRK08246 PRK08246
serine/threonine dehydratase;
7-323 7.81e-53

serine/threonine dehydratase;


Pssm-ID: 181319 [Multi-domain]  Cd Length: 310  Bit Score: 176.30  E-value: 7.81e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSIlNQIAGRNLFFKCELFQKTGSFKIRGALNAIRglipdTPEEKPKAVVTHSSGN 86
Cdd:PRK08246    5 ITRSDVRAAAQRIAPHIRRTPVLEADG-AGFGPAPVWLKLEHLQHTGSFKARGAFNRLL-----AAPVPAAGVVAASGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK08246   79 AGLAVAYAAAALGVPATVFVPETAPPAKVARLRALGAEVVVVGAEYADALEAAQAFAAETGALLCHAYDQPEVLAGAGTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAitiKALKPSVKVYAAEPSNADDCYQSKLKGEltpnlhPPETIADGVKSS--- 243
Cdd:PRK08246  159 GLEIEEQAPGVDTVLVAVGGGGLIAGIA---AWFEGRARVVAVEPEGAPTLHAALAAGE------PVDVPVSGIAADslg 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 244 ---IGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEvkNVCIVLSGGNVDLT 320
Cdd:PRK08246  230 arrVGEIAFALARAHVVTSVLVSDEAIIAARRALWEELRLAVEPGAATALAALLSGAYVPAPGE--RVAVVLCGANTDPA 307


                  ...
gi 1039737316 321 SLN 323
Cdd:PRK08246  308 TLA 310
ectoine_eutB TIGR02991
ectoine utilization protein EutB; Members of this protein family are EutB, a predicted ...
 7-319 2.92e-47

ectoine utilization protein EutB; Members of this protein family are EutB, a predicted arylmalonate decarboxylase found in a conserved ectoine utilization operon of species that include Sinorhizobium meliloti 1021 (where it is known to be induced by ectoine), Mesorhizobium loti, Silicibacter pomeroyi, Agrobacterium tumefaciens, and Pseudomonas putida. Members of this family resemble threonine dehydratases.


Pssm-ID: 132036 [Multi-domain]  Cd Length: 317  Bit Score: 161.94  E-value: 2.92e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:TIGR02991   1 VTLQDIERAAARISGRVEETPLVESPSLSELCGVPVHLKLEHRQTTGSFKLRGATNAVLSL---SDTQRAAGVVAASTGN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASI-VYCDPSDESREKVtQRIMQETEGILVHPNQEPAVIAGQGT 165
Cdd:TIGR02991  78 HGRALAYAAAEEGVRATICMSELVPQNKVDEIRRLGAEVrIVGRSQDDAQEEV-ERLVADRGLTMLPPFDHPDIVAGQGT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 166 IALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSkLKGELTPNLHPPETIADGVKSSIG 245
Cdd:TIGR02991 157 LGLEVVEQMPDLATVLVPLSGGGLASGVAMAVKAARPDTRVIGVSMERGAAMKAS-LQAGRPVLVAELPTLADSLGGGIG 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039737316 246 LN---TWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEVknvcIVLSGGNVDL 319
Cdd:TIGR02991 236 LDnrvTFAMCKALLDEIVLVSEAEIAAGIRHAYAEEREIVEGAGAVGIAALLAGKIKNPGPCA----VIVSGRNIDM 308
PRK09224 PRK09224
threonine ammonia-lyase IlvA;
39-330 1.26e-43

threonine ammonia-lyase IlvA;


Pssm-ID: 236417 [Multi-domain]  Cd Length: 504  Bit Score: 156.84  E-value: 1.26e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  39 GRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAI 118
Cdd:PRK09224   34 GNQVLLKREDLQPVFSFKLRGAYNKMAQL---TEEQLARGVITASAGNHAQGVALSAARLGIKAVIVMPVTTPDIKVDAV 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 119 QAYGASIV-YCDPSDESREKvTQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMVAGIAIT 196
Cdd:PRK09224  111 RAFGGEVVlHGDSFDEAYAH-AIELAEEEGLTFIHPFDDPDVIAGQGTIAMEILQQHPhPLDAVFVPVGGGGLIAGVAAY 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 197 IKALKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADG--VKsSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLV 274
Cdd:PRK09224  190 IKQLRPEIKVIGVEPEDSACLKAALEAGERV-DLPQVGLFADGvaVK-RIGEETFRLCQEYVDDVITVDTDEICAAIKDV 267

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039737316 275 WGRMKLLIEPTAGVALAAvLSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWVgqAER 330
Cdd:PRK09224  268 FEDTRSIAEPAGALALAG-LKKYVAQHGIEGETLVAILSGANMNFDRLRYV--AER 320
PRK12483 PRK12483
threonine dehydratase; Reviewed
 26-330 3.12e-41

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 150.72  E-value: 3.12e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:PRK12483   38 TPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAYNKMARL---PAEQLARGVITASAGNHAQGVALAAARLGVKAVIV 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 106 VPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVP-LVDALVVPV 184
Cdd:PRK12483  115 MPRTTPQLKVDGVRAHGGEVVLHGESFPDALAHALKLAEEEGLTFVPPFDDPDVIAGQGTVAMEILRQHPgPLDAIFVPV 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 185 GGGGMVAGIAITIKALKPSVKVYAAEPSNAdDCYQSKLKGELTPNLHPPETIADGVK-SSIGLNTWPIIRDLVDDVFTVT 263
Cdd:PRK12483  195 GGGGLIAGIAAYVKYVRPEIKVIGVEPDDS-NCLQAALAAGERVVLGQVGLFADGVAvAQIGEHTFELCRHYVDEVVTVS 273

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039737316 264 EDEIKYATQLVWGRMKLLIEPTAGVALAAvLSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWVgqAER 330
Cdd:PRK12483  274 TDELCAAIKDIYDDTRSITEPAGALAVAG-IKKYAEREGIEGQTLVAIDSGANVNFDRLRHV--AER 337
PRK08639 PRK08639
threonine dehydratase; Validated
 7-318 9.38e-37

threonine dehydratase; Validated


Pssm-ID: 236318 [Multi-domain]  Cd Length: 420  Bit Score: 136.86  E-value: 9.38e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK08639    7 VSAKDIDKAAKRLKDVVPETPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGAYNAISQL---SDEELAAGVVCASAGN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGAS----IVYCDPSDESrEKVTQRIMQETEGILVHPNQEPAVIAG 162
Cdd:PRK08639   84 HAQGVAYACRHLGIPGVIFMPVTTPQQKIDQVRFFGGEfveiVLVGDTFDDS-AAAAQEYAEETGATFIPPFDDPDVIAG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 163 QGTIALEVLNQV---PLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADG 239
Cdd:PRK08639  163 QGTVAVEILEQLekeGSPDYVFVPVGGGGLISGVTTYLKERSPKTKIIGVEPAGAASMKAALEAGKPVT-LEKIDKFVDG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 240 --VKsSIGLNTWPIIRDLVDDVFTVTEDEIkYATQLvwgrmKLL------IEPtAGVALAAVLSQHFQTVspEVKNVCIV 311
Cdd:PRK08639  242 aaVA-RVGDLTFEILKDVVDDVVLVPEGAV-CTTIL-----ELYnkegivAEP-AGALSIAALELYKDEI--KGKTVVCV 311


                  ....*..
gi 1039737316 312 LSGGNVD 318
Cdd:PRK08639  312 ISGGNND 318
PRK06110 PRK06110
threonine dehydratase;
8-331 1.55e-30

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 117.79  E-value: 1.55e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   8 SFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEekPKAVVTHSSGNH 87
Cdd:PRK06110    4 TLAELEAAAAVVYAAMPPTPQYRWPLLAERLGCEVWVKHENHTPTGAFKVRGGLVYFDRLARRGPR--VRGVISATRGNH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  88 GQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YCDPSDESREKVTQRimQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK06110   82 GQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAELIeHGEDFQAAREEAARL--AAERGLHMVPSFHPDLVRGVATY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGEL--TPNlhpPETIADGVKSSI 244
Cdd:PRK06110  160 ALELFRAVPDLDVVYVPIGMGSGICGAIAARDALGLKTRIVGVVSAHAPAYALSFEAGRVvtTPV---ATTLADGMACRT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 245 GL-NTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTvspEVKNVCIVLSGGNVDLTSLN 323
Cdd:PRK06110  237 PDpEALEVIRAGADRIVRVTDDEVAAAMRAYFTDTHNVAEGAGAAALAAALQERERL---AGKRVGLVLSGGNIDRAVFA 313


                  ....*....
gi 1039737316 324 -WVGQAERP 331
Cdd:PRK06110  314 rVLAGAAAE 322
PLN02550 PLN02550
threonine dehydratase
 24-325 2.47e-30

threonine dehydratase


Pssm-ID: 178165 [Multi-domain]  Cd Length: 591  Bit Score: 121.18  E-value: 2.47e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  24 HLTPVLTSSI--------------LNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQ 89
Cdd:PLN02550   94 YLTNILSAKVydvaiesplqlakkLSERLGVKVLLKREDLQPVFSFKLRGAYNMMAKL---PKEQLDKGVICSSAGNHAQ 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  90 ALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYC-DPSDESREKVTQRIMQETEgILVHPNQEPAVIAGQGTIAL 168
Cdd:PLN02550  171 GVALSAQRLGCDAVIAMPVTTPEIKWQSVERLGATVVLVgDSYDEAQAYAKQRALEEGR-TFIPPFDHPDVIAGQGTVGM 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 169 EVLNQVP-LVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADGVK-SSIGL 246
Cdd:PLN02550  250 EIVRQHQgPLHAIFVPVGGGGLIAGIAAYVKRVRPEVKIIGVEPSDANAMALSLHHGERV-MLDQVGGFADGVAvKEVGE 328

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039737316 247 NTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVlSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:PLN02550  329 ETFRLCRELVDGVVLVSRDAICASIKDMFEEKRSILEPAGALALAGA-EAYCKYYGLKDENVVAITSGANMNFDRLRIV 406
PRK08813 PRK08813
threonine dehydratase; Provisional
 7-333 4.00e-30

threonine dehydratase; Provisional


Pssm-ID: 236339 [Multi-domain]  Cd Length: 349  Bit Score: 117.42  E-value: 4.00e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316   7 ISFADVEKAHINIQDSIHLTPVltssilnQIAGR-NLFFKCELFQKTGSFKIRGALNA-IRGLipDTPEEKPkaVVTHSS 84
Cdd:PRK08813   21 VSVADVLAAQARLRRYLSPTPL-------HYAERfGVWLKLENLQRTGSYKVRGALNAlLAGL--ERGDERP--VICASA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQG 164
Cdd:PRK08813   90 GNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAYAFARELADQNGYRFLSAFDDPDVIAGQG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 165 TIALEVLNQVPlvDALVVPVGGGGMVAGIAITIKAlkPSVKVYAAEPSNADDCYQSkLKGELTpNLHPPETIADGVKSSI 244
Cdd:PRK08813  170 TVGIELAAHAP--DVVIVPIGGGGLASGVALALKS--QGVRVVGAQVEGVDSMARA-IRGDLR-EIAPVATLADGVKVKI 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 245 -GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAvlsqhFQTVSPEVKnvCIVLSGGNVDLTSLN 323
Cdd:PRK08813  244 pGFLTRRLCSSLLDDVVIVREAELRETLVRLALEEHVIAEGAGALALAA-----GRRVSGKRK--CAVVSGGNIDATVLA 316

                         330
                  ....*....|
gi 1039737316 324 WVGQAERPAP 333
Cdd:PRK08813  317 TLLSEVRPRP 326
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 26-294 3.67e-26

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 105.29  E-value: 3.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLI-PDTpeekpkAVVTHSSGNHGQALTYAAKLEG 99
Cdd:cd01561     3 TPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIedaekRGLLkPGT------TIIEPTSGNTGIGLAMVAAAKG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 100 IPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSD----ESREKVTQRIMQETEGIlVHPNQ--EPA-VIAGQGTIALEVLN 172
Cdd:cd01561    77 YRFIIVMPETMSEEKRKLLRALGAEVILTPEAEadgmKGAIAKARELAAETPNA-FWLNQfeNPAnPEAHYETTAPEIWE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 173 QVP-LVDALvvpvggggmvagIA-------IT-----IKALKPSVKVYAAEPSNADdcyqsklkgeLTPNLHPPETIADG 239
Cdd:cd01561   156 QLDgKVDAF------------VAgvgtggtITgvaryLKEKNPNVRIVGVDPVGSV----------LFSGGPPGPHKIEG 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039737316 240 vkssIGLNTWPII--RDLVDDVFTVTEDE-IKYATQLVwGRMKLLIEPTAGVALAAVL 294
Cdd:cd01561   214 ----IGAGFIPENldRSLIDEVVRVSDEEaFAMARRLA-REEGLLVGGSSGAAVAAAL 266
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
 26-316 2.81e-23

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 98.14  E-value: 2.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIpDTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:cd06448     2 TPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSA-KQGLNECVHVVCSSGGNAGLAAAYAARKLGVPCTIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 106 VPQTAPNCKKLAIQAYGASIV-----YCDPSDESREKVTQRimqETEGILVHPNQEPAVIAGQGTIALEVLNQVPL---V 177
Cdd:cd06448    81 VPESTKPRVVEKLRDEGATVVvhgkvWWEADNYLREELAEN---DPGPVYVHPFDDPLIWEGHSSMVDEIAQQLQSqekV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 178 DALVVPVGGGGMVAGIAITI-KALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSS-IGLNTW------ 249
Cdd:cd06448   158 DAIVCSVGGGGLLNGIVQGLeRNGWGDIPVVAVETEGAHSLNASLKAGKLVT-LPKITSVATSLGAKtVSSQALeyaqeh 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039737316 250 PIIRDLVDD------VFTVTEDEikyatqlvwgrmKLLIEPTAGVALAAVLSQHFQTVSPEVK-----NVCIVLSGGN 316
Cdd:cd06448   237 NIKSEVVSDrdavqaCLRFADDE------------RILVEPACGAALAVVYSGKILDLQLEVLltpldNVVVVVCGGS 302
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
 26-294 1.11e-22

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 97.58  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAGRNLFFKcELFQ-KTGSFKIRG---ALNAIRglipdtpEEKPKAVVTHSSGNHGQAL-TYAAKlEGI 100
Cdd:COG0498    67 TPLVKAPRLADELGKNLYVK-EEGHnPTGSFKDRAmqvAVSLAL-------ERGAKTIVCASSGNGSAALaAYAAR-AGI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 101 PAYIVVPQT-APNCKKLAIQAYGASIVYCDPS-DEsREKVTQRIMQETEGILVHpNQEPAVIAGQGTIALEV---LNQVP 175
Cdd:COG0498   138 EVFVFVPEGkVSPGQLAQMLTYGAHVIAVDGNfDD-AQRLVKELAADEGLYAVN-SINPARLEGQKTYAFEIaeqLGRVP 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 176 lvDAlvvpvggggmvagiaITI------------KALK-----------PsvKVYAAEPSNADDCYQSKLKGELTPNLHP 232
Cdd:COG0498   216 --DW---------------VVVptgnggnilagyKAFKelkelglidrlP--RLIAVQATGCNPILTAFETGRDEYEPER 276

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039737316 233 PETIADGVksSIG--LNTWPIIRDLVD---DVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVL 294
Cdd:COG0498   277 PETIAPSM--DIGnpSNGERALFALREsggTAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLR 341
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
 26-311 6.20e-21

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 91.50  E-value: 6.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAG-RNLFFKCELFQKTGSFKIRGALNAIRGLIpdtpEEKPKAVVTHSSGNHGQAL-TYAAKlEGIPAY 103
Cdd:cd01563    23 TPLVRAPRLGERLGgKNLYVKDEGLNPTGSFKDRGMTVAVSKAK----ELGVKAVACASTGNTSASLaAYAAR-AGIKCV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 104 IVVPQTAPNCKKLAIQAYGASIVycdPSDESRE---KVTQRIMQETEGILVHpNQEPAVIAGQGTIALEVLNQ----VPl 176
Cdd:cd01563    98 VFLPAGKALGKLAQALAYGATVL---AVEGNFDdalRLVRELAEENWIYLSN-SLNPYRLEGQKTIAFEIAEQlgweVP- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 177 vDALVVPVGGGGMVAGIAITIKALKPS------VKVYAAEPSNADDCYQSKLKG--ELTPNLHpPETIADGVKssIGlN- 247
Cdd:cd01563   173 -DYVVVPVGNGGNITAIWKGFKELKELglidrlPRMVGVQAEGAAPIVRAFKEGkdDIEPVEN-PETIATAIR--IG-Np 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 248 -TWPIIRDLVD----DVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQ-TVSPEVKNVCIV 311
Cdd:cd01563   248 aSGPKALRAVResggTAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLKKLREEgIIDKGERVVVVL 317
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 18-294 9.90e-21

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 90.49  E-value: 9.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  18 NIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLI-PDTPeekpkaVVTHSSGNHGQAL 91
Cdd:COG0031     6 SILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIedaekRGLLkPGGT------IVEATSGNTGIGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  92 TYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSD--ESREKVTQRIMQETEGIlVHPNQ--EPA-VIAGQGTI 166
Cdd:COG0031    80 AMVAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEgmKGAIDKAEELAAETPGA-FWPNQfeNPAnPEAHYETT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 167 ALEVLNQVPL-VDALvvpvggggmvagIA-------IT-----IKALKPSVKVYAAEPSNAddcyqSKLKGElTPNLHPP 233
Cdd:COG0031   159 GPEIWEQTDGkVDAF------------VAgvgtggtITgvgryLKERNPDIKIVAVEPEGS-----PLLSGG-EPGPHKI 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039737316 234 ETIADGVKSSIglntwpIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVL 294
Cdd:COG0031   221 EGIGAGFVPKI------LDPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAAL 275
thrC TIGR00260
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ...
 33-318 1.89e-15

threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 272986 [Multi-domain]  Cd Length: 327  Bit Score: 75.88  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  33 ILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIpdtpEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPN 112
Cdd:TIGR00260  31 LAANVGIKNLYVKELGHNPTLSFKDRGMAVALTKAL----ELGNDTVLCASTGNTGAAAAAYAGKAGLKVVVLYPAGKIS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 113 CKKLAIQ-AYGASIVYCDPS-DESREKVTQrIMQETEGILVHP-NQEPAVIAGQGTIALEVLNQVP--LVDALVVPVGGG 187
Cdd:TIGR00260 107 LGKLAQAlGYNAEVVAIDGNfDDAQRLVKQ-LFEDKPALGLNSaNSIPYRLEGQKTYAFEAVEQLGweAPDKVVVPVPNS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 188 GMVAGIAITIKALK-------PsvKVYAAEPSNADDCYQSKLK-GELTPNLHPpETIA---DGVKSSIGLNTWPIIRDLV 256
Cdd:TIGR00260 186 GNFGAIWKGFKEKKmlgldslP--VKRGIQAEGAADIVRAFLEgGQWEPIETP-ETLStamDIGNPANWPRALEAFRRSN 262

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039737316 257 DDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQ-TVSPEVKNVCIVLSGGNVD 318
Cdd:TIGR00260 263 GYAEDLSDEEILEAIKLLAREEGYFVEPHSAVAVAALLKLVEKgTADPAERVVCALTGNGLKD 325
PRK08329 PRK08329
threonine synthase; Validated
 24-319 4.83e-14

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 72.17  E-value: 4.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  24 HLTPVLTSSILNqiaGRNLFFKCELFQKTGSFKIRGALNAIRGLipdtPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAY 103
Cdd:PRK08329   59 HLTPPITPTVKR---SIKVYFKLDYLQPTGSFKDRGTYVTVAKL----KEEGINEVVIDSSGNAALSLALYSLSEGIKVH 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 104 IVVPQTAPNCKKLAIQAYGASIVYCDpsdESREKVTQRIMQ--ETEGIL-VHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180
Cdd:PRK08329  132 VFVSYNASKEKISLLSRLGAELHFVE---GDRMEVHEEAVKfsKRNNIPyVSHWLNPYFLEGTKTIAYEIYEQIGVPDYA 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 181 VVPVGGGGMVAGIAITIKALK--------PSVKVYAAEPSNAdDCYQSKLKGELT-----PNlhPP--ETIADGVKSSIG 245
Cdd:PRK08329  209 FVPVGSGTLFLGIWKGFKELHemgeiskmPKLVAVQAEGYES-LCKRSKSENKLAdgiaiPE--PPrkEEMLRALEESNG 285

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737316 246 LntwpiirdlvddVFTVTEDEIKYAtqLVW-GRMKLLIEPTAGVALAAVLSQHFQTVSPEVKNVCIVLSGGNVDL 319
Cdd:PRK08329  286 F------------CISVGEEETRAA--LHWlRRMGFLVEPTSAVALAAYWKLLEEGLIEGGSKVLLPLSGSGLKN 346
PRK05638 PRK05638
threonine synthase; Validated
 26-314 1.68e-13

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 71.00  E-value: 1.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIaGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtpeEKPKAVVTHSSGNHGQALT-YAAKlEGIPAYI 104
Cdd:PRK05638   67 TPLIRARISEKL-GENVYIKDETRNPTGSFRDRLATVAVSYGLP----YAANGFIVASDGNAAASVAaYSAR-AGKEAFV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 105 VVPQTAPNCKKLAIQAYGAS-IVYCDPSDESREKVTQRimQETEGIL-VHPNQEPAVIAGQGTIALEVLNQ-------VP 175
Cdd:PRK05638  141 VVPRKVDKGKLIQMIAFGAKiIRYGESVDEAIEYAEEL--ARLNGLYnVTPEYNIIGLEGQKTIAFELWEEinpthviVP 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 176 LVDALVVPVGGGGMVAGIAITIKALKPsvKVYAAEPSNADDCYQSKL--KGELTPNLHPPETIADGVKSSIGLNtwpIIR 253
Cdd:PRK05638  219 TGSGSYLYSIYKGFKELLEIGVIEEIP--KLIAVQTERCNPIASEILgnKTKCNETKALGLYVKNPVMKEYVSE---AIK 293

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039737316 254 DLVDDVFTVTEDEIKYATQLVwgrMK--LLIEPTAGVALAAVLSQHFQTVSPEVKNVCIVLSG 314
Cdd:PRK05638  294 ESGGTAVVVNEEEIMAGEKLL---AKegIFAELSSAVVMPALLKLGEEGYIEKGDKVVLVVTG 353
PRK06450 PRK06450
threonine synthase; Validated
 37-314 3.36e-11

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 63.60  E-value: 3.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  37 IAGRNLFFKCELFQKTGSFKIRGAlnaiRGLIPDTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKL 116
Cdd:PRK06450   62 IKKGNIWFKLDFLNPTGSYKDRGS----VTLISYLAEKGIKQISEDSSGNAGASIAAYGAAAGIEVKIFVPETASGGKLK 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 117 AIQAYGASIVYCdpsDESREKVtQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQ----------VPlVDA------- 179
Cdd:PRK06450  138 QIESYGAEVVRV---RGSREDV-AKAAENSGYYYASHVLQPQFRDGIRTLAYEIAKDldwkipnyvfIP-VSAgtlllgv 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 180 ------LVVPVGGGGMVAGIAITIKALKPsvkVYAaepsnaddcyqsKLKGEltpNLHPPE---TIADGVKSsiglnTWP 250
Cdd:PRK06450  213 ysgfkhLLDSGVISEMPKIVAVQTEQVSP---LCA------------KFKGI---SYTPPDkvtSIADALVS-----TRP 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039737316 251 IIRDLVDDVF-------TVTEDEIKYATQLVwGRMKLLIEPTAGVALAAvlsqhFQTVSPEvkNVCIVLSG 314
Cdd:PRK06450  270 FLLDYMVKALseygeciVVSDNEIVEAWKEL-AKKGLLVEYSSATVYAA-----YKKYSVN--DSVLVLTG 332
PRK08197 PRK08197
threonine synthase; Validated
 25-173 2.43e-09

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 58.09  E-value: 2.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  25 LTPVLTSSIL-NQIAGRNLFFKCELFQKTGSFKIRGALNAI-RGlipdtPEEKPKAVVTHSSGNHGQAL-TYAAKLeGIP 101
Cdd:PRK08197   79 MTPLLPLPRLgKALGIGRLWVKDEGLNPTGSFKARGLAVGVsRA-----KELGVKHLAMPTNGNAGAAWaAYAARA-GIR 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737316 102 AYIVVPQTAPNCKKLAIQAYGASIVYCDP--SDESReKVTQRImqETEGIL-VHPNQEPAVIAGQGTIALEVLNQ 173
Cdd:PRK08197  153 ATIFMPADAPEITRLECALAGAELYLVDGliSDAGK-IVAEAV--AEYGWFdVSTLKEPYRIEGKKTMGLELAEQ 224
PRK06381 PRK06381
threonine synthase; Validated
 26-133 3.05e-09

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 57.41  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAG-RNLFFKCELFQKTGSFKIRGALNAIRGLIpdtpEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYI 104
Cdd:PRK06381   16 TPLLRARKLEEELGlRKIYLKFEGANPTGTQKDRIAEAHVRRAM----RLGYSGITVGTCGNYGASIAYFARLYGLKAVI 91

                          90       100
                  ....*....|....*....|....*....
gi 1039737316 105 VVPQTAPNCKKLAIQAYGASIVYCDPSDE 133
Cdd:PRK06381   92 FIPRSYSNSRVKEMEKYGAEIIYVDGKYE 120
PRK08206 PRK08206
diaminopropionate ammonia-lyase; Provisional
 53-287 3.30e-08

diaminopropionate ammonia-lyase; Provisional


Pssm-ID: 236186  Cd Length: 399  Bit Score: 54.50  E-value: 3.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  53 GSFKIRGALNAIRGLIPD---------------TPEEKPKA----VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNC 113
Cdd:PRK08206   74 NAFKALGGAYAVARLLAEklgldiselsfeeltSGEVREKLgditFATATDGNHGRGVAWAAQQLGQKAVIYMPKGSSEE 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 114 KKLAIQAYGASIVYCDPS-DES-REkvTQRIMQETEGILVhpnQEPA----------VIAGQGTIALEVLNQVPlvdalv 181
Cdd:PRK08206  154 RVDAIRALGAECIITDGNyDDSvRL--AAQEAQENGWVVV---QDTAwegyeeiptwIMQGYGTMADEAVEQLK------ 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 182 vpvggggmVAGIAIT-------IKALKPSV-----KVYAA--------EPSNADDCYQSKLKGELTPNLHPPETI----A 237
Cdd:PRK08206  223 --------EMGVPPThvflqagVGSLAGAVlgyfaEVYGEqrphfvvvEPDQADCLYQSAVDGKPVAVTGDMDTImaglA 294

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039737316 238 DGVKSSIGlntWPIIRDLVDDVFTVTEDEIKYAtqlvwgrMKLLIEPTAG 287
Cdd:PRK08206  295 CGEPNPLA---WEILRNCADAFISCPDEVAALG-------MRILANPLGG 334
PRK10717 PRK10717
cysteine synthase A; Provisional
 18-274 6.64e-06

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 47.16  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  18 NIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLIpdtpeeKP-KAVVTHSSGNHGQAL 91
Cdd:PRK10717    6 DVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIwdaekRGLL------KPgGTIVEGTAGNTGIGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  92 TYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV------YCDPSDesREKVTQRIMQEtegiLVHPNQEPAVIAGQ-- 163
Cdd:PRK10717   80 ALVAAARGYKTVIVMPETQSQEKKDLLRALGAELVlvpaapYANPNN--YVKGAGRLAEE----LVASEPNGAIWANQfd 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 164 ---------GTIALEVLNQVP-LVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNAdDCYQSKLKGELTPnlhPP 233
Cdd:PRK10717  154 npanreahyETTGPEIWEQTDgKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGS-ALYSYYKTGELKA---EG 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1039737316 234 ETIADGvkssIGLN--TWPIIRDLVDDVFTVTEDE-IKYATQLV 274
Cdd:PRK10717  230 SSITEG----IGQGriTANLEGAPIDDAIRIPDEEaLSTAYRLL 269
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 26-273 2.09e-04

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 42.64  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLIpdTPEEKpkAVVTHSSGNHGQALTYAAKLEGI 100
Cdd:PLN02556   60 TPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIedaekKNLI--TPGKT--TLIEPTSGNMGISLAFMAAMKGY 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 101 PAYIVVPQTAPNCKKLAIQAYGASIVYCDPSD---ESREKVTQRIMQETEGILVHPNQEPA-VIAGQGTIALEVL-NQVP 175
Cdd:PLN02556  136 KMILTMPSYTSLERRVTMRAFGAELVLTDPTKgmgGTVKKAYELLESTPDAFMLQQFSNPAnTQVHFETTGPEIWeDTLG 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 176 LVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKlkgeltPNLHPPETIADGVKSSIglntwpIIRDL 255
Cdd:PLN02556  216 QVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGK------PGPHHITGNGVGFKPDI------LDMDV 283

                         250
                  ....*....|....*....
gi 1039737316 256 VDDVFTVT-EDEIKYATQL 273
Cdd:PLN02556  284 MEKVLEVSsEDAVNMAREL 302
cysM PRK11761
cysteine synthase CysM;
19-150 3.20e-04

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 41.78  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  19 IQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLIpdtpeeKPKAV-VTHSSGNHGQALT 92
Cdd:PRK11761    6 LEDTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIvqaekRGEI------KPGDTlIEATSGNTGIALA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039737316  93 YAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCdPSDESRE---KVTQRIMQETEGIL 150
Cdd:PRK11761   80 MIAAIKGYRMKLIMPENMSQERRAAMRAYGAELILV-PKEQGMEgarDLALQMQAEGEGKV 139
PLN02565 PLN02565
cysteine synthase
 45-294 5.24e-04

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 41.45  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  45 KCELFQKTGSFKIRGALNAI-----RGLIpdTPEEKpkAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQ 119
Cdd:PLN02565   35 KLEMMEPCSSVKDRIGYSMItdaeeKGLI--KPGES--VLIEPTSGNTGIGLAFMAAAKGYKLIITMPASMSLERRIILL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 120 AYGASIVYCDPSDESREKVtqrimQETEGILVH-PN----QE---------------PAVIAGQGTialevlnqvpLVDA 179
Cdd:PLN02565  111 AFGAELVLTDPAKGMKGAV-----QKAEEILAKtPNsyilQQfenpanpkihyettgPEIWKGTGG----------KVDA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 180 LVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSnaddcyQSKLKGELTPNLHPPETIADGVKSSIgLNTwpiirDLVDDV 259
Cdd:PLN02565  176 FVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPV------ESAVLSGGKPGPHKIQGIGAGFIPGV-LDV-----DLLDEV 243

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1039737316 260 FTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVL 294
Cdd:PLN02565  244 VQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAI 278
PLN02356 PLN02356
phosphateglycerate kinase
 21-130 9.10e-04

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 40.74  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  21 DSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIpDTPEEKPKAVVTH-SSGNHGQALTYAAKLEG 99
Cdd:PLN02356   49 DAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEAL-ESGQLFPGGVVTEgSAGSTAISLATVAPAYG 127

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1039737316 100 IPAYIVVPQTAPNCKKLAIQAYGASIVYCDP 130
Cdd:PLN02356  128 CKCHVVIPDDVAIEKSQILEALGATVERVRP 158
PLN02569 PLN02569
threonine synthase
 36-173 3.64e-03

threonine synthase


Pssm-ID: 178182 [Multi-domain]  Cd Length: 484  Bit Score: 39.03  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  36 QIAGRN-LFFKCELFQKTGSFKIRG------ALNAIRGLipdtpeEKP-KAVVTHSSGNHGQALTYAAKLEGIPAYIVVP 107
Cdd:PLN02569  145 EFLGMNdLWVKHCGISHTGSFKDLGmtvlvsQVNRLRKM------AKPvVGVGCASTGDTSAALSAYCAAAGIPSIVFLP 218

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039737316 108 QTAPNCKKLaIQ--AYGASIVYCDPSDESREKVTQRIMQETEgILVHPNQEPAVIAGQGTIALEVLNQ 173
Cdd:PLN02569  219 ADKISIAQL-VQpiANGALVLSIDTDFDGCMRLIREVTAELP-IYLANSLNSLRLEGQKTAAIEILQQ 284
PLN00011 PLN00011
cysteine synthase
 45-294 4.68e-03

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 38.45  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316  45 KCELFQKTGSFKIRGALNAIR-----GLIpdTPEEKpkAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQ 119
Cdd:PLN00011   37 KLEMMEPCSSVKDRIAYSMIKdaedkGLI--TPGKS--TLIEATAGNTGIGLACIGAARGYKVILVMPSTMSLERRIILR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 120 AYGASIVYCDPSDESR---EKVTQRIMQETEGILVHPNQEPAVIAGQ-GTIALEVL-NQVPLVDALVVPVGGGGMVAGIA 194
Cdd:PLN00011  113 ALGAEVHLTDQSIGLKgmlEKAEEILSKTPGGYIPQQFENPANPEIHyRTTGPEIWrDSAGKVDILVAGVGTGGTATGVG 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737316 195 ITIKALKPSVKVYAAEPSnaddcyQSKLKGELTPNLHPPETIADG-VKSSIGLNtwpiirdLVDDVFTVTEDEIKYATQL 273
Cdd:PLN00011  193 KFLKEKNKDIKVCVVEPV------ESAVLSGGQPGPHLIQGIGSGiIPFNLDLT-------IVDEIIQVTGEEAIETAKL 259

                         250       260
                  ....*....|....*....|.
gi 1039737316 274 VWGRMKLLIEPTAGVALAAVL 294
Cdd:PLN00011  260 LALKEGLLVGISSGAAAAAAL 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH