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Conserved domains on  [gi|1039764483|ref|XP_017175100|]
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leucine-rich repeat-containing protein 31 isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 64-331 3.58e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 79.32  E-value: 3.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  64 ETASILPLLSDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRL--TTEDVQTLGGALEMTPELEELSLSWNSq 141
Cdd:cd00116    14 RATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNA- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 142 VGGKLPRVLHTFQQGSKIRTLELVDCALTSQDGVFVGHLLPKLQ-SLQVFDLSNNRNIGSCLEVIAQGLRSASGLKELKL 220
Cdd:cd00116    93 LGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 221 RSCGLSQKSIRLLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKHLEVLDLHQCSLT-AGDVTSLTQIIPLLSNL 299
Cdd:cd00116   173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTdAGAAALASALLSPNISL 252

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1039764483 300 EELDLSSNrDVGGSSENLLCrlRFLPALKSLL 331
Cdd:cd00116   253 LTLSLSCN-DITDDGAKDLA--EVLAEKESLL 281
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 64-331 3.58e-16

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 79.32  E-value: 3.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  64 ETASILPLLSDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRL--TTEDVQTLGGALEMTPELEELSLSWNSq 141
Cdd:cd00116    14 RATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNA- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 142 VGGKLPRVLHTFQQGSKIRTLELVDCALTSQDGVFVGHLLPKLQ-SLQVFDLSNNRNIGSCLEVIAQGLRSASGLKELKL 220
Cdd:cd00116    93 LGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 221 RSCGLSQKSIRLLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKHLEVLDLHQCSLT-AGDVTSLTQIIPLLSNL 299
Cdd:cd00116   173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTdAGAAALASALLSPNISL 252

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1039764483 300 EELDLSSNrDVGGSSENLLCrlRFLPALKSLL 331
Cdd:cd00116   253 LTLSLSCN-DITDDGAKDLA--EVLAEKESLL 281
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-470 1.18e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  50 LDLNSYGLTAVDVKETASILPLLSDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEMTP 129
Cdd:COG4886    17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 130 ELEELSLSWNSqvggklprvlhTFQQGSKIRTLELVDCALTSqdgvfVGHLLPKLQSLQVFDLSNNRnigscLEVIAQGL 209
Cdd:COG4886    97 NLTELDLSGNE-----------ELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQ-----LTDLPEPL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 210 RSASGLKELKLRSCGLSQksirlLDGVFASLDVLRILDLSCNKelgggFEDVPAQLASLKHLEVLDLHQCSLTagdvtSL 289
Cdd:COG4886   156 GNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQ-----ITDLPEPLGNLTNLEELDLSGNQLT-----DL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 290 TQIIPLLSNLEELDLSSNRDVGgssenlLCRLRFLPALKSLLINSCALQSeafaaLDASVYLPALEILNLSWNKCVGGNL 369
Cdd:COG4886   221 PEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKL 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 370 ELLQQTLHLSRLLRVLRLSSCSLVTEDVVLLASVIQSGHLATLQKLDLSYNDGICDAGWAILCQNLCFLKELTELDISLR 449
Cdd:COG4886   290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369

                         410       420
                  ....*....|....*....|.
gi 1039764483 450 PSSSQDCGQWFSHLLCAVTQL 470
Cdd:COG4886   370 GLLGLLEATLLTLALLLLTLL 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-317 1.54e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 101 NKLKVLRLSSCRLTTEDVQTLGGALEMTpeleELSLSWNSqVGGKLPRVLHTFQQGSKIRTlelvdcaltsQDGVFVGHL 180
Cdd:PLN00113  356 NNLTVLDLSTNNLTGEIPEGLCSSGNLF----KLILFSNS-LEGEIPKSLGACRSLRRVRL----------QDNSFSGEL 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 181 ---LPKLQSLQVFDLSNNR---NIGS------CLEVIAQGLRSASG-----LKELKLRSCGLSQKSIR-LLDGVFASLDV 242
Cdd:PLN00113  421 pseFTKLPLVYFLDISNNNlqgRINSrkwdmpSLQMLSLARNKFFGglpdsFGSKRLENLDLSRNQFSgAVPRKLGSLSE 500

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039764483 243 LRILDLSCNKELGggfeDVPAQLASLKHLEVLDLHQCSLTaGDVTSLTQIIPLLSnleELDLSSNRDVGGSSENL 317
Cdd:PLN00113  501 LMQLKLSENKLSG----EIPDELSSCKKLVSLDLSHNQLS-GQIPASFSEMPVLS---QLDLSQNQLSGEIPKNL 567
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 64-331 3.58e-16

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 79.32  E-value: 3.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  64 ETASILPLLSDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRL--TTEDVQTLGGALEMTPELEELSLSWNSq 141
Cdd:cd00116    14 RATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNA- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 142 VGGKLPRVLHTFQQGSKIRTLELVDCALTSQDGVFVGHLLPKLQ-SLQVFDLSNNRNIGSCLEVIAQGLRSASGLKELKL 220
Cdd:cd00116    93 LGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 221 RSCGLSQKSIRLLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKHLEVLDLHQCSLT-AGDVTSLTQIIPLLSNL 299
Cdd:cd00116   173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTdAGAAALASALLSPNISL 252

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1039764483 300 EELDLSSNrDVGGSSENLLCrlRFLPALKSLL 331
Cdd:cd00116   253 LTLSLSCN-DITDDGAKDLA--EVLAEKESLL 281
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-470 1.18e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  50 LDLNSYGLTAVDVKETASILPLLSDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEMTP 129
Cdd:COG4886    17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 130 ELEELSLSWNSqvggklprvlhTFQQGSKIRTLELVDCALTSqdgvfVGHLLPKLQSLQVFDLSNNRnigscLEVIAQGL 209
Cdd:COG4886    97 NLTELDLSGNE-----------ELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQ-----LTDLPEPL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 210 RSASGLKELKLRSCGLSQksirlLDGVFASLDVLRILDLSCNKelgggFEDVPAQLASLKHLEVLDLHQCSLTagdvtSL 289
Cdd:COG4886   156 GNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQ-----ITDLPEPLGNLTNLEELDLSGNQLT-----DL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 290 TQIIPLLSNLEELDLSSNRDVGgssenlLCRLRFLPALKSLLINSCALQSeafaaLDASVYLPALEILNLSWNKCVGGNL 369
Cdd:COG4886   221 PEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKL 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 370 ELLQQTLHLSRLLRVLRLSSCSLVTEDVVLLASVIQSGHLATLQKLDLSYNDGICDAGWAILCQNLCFLKELTELDISLR 449
Cdd:COG4886   290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369

                         410       420
                  ....*....|....*....|.
gi 1039764483 450 PSSSQDCGQWFSHLLCAVTQL 470
Cdd:COG4886   370 GLLGLLEATLLTLALLLLTLL 390
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 73-281 1.18e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 72.00  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  73 SDLEELDVSWNDFARGALHMLTQQM-HPVNKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELSLSWNSQVGGKLPRVLH 151
Cdd:cd00116   108 SSLQELKLNNNGLGDRGLRLLAKGLkDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAE 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 152 TFQQGSKIRTLELVDCALTSQDGVFVGHLLPKLQSLQVFDLSNNrNIGS-CLEVIAQGLRS-ASGLKELKLRSCGLSQKS 229
Cdd:cd00116   188 GLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDN-NLTDaGAAALASALLSpNISLLTLSLSCNDITDDG 266

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039764483 230 IRLLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKH-LEVLDLHQCSL 281
Cdd:cd00116   267 AKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 177-470 9.17e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.14  E-value: 9.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 177 VGHLLPKLQSLQVFDLSNNRNIGSCLEVIAQGLRSASGLKELKLRS--CGLSQKSIRLLDGVFASLDVLRILDLSCNKEL 254
Cdd:cd00116    15 ATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLneTGRIPRGLQSLLQGLTKGCGLQELDLSDNALG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 255 GGGFEDVPAqLASLKHLEVLDLHQCSL-TAGDVTSLTQIIPLLSNLEELDLSSNRDVGGSSENLLCRLRFLPALKSLLIN 333
Cdd:cd00116    95 PDGCGVLES-LLRSSSLQELKLNNNGLgDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 334 SCALQSEAFAAL-DASVYLPALEILNLSWNKCVGGNLELLQQTLHLSRLLRVLRLSSCSLVTEDVVLLASVIQSGhLATL 412
Cdd:cd00116   174 NNGIGDAGIRALaEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSP-NISL 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039764483 413 QKLDLSYNDgICDAGWAILCQNLCFLKELTELDISLRPSSSQDCGQWFSHLLCAVTQL 470
Cdd:cd00116   253 LTLSLSCND-ITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 60-363 1.60e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.64  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  60 VDVKETASILPLLSDLEELDVSWNDFArgALHMLTQQMHPVNKLKVLRLS--SCRLTTEDV--QTLGGALEMTPELEELS 135
Cdd:COG5238    54 QSRSSITQYLRFEGQGDPGLNPVALEK--AAEAFPTQLLVVDWEGAEEVSpvALAETATAVatPPPDLRRIMAKTLEDSL 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 136 LSWNSQVGGK-LPRVLHTFQQGSKIrTLELVDCALTSQDGVFVGHLLpKLQSLQVFDLSNNRNIGSCLEVIAQGLRSASG 214
Cdd:COG5238   132 ILYLALPRRInLIQVLKDPLGGNAV-HLLGLAARLGLLAAISMAKAL-QNNSVETVYLGCNQIGDEGIEELAEALTQNTT 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 215 LKELKLRSCGLSQKSIRLLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKHLEVLDLHQCSLTAGDVTSLTQIIP 294
Cdd:COG5238   210 VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 295 LLSNLEELDLSSNRDVGGSSENLLCRLRFLPALKSLLINSCALQSEAFAALDASV-YLPALEILNLSWNK 363
Cdd:COG5238   290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALqENTTLHSLDLSDNQ 359
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 101-307 2.85e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 101 NKLKVLRLSSCRLTTEDVQTLGGALEMTPELEELSLsWNSQVGGK-LPRVLHTFQQGSKIRTLELVDCALTSQDGVFVGH 179
Cdd:COG5238   180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWL-KRNPIGDEgAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 180 LLPKLQSLQVFDLSNNRNIGSCLEVIAQGLRSASGLKELKLRSCGLSQKSIRLLDGVFASLDVLRILDLSCNKELGGGFE 259
Cdd:COG5238   259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAI 338

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1039764483 260 DVPAQLASLKHLEVLDLHQCSLTAGDVTSLTQIIPLLSNLEELDLSSN 307
Cdd:COG5238   339 ALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKN 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 184-307 3.62e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 3.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 184 LQSLQVFDLSNNRnIgSCLEviaqGLRSASGLKELKLrscgLSQksiRLLDG---------VFASLDVLRILDLSCNKEl 254
Cdd:cd21340    67 LVNLKKLYLGGNR-I-SVVE----GLENLTNLEELHI----ENQ---RLPPGekltfdprsLAALSNSLRVLNISGNNI- 132

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039764483 255 gggfeDVPAQLASLKHLEVLDLHQCSLTagDVTSLTQIIPLLSNLEELDLSSN 307
Cdd:cd21340   133 -----DSLEPLAPLRNLEQLDASNNQIS--DLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-317 1.54e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 101 NKLKVLRLSSCRLTTEDVQTLGGALEMTpeleELSLSWNSqVGGKLPRVLHTFQQGSKIRTlelvdcaltsQDGVFVGHL 180
Cdd:PLN00113  356 NNLTVLDLSTNNLTGEIPEGLCSSGNLF----KLILFSNS-LEGEIPKSLGACRSLRRVRL----------QDNSFSGEL 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 181 ---LPKLQSLQVFDLSNNR---NIGS------CLEVIAQGLRSASG-----LKELKLRSCGLSQKSIR-LLDGVFASLDV 242
Cdd:PLN00113  421 pseFTKLPLVYFLDISNNNlqgRINSrkwdmpSLQMLSLARNKFFGglpdsFGSKRLENLDLSRNQFSgAVPRKLGSLSE 500

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039764483 243 LRILDLSCNKELGggfeDVPAQLASLKHLEVLDLHQCSLTaGDVTSLTQIIPLLSnleELDLSSNRDVGGSSENL 317
Cdd:PLN00113  501 LMQLKLSENKLSG----EIPDELSSCKKLVSLDLSHNQLS-GQIPASFSEMPVLS---QLDLSQNQLSGEIPKNL 567
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 48-272 2.27e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  48 TGLDLNSYGLTAVDVKETASILPLLSDLEELDVSWNDFARGALHMLTQQMHPVNKLKVLRLSSCRLTTEDVQTLGGALEM 127
Cdd:COG5238   211 TTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQG 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 128 TPELEELSLSWNsQVGGKLPRVL-HTFQQGSKIRTLELVDCALTSQDGVFVGHLLPKLQSLQVFDLSNNRNIGSCLEVIA 206
Cdd:COG5238   291 NTTLTSLDLSVN-RIGDEGAIALaEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALA 369

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039764483 207 QGLRSASGLKELKLRSCGLS-QKSIRLLDGVfaSLDVLRILDLSCNkELGGGFEDVPAQLasLKHLE 272
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGkQGAEALIDAL--QTNRLHTLILDGN-LIGAEAQQRLEQL--LERIK 431
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-333 4.84e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483  50 LDLNSYGLTAVDvketaSILPLLSDLEELDVSWNDFARgalhmLTQQMHPVNKLKVLRLSSCRLTTedvqtLGGALEMTP 129
Cdd:COG4886   141 LDLSNNQLTDLP-----EPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLT 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 130 ELEELSLSwNSQVGgKLPRVLHTFqqgSKIRTLELVDCALTSQDGvfvghlLPKLQSLQVFDLSNNR--NIGSCLEViaq 207
Cdd:COG4886   206 NLEELDLS-GNQLT-DLPEPLANL---TNLETLDLSNNQLTDLPE------LGNLTNLEELDLSNNQltDLPPLANL--- 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 208 glrsaSGLKELKLRSCGLSQKSIRLLDGVFASLDVLRILDLSCNKELGGGFEDVPAQLASLKHLEVLDLHQCSLTAGDVT 287
Cdd:COG4886   272 -----TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1039764483 288 SLTQIIPLLSNLEELDLSSNRDVGGSSENLLCRLRFLPALKSLLIN 333
Cdd:COG4886   347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-367 5.79e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 5.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 100 VNKLKVLRLSSCRLTTEDVQTLGgalEMTpELEELSLSWNSqVGGKLPRVLhtfQQGSKIRTLELVDCALTSQDGVFVGH 179
Cdd:PLN00113  187 LTSLEFLTLASNQLVGQIPRELG---QMK-SLKWIYLGYNN-LSGEIPYEI---GGLTSLNHLDLVYNNLTGPIPSSLGN 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 180 L----------------LPK----LQSLQVFDLSNNRNIGSCLEVIAQglrsASGLKELKLRSCGLSQKsirlLDGVFAS 239
Cdd:PLN00113  259 LknlqylflyqnklsgpIPPsifsLQKLISLDLSDNSLSGEIPELVIQ----LQNLEILHLFSNNFTGK----IPVALTS 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764483 240 LDVLRILDLSCNKELGGgfedVPAQLASLKHLEVLDLHQCSLT---------AGDVTSLT--------QIIPLLS---NL 299
Cdd:PLN00113  331 LPRLQVLQLWSNKFSGE----IPKNLGKHNNLTVLDLSTNNLTgeipeglcsSGNLFKLIlfsnslegEIPKSLGacrSL 406

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039764483 300 EELDLSSNrdvgGSSENLLCRLRFLPALKSLLINSCALQSEafaaLDASVY-LPALEILNLSWNKCVGG 367
Cdd:PLN00113  407 RRVRLQDN----SFSGELPSEFTKLPLVYFLDISNNNLQGR----INSRKWdMPSLQMLSLARNKFFGG 467
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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