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Conserved domains on  [gi|1039761661|ref|XP_017174691|]
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protein TANC1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1094-1310 3.10e-52

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 186.31  E-value: 3.10e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1173
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1174 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1253
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761661 1254 HVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEE 1310
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270
PHA03095 super family cl33707
ankyrin-like protein; Provisional
 921-1233 9.70e-22

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.87  E-value: 9.70e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  921 RNLYTPNVKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLGHE---EVVTLLLEFGACLDGMSENGMNAL-CYAAAAG 994
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  995 HMKLVCLLIKKGARVDHLDKKGQCALvHSALRG---HSDILQYLLNcewsagppqpgtlrksqalqqaltaaasMGhssv 1071
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLR----------------------------KG---- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1072 vqsllgmaeeheIEVNGTDtLWGETALTA--AAGRGKVEICELLLERGAAVSRANRRGVPPL-----FCAARQGhwqVVR 1144
Cdd:PHA03095   143 ------------ADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLhhhlqSFKPRAR---IVR 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1145 LLLDRGCDVNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQT 1222
Cdd:PHA03095   207 ELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286

                          330
                   ....*....|.
gi 1039761661 1223 DKNGRTPLDLA 1233
Cdd:PHA03095   287 SSDGNTPLSLM 297
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1311-1428 3.89e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 3.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1311 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1390
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039761661 1391 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
NACHT super family cl26020
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
536-1157 2.25e-09

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5635:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 62.51  E-value: 2.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  536 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTSLRNEQKIpeeeyIILIDGLNE--A 612
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEvpD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  613 EFHKPDYGDTLSSFITKiipkFPTwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSN 692
Cdd:COG5635    271 EADRDEVLNQLRRFLER----YPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEA 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  693 ISLNGKadaaliskvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFDRALP 771
Cdd:COG5635    345 LEENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLT 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  772 ILN-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMEALSCFLIKRRDKTRMFCHPSFRE 834
Cdd:COG5635    401 IYRelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  835 WLV-----WRADGESTAFL----CEPRnGHALLAFMFSRQESKLNRQQTMELGHHILKAHIFKGLSKKTGVSS--SHLQA 903
Cdd:COG5635    480 YLAaralvEELDEELLELLaehlEDPR-WREVLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLlaLALLA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  904 LWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENG 983
Cdd:COG5635    559 LLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLL 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  984 MNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQALQQALTAA 1063
Cdd:COG5635    639 LALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAALDL 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1064 ASMGHSSVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVV 1143
Cdd:COG5635    719 LLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLLL 798

                          650
                   ....*....|....
gi 1039761661 1144 RLLLDRGCDVNLSD 1157
Cdd:COG5635    799 ILLLVLLGSLLLLR 812
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 109-383 6.95e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 54.20  E-value: 6.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  109 GSKPSEPSATEAKADNEPSCSPAAQElltrlgfllgegipSATHITIEDKNEAMV--MPEEEAAFPTCSACTLPCTALSQ 186
Cdd:pfam17823   94 GTDLSEPATREGAADGAASRALAAAA--------------SSSPSSAAQSLPAAIaaLPSEAFSAPRAAACRANASAAPR 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  187 GiSPCSTLTSSTASPSTDSPCSTLNSCVSKTAASKSPCETISSPSSTLE-----------------SKDSGIIATITSSS 249
Cdd:pfam17823  160 A-AIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTpargistaatatghpaaGTALAAVGNSSPAA 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  250 ENDDRSGSSLEWNRDGSLRLGVQK----------GVLHDRRAdncSPVAEEETTGSAESVLPKAEPSAG--------DGP 311
Cdd:pfam17823  239 GTVTAAVGTVTPAALATLAAAAGTvasaagtinmGDPHARRL---SPAKHMPSDTMARNPAAPMGAQAQgpiiqvstDQP 315

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761661  312 V----PYPQSSGSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPwHNTaggRAPEVKARFAPYKPQEIL 383
Cdd:pfam17823  316 VhntaGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL-HTS---MIPEVEATSPTTQPSPLL 387
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1094-1310 3.10e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 186.31  E-value: 3.10e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1173
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1174 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1253
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761661 1254 HVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEE 1310
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1107-1331 6.00e-24

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 107.06  E-value: 6.00e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1107 VEICELLLERGAAVSRANRRGVPPLFCAA--RQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVA--SCEGHLSTVEFLLSK 1182
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDK 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1183 GAALSSLDKeglsalswaclkghravVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRP 1262
Cdd:PHA03100   166 GVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761661 1263 LDRAIGCRNTAVVVTLLRKGaklgnaawamATSKPDILIILLQKLVEEGNVmyKKGKMKEAAQRYQYAL 1331
Cdd:PHA03100   229 LHIAILNNNKEIFKLLLNNG----------PSIKTIIETLLYFKDKDLNTI--TKIKMLKKSIMYMFLL 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1131-1223 3.12e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.49  E-value: 3.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1131 LFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAlsSLDKEGLSALSWACLKGHRAVVQ 1210
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039761661 1211 YLVEEGAEIDQTD 1223
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 921-1233 9.70e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.87  E-value: 9.70e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  921 RNLYTPNVKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLGHE---EVVTLLLEFGACLDGMSENGMNAL-CYAAAAG 994
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  995 HMKLVCLLIKKGARVDHLDKKGQCALvHSALRG---HSDILQYLLNcewsagppqpgtlrksqalqqaltaaasMGhssv 1071
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLR----------------------------KG---- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1072 vqsllgmaeeheIEVNGTDtLWGETALTA--AAGRGKVEICELLLERGAAVSRANRRGVPPL-----FCAARQGhwqVVR 1144
Cdd:PHA03095   143 ------------ADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLhhhlqSFKPRAR---IVR 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1145 LLLDRGCDVNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQT 1222
Cdd:PHA03095   207 ELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286

                          330
                   ....*....|.
gi 1039761661 1223 DKNGRTPLDLA 1233
Cdd:PHA03095   287 SSDGNTPLSLM 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
987-1118 2.01e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 2.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  987 LCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNcewsagppqpgtlrksqalqqaltaaasm 1066
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------------------- 51

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1067 ghssvvqsllgmaeeheiEVNGTDTLWGETALTAAAGRGKVEICELLLERGA 1118
Cdd:pfam12796   52 ------------------HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGA 85
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1311-1428 3.89e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 3.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1311 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1390
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039761661 1391 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
536-1157 2.25e-09

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 62.51  E-value: 2.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  536 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTSLRNEQKIpeeeyIILIDGLNE--A 612
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEvpD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  613 EFHKPDYGDTLSSFITKiipkFPTwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSN 692
Cdd:COG5635    271 EADRDEVLNQLRRFLER----YPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEA 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  693 ISLNGKadaaliskvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFDRALP 771
Cdd:COG5635    345 LEENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLT 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  772 ILN-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMEALSCFLIKRRDKTRMFCHPSFRE 834
Cdd:COG5635    401 IYRelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  835 WLV-----WRADGESTAFL----CEPRnGHALLAFMFSRQESKLNRQQTMELGHHILKAHIFKGLSKKTGVSS--SHLQA 903
Cdd:COG5635    480 YLAaralvEELDEELLELLaehlEDPR-WREVLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLlaLALLA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  904 LWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENG 983
Cdd:COG5635    559 LLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLL 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  984 MNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQALQQALTAA 1063
Cdd:COG5635    639 LALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAALDL 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1064 ASMGHSSVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVV 1143
Cdd:COG5635    719 LLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLLL 798

                          650
                   ....*....|....
gi 1039761661 1144 RLLLDRGCDVNLSD 1157
Cdd:COG5635    799 ILLLVLLGSLLLLR 812
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1094-1213 5.17e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 5.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAAVS---------RANRR-----GVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQ 1159
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039761661 1160 GRTPLMV--------ASCEghlsTVEFLLS--KGAALSSLD----KEGLSALSWACLKGHRAVVQYLV 1213
Cdd:cd22192    169 GNTVLHIlvlqpnktFACQ----MYDLILSydKEDDLQPLDlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 109-383 6.95e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 54.20  E-value: 6.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  109 GSKPSEPSATEAKADNEPSCSPAAQElltrlgfllgegipSATHITIEDKNEAMV--MPEEEAAFPTCSACTLPCTALSQ 186
Cdd:pfam17823   94 GTDLSEPATREGAADGAASRALAAAA--------------SSSPSSAAQSLPAAIaaLPSEAFSAPRAAACRANASAAPR 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  187 GiSPCSTLTSSTASPSTDSPCSTLNSCVSKTAASKSPCETISSPSSTLE-----------------SKDSGIIATITSSS 249
Cdd:pfam17823  160 A-AIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTpargistaatatghpaaGTALAAVGNSSPAA 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  250 ENDDRSGSSLEWNRDGSLRLGVQK----------GVLHDRRAdncSPVAEEETTGSAESVLPKAEPSAG--------DGP 311
Cdd:pfam17823  239 GTVTAAVGTVTPAALATLAAAAGTvasaagtinmGDPHARRL---SPAKHMPSDTMARNPAAPMGAQAQgpiiqvstDQP 315

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761661  312 V----PYPQSSGSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPwHNTaggRAPEVKARFAPYKPQEIL 383
Cdd:pfam17823  316 VhntaGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL-HTS---MIPEVEATSPTTQPSPLL 387
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1094-1234 5.04e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.07  E-value: 5.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAAVS-RAN-------------RRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQ 1159
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVPaRACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1160 GRTPLmvascegHLSTVEfllskgaALSSLDKEGLSalswaclkghRAVVQYLVEEGAEIDQTDK-------NGRTPLDL 1232
Cdd:TIGR00870  208 GNTLL-------HLLVME-------NEFKAEYEELS----------CQMYNFALSLLDKLRDSKElevilnhQGLTPLKL 263


                   ..
gi 1039761661 1233 AA 1234
Cdd:TIGR00870  264 AA 265
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 1352-1418 9.00e-04

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 44.52  E-value: 9.00e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761661 1352 SLYLNLSRCRRKTNDFGLAEEFASKALELKPkSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNN 1418
Cdd:PRK09782   577 ALYWWLHAQRYIPGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALELEPNN 642
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1225-1253 1.16e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.16e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039761661  1225 NGRTPLDLAAFYGDAETVLYLVEKGAVIE 1253
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1315-1427 3.08e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 3.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1315 YKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARA 1394
Cdd:TIGR02917  510 IQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY 576

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1039761661 1395 KRNSRQFLAALADLQEAVKLCPNNQEIKRLLAR 1427
Cdd:TIGR02917  577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
TPR_14 pfam13428
Tetratricopeptide repeat;
1386-1428 3.77e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 37.02  E-value: 3.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039761661 1386 EAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 982-1010 4.49e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.49e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039761661   982 NGMNALCYAAAAGHMKLVCLLIKKGARVD 1010
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1094-1310 3.10e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 186.31  E-value: 3.10e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1173
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1174 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1253
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761661 1254 HVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEE 1310
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1078-1289 8.07e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 182.08  E-value: 8.07e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1078 MAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSD 1157
Cdd:COG0666     71 LLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1158 KQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYG 1237
Cdd:COG0666    151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1238 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAA 1289
Cdd:COG0666    231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
948-1263 4.05e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 168.59  E-value: 4.05e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  948 LNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRG 1027
Cdd:COG0666     19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1028 HSDILQYLLncewsagppqpgtlrksqalqqaltaaasmghssvvqsllgmaeEHEIEVNGTDTlWGETALTAAAGRGKV 1107
Cdd:COG0666     99 DLEIVKLLL--------------------------------------------EAGADVNARDK-DGETPLHLAAYNGNL 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1108 EICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALS 1187
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761661 1188 SLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1263
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
915-1230 1.42e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 158.19  E-value: 1.42e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  915 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAG 994
Cdd:COG0666     19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  995 HMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLncewsagppqpgtlrksqalqqaltaaasmghssvvqs 1074
Cdd:COG0666     99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-------------------------------------- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1075 llgmaeEHEIEVNGTDTlWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVN 1154
Cdd:COG0666    141 ------EAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761661 1155 LSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPL 1230
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1075-1342 3.15e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.34  E-value: 3.15e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1075 LLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVN 1154
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1155 LSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAA 1234
Cdd:COG0666     82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAA 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1235 FYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGA------KLGNAA--WAMATSKPDILIILLQK 1306
Cdd:COG0666    162 ANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAdvnakdNDGKTAldLAAENGNLEIVKLLLEA 241

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1039761661 1307 LVEEGNVMYKKGKMKEAAQRYQYALRKFPREGLGED 1342
Cdd:COG0666    242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1107-1306 4.96e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 4.96e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1107 VEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAL 1186
Cdd:COG0666      1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1187 SSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1266
Cdd:COG0666     81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1039761661 1267 IGCRNTAVVVTLLRKGA------KLGNAA--WAMATSKPDILIILLQK 1306
Cdd:COG0666    161 AANGNLEIVKLLLEAGAdvnardNDGETPlhLAAENGHLEIVKLLLEA 208
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1107-1331 6.00e-24

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 107.06  E-value: 6.00e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1107 VEICELLLERGAAVSRANRRGVPPLFCAA--RQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVA--SCEGHLSTVEFLLSK 1182
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDK 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1183 GAALSSLDKeglsalswaclkghravVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRP 1262
Cdd:PHA03100   166 GVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761661 1263 LDRAIGCRNTAVVVTLLRKGaklgnaawamATSKPDILIILLQKLVEEGNVmyKKGKMKEAAQRYQYAL 1331
Cdd:PHA03100   229 LHIAILNNNKEIFKLLLNNG----------PSIKTIIETLLYFKDKDLNTI--TKIKMLKKSIMYMFLL 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1131-1223 3.12e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.49  E-value: 3.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1131 LFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAlsSLDKEGLSALSWACLKGHRAVVQ 1210
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039761661 1211 YLVEEGAEIDQTD 1223
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 921-1233 9.70e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.87  E-value: 9.70e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  921 RNLYTPNVKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLGHE---EVVTLLLEFGACLDGMSENGMNAL-CYAAAAG 994
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  995 HMKLVCLLIKKGARVDHLDKKGQCALvHSALRG---HSDILQYLLNcewsagppqpgtlrksqalqqaltaaasMGhssv 1071
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLR----------------------------KG---- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1072 vqsllgmaeeheIEVNGTDtLWGETALTA--AAGRGKVEICELLLERGAAVSRANRRGVPPL-----FCAARQGhwqVVR 1144
Cdd:PHA03095   143 ------------ADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLhhhlqSFKPRAR---IVR 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1145 LLLDRGCDVNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQT 1222
Cdd:PHA03095   207 ELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286

                          330
                   ....*....|.
gi 1039761661 1223 DKNGRTPLDLA 1233
Cdd:PHA03095   287 SSDGNTPLSLM 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1164-1256 3.49e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 3.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1164 LMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEgAEIDQTDkNGRTPLDLAAFYGDAETVL 1243
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039761661 1244 YLVEKGAVIEHVD 1256
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1098-1184 4.51e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 4.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1098 LTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRgCDVNLSDkQGRTPLMVASCEGHLSTVE 1177
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                   ....*..
gi 1039761661 1178 FLLSKGA 1184
Cdd:pfam12796   79 LLLEKGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 973-1289 2.58e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 86.94  E-value: 2.58e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  973 GACLDGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLL-NCEWSAGPPQPGTlr 1051
Cdd:PHA02874    25 GNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIdNGVDTSILPIPCI-- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1052 ksqalqqaltaaasmgHSSVVQSLLgmaeEHEIEVNGTDTLwGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPL 1131
Cdd:PHA02874   103 ----------------EKDMIKTIL----DCGIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPI 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1132 FCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKgHRAVVQY 1211
Cdd:PHA02874   162 HIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIEL 240

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761661 1212 LVEEgAEIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAA 1289
Cdd:PHA02874   241 LINN-ASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVLIKEA 318
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1107-1283 2.21e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 84.31  E-value: 2.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1107 VEICELLLERGAAVSRANRRGVPPLFCAARQGH-WQVVRLLLDRGCDVNLSDKQGRTPLMVASC--EGHLSTVEFLLSKG 1183
Cdd:PHA03095    63 KDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1184 AALSSLDKEGLSALSwACLKGHRA---VVQYLVEEGAEIDQTDKNGRTPL----------------------DLAAFYGD 1238
Cdd:PHA03095   143 ADVNALDLYGMTPLA-VLLKSRNAnveLLRLLIDAGADVYAVDDRFRSLLhhhlqsfkprarivreliragcDPAATDML 221

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1239 AETVLY---------------LVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGA 1283
Cdd:PHA03095   222 GNTPLHsmatgssckrslvlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1067-1157 4.21e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 4.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1067 GHSSVVQSLLgmaeEHEIEVNGTDTlWGETALTAAAGRGKVEICELLLERGAAvsRANRRGVPPLFCAARQGHWQVVRLL 1146
Cdd:pfam12796    8 GNLELVKLLL----ENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVKLL 80

                           90
                   ....*....|.
gi 1039761661 1147 LDRGCDVNLSD 1157
Cdd:pfam12796   81 LEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1197-1285 6.78e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 6.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1197 LSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVieHVDHSGMRPLDRAIGCRNTAVVV 1276
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78


                   ....*....
gi 1039761661 1277 TLLRKGAKL 1285
Cdd:pfam12796   79 LLLEKGADI 87
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1142-1285 7.22e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 7.22e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1142 VVRLLLDRGCDVNLSDKQGRTPL---MVASCEGHLSTVEFLLSKGAALSSLDKEGLSAL-SWACLKGHRAVVQYLVEEGA 1217
Cdd:PHA03095    29 EVRRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGA 108

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1218 EIDQTDKNGRTPLD--LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT--AVVVTLLRKGAKL 1285
Cdd:PHA03095   109 DVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLIDAGADV 180
Ank_2 pfam12796
Ankyrin repeats (3 copies);
987-1118 2.01e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 2.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  987 LCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNcewsagppqpgtlrksqalqqaltaaasm 1066
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------------------- 51

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1067 ghssvvqsllgmaeeheiEVNGTDTLWGETALTAAAGRGKVEICELLLERGA 1118
Cdd:pfam12796   52 ------------------HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGA 85
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1311-1428 3.89e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 3.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1311 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1390
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039761661 1391 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 869-1285 5.34e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.86  E-value: 5.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  869 LNRQQTMELGHHILKAhifkglskktGVSSSHLQALWIGYSTEGLSAALASLRNlytPNVKVSRLLILGGANVNYRtEVL 948
Cdd:PHA02876   112 LNKHKLDEACIHILKE----------AISGNDIHYDKINESIEYMKLIKERIQQ---DELLIAEMLLEGGADVNAK-DIY 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  949 NNAPILCVQSHlGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDhldkKGQCALVhSALRgH 1028
Cdd:PHA02876   178 CITPIHYAAER-GNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN----KNDLSLL-KAIR-N 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1029 SDILQYLLncEWSAGPPQPGTLRKSQALQQALTAAASMghSSVVQSLLgmaeEHEIEVNGTDtLWGETALTAAAGRG-KV 1107
Cdd:PHA02876   251 EDLETSLL--LYDAGFSVNSIDDCKNTPLHHASQAPSL--SRLVPKLL----ERGADVNAKN-IKGETPLYLMAKNGyDT 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1108 EICELLLERGAAVSRANRRGVPPLFCAARQGHWQ-VVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAL 1186
Cdd:PHA02876   322 ENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1187 SSLDKEGLSALSWA-CLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHSGMRPLD 1264
Cdd:PHA02876   402 EALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLL 481

                          410       420
                   ....*....|....*....|.
gi 1039761661 1265 RAIGCRntAVVVTLLRKGAKL 1285
Cdd:PHA02876   482 IALEYH--GIVNILLHYGAEL 500
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 963-1220 1.02e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 1.02e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  963 EEVVTLLLEFGACLDGMSENGMNALCYAAAAGH-----MKLVCLLIKKGARVDHLDKKGqcalvhsalrghSDILQYLLn 1037
Cdd:PHA03100    48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNG------------ITPLLYAI- 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1038 cewsagppqpgtlrksqalqqaltaAASMGHSSVVQSLLgmaeEHEIEVNgTDTLWGETALTAAA--GRGKVEICELLLE 1115
Cdd:PHA03100   115 -------------------------SKKSNSYSIVEYLL----DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLID 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1116 RGAAVSRANRrgvpplfcaarqghwqvVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLS 1195
Cdd:PHA03100   165 KGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                          250       260
                   ....*....|....*....|....*
gi 1039761661 1196 ALSWACLKGHRAVVQYLVEEGAEID 1220
Cdd:PHA03100   228 PLHIAILNNNKEIFKLLLNNGPSIK 252
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1311-1431 1.34e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 1.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1311 GNVMYKKGKMKEAAQRYQYALRKFPReglgedmrpfnelRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1390
Cdd:COG0457     49 GLAYLRLGRYEEALADYEQALELDPD-------------DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1039761661 1391 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEEE 1431
Cdd:COG0457    116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEK 156
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1283-1418 1.38e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.06  E-value: 1.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1283 AKLGNAAWAMATSKPDILIILLQKLVEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrV 1351
Cdd:COG4783      6 ALYALAQALLLAGDYDEAEALLEKALELdpdnpeafallGEILLQLGDLDEAIVLLHEALELDPDE-------------P 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761661 1352 SLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNN 1418
Cdd:COG4783     73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
Ank_2 pfam12796
Ankyrin repeats (3 copies);
961-1039 2.66e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 2.66e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761661  961 GHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIKKgARVDHLDkKGQCALVHSALRGHSDILQYLLNCE 1039
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1288-1425 3.09e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.48  E-value: 3.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1288 AAWAMATSKPDILIILLQKLVEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLN 1356
Cdd:COG3914     85 ALLLQALGRYEEALALYRRALALnpdnaealfnlGNLLLALGRLEEALAALRRALALNPDF-------------AEAYLN 151

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761661 1357 LSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLL 1425
Cdd:COG3914    152 LGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
PHA03095 PHA03095
ankyrin-like protein; Provisional
 907-1173 9.00e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.59  E-value: 9.00e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  907 GYSTEGLSAALASLRNLYTpnVKVSRLLILGGANVNYRTEVLNNApilcVQSHLG----HEEVVTLLLEFGACLDGMSEN 982
Cdd:PHA03095    78 APERCGFTPLHLYLYNATT--LDVIKLLIKAGADVNAKDKVGRTP----LHVYLSgfniNPKVIRLLLRKGADVNALDLY 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  983 GMNAL-CYAAAAG-HMKLVCLLIKKGARVDHLDKKGQCALVHsalrghsdILQYllncewsagppqpgtLRKSqalqqal 1060
Cdd:PHA03095   152 GMTPLaVLLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHH--------HLQS---------------FKPR------- 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1061 taaasmghSSVVQSLLgmaeEHEIEVNGTDTLwGETALTAAA--GRGKVEICELLLERGAAVSRANRRGVPPLFCAARQG 1138
Cdd:PHA03095   202 --------ARIVRELI----RAGCDPAATDML-GNTPLHSMAtgSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFN 268

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1039761661 1139 HWQVVRLLLDRGCDVNLSDKQGRTPL--MVASCEGHL 1173
Cdd:PHA03095   269 NPRACRRLIALGADINAVSSDGNTPLslMVRNNNGRA 305
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1300-1428 1.82e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.78  E-value: 1.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1300 LIILLQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALE 1379
Cdd:COG3914     74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPDN-------------AEALFNLGNLLLALGRLEEALAALRRALA 140

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1039761661 1380 LKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG3914    141 LNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1141-1290 1.94e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.29  E-value: 1.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1141 QVVRLLLDRGCDVNLSDK-QGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEI 1219
Cdd:PHA02878   148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039761661 1220 DQTDKNGRTPLDLAAFY-GDAETVLYLVEKGAVIEHVDH-SGMRPLDRAIgcRNTAVVVTLLRKGAKLGNAAW 1290
Cdd:PHA02878   228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLNS 298
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1311-1430 2.49e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 2.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1311 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1390
Cdd:COG4235     24 GRAYLRLGRYDEALAAYEKALRLDPDN-------------ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039761661 1391 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEE 1430
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1304-1431 3.08e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.21  E-value: 3.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1304 LQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPK 1383
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELDPDN-------------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1039761661 1384 SYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEEE 1431
Cdd:COG4783     71 EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1322-1431 4.28e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 4.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1322 EAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQF 1401
Cdd:COG4235      1 EAIARLRQALAANPND-------------AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT 67

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039761661 1402 LAALADLQEAVKLCPNNQEIKRLLARVEEE 1431
Cdd:COG4235     68 EEAEELLERALALDPDNPEALYLLGLAAFQ 97
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1313-1420 4.34e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 58.26  E-value: 4.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1313 VMYKKGKMKEAAQRYQYALRKFPREGlgedmrpfnelrvSLYLNLSRCRRKTNDFGLAEEFaSKALELKPKSYEAFYARA 1392
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNA-------------DALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLA 66

                           90       100
                   ....*....|....*....|....*...
gi 1039761661 1393 RAKRNSRQFLAALADLQEAVKLCPNNQE 1420
Cdd:COG3063     67 ELLLELGDYDEALAYLERALELDPSALR 94
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1098-1282 4.79e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 64.89  E-value: 4.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1098 LTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHlSTVE 1177
Cdd:PLN03192   529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH-HKIF 607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1178 FLLSKGAALSSLDKEGlSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVD- 1256
Cdd:PLN03192   608 RILYHFASISDPHAAG-DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANt 686

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1039761661 1257 HSGMRPLD-------RAIGCRNT------AVVVTLLRKG 1282
Cdd:PLN03192   687 DDDFSPTElrellqkRELGHSITivdsvpADEPDLGRDG 725
Ank_4 pfam13637
Ankyrin repeats (many copies);
1193-1246 4.80e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.51  E-value: 4.80e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761661 1193 GLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLV 1246
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1300-1428 7.56e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.59  E-value: 7.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1300 LIILLQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREGLGEDMRPFNELRVSLYLNLSRCRRKTNDFGLAEEFASKALE 1379
Cdd:COG5010      3 ALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1039761661 1380 LKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG5010     83 LDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAAL 131
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1095-1226 2.06e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.93  E-value: 2.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1095 ETALTAAAGRGKVEICELLLERGAAVSRA-NRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1173
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039761661 1174 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNG 1226
Cdd:PHA02875   149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG 201
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
536-1157 2.25e-09

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 62.51  E-value: 2.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  536 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTSLRNEQKIpeeeyIILIDGLNE--A 612
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEvpD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  613 EFHKPDYGDTLSSFITKiipkFPTwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSN 692
Cdd:COG5635    271 EADRDEVLNQLRRFLER----YPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEA 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  693 ISLNGKadaaliskvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFDRALP 771
Cdd:COG5635    345 LEENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLT 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  772 ILN-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMEALSCFLIKRRDKTRMFCHPSFRE 834
Cdd:COG5635    401 IYRelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  835 WLV-----WRADGESTAFL----CEPRnGHALLAFMFSRQESKLNRQQTMELGHHILKAHIFKGLSKKTGVSS--SHLQA 903
Cdd:COG5635    480 YLAaralvEELDEELLELLaehlEDPR-WREVLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLlaLALLA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  904 LWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENG 983
Cdd:COG5635    559 LLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLL 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  984 MNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQALQQALTAA 1063
Cdd:COG5635    639 LALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAALDL 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1064 ASMGHSSVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVV 1143
Cdd:COG5635    719 LLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLLL 798

                          650
                   ....*....|....
gi 1039761661 1144 RLLLDRGCDVNLSD 1157
Cdd:COG5635    799 ILLLVLLGSLLLLR 812
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1285-1416 2.30e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.05  E-value: 2.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1285 LGNAAWAMATSKPDILIILLQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREGlgedmrpfnelrvSLYLNLSRCRRKT 1364
Cdd:COG5010     35 NNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNP-------------ELYYNLALLYSRS 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1365 NDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCP 1416
Cdd:COG5010    102 GDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Ank_2 pfam12796
Ankyrin repeats (3 copies);
932-1013 2.73e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 2.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  932 RLLILGGANVNYRTEVLNNAPILCVQShlGHEEVVTLLLEFGACldGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDH 1011
Cdd:pfam12796   14 KLLLENGADANLQDKNGRTALHLAAKN--GHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89


                   ..
gi 1039761661 1012 LD 1013
Cdd:pfam12796   90 KD 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1301-1431 2.86e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 2.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1301 IILLQKLVEE-----------GNVMYKKGKMKEAAQRYQYALrkfpreglgeDMRPFNElrvSLYLNLSRCRRKTNDFGL 1369
Cdd:COG2956     62 IRIHQKLLERdpdraeallelAQDYLKAGLLDRAEELLEKLL----------ELDPDDA---EALRLLAEIYEQEGDWEK 128

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1370 AEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEEE 1431
Cdd:COG2956    129 AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLE 190
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1283-1420 3.18e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 3.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1283 AKLGNAAWAMATSKPDILIILLqklvEEGNVMYKKGKMKEAAQRYQYALRKFPReglgedmrpfnelRVSLYLNLSRCRR 1362
Cdd:COG4785     56 AALAAERIDRALALPDLAQLYY----ERGVAYDSLGDYDLAIADFDQALELDPD-------------LAEAYNNRGLAYL 118

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039761661 1363 KTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQE 1420
Cdd:COG4785    119 LLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPE 176
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1143-1226 4.47e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.45  E-value: 4.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1143 VRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQT 1222
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177


                   ....
gi 1039761661 1223 DKNG 1226
Cdd:PTZ00322   178 GANA 181
Ank_4 pfam13637
Ankyrin repeats (many copies);
1127-1180 6.23e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.43  E-value: 6.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761661 1127 GVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLL 1180
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
983-1036 8.36e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 8.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761661  983 GMNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLL 1036
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1081-1233 1.68e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 59.12  E-value: 1.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1081 EHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQG 1160
Cdd:PHA02878   155 SYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCG 234

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761661 1161 RTPLMVASceGHL---STVEFLLSKGA---ALSSLdkEGLSALSWAcLKGHRaVVQYLVEEGAEIDQTDKNGRTPLDLA 1233
Cdd:PHA02878   235 NTPLHISV--GYCkdyDILKLLLEHGVdvnAKSYI--LGLTALHSS-IKSER-KLKLLLEYGADINSLNSYKLTPLSSA 307
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1311-1411 3.47e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.55  E-value: 3.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1311 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1390
Cdd:COG0457     83 GLALQALGRYEEALEDYDKALELDPDD-------------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                           90       100
                   ....*....|....*....|.
gi 1039761661 1391 RARAKRNSRQFLAALADLQEA 1411
Cdd:COG0457    150 LGIALEKLGRYEEALELLEKL 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
1096-1147 4.33e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 4.33e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1096 TALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLL 1147
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1354-1428 4.62e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 4.62e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039761661 1354 YLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1107-1193 5.52e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 5.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1107 VEICEL-----------LLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLST 1175
Cdd:PTZ00322    84 VELCQLaasgdavgariLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163

                           90
                   ....*....|....*...
gi 1039761661 1176 VEFLLSKGAALSSLDKEG 1193
Cdd:PTZ00322   164 VQLLSRHSQCHFELGANA 181
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 925-1155 5.76e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 5.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  925 TPNVKVSRLLILGGANVNYrtEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIK 1004
Cdd:PHA02875    12 FGELDIARRLLDIGINPNF--EIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1005 KGARVDH-LDKKGQCALVHSALRGHSDILQYLLncEWSAGPPQPGTLRKSQAlqqaltaaasmgHSSVVQSLLGMAE--- 1080
Cdd:PHA02875    90 LGKFADDvFYKDGMTPLHLATILKKLDIMKLLI--ARGADPDIPNTDKFSPL------------HLAVMMGDIKGIElli 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761661 1081 EHEIEVNGTDTlWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHW-QVVRLLLDRGCDVNL 1155
Cdd:PHA02875   156 DHKACLDIEDC-CGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiDIVRLFIKRGADCNI 230
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1094-1283 5.91e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 5.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAaVSRANRRGV-PPLFCAARQGHWQVVRLLLDRGCDVN-LSDKQGRTPLMVASCEG 1171
Cdd:PHA02875    35 GISPIKLAMKFRDSEAIKLLMKHGA-IPDVKYPDIeSELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILK 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1172 HLSTVEFLLSKGA--ALSSLDKegLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKG 1249
Cdd:PHA02875   114 KLDIMKLLIARGAdpDIPNTDK--FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1039761661 1250 AVIEHVDHSG-MRPLDRAIGCRNTAVVVTLLRKGA 1283
Cdd:PHA02875   192 ANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGA 226
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1350-1428 9.73e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.89  E-value: 9.73e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761661 1350 RVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG4783      3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81
Ank_4 pfam13637
Ankyrin repeats (many copies);
952-1003 1.24e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 1.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761661  952 PILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLI 1003
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
1179-1233 1.24e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.04  E-value: 1.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761661 1179 LLSKG-AALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLA 1233
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
1160-1213 1.59e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 1.59e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761661 1160 GRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1213
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 1107-1235 2.50e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 53.28  E-value: 2.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1107 VEICELLLERGAAVSRANR-RGVPPLfcaarqGHW---------QVVRLLLDRGCDVNLSDKQGRTPLMV--ASCEGHLS 1174
Cdd:PHA02859    66 VEILKFLIENGADVNFKTRdNNLSAL------HHYlsfnknvepEILKILIDSGSSITEEDEDGKNLLHMymCNFNVRIN 139

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1175 TVEFLLSKGAALSSLDKEGLSAL-SWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAF 1235
Cdd:PHA02859   140 VIKLLIDSGVSFLNKDFDNNNILySYILFHSDKKIFDFLTSLGIDINETNKSGYNCYDLIKF 201
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1094-1218 3.73e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.61  E-value: 3.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1173
Cdd:PHA02875   102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDI 181

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039761661 1174 STVEFLLSKGAALSSLDKEG-LSALSWACLKGHRAVVQYLVEEGAE 1218
Cdd:PHA02875   182 AICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGAD 227
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1323-1421 3.78e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 53.00  E-value: 3.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1323 AAQRYQYALRKFPREGLGEDMRPFNELR----VSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNS 1398
Cdd:COG4785     41 LADLALALAAAALAAAALAAERIDRALAlpdlAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLL 120

                           90       100
                   ....*....|....*....|...
gi 1039761661 1399 RQFLAALADLQEAVKLCPNNQEI 1421
Cdd:COG4785    121 GDYDAALEDFDRALELDPDYAYA 143
PHA02946 PHA02946
ankyin-like protein; Provisional
 1111-1279 4.81e-07

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 54.29  E-value: 4.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1111 ELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAAL-S 1187
Cdd:PHA02946    56 EELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKInN 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1188 SLDKEGLSALsWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPL--DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDr 1265
Cdd:PHA02946   136 SVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLH- 213

                          170
                   ....*....|....
gi 1039761661 1266 aIGCRNTAVVVTLL 1279
Cdd:PHA02946   214 -IVCSKTVKNVDII 226
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1360-1431 5.05e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.40  E-value: 5.05e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1360 CRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALAdLQEAVKLCPNNQEIKRLLARVEEE 1431
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLE 71
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1094-1213 5.17e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 5.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAAVS---------RANRR-----GVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQ 1159
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039761661 1160 GRTPLMV--------ASCEghlsTVEFLLS--KGAALSSLD----KEGLSALSWACLKGHRAVVQYLV 1213
Cdd:cd22192    169 GNTVLHIlvlqpnktFACQ----MYDLILSydKEDDLQPLDlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1164-1245 5.32e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 5.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1164 LMVASCE----GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDA 1239
Cdd:PTZ00322    82 LTVELCQlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFR 161


                   ....*.
gi 1039761661 1240 ETVLYL 1245
Cdd:PTZ00322   162 EVVQLL 167
Ank_4 pfam13637
Ankyrin repeats (many copies);
1226-1279 6.94e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 6.94e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761661 1226 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLL 1279
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 109-383 6.95e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 54.20  E-value: 6.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  109 GSKPSEPSATEAKADNEPSCSPAAQElltrlgfllgegipSATHITIEDKNEAMV--MPEEEAAFPTCSACTLPCTALSQ 186
Cdd:pfam17823   94 GTDLSEPATREGAADGAASRALAAAA--------------SSSPSSAAQSLPAAIaaLPSEAFSAPRAAACRANASAAPR 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  187 GiSPCSTLTSSTASPSTDSPCSTLNSCVSKTAASKSPCETISSPSSTLE-----------------SKDSGIIATITSSS 249
Cdd:pfam17823  160 A-AIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTpargistaatatghpaaGTALAAVGNSSPAA 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  250 ENDDRSGSSLEWNRDGSLRLGVQK----------GVLHDRRAdncSPVAEEETTGSAESVLPKAEPSAG--------DGP 311
Cdd:pfam17823  239 GTVTAAVGTVTPAALATLAAAAGTvasaagtinmGDPHARRL---SPAKHMPSDTMARNPAAPMGAQAQgpiiqvstDQP 315

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761661  312 V----PYPQSSGSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPwHNTaggRAPEVKARFAPYKPQEIL 383
Cdd:pfam17823  316 VhntaGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL-HTS---MIPEVEATSPTTQPSPLL 387
Ank_5 pfam13857
Ankyrin repeats (many copies);
1113-1167 7.23e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 7.23e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761661 1113 LLERG-AAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVA 1167
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1315-1430 1.06e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.22  E-value: 1.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1315 YKKGKMKEAAQRYQYALRKFPReglgedmrpfNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSY---EAFYAR 1391
Cdd:COG1729      4 LKAGDYDEAIAAFKAFLKRYPN----------SPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLKL 73

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039761661 1392 ARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEE 1430
Cdd:COG1729     74 GLSYLELGDYDKARATLEELIKKYPDSEAAKEARARLAR 112
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1263-1433 1.39e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 1.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1263 LDRAIgcrntAVVVTLLRKGAKLGNAAWAMA-----TSKPDILIILLQKLVEE-----------GNVMYKKGKMKEAAQR 1326
Cdd:COG2956     92 LDRAE-----ELLEKLLELDPDDAEALRLLAeiyeqEGDWEKAIEVLERLLKLgpenahaycelAELYLEQGDYDEAIEA 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1327 YQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALA 1406
Cdd:COG2956    167 LEKALKLDPDC-------------ARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALE 233

                          170       180
                   ....*....|....*....|....*..
gi 1039761661 1407 DLQEAVKLCPNNqEIKRLLARVEEECK 1433
Cdd:COG2956    234 LLRKALELDPSD-DLLLALADLLERKE 259
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1065-1192 1.75e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.33  E-value: 1.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1065 SMGHSSVVQSLLgmaeEHEIEVNGTDtLWGETALTAAAGRGKVEICELLLERgAAVSRANRRGvpPLFC-AARQGHWQVV 1143
Cdd:PLN03192   567 SKGYEDCVLVLL----KHACNVHIRD-ANGNTALWNAISAKHHKIFRILYHF-ASISDPHAAG--DLLCtAAKRNDLTAM 638

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039761661 1144 RLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAL--SSLDKE 1192
Cdd:PLN03192   639 KELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdkANTDDD 689
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1311-1396 3.31e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 47.68  E-value: 3.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1311 GNVMYKKGKMKEAAQRYQYALRKFPReglgedmrpfNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1390
Cdd:COG1729     37 GEAYYALGDYDEAAEAFEKLLKRYPD----------SPKAPDALLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106


                   ....*.
gi 1039761661 1391 RARAKR 1396
Cdd:COG1729    107 RARLAR 112
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 925-1154 2.03e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 2.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  925 TPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKL--VCLL 1002
Cdd:PHA03100    83 TDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1003 IKKGARVDHLDKkgqcalvhsalrghsdiLQYLLncewsagppqpgtlrksqalqqaltaaasmghssvvqsllgmaeEH 1082
Cdd:PHA03100   163 IDKGVDINAKNR-----------------VNYLL--------------------------------------------SY 181

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761661 1083 EIEVNGTDtLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVN 1154
Cdd:PHA03100   182 GVPINIKD-VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1142-1258 3.87e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 48.29  E-value: 3.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1142 VVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLL---SKGAALSSLDKEGLSALSWACLKGHRA---VVQYLVEE 1215
Cdd:PHA02798    91 IVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLfmiENGADTTLLDKDGFTMLQVYLQSNHHIdieIIKLLLEK 170

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1039761661 1216 GAEIDQ-TDKNGRTPLDLAAFYG----DAETVLYLVEKGAVIEHVDHS 1258
Cdd:PHA02798   171 GVDINThNNKEKYDTLHCYFKYNidriDADILKLFVDNGFIINKENKS 218
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1131-1283 4.12e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 4.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1131 LFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1210
Cdd:PLN03192   529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039761661 1211 YLVEEGAEIDQtdKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGA 1283
Cdd:PLN03192   609 ILYHFASISDP--HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1071-1248 2.30e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 46.29  E-value: 2.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1071 VVQSLLGMAEEHEIE---VNGTDT---LWGETALTAAAGRGKVEICELLLERGAAVSrANRRGVppLFcaarqghwqvvr 1144
Cdd:cd22194    112 IVRILLAFAEENGILdrfINAEYTeeaYEGQTALNIAIERRQGDIVKLLIAKGADVN-AHAKGV--FF------------ 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1145 llldrgcdvNLSDKQ-----GRTPLMVASCEGHLSTVEFLLSKGAA-LSSLDKEG---LSALSWAC--LKGHRAVVQYLV 1213
Cdd:cd22194    177 ---------NPKYKHegfyfGETPLALAACTNQPEIVQLLMEKESTdITSQDSRGntvLHALVTVAedSKTQNDFVKRMY 247

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039761661 1214 E------EGAEIDQ-TDKNGRTPLDLAAFYGDAETVLYLVEK 1248
Cdd:cd22194    248 DmillksENKNLETiRNNEGLTPLQLAAKMGKAEILKYILSR 289
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1317-1428 2.67e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 2.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1317 KGKMKEAAQRYQYALRKFPReglgedmrpfnelRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKR 1396
Cdd:COG2956     21 NGQPDKAIDLLEEALELDPE-------------TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1039761661 1397 NSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG2956     88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1130-1158 2.71e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.71e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1039761661 1130 PLFCAA-RQGHWQVVRLLLDRGCDVNLSDK 1158
Cdd:pfam00023    5 PLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 920-1176 4.80e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 4.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  920 LRNLYTPNVKVSRLLI--LGGANVNYRTEVLNNAPILCVQShLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMK 997
Cdd:PLN03192   494 LKNFLQHHKELHDLNVgdLLGDNGGEHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYED 572

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  998 LVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLrksqalqqaltaaasmghssvvqsllg 1077
Cdd:PLN03192   573 CVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAAGDL--------------------------- 625

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1078 maeeheievngtdtlwgetaLTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDV---N 1154
Cdd:PLN03192   626 --------------------LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdkaN 685

                          250       260
                   ....*....|....*....|....*
gi 1039761661 1155 LSDKQGRTPL--MVASCE-GHLSTV 1176
Cdd:PLN03192   686 TDDDFSPTELreLLQKRElGHSITI 710
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1094-1234 5.04e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.07  E-value: 5.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1094 GETALTAAAGRGKVEICELLLERGAAVS-RAN-------------RRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQ 1159
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVPaRACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1160 GRTPLmvascegHLSTVEfllskgaALSSLDKEGLSalswaclkghRAVVQYLVEEGAEIDQTDK-------NGRTPLDL 1232
Cdd:TIGR00870  208 GNTLL-------HLLVME-------NEFKAEYEELS----------CQMYNFALSLLDKLRDSKElevilnhQGLTPLKL 263


                   ..
gi 1039761661 1233 AA 1234
Cdd:TIGR00870  264 AA 265
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1159-1191 6.14e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 6.14e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039761661 1159 QGRTPLMVASCE-GHLSTVEFLLSKGAALSSLDK 1191
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1089-1265 6.51e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.49  E-value: 6.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1089 TDTLW-GETALTAAAGRGKVEICELLLERGAAVS-RANRR------------GVPPLFCAARQGHWQVVRLLLDRGCD-- 1152
Cdd:cd21882     67 TDEFYqGQTALHIAIENRNLNLVRLLVENGADVSaRATGRffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQpa 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1153 -VNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRavvqylveegaeidqtdknGRTP 1229
Cdd:cd21882    147 aLEAQDSLGNTVLhaLVLQADNTPENSAFVCQMYNLLLSYGAHLDPTQQLEEIPNHQ-------------------GLTP 207

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1039761661 1230 LDLAAFYGDAETVLYLVEKGAviehvdHSGMRPLDR 1265
Cdd:cd21882    208 LKLAAVEGKIVMFQHILQREF------SGPYQPLSR 237
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 1352-1418 9.00e-04

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 44.52  E-value: 9.00e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761661 1352 SLYLNLSRCRRKTNDFGLAEEFASKALELKPkSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNN 1418
Cdd:PRK09782   577 ALYWWLHAQRYIPGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALELEPNN 642
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1225-1253 1.16e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.16e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039761661  1225 NGRTPLDLAAFYGDAETVLYLVEKGAVIE 1253
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1126-1154 1.25e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 1.25e-03
                           10        20
                   ....*....|....*....|....*....
gi 1039761661 1126 RGVPPLFCAARQGHWQVVRLLLDRGCDVN 1154
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1159-1184 1.34e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.34e-03
                            10        20
                    ....*....|....*....|....*.
gi 1039761661  1159 QGRTPLMVASCEGHLSTVEFLLSKGA 1184
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1209-1298 2.01e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1209 VQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNA 1288
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                           90
                   ....*....|
gi 1039761661 1289 AwamATSKPD 1298
Cdd:PTZ00322   178 G---ANAKPD 184
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1126-1155 2.04e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 2.04e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1039761661  1126 RGVPPLFCAARQGHWQVVRLLLDRGCDVNL 1155
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1130-1263 2.48e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 2.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1130 PLFCAARQGHWQVV-RLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAL------SSLdKEGLSALSWACL 1202
Cdd:cd22192     20 PLLLAAKENDVQAIkKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvnepmtSDL-YQGETALHIAVV 98

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039761661 1203 KGHRAVVQYLVEEGAEIDQ----------TDKN----GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1263
Cdd:cd22192     99 NQNLNLVRELIARGADVVSpratgtffrpGPKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1315-1427 3.08e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 3.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1315 YKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARA 1394
Cdd:TIGR02917  510 IQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY 576

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1039761661 1395 KRNSRQFLAALADLQEAVKLCPNNQEIKRLLAR 1427
Cdd:TIGR02917  577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1257-1429 3.46e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1257 HSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEE-----------GNVMYKKGKMKEAAQ 1325
Cdd:TIGR02917  135 YLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTAdpgnvdalllkGDLLLSLGNIELALA 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1326 RYQYALRkfpreglgedMRPFNelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAAL 1405
Cdd:TIGR02917  215 AYRKAIA----------LRPNN---IAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDAR 281

                          170       180
                   ....*....|....*....|....
gi 1039761661 1406 ADLQEAVKLCPNNQEIKRLLARVE 1429
Cdd:TIGR02917  282 ETLQDALKSAPEYLPALLLAGASE 305
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 1348-1428 3.75e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 41.43  E-value: 3.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661 1348 ELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFY-ARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLA 1426
Cdd:COG3071     47 EAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELAVLlTRAELLLDQGQAEQALATLEALRAGAPRHPQVLRLLL 126


                   ..
gi 1039761661 1427 RV 1428
Cdd:COG3071    127 QA 128
TPR_14 pfam13428
Tetratricopeptide repeat;
1386-1428 3.77e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 37.02  E-value: 3.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039761661 1386 EAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1378-1428 3.93e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 3.93e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039761661 1378 LELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1428
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLA 51
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 982-1010 4.49e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.49e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039761661   982 NGMNALCYAAAAGHMKLVCLLIKKGARVD 1010
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 982-1014 4.75e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 4.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039761661  982 NGMNALCYAAA-AGHMKLVCLLIKKGARVDHLDK 1014
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 926-1044 6.15e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 6.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761661  926 PNVKVSRLLILGGANVNYrTEVLNNAPILCVQSHlGHEEVVTLLLEFGACLDGMSENGMNALCYAAAA-GHMKLVCLLIK 1004
Cdd:PHA02878   179 KDQRLTELLLSYGANVNI-PDKTNNSPLHHAVKH-YNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLE 256

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039761661 1005 KGARVDHLDKKGQCALVHSALRGhSDILQYLLncEWSAGP 1044
Cdd:PHA02878   257 HGVDVNAKSYILGLTALHSSIKS-ERKLKLLL--EYGADI 293
TPR_12 pfam13424
Tetratricopeptide repeat;
1311-1383 6.26e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 6.26e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039761661 1311 GNVMYKKGKMKEAAQRYQYALRKFpREGLGEDmrpfNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPK 1383
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1225-1257 6.83e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 6.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039761661 1225 NGRTPLDLAA-FYGDAETVLYLVEKGAVIEHVDH 1257
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1094-1125 7.25e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 7.25e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039761661 1094 GETALTAAAGR-GKVEICELLLERGAAVSRANR 1125
Cdd:pfam00023    2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1192-1220 9.31e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 9.31e-03
                           10        20
                   ....*....|....*....|....*....
gi 1039761661 1192 EGLSALSWACLKGHRAVVQYLVEEGAEID 1220
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
1067-1114 9.70e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 9.70e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039761661 1067 GHSSVVQSLLgmaeEHEIEVNGTDtLWGETALTAAAGRGKVEICELLL 1114
Cdd:pfam13637   12 GHLELLRLLL----EKGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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