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Conserved domains on  [gi|1039756164|ref|XP_017173423|]
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zinc finger protein 236 isoform X6 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-617 2.09e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  212 NEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGS 288
Cdd:COG5048     28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASS 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  289 LRRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEaSSMDDDSTVDQQSMHVAAPMPVEIESAELQ 368
Cdd:COG5048    108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNS-SSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  369 QTPETVAADPESILELGPQHvvgtedaalgqQLADQPLEADEDGFTASQAPLPGHMDQFEEQGTPQPSfesagLPQGFTV 448
Cdd:COG5048    187 LISSNVSTSIPSSSENSPLS-----------SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSS 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  449 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPNSDAINvatrllPESSQEDlDLQTQGPQFLEDSEDQSRRS 528
Cdd:COG5048    251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  529 YRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKS-------HEKTHTGVKAFSC--SICNASFTTNGS 599
Cdd:COG5048    324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                          410
                   ....*....|....*...
gi 1039756164  600 LTRHMATHMSMKPYKCPF 617
Cdd:COG5048    404 LSLHIITHLSFRPYNCKN 421
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 899-1175 3.47e-08

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 58.62  E-value: 3.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  899 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQGSLLAQPITGE 974
Cdd:COG3210    802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  975 SSTASQNSSLQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGphe 1054
Cdd:COG3210    882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1055 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1134
Cdd:COG3210    959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1039756164 1135 DTQGVLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1175
Cdd:COG3210   1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-876 8.32e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 8.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  496 ATRLLPESSQEDLDLQTQGPQFLEDSEDQSRRSYRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKSH 575
Cdd:COG5048      1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  576 ---EKTHTGVKAFSCSICNASFTTNGSLTRHMATHMSMKPYKCPFCEEGfrtavhcrkHMKRHQAVSSAAAAAAETEGGD 652
Cdd:COG5048     81 rhlRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLP---------PSSRDPQLPDLLSISNLRNNPL 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  653 TCVEEDEENSDRSASRKPRPEVITFTEEETAQLAKIqPQESATVSEKV------LVQSAAEKDRISEMKDKQAELEAEPK 726
Cdd:COG5048    152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL-ISSNVSTSIPSssenspLSSSYSIPSSSSDQNLENSSSSLPLT 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  727 HANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGKSFTVKSTLDCHVKTHTGQKLFSCH-VCSNAFSTKGSLKVHMR 805
Cdd:COG5048    231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSkQCNISFSRSSPLTRHLR 310

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039756164  806 --LHTG--AKPFKCPH--CELRFRTSGRRKTHMQFHYKSDPKKarKPVTRSSSESLQSVNLLNSSSTDPNVFIMNNS 876
Cdd:COG5048    311 svNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK--EKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1299-1323 5.14e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 5.14e-06
                           10        20
                   ....*....|....*....|....*
gi 1039756164 1299 LERHSRIHTGERPFHCTLCDKAFNQ 1323
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 1.01e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.01e-04
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  113 SLKVHIRLHTGVRPFACPHCDKKFRT 138
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1326-1351 6.91e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 6.91e-04
                           10        20
                   ....*....|....*....|....*.
gi 1039756164 1326 ALQVHLKKHTGERPYRCDYCVMGFTQ 1351
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
43-324 1.24e-03

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164   43 HVCPYCTKEFRKPSDLVRHIRIHTHEKPFKC--PQCFRAFAVKSTLTAHIKTHTGIKAFKC--QYCMKSFSTSGSLKVHI 118
Cdd:COG5048     34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSSS 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  119 RLHTgVRPFACPHCDKKFRT------SGHRKTHVASHFKHTELRKLRQQRKPVKGRVGKSSVPVPDIPLQEPILITDLGL 192
Cdd:COG5048    114 SSNS-NDNNLLSSHSLPPSSrdpqlpDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNV 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  193 IQPIPKNQFFQNY-FNNSFGNEADRPYKC------FYCHRAYKKSCHLKQHIRSHTGEKPFKCS--------QCGRGFVS 257
Cdd:COG5048    193 STSIPSSSENSPLsSSYSIPSSSSDQNLEnsssslPLTTNSQLSPKSLLSQSPSSLSSSDSSSSasesprssLPTASSQS 272

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039756164  258 AGVLKAHVRTHTG-LKSFKCLICNGAFTTGGSLRRHM--GIHN--DLRPYMCPY--CQKTFKTSLNCKKHMKTH 324
Cdd:COG5048    273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLH 346
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1221-1269 1.27e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 1.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1039756164 1221 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1269
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-617 2.09e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  212 NEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGS 288
Cdd:COG5048     28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASS 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  289 LRRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEaSSMDDDSTVDQQSMHVAAPMPVEIESAELQ 368
Cdd:COG5048    108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNS-SSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  369 QTPETVAADPESILELGPQHvvgtedaalgqQLADQPLEADEDGFTASQAPLPGHMDQFEEQGTPQPSfesagLPQGFTV 448
Cdd:COG5048    187 LISSNVSTSIPSSSENSPLS-----------SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSS 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  449 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPNSDAINvatrllPESSQEDlDLQTQGPQFLEDSEDQSRRS 528
Cdd:COG5048    251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  529 YRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKS-------HEKTHTGVKAFSC--SICNASFTTNGS 599
Cdd:COG5048    324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                          410
                   ....*....|....*...
gi 1039756164  600 LTRHMATHMSMKPYKCPF 617
Cdd:COG5048    404 LSLHIITHLSFRPYNCKN 421
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 899-1175 3.47e-08

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 58.62  E-value: 3.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  899 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQGSLLAQPITGE 974
Cdd:COG3210    802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  975 SSTASQNSSLQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGphe 1054
Cdd:COG3210    882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1055 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1134
Cdd:COG3210    959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1039756164 1135 DTQGVLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1175
Cdd:COG3210   1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-876 8.32e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 8.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  496 ATRLLPESSQEDLDLQTQGPQFLEDSEDQSRRSYRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKSH 575
Cdd:COG5048      1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  576 ---EKTHTGVKAFSCSICNASFTTNGSLTRHMATHMSMKPYKCPFCEEGfrtavhcrkHMKRHQAVSSAAAAAAETEGGD 652
Cdd:COG5048     81 rhlRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLP---------PSSRDPQLPDLLSISNLRNNPL 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  653 TCVEEDEENSDRSASRKPRPEVITFTEEETAQLAKIqPQESATVSEKV------LVQSAAEKDRISEMKDKQAELEAEPK 726
Cdd:COG5048    152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL-ISSNVSTSIPSssenspLSSSYSIPSSSSDQNLENSSSSLPLT 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  727 HANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGKSFTVKSTLDCHVKTHTGQKLFSCH-VCSNAFSTKGSLKVHMR 805
Cdd:COG5048    231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSkQCNISFSRSSPLTRHLR 310

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039756164  806 --LHTG--AKPFKCPH--CELRFRTSGRRKTHMQFHYKSDPKKarKPVTRSSSESLQSVNLLNSSSTDPNVFIMNNS 876
Cdd:COG5048    311 svNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK--EKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
zf-H2C2_2 pfam13465
Zinc-finger double domain;
743-767 1.17e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 1.17e-06
                           10        20
                   ....*....|....*....|....*
gi 1039756164  743 DLVRHVRIHTGEKPYKCDECGKSFT 767
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-568 2.85e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 2.85e-06
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  543 HLKQHVRSHTGEKPYKCKLCGRAFVS 568
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1299-1323 5.14e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 5.14e-06
                           10        20
                   ....*....|....*....|....*
gi 1039756164 1299 LERHSRIHTGERPFHCTLCDKAFNQ 1323
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 933-1234 1.07e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.30  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  933 PNVQISGIDASSINNITLQIDPS----ILQQTLQQGSLLAQPITGESSTASQNSSLQTSDSTVPA---SVVIQPLSGLSL 1005
Cdd:pfam05109  567 PNATIPTLGKTSPTSAVTTPTPNatspTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTgqhNITSSSTSSMSL 646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1006 QPTVTSAnlTIGPLSEQDSV----LTTSS--SGSQDLSQVMTSqglvstSTGPHEITlTINNSSLSQVLAQAAGPTASSS 1079
Cdd:pfam05109  647 RPSSISE--TLSPSTSDNSTshmpLLTSAhpTGGENITQVTPA------STSTHHVS-TSSPAPRPGTTSQASGPGNSST 717

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1080 SGSPQEITLTiselnpsSGSLP--STAPMSPSAISAQNLVMSSSGVGADASvtltladtqgvlSGGLDTvtlniTSQGQQ 1157
Cdd:pfam05109  718 STKPGEVNVT-------KGTPPknATSPQAPSGQKTAVPTVTSTGGKANST------------TGGKHT-----TGHGAR 773

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1158 FPallTDPSLSGQGGAGSPQVILVSHT---PQSSSAAGEEIAYQVTDV-PAQLT----PHSQPEKEGLSHQCLDcdraFS 1229
Cdd:pfam05109  774 TS---TEPTTDYGGDSTTPRTRYNATTylpPSTSSKLRPRWTFTSPPVtTAQATvpvpPTSQPRFSNLSMLVLQ----WA 846


                   ....*
gi 1039756164 1230 SAAVL 1234
Cdd:pfam05109  847 SLAVL 851
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 1.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.01e-04
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  113 SLKVHIRLHTGVRPFACPHCDKKFRT 138
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 216-267 1.13e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 1.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039756164  216 RPYkCFYCHRAYKKSCHLKQHIRSHTgekpFKCSQCGRGFVSAGVLKAHVRT 267
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1326-1351 6.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 6.91e-04
                           10        20
                   ....*....|....*....|....*.
gi 1039756164 1326 ALQVHLKKHTGERPYRCDYCVMGFTQ 1351
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
43-324 1.24e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164   43 HVCPYCTKEFRKPSDLVRHIRIHTHEKPFKC--PQCFRAFAVKSTLTAHIKTHTGIKAFKC--QYCMKSFSTSGSLKVHI 118
Cdd:COG5048     34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSSS 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  119 RLHTgVRPFACPHCDKKFRT------SGHRKTHVASHFKHTELRKLRQQRKPVKGRVGKSSVPVPDIPLQEPILITDLGL 192
Cdd:COG5048    114 SSNS-NDNNLLSSHSLPPSSrdpqlpDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNV 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  193 IQPIPKNQFFQNY-FNNSFGNEADRPYKC------FYCHRAYKKSCHLKQHIRSHTGEKPFKCS--------QCGRGFVS 257
Cdd:COG5048    193 STSIPSSSENSPLsSSYSIPSSSSDQNLEnsssslPLTTNSQLSPKSLLSQSPSSLSSSDSSSSasesprssLPTASSQS 272

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039756164  258 AGVLKAHVRTHTG-LKSFKCLICNGAFTTGGSLRRHM--GIHN--DLRPYMCPY--CQKTFKTSLNCKKHMKTH 324
Cdd:COG5048    273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLH 346
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1221-1269 1.27e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 1.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1039756164 1221 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1269
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 921-1187 1.28e-03

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 43.37  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  921 GIQLQLAANLV---GPNVQISGIDASSINNITLQIdpsilqQTLQQGSLLAqPITGESSTASQNSSLQ-TSDSTVPasVV 996
Cdd:cd22536    141 SVQYQVIPQIQtveGQQIQISPANATALQDLQGQI------QLIPAGNNQA-ILTTPNRTASGNIIAQnLANQTVP--VQ 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  997 IQPLSGLSLQ---------PTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGlvSTSTGPHEITLTINNSSLSqv 1067
Cdd:cd22536    212 IRPGVSIPLQlqtipgaqaQVVTTLPINIGGVTLALPVINNVAAGGGSGQLVQPSDG--GVSNGNQLVSTPITTASVS-- 287

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1068 laqaagpTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLADTQgVLSGGLDTV 1147
Cdd:cd22536    288 -------TMPESPSSSTTCTTTASTSLTSSDTLVSSAETGQYASTAASSERTEEEPQTSAAESEAQSSSQ-LQSNGLQNV 359

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1039756164 1148 TLNitSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQS 1187
Cdd:cd22536    360 QDQ--SNSLQQVQIVGQPILQQIQIQQPQQQIIQAIQPQS 397
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 43-65 1.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|...
gi 1039756164   43 HVCPYCTKEFRKPSDLVRHIRIH 65
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 69-117 1.65e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 1.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1039756164   69 KPFkCPQCFRAFAVKSTLTAHIKTHTgikaFKCQYCMKSFSTSGSLKVH 117
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 755-804 2.19e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 2.19e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039756164  755 KPYkCDECGKSFTVKSTLDCHVKTHTgqklFSCHVCSNAFSTKGSLKVHM 804
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
PHA00733 PHA00733
hypothetical protein
 96-146 3.23e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 3.23e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039756164   96 IKAFKCQYCMKSFSTSGSLKVHIRL--HTGVrpfaCPHCDKKFRTSGHRKTHV 146
Cdd:PHA00733    71 VSPYVCPLCLMPFSSSVSLKQHIRYteHSKV----CPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-617 2.09e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  212 NEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGS 288
Cdd:COG5048     28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASS 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  289 LRRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEaSSMDDDSTVDQQSMHVAAPMPVEIESAELQ 368
Cdd:COG5048    108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNS-SSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  369 QTPETVAADPESILELGPQHvvgtedaalgqQLADQPLEADEDGFTASQAPLPGHMDQFEEQGTPQPSfesagLPQGFTV 448
Cdd:COG5048    187 LISSNVSTSIPSSSENSPLS-----------SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSS 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  449 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPNSDAINvatrllPESSQEDlDLQTQGPQFLEDSEDQSRRS 528
Cdd:COG5048    251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  529 YRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKS-------HEKTHTGVKAFSC--SICNASFTTNGS 599
Cdd:COG5048    324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                          410
                   ....*....|....*...
gi 1039756164  600 LTRHMATHMSMKPYKCPF 617
Cdd:COG5048    404 LSLHIITHLSFRPYNCKN 421
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 899-1175 3.47e-08

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 58.62  E-value: 3.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  899 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQGSLLAQPITGE 974
Cdd:COG3210    802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  975 SSTASQNSSLQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGphe 1054
Cdd:COG3210    882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1055 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1134
Cdd:COG3210    959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1039756164 1135 DTQGVLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1175
Cdd:COG3210   1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 904-1192 3.65e-07

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 55.16  E-value: 3.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  904 GGDLTVslTDGSLATLEGIQLQLAANLVGPNVQISGIDASSINNITLQIDPSILQQTLqQGSLLAQPITGESSTASQNSS 983
Cdd:COG3210    818 GGTITI--NTATTGLTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAAT-AASITVGSGGVATSTGTANAG 894

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  984 LQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGPHEITLTINNSS 1063
Cdd:COG3210    895 TLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAASASDGAGDTGASSAAGS 974

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1064 LSQVLAQAAGPTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLADTQGVLSGG 1143
Cdd:COG3210    975 SAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAATAGGQNGVGVNASGIS 1054

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1039756164 1144 LDTVTLNITSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQSSSAAG 1192
Cdd:COG3210   1055 GGNAAALTASGTAGTTGGTAASNGGGGTAQASGAGTTHTLGGITNGGAT 1103
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-876 8.32e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 8.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  496 ATRLLPESSQEDLDLQTQGPQFLEDSEDQSRRSYRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKSH 575
Cdd:COG5048      1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  576 ---EKTHTGVKAFSCSICNASFTTNGSLTRHMATHMSMKPYKCPFCEEGfrtavhcrkHMKRHQAVSSAAAAAAETEGGD 652
Cdd:COG5048     81 rhlRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLP---------PSSRDPQLPDLLSISNLRNNPL 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  653 TCVEEDEENSDRSASRKPRPEVITFTEEETAQLAKIqPQESATVSEKV------LVQSAAEKDRISEMKDKQAELEAEPK 726
Cdd:COG5048    152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL-ISSNVSTSIPSssenspLSSSYSIPSSSSDQNLENSSSSLPLT 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  727 HANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGKSFTVKSTLDCHVKTHTGQKLFSCH-VCSNAFSTKGSLKVHMR 805
Cdd:COG5048    231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSkQCNISFSRSSPLTRHLR 310

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039756164  806 --LHTG--AKPFKCPH--CELRFRTSGRRKTHMQFHYKSDPKKarKPVTRSSSESLQSVNLLNSSSTDPNVFIMNNS 876
Cdd:COG5048    311 svNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK--EKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
zf-H2C2_2 pfam13465
Zinc-finger double domain;
743-767 1.17e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 1.17e-06
                           10        20
                   ....*....|....*....|....*
gi 1039756164  743 DLVRHVRIHTGEKPYKCDECGKSFT 767
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-568 2.85e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 2.85e-06
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  543 HLKQHVRSHTGEKPYKCKLCGRAFVS 568
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1299-1323 5.14e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 5.14e-06
                           10        20
                   ....*....|....*....|....*
gi 1039756164 1299 LERHSRIHTGERPFHCTLCDKAFNQ 1323
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
232-257 7.98e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 7.98e-06
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  232 HLKQHIRSHTGEKPFKCSQCGRGFVS 257
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 933-1234 1.07e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.30  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  933 PNVQISGIDASSINNITLQIDPS----ILQQTLQQGSLLAQPITGESSTASQNSSLQTSDSTVPA---SVVIQPLSGLSL 1005
Cdd:pfam05109  567 PNATIPTLGKTSPTSAVTTPTPNatspTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTgqhNITSSSTSSMSL 646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1006 QPTVTSAnlTIGPLSEQDSV----LTTSS--SGSQDLSQVMTSqglvstSTGPHEITlTINNSSLSQVLAQAAGPTASSS 1079
Cdd:pfam05109  647 RPSSISE--TLSPSTSDNSTshmpLLTSAhpTGGENITQVTPA------STSTHHVS-TSSPAPRPGTTSQASGPGNSST 717

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1080 SGSPQEITLTiselnpsSGSLP--STAPMSPSAISAQNLVMSSSGVGADASvtltladtqgvlSGGLDTvtlniTSQGQQ 1157
Cdd:pfam05109  718 STKPGEVNVT-------KGTPPknATSPQAPSGQKTAVPTVTSTGGKANST------------TGGKHT-----TGHGAR 773

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1158 FPallTDPSLSGQGGAGSPQVILVSHT---PQSSSAAGEEIAYQVTDV-PAQLT----PHSQPEKEGLSHQCLDcdraFS 1229
Cdd:pfam05109  774 TS---TEPTTDYGGDSTTPRTRYNATTylpPSTSSKLRPRWTFTSPPVtTAQATvpvpPTSQPRFSNLSMLVLQ----WA 846


                   ....*
gi 1039756164 1230 SAAVL 1234
Cdd:pfam05109  847 SLAVL 851
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 847-1192 1.64e-05

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 49.76  E-value: 1.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  847 VTRSSSESLQSVNLLNSSSTDPNVFIMNNSVLTGQFDQNVLQPGLVGQAILPASVSAGGDLTVSLTDGSLATLEGIQLQL 926
Cdd:COG3210    509 GIATGLTGITAGGGGGGNATSGGTGGDGTTLSGSGLTTTVSGGASGTTAASGSNTANTLGVLAATGGTSNATTAGNSTSA 588

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  927 AANLVGPNVQISGIDASSINNITLQIDPSILQQTLQQGSLLAQPITGESSTASQNSSLQTSDSTVPASVVIQPLSGLSLQ 1006
Cdd:COG3210    589 TGGTGTNSGGTVLSIGTGSAGATGTITLGAGTSGAGANATGGGAGLTGSAVGAALSGTGSGTTGTASANGSNTTGVNTAG 668

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1007 PTVTSANLTIGPLSEQDSVLTTSSSGSQDL-----------SQVMTSQGLVSTSTGPHEITLTINNSSLSQVLAQAAGPT 1075
Cdd:COG3210    669 GTGGGTTGTVTSGATGGTTGTTLNAATGGTlnnagntltisTGSITVTGQIGALANANGDTVTFGNLGTGATLTLNAGVT 748

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1076 ASS-SSGSP------------QEITLTISELNPSSGSL--PSTAPMSPSAISAQNLVMSSSGV----GADASVTLTLADT 1136
Cdd:COG3210    749 ITSgNAGTLsigltanttasgTTLTLANANGNTSAGATldNAGAEISIDITADGTITAAGTTAinvtGSGGTITINTATT 828

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039756164 1137 qGVLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQSSSAAG 1192
Cdd:COG3210    829 -GLTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGSGG 883
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 1.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.01e-04
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  113 SLKVHIRLHTGVRPFACPHCDKKFRT 138
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 216-267 1.13e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 1.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039756164  216 RPYkCFYCHRAYKKSCHLKQHIRSHTgekpFKCSQCGRGFVSAGVLKAHVRT 267
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
599-624 1.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.80e-04
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  599 SLTRHMATHMSMKPYKCPFCEEGFRT 624
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 244-293 2.28e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.00  E-value: 2.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039756164  244 KPFkCSQCGRGFVSAGVLKAHVRTHTglksFKCLICNGAFTTGGSLRRHM 293
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
799-824 2.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.80e-04
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  799 SLKVHMRLHTGAKPFKCPHCELRFRT 824
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 531-575 3.21e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.62  E-value: 3.21e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039756164  531 CDYCNKGFKKSSHLKQHVRSHTgekpYKCKLCGRAFVSSGVLKSH 575
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 529-551 6.18e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 6.18e-04
                           10        20
                   ....*....|....*....|...
gi 1039756164  529 YRCDYCNKGFKKSSHLKQHVRSH 551
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1326-1351 6.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 6.91e-04
                           10        20
                   ....*....|....*....|....*.
gi 1039756164 1326 ALQVHLKKHTGERPYRCDYCVMGFTQ 1351
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
43-324 1.24e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164   43 HVCPYCTKEFRKPSDLVRHIRIHTHEKPFKC--PQCFRAFAVKSTLTAHIKTHTGIKAFKC--QYCMKSFSTSGSLKVHI 118
Cdd:COG5048     34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSSS 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  119 RLHTgVRPFACPHCDKKFRT------SGHRKTHVASHFKHTELRKLRQQRKPVKGRVGKSSVPVPDIPLQEPILITDLGL 192
Cdd:COG5048    114 SSNS-NDNNLLSSHSLPPSSrdpqlpDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNV 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  193 IQPIPKNQFFQNY-FNNSFGNEADRPYKC------FYCHRAYKKSCHLKQHIRSHTGEKPFKCS--------QCGRGFVS 257
Cdd:COG5048    193 STSIPSSSENSPLsSSYSIPSSSSDQNLEnsssslPLTTNSQLSPKSLLSQSPSSLSSSDSSSSasesprssLPTASSQS 272

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039756164  258 AGVLKAHVRTHTG-LKSFKCLICNGAFTTGGSLRRHM--GIHN--DLRPYMCPY--CQKTFKTSLNCKKHMKTH 324
Cdd:COG5048    273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLH 346
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1221-1269 1.27e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 1.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1039756164 1221 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1269
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 921-1187 1.28e-03

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 43.37  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  921 GIQLQLAANLV---GPNVQISGIDASSINNITLQIdpsilqQTLQQGSLLAqPITGESSTASQNSSLQ-TSDSTVPasVV 996
Cdd:cd22536    141 SVQYQVIPQIQtveGQQIQISPANATALQDLQGQI------QLIPAGNNQA-ILTTPNRTASGNIIAQnLANQTVP--VQ 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  997 IQPLSGLSLQ---------PTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGlvSTSTGPHEITLTINNSSLSqv 1067
Cdd:cd22536    212 IRPGVSIPLQlqtipgaqaQVVTTLPINIGGVTLALPVINNVAAGGGSGQLVQPSDG--GVSNGNQLVSTPITTASVS-- 287

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1068 laqaagpTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLADTQgVLSGGLDTV 1147
Cdd:cd22536    288 -------TMPESPSSSTTCTTTASTSLTSSDTLVSSAETGQYASTAASSERTEEEPQTSAAESEAQSSSQ-LQSNGLQNV 359

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1039756164 1148 TLNitSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQS 1187
Cdd:cd22536    360 QDQ--SNSLQQVQIVGQPILQQIQIQQPQQQIIQAIQPQS 397
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 43-65 1.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|...
gi 1039756164   43 HVCPYCTKEFRKPSDLVRHIRIH 65
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 69-117 1.65e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 1.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1039756164   69 KPFkCPQCFRAFAVKSTLTAHIKTHTgikaFKCQYCMKSFSTSGSLKVH 117
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-313 2.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 2.18e-03
                           10        20
                   ....*....|....*....|....*.
gi 1039756164  288 SLRRHMGIHNDLRPYMCPYCQKTFKT 313
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 755-804 2.19e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 2.19e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039756164  755 KPYkCDECGKSFTVKSTLDCHVKTHTgqklFSCHVCSNAFSTKGSLKVHM 804
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
PHA00733 PHA00733
hypothetical protein
 96-146 3.23e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 3.23e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039756164   96 IKAFKCQYCMKSFSTSGSLKVHIRL--HTGVrpfaCPHCDKKFRTSGHRKTHV 146
Cdd:PHA00733    71 VSPYVCPLCLMPFSSSVSLKQHIRYteHSKV----CPVCGKEFRNTDSTLDHV 119
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1276-1345 3.49e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 3.49e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039756164 1276 LSSQKPRVFKCDSCEKAFAKPSQLERHSRIHTGERPFHCTL--CDKAFNQKSALQVHLKKHTGERPYRCDYC 1345
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
zf-H2C2_2 pfam13465
Zinc-finger double domain;
86-110 3.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 3.86e-03
                           10        20
                   ....*....|....*....|....*
gi 1039756164   86 LTAHIKTHTGIKAFKCQYCMKSFST 110
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 585-607 4.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.23e-03
                           10        20
                   ....*....|....*....|...
gi 1039756164  585 FSCSICNASFTTNGSLTRHMATH 607
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1312-1334 4.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 4.99e-03
                           10        20
                   ....*....|....*....|...
gi 1039756164 1312 FHCTLCDKAFNQKSALQVHLKKH 1334
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 731-751 5.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 5.79e-03
                           10        20
                   ....*....|....*....|.
gi 1039756164  731 CTYCPKSFKKPSDLVRHVRIH 751
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
57-81 6.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 6.12e-03
                           10        20
                   ....*....|....*....|....*
gi 1039756164   57 DLVRHIRIHTHEKPFKCPQCFRAFA 81
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 553-623 6.48e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 6.48e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039756164  553 GEKPYKCKL--CGRAFVSSGVLKSHEKT-HtgvkafscsiCNASFTTNGSLTRHMATHMSMKPYKCPFCEEGFR 623
Cdd:COG5189    346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 847-1150 6.57e-03

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 41.09  E-value: 6.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  847 VTRSSSESLQSVNLLNSSSTDPNVFIMNNSVLTGQFDQNVLQPGLVGQAILPASVSAGGDLTVSLTDGSLATLEGIQLQL 926
Cdd:COG3468    152 TGAAAAGGGTGSGGGGSGGGGGAGGGGGGGAGGSGGAGSTGSGAGGGGGGSGGGGGAAGTGGGGGGGGGAGGATGGAGSG 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  927 AANLVGPNVQISGIDASSINNITLQIDPSILQQTLQQGSLLAQPITGESSTASQNSSLQTSDSTVpasvviqplsglslq 1006
Cdd:COG3468    232 GNTGGGVGGGGGSAGGTGGGGLTGGGAAGTGGGGGGTGTGSGGGGGGGANGGGSGGGGGASGTGG--------------- 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1007 ptvtSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGPHEITLTINNSSLSQVLAQAAGPTASSSSGSPQEI 1086
Cdd:COG3468    297 ----GGTASTGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTTLNGAGSAGGGTGAALAGTGGSGSGGGGGGG 372

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039756164 1087 TLTISELNPSSGSLPSTAPMSpSAISAQNLVMSSSGVGADASVTLTLADTQ----GVLSGGLDTVTLN 1150
Cdd:COG3468    373 SGGGGGAGGGGANTGSDGVGT-GLTTGGTGNNGGGGVGGGGGGGLTLTGGTltvnGNYTGNNGTLVLN 439
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 218-240 6.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 6.97e-03
                           10        20
                   ....*....|....*....|...
gi 1039756164  218 YKCFYCHRAYKKSCHLKQHIRSH 240
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SP3_N cd22537
N-terminal domain of transcription factor Specificity Protein (SP) 3; Specificity Proteins ...
 897-1212 7.14e-03

N-terminal domain of transcription factor Specificity Protein (SP) 3; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP1 and SP3 can interact with and recruit a large number of proteins including the transcription initiation complex, histone modifying enzymes, and chromatin remodeling complexes, which strongly suggest that SP1 and SP3 are important transcription factors in remodeling chromatin and the regulation of gene expression. SP3 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP3.


Pssm-ID: 411774 [Multi-domain]  Cd Length: 574  Bit Score: 40.70  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  897 LPASVSAGGDLTVSLTDGSLATLEGIQLQLAAN---LVGPNVQISGIDASSInnitLQIDPSILQQTLQQGSLLAQPITG 973
Cdd:cd22537     24 SPSPGDDAAAAGNAASAGQTGDLASAQLTGAPNrweVLTPTPTTIKDEAGNL----VQIPGGGTVTSSGQYVLPLQSLQN 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  974 ES--STASQNSSLQTSDSTVPASVV--IQPLSGLSLQ--PTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVS 1047
Cdd:cd22537    100 QQifSVAPGSDASNGTVPNVQYQVIpqIQTTDGQQVQlgFATSSDNTGLQQEGGQIQIIPGSNQTIIASGTPSAVQQLLS 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1048 TSTGPHEI-TLTINNSSL---SQVLAQAAgptasssSGSPQEITLT-ISELNPSS-GSLPSTAPMSPSAISAQNLVM--- 1118
Cdd:cd22537    180 QSGHVVQIqGVSIGGSSFpgqTQVVANVP-------LGLPGNITFVpINSVDLDSlGLSGTSQTMTTGITADGQLINtgq 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164 1119 ---SSSGVGADASVTLTLADTQG-------VLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQSS 1188
Cdd:cd22537    253 avqSSDNSGESGKVSPDINETNTnadlfvpTSSSSQLPVTIDSTGILQQNASSLTTVSGQVHTSDLQGNYIQAPVSDETQ 332

                          330       340
                   ....*....|....*....|....
gi 1039756164 1189 SAAGEEIAYQVTDVPAQLTPHSQP 1212
Cdd:cd22537    333 AQNIQVSTAQPSVQQIQLHESQQP 356
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 555-604 8.15e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 8.15e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039756164  555 KPYkCKLCGRAFVSSGVLKSHEKTHTgvkaFSCSICNASFTTNGSLTRHM 604
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
69-264 8.50e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 8.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164   69 KPFKCPQCFRAFAVKSTLTAHIKT--HTG--IKAFKC--QYCMKSFSTSGSLKVHIRLHTGVRPFACP--HCDKKFRTSG 140
Cdd:COG5048    288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756164  141 HRKtHVASHFKHTELRKLRQQRKpvkgrvgkssvpvpdiplqepiliTDLGLIQPIPKNQFFQNYFNNSFGNEaDRPYKC 220
Cdd:COG5048    368 NNE-PPQSLQQYKDLKNDKKSET------------------------LSNSCIRNFKRDSNLSLHIITHLSFR-PYNCKN 421

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1039756164  221 FYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRgFVSAGVLKAH 264
Cdd:COG5048    422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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