NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039737572|ref|XP_017170125|]
View 

ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
63-127 7.69e-08

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 7.69e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737572   63 NFQGNEAMFEAVEQQDLDAVQLLLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 222-293 1.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 1.49e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039737572  222 EPLSVNAAVVTRYKVEWSMSKDFSPLagEIIMDNLQTLRCTITGLTTGQQYFVQVSAYNMKGWGPAQTTTPV 293
Cdd:cd00063     22 TPPEDDGGPITGYVVEYREKGSGDWK--EVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
63-127 7.69e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 7.69e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737572   63 NFQGNEAMFEAVEQQDLDAVQLLLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 222-293 1.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 1.49e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039737572  222 EPLSVNAAVVTRYKVEWSMSKDFSPLagEIIMDNLQTLRCTITGLTTGQQYFVQVSAYNMKGWGPAQTTTPV 293
Cdd:cd00063     22 TPPEDDGGPITGYVVEYREKGSGDWK--EVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
222-286 8.22e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 8.22e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737572  222 EPLSVNAAVVTRYKVEWSMSKDFSPLAgEIIMDNlQTLRCTITGLTTGQQYFVQVSAYNMKGWGP 286
Cdd:pfam00041   21 TPPPDGNGPITGYEVEYRPKNSGEPWN-EITVPG-TTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-127 1.18e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 1.18e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039737572   66 GNEAMFEAVEQQDLDAVQLLLyqytpEELDLNtPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLL-----EHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKGA 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 232-285 1.22e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.22e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1039737572   232 TRYKVEWSMSKDFSPLAGEIIMDNLQTLRCTITGLTTGQQYFVQVSAYNMKGWG 285
Cdd:smart00060   30 TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
63-127 7.69e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 7.69e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737572   63 NFQGNEAMFEAVEQQDLDAVQLLLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 222-293 1.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 1.49e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039737572  222 EPLSVNAAVVTRYKVEWSMSKDFSPLagEIIMDNLQTLRCTITGLTTGQQYFVQVSAYNMKGWGPAQTTTPV 293
Cdd:cd00063     22 TPPEDDGGPITGYVVEYREKGSGDWK--EVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
63-127 3.19e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.42  E-value: 3.19e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737572   63 NFQGNEAMFEAVEQQDLDAVQLLLYQytpeELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEA----GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
62-127 4.91e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.91e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039737572   62 VNFQGNEAMFEAVEQQDLDAVQLLLyqytpeEL--DLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:COG0666    116 RDKDGETPLHLAAYNGNLEIVKLLL------EAgaDVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177
fn3 pfam00041
Fibronectin type III domain;
222-286 8.22e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 8.22e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039737572  222 EPLSVNAAVVTRYKVEWSMSKDFSPLAgEIIMDNlQTLRCTITGLTTGQQYFVQVSAYNMKGWGP 286
Cdd:pfam00041   21 TPPPDGNGPITGYEVEYRPKNSGEPWN-EITVPG-TTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-127 1.18e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 1.18e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039737572   66 GNEAMFEAVEQQDLDAVQLLLyqytpEELDLNtPNSEGLTPLDIAIMTNNVPIARILLRTGA 127
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLL-----EHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKGA 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 232-285 1.22e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.22e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1039737572   232 TRYKVEWSMSKDFSPLAGEIIMDNLQTLRCTITGLTTGQQYFVQVSAYNMKGWG 285
Cdd:smart00060   30 TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
70-123 4.49e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 4.49e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039737572   70 MFEAVEQQDLDAVQLLLYqytpEELDLNTPNSEGLTPLDIAIMTNNVPIARILL 123
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLE----NGADANLQDKNGRTALHLAAKNGHLEIVKLLL 50
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-123 5.93e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 5.93e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039737572   66 GNEAMFEAVEQQDLDAVQLLLYQytpeELDLNTPNSEGLTPLDIAIMTNNVPIARILL 123
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK----GADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
62-129 1.52e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.94  E-value: 1.52e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737572   62 VNFQGNEAMFEAVEQQDLDAVQLLLyqytpeEL--DLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARE 129
Cdd:COG0666    182 RDNDGETPLHLAAENGHLEIVKLLL------EAgaDVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH