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Conserved domains on  [gi|1039766293|ref|XP_017175387|]
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dyslexia-associated protein KIAA0319-like protein isoform X2 [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 20244047)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; similar to Mus musculus dyslexia-associated protein KIAA0319-like protein

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779
SCOP:  4003198

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 383-765 4.85e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 148.65  E-value: 4.85e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  383 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 453
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  454 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 532
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  533 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 609
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  610 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 686
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  687 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 764
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 1039766293  765 R 765
Cdd:NF038112  1562 R 1562
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 869-889 8.80e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.80e-03
                           10        20
                   ....*....|....*....|.
gi 1039766293  869 CSDHGHCDSFTKRCVCDPFWM 889
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 383-765 4.85e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 148.65  E-value: 4.85e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  383 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 453
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  454 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 532
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  533 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 609
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  610 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 686
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  687 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 764
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 1039766293  765 R 765
Cdd:NF038112  1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 261-671 2.59e-31

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 133.24  E-value: 2.59e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  261 PSYSYATPTP---QASSQSTSAPHPVVkelvvSAGKSVQItLPKNEVQLN--AFVLPEaepGETYTYDWqlithpTDYSG 335
Cdd:NF038112  1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSFDPD---GDPLTYAW------TQVSG 1228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  336 -EVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQNAHGEGYVNVTVKpepRKNRPPVAVVSPQfQEISLPTTSTIiDG 408
Cdd:NF038112  1229 pAVTLTGADTATPSFTAPEVTAdtvltFQLVVsDGTKTSAPDTVTVLVR---NVNRAPVAVAGAP-ATVDERSTVTL-DG 1303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  409 SQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDGaTNSTTASLTVN-KAVDYPPVAN 484
Cdd:NF038112  1304 SGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDG-TASATDTVTVTvRNVNRAPVAN 1379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  485 AGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSA---MQEGDYTYQLTVTdtAGQQA 561
Cdd:NF038112  1380 AGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVS--ADGQA 1453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  562 TAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSTDDQRVVSYLWEQSRGPdGVQLENANSSVATVTGLQVG- 639
Cdd:NF038112  1454 SADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAPEVSa 1531

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1039766293  640 --TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 671
Cdd:NF038112  1532 dtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 267-578 5.46e-18

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 90.10  E-value: 5.46e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  267 TPTPQASSQSTSAPHPVVKELVVSAG------KSVQITLPK---------------NE---VQLNAFVlpEAEPGETYTY 322
Cdd:NF038112  1238 TATPSFTAPEVTADTVLTFQLVVSDGtktsapDTVTVLVRNvnrapvavagapatvDErstVTLDGSG--TDADGDALTY 1315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  323 DWQLITHPTdysgeVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQnAHGEGYVNVTVKPeprKNRPPVAVVSPQfQE 396
Cdd:NF038112  1316 AWTQTSGPA-----VTLTGATTATATFTAPEVTAdtqltFTLTVsDGT-ASATDTVTVTVRN---VNRAPVANAGAD-QT 1385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  397 ISLPTTSTIiDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLTVVDSDGATNSTTASLTV 473
Cdd:NF038112  1386 VDERSTVTL-SGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLTVSADGQASADVTVTVTV 1463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  474 NKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSAMQEG---DYTYQ 550
Cdd:NF038112  1464 RN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAKLTFTAPEVSadtTLTFS 1538

                          330       340
                   ....*....|....*....|....*...
gi 1039766293  551 LTVTDTAGQQATAQVTVIVQPENNKPPQ 578
Cdd:NF038112  1539 LTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 668-758 3.62e-09

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 54.58  E-value: 3.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  668 NKPPVAKIAGNVVVTlPTSTAELDGSRSSD-DKGIVSYLWTRDETSPAAGEVLNHSDHHPvlflsnlveGTYTFHLKVTD 746
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 1039766293  747 AKG---ESDTDRTTV 758
Cdd:pfam18911   71 DSGasnSTATDTVTV 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
451-753 3.53e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 3.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  451 YTFSLTVVDSDGATN-STTASLTVNKAvdyPPVANAGPNQVITLPqNSITLfgN-QSTDDHGITSYEWSLSPSSKGKVVE 528
Cdd:COG3401    205 YYYRVAATDTGGESApSNEVSVTTPTT---PPSAPTGLTATADTP-GSVTL--SwDPVTESDATGYRVYRSNSGDGPFTK 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  529 MQGVRTPALQLSAMQEG-DYTYQLTVTDTAGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSTDDQrV 607
Cdd:COG3401    279 VATVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDAD-V 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  608 VSYLWEQSRGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTL 683
Cdd:COG3401    356 TGYNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPL 435

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  684 PTSTAELDGSRSSDDKGIVSYLWTRDETSPAAGEVLNHSDHHPVlflsNLVEGTYTFHLKVTDAKGESDT 753
Cdd:COG3401    436 TDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA----TTTDTTTANLSVTTGSLVGGSG 501
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 482-570 9.97e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 9.97e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293   482 VANAGPNQVITLPQNSITlFGNQSTDDHGITSYEWSLS--PSSKGKVVEMQGVRtpalqlsamqEGDYTYQLTVTDTAGq 559
Cdd:smart00089    1 VADVSASPTVGVAGESVT-FTATSSDDGSIVSYTWDFGdgTSSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 1039766293   560 QATAQVTVIVQ 570
Cdd:smart00089   69 SASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 671-760 1.46e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.02  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  671 PVAKIAGNVVVTLPTStAELDGSRSSDDKgIVSYLWTRdetspaaGEVLNHSDHHPVLFLSNLVEGTYTFHLKVTDAKGE 750
Cdd:cd00146      1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDF-------GDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                           90
                   ....*....|
gi 1039766293  751 SDTDRTTVEV 760
Cdd:cd00146     72 SSTKTTTVVV 81
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 869-889 8.80e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.80e-03
                           10        20
                   ....*....|....*....|.
gi 1039766293  869 CSDHGHCDSFTKRCVCDPFWM 889
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 383-765 4.85e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 148.65  E-value: 4.85e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  383 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 453
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  454 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 532
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  533 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 609
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  610 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 686
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  687 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 764
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 1039766293  765 R 765
Cdd:NF038112  1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 261-671 2.59e-31

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 133.24  E-value: 2.59e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  261 PSYSYATPTP---QASSQSTSAPHPVVkelvvSAGKSVQItLPKNEVQLN--AFVLPEaepGETYTYDWqlithpTDYSG 335
Cdd:NF038112  1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSFDPD---GDPLTYAW------TQVSG 1228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  336 -EVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQNAHGEGYVNVTVKpepRKNRPPVAVVSPQfQEISLPTTSTIiDG 408
Cdd:NF038112  1229 pAVTLTGADTATPSFTAPEVTAdtvltFQLVVsDGTKTSAPDTVTVLVR---NVNRAPVAVAGAP-ATVDERSTVTL-DG 1303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  409 SQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDGaTNSTTASLTVN-KAVDYPPVAN 484
Cdd:NF038112  1304 SGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDG-TASATDTVTVTvRNVNRAPVAN 1379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  485 AGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSA---MQEGDYTYQLTVTdtAGQQA 561
Cdd:NF038112  1380 AGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVS--ADGQA 1453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  562 TAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSTDDQRVVSYLWEQSRGPdGVQLENANSSVATVTGLQVG- 639
Cdd:NF038112  1454 SADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAPEVSa 1531

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1039766293  640 --TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 671
Cdd:NF038112  1532 dtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 267-578 5.46e-18

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 90.10  E-value: 5.46e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  267 TPTPQASSQSTSAPHPVVKELVVSAG------KSVQITLPK---------------NE---VQLNAFVlpEAEPGETYTY 322
Cdd:NF038112  1238 TATPSFTAPEVTADTVLTFQLVVSDGtktsapDTVTVLVRNvnrapvavagapatvDErstVTLDGSG--TDADGDALTY 1315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  323 DWQLITHPTdysgeVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQnAHGEGYVNVTVKPeprKNRPPVAVVSPQfQE 396
Cdd:NF038112  1316 AWTQTSGPA-----VTLTGATTATATFTAPEVTAdtqltFTLTVsDGT-ASATDTVTVTVRN---VNRAPVANAGAD-QT 1385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  397 ISLPTTSTIiDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLTVVDSDGATNSTTASLTV 473
Cdd:NF038112  1386 VDERSTVTL-SGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLTVSADGQASADVTVTVTV 1463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  474 NKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSAMQEG---DYTYQ 550
Cdd:NF038112  1464 RN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAKLTFTAPEVSadtTLTFS 1538

                          330       340
                   ....*....|....*....|....*...
gi 1039766293  551 LTVTDTAGQQATAQVTVIVQPENNKPPQ 578
Cdd:NF038112  1539 LTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 668-758 3.62e-09

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 54.58  E-value: 3.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  668 NKPPVAKIAGNVVVTlPTSTAELDGSRSSD-DKGIVSYLWTRDETSPAAGEVLNHSDHHPvlflsnlveGTYTFHLKVTD 746
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 1039766293  747 AKG---ESDTDRTTV 758
Cdd:pfam18911   71 DSGasnSTATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 480-567 7.08e-07

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 48.04  E-value: 7.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  480 PPVANAGPNQVITLPQnSITLFGNQSTD-DHGITSYEWSLS--PSSKGKVVemqgVRTpalqlsAMQEGDYTYQLTVTDT 556
Cdd:pfam18911    3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGdgTTATGANV----SHT------YAAPGTYTVTLTVTDD 71

                           90
                   ....*....|....
gi 1039766293  557 AGQQ---ATAQVTV 567
Cdd:pfam18911   72 SGASnstATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 574-663 1.64e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.88  E-value: 1.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  574 NKPPQADAGPDKELTlPVDSTTLDGSKSTD-DQRVVSYLWEQSrgpDGvqlenanssvATVTGLQV-------GTYVFTL 645
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFG---DG----------TTATGANVshtyaapGTYTVTL 66

                           90
                   ....*....|....*...
gi 1039766293  646 TVKDERNLQSQSSVNVIV 663
Cdd:pfam18911   67 TVTDDSGASNSTATDTVT 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
451-753 3.53e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 3.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  451 YTFSLTVVDSDGATN-STTASLTVNKAvdyPPVANAGPNQVITLPqNSITLfgN-QSTDDHGITSYEWSLSPSSKGKVVE 528
Cdd:COG3401    205 YYYRVAATDTGGESApSNEVSVTTPTT---PPSAPTGLTATADTP-GSVTL--SwDPVTESDATGYRVYRSNSGDGPFTK 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  529 MQGVRTPALQLSAMQEG-DYTYQLTVTDTAGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSTDDQrV 607
Cdd:COG3401    279 VATVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDAD-V 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  608 VSYLWEQSRGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTL 683
Cdd:COG3401    356 TGYNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPL 435

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  684 PTSTAELDGSRSSDDKGIVSYLWTRDETSPAAGEVLNHSDHHPVlflsNLVEGTYTFHLKVTDAKGESDT 753
Cdd:COG3401    436 TDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA----TTTDTTTANLSVTTGSLVGGSG 501
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 482-570 9.97e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 9.97e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293   482 VANAGPNQVITLPQNSITlFGNQSTDDHGITSYEWSLS--PSSKGKVVEMQGVRtpalqlsamqEGDYTYQLTVTDTAGq 559
Cdd:smart00089    1 VADVSASPTVGVAGESVT-FTATSSDDGSIVSYTWDFGdgTSSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 1039766293   560 QATAQVTVIVQ 570
Cdd:smart00089   69 SASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 671-760 1.46e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.02  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  671 PVAKIAGNVVVTLPTStAELDGSRSSDDKgIVSYLWTRdetspaaGEVLNHSDHHPVLFLSNLVEGTYTFHLKVTDAKGE 750
Cdd:cd00146      1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDF-------GDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                           90
                   ....*....|
gi 1039766293  751 SDTDRTTVEV 760
Cdd:cd00146     72 SSTKTTTVVV 81
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 438-671 2.43e-05

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 47.88  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  438 TAILKLSKLVPGNYTFSLTVVDSDGATNSTTASLTVN-KAVDYPPVANAGPNQVITLpQNSITLFGNQSTD------DHG 510
Cdd:pfam02010   42 QLTIPSGTLPYGTYVFTLTVSLSSTPSLAGTDIITVTvQPSPLVAVIDGGSSRVVGY-NQDLTLDGSESYDpdvdpgSSS 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  511 ITSYEWS---------LSPSSKGKVVE------MQGVRTPALQLSA-MQEGDYTYQ--LTVTDTAGQQATAQVTVIVQPE 572
Cdd:pfam02010  121 GLTYLWScrrsssgdnPLLNNDPVCFSdqnegtLLQSTSSSLTIPAsTLQANVTYTfkLTVSKGSRNSASTTQTILVVDG 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  573 NnkPPQAD---AGPDKELTLPVDSTTLDGSKSTDDQRV---VSYLWE-QSRGPDGVQLENANSSVATVTG---------- 635
Cdd:pfam02010  201 N--PPIIIlscISNCNRKNNPVDRLVLLASTCLNCSSDlsdVTYRWLsLGSENTSLVLDQLNSQTSTGRSgpylvikagv 278

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1039766293  636 LQVGT-YVFTLTVKDeRNLQSQSSVNVIVKeeINKPP 671
Cdd:pfam02010  279 LQSGVsYRFTLIVTV-YPGLVSGLASISFI--TNAPP 312
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 672-761 3.20e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.21  E-value: 3.20e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293   672 VAKIAGNVVVTLPTSTAELDGSrSSDDKGIVSYLWTRDETSPAAGEVLNHSdhhpvlFLSnlvEGTYTFHLKVTDAKGeS 751
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGTSSTGPTVTHT------YTK---PGTYTVTLTVTNAVG-S 69

                            90
                    ....*....|
gi 1039766293   752 DTDRTTVEVK 761
Cdd:smart00089   70 ASATVTVVVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 387-473 3.39e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.21  E-value: 3.39e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293   387 VAVVSPQFQEISLPTTSTIIDgsQSTDDDKIVQYHWEELKGPLREEKisedTAILKLSKlvPGNYTFSLTVVDSDGaTNS 466
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGP----TVTHTYTK--PGTYTVTLTVTNAVG-SAS 71


                    ....*..
gi 1039766293   467 TTASLTV 473
Cdd:smart00089   72 ATVTVVV 78
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 344-690 6.78e-05

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 46.73  E-value: 6.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  344 SLQLSKLTPGLYEFKVTV---DGQNAHGEGYVNVTVKPEPRknrppVAVVSPQfQEISLPTTSTII-DGSQSTDDDK--- 416
Cdd:pfam02010   44 TIPSGTLPYGTYVFTLTVslsSTPSLAGTDIITVTVQPSPL-----VAVIDGG-SSRVVGYNQDLTlDGSESYDPDVdpg 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  417 ---IVQYHWEELKGPLREEKISEDTA-----------------ILKL--SKLVPG-NYTFSLTVVDSDGATNSTTASLTV 473
Cdd:pfam02010  118 sssGLTYLWSCRRSSSGDNPLLNNDPvcfsdqnegtllqstssSLTIpaSTLQANvTYTFKLTVSKGSRNSASTTQTILV 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  474 nkaVDYPP-------VANAGPnqvITLPQNSITLFGNQSTDDHGITS---YEWSLSPSSKGKVVE-------MQGVRTPA 536
Cdd:pfam02010  198 ---VDGNPpiiilscISNCNR---KNNPVDRLVLLASTCLNCSSDLSdvtYRWLSLGSENTSLVLdqlnsqtSTGRSGPY 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  537 LQLSA--MQEG-DYTYQLTVTDTAGQ-QATAQVTVIvqpeNNKPPQ---ADAGPDKELTLpVDSTTLDGSKSTDDQRVVS 609
Cdd:pfam02010  272 LVIKAgvLQSGvSYRFTLIVTVYPGLvSGLASISFI----TNAPPTggtCSVTPTEGTAL-ETKFTVTCQGWTDDDLPLT 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  610 Y----LWEQSRGPDGVQLENANSSVATVTGLQVGT----YVFTL--TVKDerNLQSQSSVNVIVKeeinkppvakiagnv 679
Cdd:pfam02010  347 YqfgdISFREASEEWFLLYEGSSQISISTFLPPGLpandYQVTVvvVVYD--SLGAATSVSLTIT--------------- 409

                          410
                   ....*....|.
gi 1039766293  680 vVTLPTSTAEL 690
Cdd:pfam02010  410 -VTPPSSSDEL 419
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
448-713 9.23e-05

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 45.82  E-value: 9.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  448 PGNYTFSLTVVDSDGATNSTTASLTVNKAVDYPPVA--NAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGK 525
Cdd:COG3291     49 PGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVttSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGG 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  526 VVEMQGVRTPALQLSAMQEGDYTYQLTVTDTAGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSTDDQ 605
Cdd:COG3291    129 GTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTA 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  606 RVVSYlWEQSRGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTLPT 685
Cdd:COG3291    209 GVTTG-ATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGG 287

                          250       260
                   ....*....|....*....|....*...
gi 1039766293  686 STAELDGSRSSDDKGIVSYLWTRDETSP 713
Cdd:COG3291    288 LGTTTAITPGNVSTTADVTGGTATLAVS 315
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 481-569 2.58e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 40.56  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  481 PVANAGPNQVITLPQnSITLFGNqSTDDHGITSYEWSLSpsskGKVVEMQGVRTPalQLSAMQEGDYTYQLTVTDTAGQQ 560
Cdd:cd00146      1 PTASVSAPPVAELGA-SVTFSAS-DSSGGSIVSYKWDFG----DGEVSSSGEPTV--THTYTKPGTYTVTLTVTNAVGSS 72


                   ....*....
gi 1039766293  561 ATAQVTVIV 569
Cdd:cd00146     73 STKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 579-664 5.22e-04

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 39.74  E-value: 5.22e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293   579 ADAGPDKELTLPVDSTTLDGSkSTDDQRVVSYLWEQsrgPDGVQLENANssvATVTGLQVGTYVFTLTVKDErNLQSQSS 658
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDF---GDGTSSTGPT---VTHTYTKPGTYTVTLTVTNA-VGSASAT 73


                    ....*.
gi 1039766293   659 VNVIVK 664
Cdd:smart00089   74 VTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 601-663 8.68e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 39.02  E-value: 8.68e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039766293  601 STDDQRVVSYLWeqSRGPDGVQLENAnsSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIV 663
Cdd:cd00146     23 DSSGGSIVSYKW--DFGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
Big_13 pfam19077
Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in ...
 457-567 6.88e-03

Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in bacterial cell surface proteins.


Pssm-ID: 465968 [Multi-domain]  Cd Length: 102  Bit Score: 37.25  E-value: 6.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  457 VVDSDGATNSTTASLTVnKAVDyppvanagpNQVITLpqnSITLFGNQST-----DDHGItsyeWSLSPSSkgkvvemqg 531
Cdd:pfam19077   17 VSDSDNITNDTTPTFTG-TNED---------GDVVTV---TVSIDGNGVTgtataGADGN----WSFTPPA--------- 70

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039766293  532 vrtpalqlsAMQEGDYTYQLTVTDTAGQQATA---QVTV 567
Cdd:pfam19077   71 ---------ALADGTYTLTVTVTDIAGNTATSsplSFTI 100
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 869-889 8.80e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.80e-03
                           10        20
                   ....*....|....*....|.
gi 1039766293  869 CSDHGHCDSFTKRCVCDPFWM 889
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 385-473 8.87e-03

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 36.32  E-value: 8.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766293  385 PPVAVVSPQFQEISLPTTSTIidgsQSTDDDKIVQYHWEELKGPLreekISEDTAILKLSKLVPGNYTFSLTVVDSDGAT 464
Cdd:cd00146      1 PTASVSAPPVAELGASVTFSA----SDSSGGSIVSYKWDFGDGEV----SSSGEPTVTHTYTKPGTYTVTLTVTNAVGSS 72


                   ....*....
gi 1039766293  465 NSTTASLTV 473
Cdd:cd00146     73 STKTTTVVV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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