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Conserved domains on  [gi|1039762086|ref|XP_017174777|]
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collagen alpha-1(XX) chain isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 495-689 8.79e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member smart00210:

Pssm-ID: 473984  Cd Length: 184  Bit Score: 125.55  E-value: 8.79e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  495 GFDLMVAFGLVAKEYASIRGVAMEPSalgvVPTFTLFKDAQLMRRVSDIYPATLPPEHTIVFLVRLlpeTPREAFALWQM 574
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPG----SPAYRLGDPALVPQPTRDLFPSGLPEDFSLLTTFRQ---TPKSRGVLFAI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  575 MAEDFQPILGVLLDAGRKSLTYFNHDSRAALQEVTFDlqdAKKIFFGSFHKVHIAVGHSKVRLYVDCRKVAERPIGDAGS 654
Cdd:smart00210  74 YDAQNVRQFGLEVDGRANTLLLRYQGVDGKQHTVSFR---NLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1039762086  655 PP--TGGFITLGRLAKARGPrsssATFQLQMLQIVCS 689
Cdd:smart00210 151 PPidTDGIEVRGAQAADRKP----FQGDLQQLKIVCD 183
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 740-876 5.12e-15

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 78.41  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 740 GPPGQQGHPGPKGEPGPPGQTGPEGPGGQQGSPGTQG----RAVQGPMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGL 815
Cdd:NF038329  126 GPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGpagpQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGE 205

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039762086 816 QGPKGMRGL--EGPAGLPGPPGPRGFQGLAGARGTNGERGAPGAVGPTGLPGSKGERGEKGEP 876
Cdd:NF038329  206 QGPAGPAGPdgEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEA 268
fn3 pfam00041
Fibronectin type III domain;
405-473 8.72e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 8.72e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039762086 405 TPNSLQVNWTPP---SGHVLHYRLNYTLASGSGPEKSISVPGTRSHAVLRDLMSATKYRVLVSAVYRAGESM 473
Cdd:pfam00041  12 TSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
fn3 pfam00041
Fibronectin type III domain;
289-365 5.97e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 5.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 289 PSPGQLSVMELPGDAVKLSWLA-TALSGVLV-YQIKWMPLGEGKA-REISVPGTLGTATLPGLMKHVEYEITILAYYRDG 365
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPpPDGNGPITgYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
fn3 pfam00041
Fibronectin type III domain;
128-196 2.21e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 2.21e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039762086 128 GPPRHLTFSDVRYNSTCVSWEA----QRPVRLVKVSYISSDGSHSGQTQ-VPGNLTSATLGPLSSSTMYTVRVT 196
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
47-111 1.18e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039762086  47 AVTPRTLHVTW-PPSAG---VTQYLVQYLLATSTGEEQKREVHVGQPEVLLDGLEPGQDYDVSVQSLRG 111
Cdd:pfam00041  10 DVTSTSLTVSWtPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 495-689 8.79e-33

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 125.55  E-value: 8.79e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  495 GFDLMVAFGLVAKEYASIRGVAMEPSalgvVPTFTLFKDAQLMRRVSDIYPATLPPEHTIVFLVRLlpeTPREAFALWQM 574
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPG----SPAYRLGDPALVPQPTRDLFPSGLPEDFSLLTTFRQ---TPKSRGVLFAI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  575 MAEDFQPILGVLLDAGRKSLTYFNHDSRAALQEVTFDlqdAKKIFFGSFHKVHIAVGHSKVRLYVDCRKVAERPIGDAGS 654
Cdd:smart00210  74 YDAQNVRQFGLEVDGRANTLLLRYQGVDGKQHTVSFR---NLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1039762086  655 PP--TGGFITLGRLAKARGPrsssATFQLQMLQIVCS 689
Cdd:smart00210 151 PPidTDGIEVRGAQAADRKP----FQGDLQQLKIVCD 183
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 740-876 5.12e-15

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 78.41  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 740 GPPGQQGHPGPKGEPGPPGQTGPEGPGGQQGSPGTQG----RAVQGPMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGL 815
Cdd:NF038329  126 GPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGpagpQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGE 205

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039762086 816 QGPKGMRGL--EGPAGLPGPPGPRGFQGLAGARGTNGERGAPGAVGPTGLPGSKGERGEKGEP 876
Cdd:NF038329  206 QGPAGPAGPdgEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEA 268
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 777-876 5.08e-14

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 75.33  E-value: 5.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 777 RAVQGPMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGLQGPKGMRGLEGPaglpgppgprgfQGLAGARGTNGERGAPG 856
Cdd:NF038329  119 KGEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGE------------AGPQGPAGKDGEAGAKG 186

                          90       100
                  ....*....|....*....|
gi 1039762086 857 AVGPTGLPGSKGERGEKGEP 876
Cdd:NF038329  187 PAGEKGPQGPRGETGPAGEQ 206
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 702-876 2.73e-12

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 69.93  E-value: 2.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 702 PALRDGETCPAFPSAcaysseTPGPPGPQGPPGLPGRNGPPGQQGHPGPKGEPGPPGQTGPEGPGGQQGSPGTQGRAVQG 781
Cdd:NF038329  163 PAGPQGEAGPQGPAG------KDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQG 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 782 PMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGLQGPKGMRGLEGPAglpgppgprgfqGLAGARGTNGERGAPGAVGP- 860
Cdd:NF038329  237 PDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGKDGERGPV------------GPAGKDGQNGKDGLPGKDGKd 304

                         170
                  ....*....|....*...
gi 1039762086 861 --TGLPGSKGERGEKGEP 876
Cdd:NF038329  305 gqNGKDGLPGKDGKDGQP 322
fn3 pfam00041
Fibronectin type III domain;
405-473 8.72e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 8.72e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039762086 405 TPNSLQVNWTPP---SGHVLHYRLNYTLASGSGPEKSISVPGTRSHAVLRDLMSATKYRVLVSAVYRAGESM 473
Cdd:pfam00041  12 TSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 405-472 4.59e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 4.59e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039762086 405 TPNSLQVNWTPPS---GHVLHYRLNYTLASGSGPEKSISVPGTRSHAVLRDLMSATKYRVLVSAVYRAGES 472
Cdd:cd00063    13 TSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 405-472 2.37e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 2.37e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039762086  405 TPNSLQVNWTPPS-----GHVLHYRLNYTlaSGSGPEKSISVPGTRSHAVLRDLMSATKYRVLVSAVYRAGES 472
Cdd:smart00060  13 TSTSVTLSWEPPPddgitGYIVGYRVEYR--EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
289-365 5.97e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 5.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 289 PSPGQLSVMELPGDAVKLSWLA-TALSGVLV-YQIKWMPLGEGKA-REISVPGTLGTATLPGLMKHVEYEITILAYYRDG 365
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPpPDGNGPITgYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
fn3 pfam00041
Fibronectin type III domain;
128-196 2.21e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 2.21e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039762086 128 GPPRHLTFSDVRYNSTCVSWEA----QRPVRLVKVSYISSDGSHSGQTQ-VPGNLTSATLGPLSSSTMYTVRVT 196
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQ 74
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 808-876 7.46e-08

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 49.80  E-value: 7.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039762086 808 GIPGKTGLQGPKGMRGlegpagLPgppgprgfqGLAGARGTNGERGAPGAVGPTGLPGSKGERGEKGEP 876
Cdd:pfam01391   1 GPPGPPGPPGPPGPPG------PP---------GPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAP 54
fn3 pfam00041
Fibronectin type III domain;
47-111 1.18e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039762086  47 AVTPRTLHVTW-PPSAG---VTQYLVQYLLATSTGEEQKREVHVGQPEVLLDGLEPGQDYDVSVQSLRG 111
Cdd:pfam00041  10 DVTSTSLTVSWtPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 47-107 1.78e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 1.78e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039762086   47 AVTPRTLHVTW--PPSAGVTQYLVQYLLATSTGEEQKREVHV--GQPEVLLDGLEPGQDYDVSVQ 107
Cdd:smart00060  11 DVTSTSVTLSWepPPDDGITGYIVGYRVEYREEGSEWKEVNVtpSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 47-124 4.07e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 4.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  47 AVTPRTLHVTWPPSAG----VTQYLVQYLLATSTGEEQKREVHVGQPEVLLDGLEPGQDYDVSVQSLRGPEASE-VQSIR 121
Cdd:cd00063    11 DVTSTSVTLSWTPPEDdggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPpSESVT 90


                  ...
gi 1039762086 122 ART 124
Cdd:cd00063    91 VTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 291-372 6.14e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 6.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 291 PGQLSVMELPGDAVKLSWLATALSG--VLVYQIKWMPLGEGKAREISV-PGTLGTATLPGLMKHVEYEITILAYYRDGtR 367
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG-E 82


                  ....*
gi 1039762086 368 SDPVS 372
Cdd:cd00063    83 SPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
288-492 7.80e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.08  E-value: 7.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 288 APS-PGQLSVMELPGDAVKLSWLATALSGVLVYQIKWMPLGEGKAREI-SVPGTlgTATLPGLMKHVEYEITILAYYRDG 365
Cdd:COG3401   232 PPSaPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVaTVTTT--SYTDTGLTNGTTYYYRVTAVDAAG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 366 TRSDP---VSLryTPLLNSTLPCHWIAAASrsppsslalssETPNSLQVNWTPPSG-HVLHYRLnYTLASGSGPEKSISV 441
Cdd:COG3401   310 NESAPsnvVSV--TTDLTPPAAPSGLTATA-----------VGSSSITLSWTASSDaDVTGYNV-YRSTSGGGTYTKIAE 375

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039762086 442 PGTRSHAVLRDLMSATKYRVLVSAVYRAGESMAVSATYR---TAACPALHPDSS 492
Cdd:COG3401   376 TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSattASAASGESLTAS 429
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 128-204 7.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 7.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  128 GPPRHLTFSDVRYNSTCVSWE--AQRPVRLVKVSYISSDGSHSGQTQ---VPGNLTSATLGPLSSSTMYTVRVTCFYLGG 202
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEppPDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                   ..
gi 1039762086  203 GS 204
Cdd:smart00060  82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 128-213 1.07e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 128 GPPRHLTFSDVRYNSTCVSWEA----QRPVRLVKVSYISSDGSHSGQ-TQVPGNLTSATLGPLSSSTMYTVRVTCFYLGG 202
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPpeddGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 1039762086 203 -GSSVLTGHVTT 213
Cdd:cd00063    82 eSPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 289-365 1.07e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  289 PSPGQLSVMELPGDAVKLSWLATALSGVLVYQIKWMPLGEGKA---REISVPGTLGTATLPGLMKHVEYEITILAYYRDG 365
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 781-823 1.01e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 42.58  E-value: 1.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1039762086 781 GPMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGLQGPKGMRG 823
Cdd:NF038329  293 GKDGLPGKDGKDGQNGKDGLPGKDGKDGQPGKDGLPGKDGKDG 335
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 495-689 8.79e-33

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 125.55  E-value: 8.79e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  495 GFDLMVAFGLVAKEYASIRGVAMEPSalgvVPTFTLFKDAQLMRRVSDIYPATLPPEHTIVFLVRLlpeTPREAFALWQM 574
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPG----SPAYRLGDPALVPQPTRDLFPSGLPEDFSLLTTFRQ---TPKSRGVLFAI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  575 MAEDFQPILGVLLDAGRKSLTYFNHDSRAALQEVTFDlqdAKKIFFGSFHKVHIAVGHSKVRLYVDCRKVAERPIGDAGS 654
Cdd:smart00210  74 YDAQNVRQFGLEVDGRANTLLLRYQGVDGKQHTVSFR---NLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1039762086  655 PP--TGGFITLGRLAKARGPrsssATFQLQMLQIVCS 689
Cdd:smart00210 151 PPidTDGIEVRGAQAADRKP----FQGDLQQLKIVCD 183
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 740-876 5.12e-15

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 78.41  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 740 GPPGQQGHPGPKGEPGPPGQTGPEGPGGQQGSPGTQG----RAVQGPMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGL 815
Cdd:NF038329  126 GPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGpagpQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGE 205

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039762086 816 QGPKGMRGL--EGPAGLPGPPGPRGFQGLAGARGTNGERGAPGAVGPTGLPGSKGERGEKGEP 876
Cdd:NF038329  206 QGPAGPAGPdgEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEA 268
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 777-876 5.08e-14

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 75.33  E-value: 5.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 777 RAVQGPMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGLQGPKGMRGLEGPaglpgppgprgfQGLAGARGTNGERGAPG 856
Cdd:NF038329  119 KGEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGE------------AGPQGPAGKDGEAGAKG 186

                          90       100
                  ....*....|....*....|
gi 1039762086 857 AVGPTGLPGSKGERGEKGEP 876
Cdd:NF038329  187 PAGEKGPQGPRGETGPAGEQ 206
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 702-876 2.73e-12

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 69.93  E-value: 2.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 702 PALRDGETCPAFPSAcaysseTPGPPGPQGPPGLPGRNGPPGQQGHPGPKGEPGPPGQTGPEGPGGQQGSPGTQGRAVQG 781
Cdd:NF038329  163 PAGPQGEAGPQGPAG------KDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQG 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 782 PMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGLQGPKGMRGLEGPAglpgppgprgfqGLAGARGTNGERGAPGAVGP- 860
Cdd:NF038329  237 PDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGKDGERGPV------------GPAGKDGQNGKDGLPGKDGKd 304

                         170
                  ....*....|....*...
gi 1039762086 861 --TGLPGSKGERGEKGEP 876
Cdd:NF038329  305 gqNGKDGLPGKDGKDGQP 322
fn3 pfam00041
Fibronectin type III domain;
405-473 8.72e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 8.72e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039762086 405 TPNSLQVNWTPP---SGHVLHYRLNYTLASGSGPEKSISVPGTRSHAVLRDLMSATKYRVLVSAVYRAGESM 473
Cdd:pfam00041  12 TSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 405-472 4.59e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 4.59e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039762086 405 TPNSLQVNWTPPS---GHVLHYRLNYTLASGSGPEKSISVPGTRSHAVLRDLMSATKYRVLVSAVYRAGES 472
Cdd:cd00063    13 TSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 405-472 2.37e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 2.37e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039762086  405 TPNSLQVNWTPPS-----GHVLHYRLNYTlaSGSGPEKSISVPGTRSHAVLRDLMSATKYRVLVSAVYRAGES 472
Cdd:smart00060  13 TSTSVTLSWEPPPddgitGYIVGYRVEYR--EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
289-365 5.97e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 5.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 289 PSPGQLSVMELPGDAVKLSWLA-TALSGVLV-YQIKWMPLGEGKA-REISVPGTLGTATLPGLMKHVEYEITILAYYRDG 365
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPpPDGNGPITgYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
fn3 pfam00041
Fibronectin type III domain;
128-196 2.21e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 2.21e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039762086 128 GPPRHLTFSDVRYNSTCVSWEA----QRPVRLVKVSYISSDGSHSGQTQ-VPGNLTSATLGPLSSSTMYTVRVT 196
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQ 74
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 808-876 7.46e-08

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 49.80  E-value: 7.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039762086 808 GIPGKTGLQGPKGMRGlegpagLPgppgprgfqGLAGARGTNGERGAPGAVGPTGLPGSKGERGEKGEP 876
Cdd:pfam01391   1 GPPGPPGPPGPPGPPG------PP---------GPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAP 54
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 780-823 1.03e-07

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 49.41  E-value: 1.03e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1039762086 780 QGPMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGLQGPKGMRG 823
Cdd:pfam01391   9 PGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPG 52
fn3 pfam00041
Fibronectin type III domain;
47-111 1.18e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039762086  47 AVTPRTLHVTW-PPSAG---VTQYLVQYLLATSTGEEQKREVHVGQPEVLLDGLEPGQDYDVSVQSLRG 111
Cdd:pfam00041  10 DVTSTSLTVSWtPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 47-107 1.78e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 1.78e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039762086   47 AVTPRTLHVTW--PPSAGVTQYLVQYLLATSTGEEQKREVHV--GQPEVLLDGLEPGQDYDVSVQ 107
Cdd:smart00060  11 DVTSTSVTLSWepPPDDGITGYIVGYRVEYREEGSEWKEVNVtpSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 47-124 4.07e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 4.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  47 AVTPRTLHVTWPPSAG----VTQYLVQYLLATSTGEEQKREVHVGQPEVLLDGLEPGQDYDVSVQSLRGPEASE-VQSIR 121
Cdd:cd00063    11 DVTSTSVTLSWTPPEDdggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPpSESVT 90


                  ...
gi 1039762086 122 ART 124
Cdd:cd00063    91 VTT 93
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 780-876 5.29e-07

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 5.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 780 QGPMGPPGAKGEKgdqglsglqglsGQQGIPGKTGLQGPKgmrglegpaglpgppgprgfqglagargtnGERGAPGAVG 859
Cdd:pfam01391   3 PGPPGPPGPPGPP------------GPPGPPGPPGPPGPP------------------------------GEPGPPGPPG 40

                          90
                  ....*....|....*..
gi 1039762086 860 PTGLPGSKGERGEKGEP 876
Cdd:pfam01391  41 PPGPPGPPGAPGAPGPP 57
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 291-372 6.14e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 6.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 291 PGQLSVMELPGDAVKLSWLATALSG--VLVYQIKWMPLGEGKAREISV-PGTLGTATLPGLMKHVEYEITILAYYRDGtR 367
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG-E 82


                  ....*
gi 1039762086 368 SDPVS 372
Cdd:cd00063    83 SPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
288-492 7.80e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.08  E-value: 7.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 288 APS-PGQLSVMELPGDAVKLSWLATALSGVLVYQIKWMPLGEGKAREI-SVPGTlgTATLPGLMKHVEYEITILAYYRDG 365
Cdd:COG3401   232 PPSaPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVaTVTTT--SYTDTGLTNGTTYYYRVTAVDAAG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 366 TRSDP---VSLryTPLLNSTLPCHWIAAASrsppsslalssETPNSLQVNWTPPSG-HVLHYRLnYTLASGSGPEKSISV 441
Cdd:COG3401   310 NESAPsnvVSV--TTDLTPPAAPSGLTATA-----------VGSSSITLSWTASSDaDVTGYNV-YRSTSGGGTYTKIAE 375

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039762086 442 PGTRSHAVLRDLMSATKYRVLVSAVYRAGESMAVSATYR---TAACPALHPDSS 492
Cdd:COG3401   376 TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSattASAASGESLTAS 429
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 128-204 7.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 7.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  128 GPPRHLTFSDVRYNSTCVSWE--AQRPVRLVKVSYISSDGSHSGQTQ---VPGNLTSATLGPLSSSTMYTVRVTCFYLGG 202
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEppPDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                   ..
gi 1039762086  203 GS 204
Cdd:smart00060  82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 128-213 1.07e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 128 GPPRHLTFSDVRYNSTCVSWEA----QRPVRLVKVSYISSDGSHSGQ-TQVPGNLTSATLGPLSSSTMYTVRVTCFYLGG 202
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPpeddGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 1039762086 203 -GSSVLTGHVTT 213
Cdd:cd00063    82 eSPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 289-365 1.07e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  289 PSPGQLSVMELPGDAVKLSWLATALSGVLVYQIKWMPLGEGKA---REISVPGTLGTATLPGLMKHVEYEITILAYYRDG 365
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 781-823 1.01e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 42.58  E-value: 1.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1039762086 781 GPMGPPGAKGEKGDQGLSGLQGLSGQQGIPGKTGLQGPKGMRG 823
Cdd:NF038329  293 GKDGLPGKDGKDGQNGKDGLPGKDGKDGQPGKDGLPGKDGKDG 335
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
47-235 5.09e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.76  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086  47 AVTPRTLHVTWPPSA--GVTQYLVQYllATSTGEEQKREVHVGQPEVLLDGLEPGQDYDVSVQSL--RGPE--ASEVQSI 120
Cdd:COG3401   243 ADTPGSVTLSWDPVTesDATGYRVYR--SNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNEsaPSNVVSV 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039762086 121 RARTSALGPPRHLTFSDVRYNSTCVSWEAQRPVRLvkVSYI-----SSDGSHSGQTQVPGNlTSATLGPLSSSTMYTVRV 195
Cdd:COG3401   321 TTDLTPPAAPSGLTATAVGSSSITLSWTASSDADV--TGYNvyrstSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKV 397

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1039762086 196 TCFYLGGGSS----VLTGHVTTRESAKSRLGCSWTVPLCPTEGP 235
Cdd:COG3401   398 TAVDAAGNESapseEVSATTASAASGESLTASVDAVPLTDVAGA 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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