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Conserved domains on  [gi|1039767769|ref|XP_017175712|]
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myomesin-3 isoform X1 [Mus musculus]

Protein Classification

Ig and FN3 domain-containing protein( domain architecture ID 10307510)

Ig and FN3 domain-containing protein similar to Homo sapiens contactins, which are comprised of six immunoglobulin (Ig)-like domains followed by four fibronectin type III (Fn3) domains anchored to the membrane by glycosylphosphatidylinositol, and to Robo (roundabout) receptors which typically contain five Ig-like domains and three FN3 domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
437-709 3.92e-32

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 133.97  E-value: 3.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  437 GLVEGQSYQFRVRAISKAGTSLPSKASEAVVtgdydavhksteipydlgskitiskndfedAVTIPSAPTNVHASEIREA 516
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTT------------------------------PTTPPSAPTGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  517 YAVLSWEEPrPRGRApLTYTLEKSVIGSGTWEAISTetpIKSPRFALLDLEKGKSYVFRVRALNQYGmsDPSEPSEPVAL 596
Cdd:COG3401    248 SVTLSWDPV-TESDA-TGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNGTTYYYRVTAVDAAG--NESAPSNVVSV 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  597 KGKPATLPPPAQVQAFRNTQTSVSLAWEPVDgGSELLGYYIYSREAGASEWQTVnNKPIQDTKFTVPGLRTGKEYDFCIR 676
Cdd:COG3401    321 TTDLTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRSTSGGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVT 398

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1039767769  677 SVSEAgvGESSAATQPVRVKQALATPSAPYDFA 709
Cdd:COG3401    399 AVDAA--GNESAPSEEVSATTASAASGESLTAS 429
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 154-248 2.39e-26

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20951:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 94  Bit Score: 104.04  E-value: 2.39e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPRLFPaGKYRITNNYGLLTLEIMRCTVEDSATYTVLVK 233
Cdd:cd20951      1 PEFIIRLQSHTVWEKSDAKLRVEVQGKPDPEVKWYKNGVPIDPSSIP-GKYKIESEYGVHVLHIRRVTVEDSAVYSAVAK 79

                           90
                   ....*....|....*
gi 1039767769  234 NAYGQASSFAKVLIR 248
Cdd:cd20951     80 NIHGEASSSASVVVE 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-893 2.27e-25

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 101.03  E-value: 2.27e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  804 PGPPYDVRVSEVQATSVMLQWEPPLYIGaGPVTGYHVSFQEKGSEEWKPVTPDATSDTHLRVSDLQPGKQYMFRVQAMNS 883
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDG-GPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|
gi 1039767769  884 AGLGQPSVPT 893
Cdd:cd00063     80 GGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 374-467 3.35e-20

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 86.40  E-value: 3.35e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  374 PGSPLNVRCLNVHRDCLTLTWVPPSDTrGSTITGYSIEMCQGDSEEWMPCLKAPGGTCRCPIQGLVEGQSYQFRVRAISK 453
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDD-GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1039767769  454 AGTSLPSKASEAVV 467
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 702-792 6.76e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 6.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  702 PSAPYDFALLNCGKNEMVIGWKPPkRRGGGKILGYFMDQHDSVESDWHPVNRQPIPSRVCKVTNLHEGHFYEFRARAVNW 781
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|.
gi 1039767769  782 AGIGELSAPSS 792
Cdd:cd00063     80 GGESPPSESVT 90
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 272-363 7.84e-09

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 90  Bit Score: 53.80  E-value: 7.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  272 EFTSVLKPIFAQEKEPFSLTCLFSDDvleAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSP 351
Cdd:pfam07679    2 KFTQKPKDVEVQEGESARFTCTVTGT---PDPEVSWFKDGQPLRSSDRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNS 78

                           90
                   ....*....|..
gi 1039767769  352 FGPQEQSAYVFI 363
Cdd:pfam07679   79 AGEAEASAELTV 90
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
437-709 3.92e-32

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 133.97  E-value: 3.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  437 GLVEGQSYQFRVRAISKAGTSLPSKASEAVVtgdydavhksteipydlgskitiskndfedAVTIPSAPTNVHASEIREA 516
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTT------------------------------PTTPPSAPTGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  517 YAVLSWEEPrPRGRApLTYTLEKSVIGSGTWEAISTetpIKSPRFALLDLEKGKSYVFRVRALNQYGmsDPSEPSEPVAL 596
Cdd:COG3401    248 SVTLSWDPV-TESDA-TGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNGTTYYYRVTAVDAAG--NESAPSNVVSV 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  597 KGKPATLPPPAQVQAFRNTQTSVSLAWEPVDgGSELLGYYIYSREAGASEWQTVnNKPIQDTKFTVPGLRTGKEYDFCIR 676
Cdd:COG3401    321 TTDLTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRSTSGGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVT 398

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1039767769  677 SVSEAgvGESSAATQPVRVKQALATPSAPYDFA 709
Cdd:COG3401    399 AVDAA--GNESAPSEEVSATTASAASGESLTAS 429
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
 154-248 2.39e-26

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 104.04  E-value: 2.39e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPRLFPaGKYRITNNYGLLTLEIMRCTVEDSATYTVLVK 233
Cdd:cd20951      1 PEFIIRLQSHTVWEKSDAKLRVEVQGKPDPEVKWYKNGVPIDPSSIP-GKYKIESEYGVHVLHIRRVTVEDSAVYSAVAK 79

                           90
                   ....*....|....*
gi 1039767769  234 NAYGQASSFAKVLIR 248
Cdd:cd20951     80 NIHGEASSSASVVVE 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-893 2.27e-25

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 101.03  E-value: 2.27e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  804 PGPPYDVRVSEVQATSVMLQWEPPLYIGaGPVTGYHVSFQEKGSEEWKPVTPDATSDTHLRVSDLQPGKQYMFRVQAMNS 883
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDG-GPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|
gi 1039767769  884 AGLGQPSVPT 893
Cdd:cd00063     80 GGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 374-467 3.35e-20

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 86.40  E-value: 3.35e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  374 PGSPLNVRCLNVHRDCLTLTWVPPSDTrGSTITGYSIEMCQGDSEEWMPCLKAPGGTCRCPIQGLVEGQSYQFRVRAISK 453
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDD-GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1039767769  454 AGTSLPSKASEAVV 467
Cdd:cd00063     80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
805-890 4.71e-20

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.54  E-value: 4.71e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  805 GPPYDVRVSEVQATSVMLQWEPPLYiGAGPVTGYHVSFQEKGSEE-WKPVTPDATSDTHLrVSDLQPGKQYMFRVQAMNS 883
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVT-LTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 1039767769  884 AGLGQPS 890
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 604-691 8.34e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.46  E-value: 8.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  604 PPPAQVQAFRNTQTSVSLAWE-PVDGGSELLGYYIYSREAGASEWQTVNNKPIQDTKFTVPGLRTGKEYDFCIRSVSEAG 682
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*....
gi 1039767769  683 VGESSAATQ 691
Cdd:cd00063     82 ESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-887 1.37e-17

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 78.81  E-value: 1.37e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   804 PGPPYDVRVSEVQATSVMLQWEPPLYIGA-GPVTGYHVSFQEKGSEeWKPVTPDaTSDTHLRVSDLQPGKQYMFRVQAMN 882
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYREEGSE-WKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039767769   883 SAGLG 887
Cdd:smart00060   79 GAGEG 83
I-set pfam07679
Immunoglobulin I-set domain;
154-247 5.41e-17

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 77.30  E-value: 5.41e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDprlfPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVK 233
Cdd:pfam07679    1 PKFTQKPKDVEVQEGESARFTCTVTGTPDPEVSWFKDGQPLR----SSDRFKVTYEGGTYTLTISNVQPDDSGKYTCVAT 76

                           90
                   ....*....|....
gi 1039767769  234 NAYGQASSFAKVLI 247
Cdd:pfam07679   77 NSAGEAEASAELTV 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 161-247 4.51e-16

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 74.46  E-value: 4.51e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   161 RSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIdprLFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQAS 240
Cdd:smart00410    2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKL---LAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSAS 78


                    ....*..
gi 1039767769   241 SFAKVLI 247
Cdd:smart00410   79 SGTTLTV 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 702-792 6.76e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 6.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  702 PSAPYDFALLNCGKNEMVIGWKPPkRRGGGKILGYFMDQHDSVESDWHPVNRQPIPSRVCKVTNLHEGHFYEFRARAVNW 781
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|.
gi 1039767769  782 AGIGELSAPSS 792
Cdd:cd00063     80 GGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 374-457 3.74e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.10  E-value: 3.74e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   374 PGSPLNVRCLNVHRDCLTLTWVPP-SDTRGSTITGYSIEMCQgDSEEWMPCLKAPGGTcRCPIQGLVEGQSYQFRVRAIS 452
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYRE-EGSEWKEVNVTPSST-SYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039767769   453 KAGTS 457
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
375-460 1.52e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 1.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  375 GSPLNVRCLNVHRDCLTLTWVPPSDTRGsTITGYSIEMCQGDSEEWMPCLKAPGGTCRCPIQGLVEGQSYQFRVRAISKA 454
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 1039767769  455 GTSLPS 460
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
604-687 1.92e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 1.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  604 PPPAQVQAFRNTQTSVSLAWE-PVDGGSELLGYYI-YSREAGASEWQTVNNKPIQDTkFTVPGLRTGKEYDFCIRSVSEA 681
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpPPDGNGPITGYEVeYRPKNSGEPWNEITVPGTTTS-VTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 1039767769  682 GVGESS 687
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 604-684 2.66e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 2.66e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   604 PPPAQVQAFRNTQTSVSLAWEPVD---GGSELLGYYIYSREAGaSEWQTVNNKPiQDTKFTVPGLRTGKEYDFCIRSVSE 680
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgITGYIVGYRVEYREEG-SEWKEVNVTP-SSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039767769   681 AGVG 684
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 702-785 4.08e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 4.08e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   702 PSAPYDFALLNCGKNEMVIGWKPPKRRGGGK-ILGYFMdQHDSVESDWHPVNRQPiPSRVCKVTNLHEGHFYEFRARAVN 780
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRV-EYREEGSEWKEVNVTP-SSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039767769   781 WAGIG 785
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
703-788 1.60e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  703 SAPYDFALLNCGKNEMVIGWKPPKRrGGGKILGYFMD-QHDSVESDWHPVNRqPIPSRVCKVTNLHEGHFYEFRARAVNW 781
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPD-GNGPITGYEVEyRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 1039767769  782 AGIGELS 788
Cdd:pfam00041   79 GGEGPPS 85
I-set pfam07679
Immunoglobulin I-set domain;
272-363 7.84e-09

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 53.80  E-value: 7.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  272 EFTSVLKPIFAQEKEPFSLTCLFSDDvleAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSP 351
Cdd:pfam07679    2 KFTQKPKDVEVQEGESARFTCTVTGT---PDPEVSWFKDGQPLRSSDRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNS 78

                           90
                   ....*....|..
gi 1039767769  352 FGPQEQSAYVFI 363
Cdd:pfam07679   79 AGEAEASAELTV 90
IgI_2_Titin_Z1z2-like cd20972
Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and ...
 304-363 6.59e-05

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409564 [Multi-domain]  Cd Length: 91  Bit Score: 42.96  E-value: 6.59e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  304 RIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQSAYVFI 363
Cdd:cd20972     32 VVRWFCEGKELQNSPDIQIHQEGDLHSLIIAEAFEEDTGRYSCLATNSVGSDTTSAEIFV 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 282-363 1.44e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 1.44e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   282 AQEKEPFSLTCLFSDDvleAEQRIQWYRDG-RLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQSAY 360
Cdd:smart00410    6 VKEGESVTLSCEASGS---PPPEVTWYKQGgKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTT 82


                    ...
gi 1039767769   361 VFI 363
Cdd:smart00410   83 LTV 85
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
437-709 3.92e-32

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 133.97  E-value: 3.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  437 GLVEGQSYQFRVRAISKAGTSLPSKASEAVVtgdydavhksteipydlgskitiskndfedAVTIPSAPTNVHASEIREA 516
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTT------------------------------PTTPPSAPTGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  517 YAVLSWEEPrPRGRApLTYTLEKSVIGSGTWEAISTetpIKSPRFALLDLEKGKSYVFRVRALNQYGmsDPSEPSEPVAL 596
Cdd:COG3401    248 SVTLSWDPV-TESDA-TGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNGTTYYYRVTAVDAAG--NESAPSNVVSV 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  597 KGKPATLPPPAQVQAFRNTQTSVSLAWEPVDgGSELLGYYIYSREAGASEWQTVnNKPIQDTKFTVPGLRTGKEYDFCIR 676
Cdd:COG3401    321 TTDLTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRSTSGGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVT 398

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1039767769  677 SVSEAgvGESSAATQPVRVKQALATPSAPYDFA 709
Cdd:COG3401    399 AVDAA--GNESAPSEEVSATTASAASGESLTAS 429
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
 154-248 2.39e-26

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 104.04  E-value: 2.39e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPRLFPaGKYRITNNYGLLTLEIMRCTVEDSATYTVLVK 233
Cdd:cd20951      1 PEFIIRLQSHTVWEKSDAKLRVEVQGKPDPEVKWYKNGVPIDPSSIP-GKYKIESEYGVHVLHIRRVTVEDSAVYSAVAK 79

                           90
                   ....*....|....*
gi 1039767769  234 NAYGQASSFAKVLIR 248
Cdd:cd20951     80 NIHGEASSSASVVVE 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-893 2.27e-25

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 101.03  E-value: 2.27e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  804 PGPPYDVRVSEVQATSVMLQWEPPLYIGaGPVTGYHVSFQEKGSEEWKPVTPDATSDTHLRVSDLQPGKQYMFRVQAMNS 883
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDG-GPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|
gi 1039767769  884 AGLGQPSVPT 893
Cdd:cd00063     80 GGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 374-467 3.35e-20

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 86.40  E-value: 3.35e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  374 PGSPLNVRCLNVHRDCLTLTWVPPSDTrGSTITGYSIEMCQGDSEEWMPCLKAPGGTCRCPIQGLVEGQSYQFRVRAISK 453
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDD-GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1039767769  454 AGTSLPSKASEAVV 467
Cdd:cd00063     80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
805-890 4.71e-20

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.54  E-value: 4.71e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  805 GPPYDVRVSEVQATSVMLQWEPPLYiGAGPVTGYHVSFQEKGSEE-WKPVTPDATSDTHLrVSDLQPGKQYMFRVQAMNS 883
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVT-LTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 1039767769  884 AGLGQPS 890
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 604-691 8.34e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.46  E-value: 8.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  604 PPPAQVQAFRNTQTSVSLAWE-PVDGGSELLGYYIYSREAGASEWQTVNNKPIQDTKFTVPGLRTGKEYDFCIRSVSEAG 682
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*....
gi 1039767769  683 VGESSAATQ 691
Cdd:cd00063     82 ESPPSESVT 90
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
343-708 8.59e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.91  E-value: 8.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  343 FYTIRVSSPFGPQEQSAYVFIRDAAAekpgAPGSPLNVRCLNVHRDCLTLTWVPPSDTRgstITGYSIEMCQGDSEEWmp 422
Cdd:COG3401    206 YYRVAATDTGGESAPSNEVSVTTPTT----PPSAPTGLTATADTPGSVTLSWDPVTESD---ATGYRVYRSNSGDGPF-- 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  423 clkapggtcrCPI----------QGLVEGQSYQFRVRAISKAGTslPSKASEAV-VTGDydavhksteipydlgskitis 491
Cdd:COG3401    277 ----------TKVatvtttsytdTGLTNGTTYYYRVTAVDAAGN--ESAPSNVVsVTTD--------------------- 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  492 kndfedaVTIPSAPTNVHASEIREAYAVLSWEEPRPRGRAplTYTLEKSVIGSGTWEAISteTPIKSPRFALLDLEKGKS 571
Cdd:COG3401    324 -------LTPPAAPSGLTATAVGSSSITLSWTASSDADVT--GYNVYRSTSGGGTYTKIA--ETVTTTSYTDTGLTPGTT 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  572 YVFRVRALNQYGMSdpSEPSEPV-ALKGKPATLPPPAQVQAFRNTQTSVSLAWEPVDGGSELLGYYIYSreAGASEWQTV 650
Cdd:COG3401    393 YYYKVTAVDAAGNE--SAPSEEVsATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLA--DGGDTGNAV 468

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039767769  651 NNKPIQDTKFTVPGLRTGKEYDFCIRSVSEAGVGESSAATQPVRVKQALATPSAPYDF 708
Cdd:COG3401    469 PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDG 526
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-887 1.37e-17

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 78.81  E-value: 1.37e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   804 PGPPYDVRVSEVQATSVMLQWEPPLYIGA-GPVTGYHVSFQEKGSEeWKPVTPDaTSDTHLRVSDLQPGKQYMFRVQAMN 882
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYREEGSE-WKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039767769   883 SAGLG 887
Cdd:smart00060   79 GAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
443-896 1.87e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 87.75  E-value: 1.87e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  443 SYQFRVRAISKAGTSLPSKASEAVVTGDYDAVHKSTEIPYDLGSkitiSKNDFEDAVTIPSAPTNVHASEIREAYAVLSW 522
Cdd:COG3401     59 AGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGS----VGGATNTGLTSSDEVPSPAVGTATTATAVAGG 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  523 EEPRPRGRAPLTYTLEKSVIGSGTWEAISTETPIKSPRFAL---------------------LDLEKGKSYVFRVRALNQ 581
Cdd:COG3401    135 AATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSataavattsltvtsttlvdggGDIEPGTTYYYRVAATDT 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  582 YGMSDPSEPSEPVAlkgkPATLP-PPAQVQAFRNTQTSVSLAWEPVDGgSELLGYYIYSREAGASEWQTVNNkpIQDTKF 660
Cdd:COG3401    215 GGESAPSNEVSVTT----PTTPPsAPTGLTATADTPGSVTLSWDPVTE-SDATGYRVYRSNSGDGPFTKVAT--VTTTSY 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  661 TVpglrtgkeydfcirsvseagvgessaatqpvrvkqalatpsapydfallncgknemvigwkppkrrgggkilgyfmdq 740
Cdd:COG3401    288 TD------------------------------------------------------------------------------ 289

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  741 hdsvesdwhpvnrqpipsrvckvTNLHEGHFYEFRARAVNwaGIGELSAPSSLFECKEWTMPePGPPYDVRVSEVQATSV 820
Cdd:COG3401    290 -----------------------TGLTNGTTYYYRVTAVD--AAGNESAPSNVVSVTTDLTP-PAAPSGLTATAVGSSSI 343

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039767769  821 MLQWEPPLyigAGPVTGYHVSFQEKGSEEWKPVTPDATSdTHLRVSDLQPGKQYMFRVQAMNSAGLGqpSVPTDPV 896
Cdd:COG3401    344 TLSWTASS---DADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEV 413
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 502-592 1.91e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 78.69  E-value: 1.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  502 PSAPTNVHASEIREAYAVLSWEEPRPRGRAPLTYTLEKSVIGSGTWEAISTeTPIKSPRFALLDLEKGKSYVFRVRALNQ 581
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEV-TPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|.
gi 1039767769  582 YGMSDPSEPSE 592
Cdd:cd00063     80 GGESPPSESVT 90
I-set pfam07679
Immunoglobulin I-set domain;
154-247 5.41e-17

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 77.30  E-value: 5.41e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDprlfPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVK 233
Cdd:pfam07679    1 PKFTQKPKDVEVQEGESARFTCTVTGTPDPEVSWFKDGQPLR----SSDRFKVTYEGGTYTLTISNVQPDDSGKYTCVAT 76

                           90
                   ....*....|....
gi 1039767769  234 NAYGQASSFAKVLI 247
Cdd:pfam07679   77 NSAGEAEASAELTV 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 161-247 4.51e-16

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 74.46  E-value: 4.51e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   161 RSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIdprLFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQAS 240
Cdd:smart00410    2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKL---LAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSAS 78


                    ....*..
gi 1039767769   241 SFAKVLI 247
Cdd:smart00410   79 SGTTLTV 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 702-792 6.76e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 6.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  702 PSAPYDFALLNCGKNEMVIGWKPPkRRGGGKILGYFMDQHDSVESDWHPVNRQPIPSRVCKVTNLHEGHFYEFRARAVNW 781
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|.
gi 1039767769  782 AGIGELSAPSS 792
Cdd:cd00063     80 GGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 374-457 3.74e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.10  E-value: 3.74e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   374 PGSPLNVRCLNVHRDCLTLTWVPP-SDTRGSTITGYSIEMCQgDSEEWMPCLKAPGGTcRCPIQGLVEGQSYQFRVRAIS 452
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYRE-EGSEWKEVNVTPSST-SYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039767769   453 KAGTS 457
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
375-460 1.52e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 1.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  375 GSPLNVRCLNVHRDCLTLTWVPPSDTRGsTITGYSIEMCQGDSEEWMPCLKAPGGTCRCPIQGLVEGQSYQFRVRAISKA 454
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 1039767769  455 GTSLPS 460
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
604-687 1.92e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 1.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  604 PPPAQVQAFRNTQTSVSLAWE-PVDGGSELLGYYI-YSREAGASEWQTVNNKPIQDTkFTVPGLRTGKEYDFCIRSVSEA 681
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpPPDGNGPITGYEVeYRPKNSGEPWNEITVPGTTTS-VTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 1039767769  682 GVGESS 687
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 604-684 2.66e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 2.66e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   604 PPPAQVQAFRNTQTSVSLAWEPVD---GGSELLGYYIYSREAGaSEWQTVNNKPiQDTKFTVPGLRTGKEYDFCIRSVSE 680
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgITGYIVGYRVEYREEG-SEWKEVNVTP-SSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039767769   681 AGVG 684
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
503-588 7.99e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 7.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  503 SAPTNVHASEIREAYAVLSWEEPRPRGRAPLTYTLEKSVIGSGTWEaisTETPIKSP--RFALLDLEKGKSYVFRVRALN 580
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPW---NEITVPGTttSVTLTGLKPGTEYEVRVQAVN 77


                   ....*...
gi 1039767769  581 QYGMSDPS 588
Cdd:pfam00041   78 GGGEGPPS 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 171-241 3.03e-11

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 60.04  E-value: 3.03e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039767769  171 VLLTCTVQGSPPFQVTWYKNDIRIDprlfPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQASS 241
Cdd:cd00096      1 VTLTCSASGNPPPTITWYKNGKPLP----PSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSAS 67
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 702-785 4.08e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 4.08e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   702 PSAPYDFALLNCGKNEMVIGWKPPKRRGGGK-ILGYFMdQHDSVESDWHPVNRQPiPSRVCKVTNLHEGHFYEFRARAVN 780
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRV-EYREEGSEWKEVNVTP-SSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039767769   781 WAGIG 785
Cdd:smart00060   79 GAGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
493-682 4.77e-11

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 67.28  E-value: 4.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  493 NDFEDAVTIPSAPTNVHASE--------IREAYAVLSWEEPRPRGRAPLTYTleksvIGSGTWEAISTETpikSPRFALL 564
Cdd:COG4733    521 AGAFDDVPPQWPPVNVTTSEslsvvaqgTAVTTLTVSWDAPAGAVAYEVEWR-----RDDGNWVSVPRTS---GTSFEVP 592

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  565 DLEKGkSYVFRVRALNQYGMSDPSEPSEPVALKGKPAtlpPPAQVQAFRNTQ--TSVSLAWEPVDgGSELLGYYIYSREA 642
Cdd:COG4733    593 GIYAG-DYEVRVRAINALGVSSAWAASSETTVTGKTA---PPPAPTGLTATGglGGITLSWSFPV-DADTLRTEIRYSTT 667

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1039767769  643 GASEWQTVNNKPIQDTKFTVPGLRTGKEYDFCIRSVSEAG 682
Cdd:COG4733    668 GDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 158-234 9.68e-11

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 59.12  E-value: 9.68e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039767769  158 IPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPRLFPAGKYRITNnyglLTLEIMRCTVEDSATYTVLVKN 234
Cdd:pfam13927    6 VSPSSVTVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTRSRSLSGSN----STLTISNVTRSDAGTYTCVASN 78
fn3 pfam00041
Fibronectin type III domain;
703-788 1.60e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  703 SAPYDFALLNCGKNEMVIGWKPPKRrGGGKILGYFMD-QHDSVESDWHPVNRqPIPSRVCKVTNLHEGHFYEFRARAVNW 781
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPD-GNGPITGYEVEyRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 1039767769  782 AGIGELS 788
Cdd:pfam00041   79 GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 502-585 2.01e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 2.01e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   502 PSAPTNVHASEIREAYAVLSWEEP-RPRGRAPLTYTLEKSVIGSGTWEAISTETPikSPRFALLDLEKGKSYVFRVRALN 580
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039767769   581 QYGMS 585
Cdd:smart00060   79 GAGEG 83
IgI_2_Titin_Z1z2-like cd20972
Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and ...
 154-247 3.79e-09

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409564 [Multi-domain]  Cd Length: 91  Bit Score: 54.90  E-value: 3.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPRLfpagKYRITNNYGLLTLEIMRCTVEDSATYTVLVK 233
Cdd:cd20972      2 PQFIQKLRSQEVAEGSKVRLECRVTGNPTPVVRWFCEGKELQNSP----DIQIHQEGDLHSLIIAEAFEEDTGRYSCLAT 77

                           90
                   ....*....|....
gi 1039767769  234 NAYGQASSFAKVLI 247
Cdd:cd20972     78 NSVGSDTTSAEIFV 91
I-set pfam07679
Immunoglobulin I-set domain;
272-363 7.84e-09

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 53.80  E-value: 7.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  272 EFTSVLKPIFAQEKEPFSLTCLFSDDvleAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSP 351
Cdd:pfam07679    2 KFTQKPKDVEVQEGESARFTCTVTGT---PDPEVSWFKDGQPLRSSDRFKVTYEGGTYTLTISNVQPDDSGKYTCVATNS 78

                           90
                   ....*....|..
gi 1039767769  352 FGPQEQSAYVFI 363
Cdd:pfam07679   79 AGEAEASAELTV 90
IgI_M-protein_C cd05891
C-terminal immunoglobulin (Ig)-like domain of M-protein; member of the I-set of Ig superfamily ...
 165-237 8.47e-09

C-terminal immunoglobulin (Ig)-like domain of M-protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of M-protein (also known as myomesin-2). M-protein is a structural protein localized to the M-band, a transverse structure in the center of the sarcomere, and is a candidate for M-band bridges. M-protein is modular consisting mainly of repetitive IG-like and fibronectin type III (FnIII) domains and has a muscle-type specific expression pattern. M-protein is present in fast fibers.


Pssm-ID: 143299  Cd Length: 92  Bit Score: 54.15  E-value: 8.47e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039767769  165 VWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDprlfPAGKYRITNNYG-LLTLEIMRCTVEDSATYTVLVKNAYG 237
Cdd:cd05891     13 IMEGKTLNLTCTVFGNPDPEVIWFKNDQDIE----LSEHYSVKLEQGkYASLTIKGVTSEDSGKYSINVKNKYG 82
IgI_1_Palladin_C cd05893
First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig ...
 154-247 2.57e-08

First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of palladin. Palladin belongs to the palladin-myotilin-myopalladin family. Proteins belonging to this family contain multiple Ig-like domains and function as scaffolds, modulating actin cytoskeleton. Palladin binds to alpha-actinin ezrin, vasodilator-stimulated phosphoprotein VASP, SPIN90 (also known as DIP or mDia interacting protein), and Src. Palladin also binds F-actin directly, via its Ig3 domain. Palladin is expressed as several alternatively spliced isoforms, having various combinations of Ig-like domains, in a cell-type-specific manner. It has been suggested that palladin's different Ig-like domains may be specialized for distinct functions. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409474  Cd Length: 92  Bit Score: 52.79  E-value: 2.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPRlfpAGKYRITNNY-GLLTLEIMRCTVEDSATYTVLV 232
Cdd:cd05893      1 PFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPK---SDHYTIQRDLdGTCSLHTTASTLDDDGNYTIMA 77

                           90
                   ....*....|....*
gi 1039767769  233 KNAYGQASSFAKVLI 247
Cdd:cd05893     78 ANPQGRISCTGRLMV 92
IgI_Myomesin_like_C cd05737
C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of ...
 165-241 4.85e-08

C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein (also known as myomesin-2). Myomesin and M-protein are both structural proteins localized to the M-band, a transverse structure in the center of the sarcomere, and are candidates for M-band bridges. Both proteins are modular, consisting mainly of repetitive Ig-like and fibronectin type III (FnIII) domains. Myomesin is expressed in all types of vertebrate striated muscle; M-protein has a muscle-type specific expression pattern. Myomesin is present in both slow and fast fibers; M-protein is present only in fast fibers. It has been suggested that myomesin acts as a molecular spring with alternative splicing as a means of modifying its elasticity.


Pssm-ID: 319300  Cd Length: 92  Bit Score: 51.82  E-value: 4.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  165 VWEHTTVLLTCTVQGSPPFQVTWYKND--IRIDPRL---FPAGKYritnnyglLTLEIMRCTVEDSATYTVLVKNAYGQA 239
Cdd:cd05737     13 IMEGKTLNLTCNVWGDPPPEVSWLKNDqaLAFLDHCnlkVEAGRT--------VYFTINGVSSEDSGKYGLVVKNKYGSE 84


                   ..
gi 1039767769  240 SS 241
Cdd:cd05737     85 TS 86
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 158-245 5.33e-08

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 51.43  E-value: 5.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  158 IPLRSHAVWEHTTVLLTCTV-QGSPPFQVTWYKND-IRIDPRLFPAGKYRITNNygllTLEIMRCTVEDSATYTVLVKNA 235
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSAsTGSPGPDVTWSKEGgTLIESLKVKHDNGRTTQS----SLLISNVTKEDAGTYTCVVNNP 76

                           90
                   ....*....|
gi 1039767769  236 YGQASSFAKV 245
Cdd:pfam00047   77 GGSATLSTSL 86
IgI_Twitchin_like cd20949
C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, ...
 175-240 8.06e-08

C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, and similar domains; member of the I-set IgSF domains; The members here are composed of the C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin and similar proteins, including Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. In humans these proteins are called Titin. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig-like domain of the Twitchin is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins (titin, telokin, and twitchin), the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D.


Pssm-ID: 409541 [Multi-domain]  Cd Length: 89  Bit Score: 51.18  E-value: 8.06e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039767769  175 CTVQGSPPFQVTWYKNDIRIDPRLFPAGKYRItNNYGLLtleIMRCTVEDSATYTVLVKNAYGQAS 240
Cdd:cd20949     21 CEVKGEPQPNVTWHFNGQPISASVADMSKYRI-LADGLL---INKVTQDDTGEYTCRAYQVNSIAS 82
Ig_Titin_like cd05748
Immunoglobulin (Ig)-like domain of titin and similar proteins; The members here are composed ...
 177-245 1.56e-07

Immunoglobulin (Ig)-like domain of titin and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain found in titin-like proteins and similar proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is a giant protein; depending on isoform composition, it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone. It appears to function similarly to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. Within the sarcomere, titin is also attached to or is associated with myosin binding protein C (MyBP-C). MyBP-C appears to contribute to the generation of passive tension by titin and like titin has repeated Ig-like and FN-III domains. Also included in this group are worm twitchin and insect projectin, thick filament proteins of invertebrate muscle which also have repeated Ig-like and FN-III domains.


Pssm-ID: 409406 [Multi-domain]  Cd Length: 82  Bit Score: 49.90  E-value: 1.56e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039767769  177 VQGSPPFQVTWYKNDIRIDPRlfpaGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQASSFAKV 245
Cdd:cd05748     16 IKGRPTPTVTWSKDGQPLKET----GRVQIETTASSTSLVIKNAKRSDSGKYTLTLKNSAGEKSATINV 80
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
390-585 3.65e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 54.95  E-value: 3.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  390 LTLTWVPPSDTrgstiTGYSIEMCQGDSEeWMPclKAPGGTCRCPIQGLVEGQsYQFRVRAISKAGT-SLPSKASEAVVT 468
Cdd:COG4733    554 LTVSWDAPAGA-----VAYEVEWRRDDGN-WVS--VPRTSGTSFEVPGIYAGD-YEVRVRAINALGVsSAWAASSETTVT 624

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  469 GDydavhksteipydlgskitiskndfedaVTIPSAPTNVHASEIREaYAVLSWEEPRPrgrAPLTYTlEKSVIGSGTWE 548
Cdd:COG4733    625 GK----------------------------TAPPPAPTGLTATGGLG-GITLSWSFPVD---ADTLRT-EIRYSTTGDWA 671

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1039767769  549 -AISTETPIKSPRFALLDLEKGKSYVFRVRALNQYGMS 585
Cdd:COG4733    672 sATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNV 709
IgI_4_MYLK-like cd20976
Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...
 164-245 6.29e-07

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409568 [Multi-domain]  Cd Length: 90  Bit Score: 48.40  E-value: 6.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  164 AVWEHTTVLLTCTVQGSPPFQVTWYKN--DIRIDPRlfpagkyRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQASS 241
Cdd:cd20976     12 EAVEGQDFVAQCSARGKPVPRITWIRNaqPLQYAAD-------RSTCEAGVGELHIQDVLPEDHGTYTCLAKNAAGQVSC 84


                   ....
gi 1039767769  242 FAKV 245
Cdd:cd20976     85 SAWV 88
IgI_Myotilin_C cd05892
C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily ...
 154-245 1.34e-06

C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of myotilin. Mytolin belongs to the palladin-myotilin-myopalladin family. Proteins belonging to the latter family contain multiple Ig-like domains and function as scaffolds, modulating the actin cytoskeleton. Myotilin is most abundant in skeletal and cardiac muscle and is involved in maintaining sarcomere integrity. It binds to alpha-actinin, filamin, and actin. Mutations in myotilin lead to muscle disorders. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409473  Cd Length: 92  Bit Score: 47.84  E-value: 1.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKND--IRIDPRlfpagkyRIT---NNYGLLTLEIMRCTVEDSATY 228
Cdd:cd05892      1 PMFIQKPQNKKVLEGDPVRLECQISAIPPPQIFWKKNNemLQYNTD-------RISlyqDNCGRICLLIQNANKKDAGWY 73

                           90
                   ....*....|....*..
gi 1039767769  229 TVLVKNAYGQASSFAKV 245
Cdd:cd05892     74 TVSAVNEAGVVSCNARL 90
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 170-243 1.78e-06

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 47.00  E-value: 1.78e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039767769  170 TVLLTCTVQGSPPFQVTWYKNDIRIdprlfPAGKYRITNNYgllTLEIMRCTVEDSATYTVLVKNAYGQASSFA 243
Cdd:cd05725     14 SAEFQCEVGGDPVPTVRWRKEDGEL-----PKGRYEILDDH---SLKIRKVTAGDMGSYTCVAENMVGKIEASA 79
IgI_2_FGFR cd05857
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of ...
 161-237 3.25e-06

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor. FGF receptors bind FGF signaling polypeptides. FGFs participate in multiple processes such as morphogenesis, development, and angiogenesis. FGFs bind to four FGF receptor tyrosine kinases (FGFR1, FGFR2, FGFR3, FGFR4). Receptor diversity is controlled by alternative splicing producing splice variants with different ligand binding characteristics and different expression patterns. FGFRs have an extracellular region comprised of three IG-like domains, a single transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding and specificity reside in the Ig-like domains 2 and 3, and the linker region that connects these two. FGFR activation and signaling depend on FGF-induced dimerization, a process involving cell surface heparin or heparin sulfate proteoglycans.


Pssm-ID: 409443 [Multi-domain]  Cd Length: 95  Bit Score: 46.77  E-value: 3.25e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039767769  161 RSHAVWEHTTVLLTCTVQGSPPFQVTWYKN--DIRIDPRLfpaGKYRITNNYGLLTLEimRCTVEDSATYTVLVKNAYG 237
Cdd:cd05857     12 KLHAVPAANTVKFRCPAAGNPTPTMRWLKNgkEFKQEHRI---GGYKVRNQHWSLIME--SVVPSDKGNYTCVVENEYG 85
IgI_1_Titin_Z1z2-like cd20974
First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and ...
 154-247 3.70e-06

First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409566 [Multi-domain]  Cd Length: 93  Bit Score: 46.58  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPRLFPagKYRITNNYGLLTLEIMRCTVEDSATYTVLVK 233
Cdd:cd20974      1 PVFTQPLQSVVVLEGSTATFEAHVSGKPVPEVSWFRDGQVISTSTLP--GVQISFSDGRAKLSIPAVTKANSGRYSLTAT 78

                           90
                   ....*....|....
gi 1039767769  234 NAYGQASSFAKVLI 247
Cdd:cd20974     79 NGSGQATSTAELLV 92
IgI_Myotilin_C_like cd05744
Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...
 154-247 6.52e-06

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in myotilin, palladin, and myopalladin. Myotilin, palladin, and myopalladin function as scaffolds that regulate actin organization. Myotilin and myopalladin are most abundant in skeletal and cardiac muscle; palladin is ubiquitously expressed in the organs of developing vertebrates and plays a key role in cellular morphogenesis. The three family members each interact with specific molecular partners with all three binding to alpha-actinin; In addition, palladin also binds to vasodilator-stimulated phosphoprotein (VASP) and ezrin, myotilin binds to filamin and actin, and myopalladin also binds to nebulin and cardiac ankyrin repeat protein (CARP). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409405 [Multi-domain]  Cd Length: 91  Bit Score: 45.56  E-value: 6.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  154 PWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDiriDPRLFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVK 233
Cdd:cd05744      1 PHFLQAPGDLEVQEGRLCRFDCKVSGLPTPDLFWQLNG---KPVRPDSAHKMLVRENGRHSLIIEPVTKRDAGIYTCIAR 77

                           90
                   ....*....|....
gi 1039767769  234 NAYGQASSFAKVLI 247
Cdd:cd05744     78 NRAGENSFNAELVV 91
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
607-792 8.54e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 50.33  E-value: 8.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  607 AQVQAFRNTQTSVSLAWEPVDGGSellGYYIYSReAGASEWQTVNNkpIQDTKFTVPGLRTGkEYDFCIRSVSEAGVGES 686
Cdd:COG4733    542 LSVVAQGTAVTTLTVSWDAPAGAV---AYEVEWR-RDDGNWVSVPR--TSGTSFEVPGIYAG-DYEVRVRAINALGVSSA 614

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  687 SAATQPVRVKQALATPSAPYDFaLLNCGKNEMVIGWKPPKrrgGGKILGY--FMDQHDSVESDWHPVNRQPIPSRVckVT 764
Cdd:COG4733    615 WAASSETTVTGKTAPPPAPTGL-TATGGLGGITLSWSFPV---DADTLRTeiRYSTTGDWASATVAQALYPGNTYT--LA 688

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1039767769  765 NLHEGHFYEFRARAVN-------WAGIGELSAPSS 792
Cdd:COG4733    689 GLKAGQTYYYRARAVDrsgnvsaWWVSGQASADAA 723
IgI_Titin_like cd05747
Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the ...
 161-243 9.37e-06

Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain from the C-terminus of human titin x and similar proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is gigantic; depending on isoform composition it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone and appears to function similar to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 143224 [Multi-domain]  Cd Length: 92  Bit Score: 45.42  E-value: 9.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  161 RSHAVWEHTTVLLTCTVQGSPPFQVTWykndIRIDPRLFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYG-QA 239
Cdd:cd05747     11 RSLTVSEGESARFSCDVDGEPAPTVTW----MREGQIIVSSQRHQITSTEYKSTFEISKVQMSDEGNYTVVVENSEGkQE 86


                   ....
gi 1039767769  240 SSFA 243
Cdd:cd05747     87 AQFT 90
IgI_2_Titin_Z1z2-like cd20972
Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and ...
 304-363 6.59e-05

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409564 [Multi-domain]  Cd Length: 91  Bit Score: 42.96  E-value: 6.59e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  304 RIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQSAYVFI 363
Cdd:cd20972     32 VVRWFCEGKELQNSPDIQIHQEGDLHSLIIAEAFEEDTGRYSCLATNSVGSDTTSAEIFV 91
IgI_4_Dscam cd20956
Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 169-245 1.05e-04

Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409548 [Multi-domain]  Cd Length: 96  Bit Score: 42.55  E-value: 1.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039767769  169 TTVLLTCTVQGSPPFQVTWYKNDIRI--DPRlFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQASSFAKV 245
Cdd:cd20956     17 PSVSLKCVASGNPLPQITWTLDGFPIpeSPR-FRVGDYVTSDGDVVSYVNISSVRVEDGGEYTCTATNDVGSVSHSARI 94
Ig_Titin_like cd05748
Immunoglobulin (Ig)-like domain of titin and similar proteins; The members here are composed ...
 305-364 1.17e-04

Immunoglobulin (Ig)-like domain of titin and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain found in titin-like proteins and similar proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is a giant protein; depending on isoform composition, it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone. It appears to function similarly to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. Within the sarcomere, titin is also attached to or is associated with myosin binding protein C (MyBP-C). MyBP-C appears to contribute to the generation of passive tension by titin and like titin has repeated Ig-like and FN-III domains. Also included in this group are worm twitchin and insect projectin, thick filament proteins of invertebrate muscle which also have repeated Ig-like and FN-III domains.


Pssm-ID: 409406 [Multi-domain]  Cd Length: 82  Bit Score: 41.81  E-value: 1.17e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  305 IQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGpqEQSAYVFIR 364
Cdd:cd05748     24 VTWSKDGQPLKETGRVQIETTASSTSLVIKNAKRSDSGKYTLTLKNSAG--EKSATINVK 81
IgI_2_FGFR_like cd05729
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and similar ...
 161-238 1.26e-04

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and similar domains; member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor. FGF receptors bind FGF signaling polypeptides. FGFs participate in multiple processes such as morphogenesis, development, and angiogenesis. FGFs bind to four FGF receptor tyrosine kinases (FGFR1, FGFR2, FGFR3, FGFR4). Receptor diversity is controlled by alternative splicing producing splice variants with different ligand binding characteristics and different expression patterns. FGFRs have an extracellular region comprised of three Ig-like domains, a single transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding and specificity reside in the Ig-like domains 2 and 3, and the linker region that connects these two. FGFR activation and signaling depend on FGF-induced dimerization, a process involving cell surface heparin or heparin sulfate proteoglycans. This group also contains fibroblast growth factor (FGF) receptor like-1(FGFRL1). FGFRL1 does not have a protein tyrosine kinase domain at its C-terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.


Pssm-ID: 409393 [Multi-domain]  Cd Length: 95  Bit Score: 42.21  E-value: 1.26e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039767769  161 RSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPrLFPAGKYRITNNYGLLTLEimRCTVEDSATYTVLVKNAYGQ 238
Cdd:cd05729     12 REHALPAANKVRLECGAGGNPMPNITWLKDGKEFKK-EHRIGGTKVEEKGWSLIIE--RAIPRDKGKYTCIVENEYGS 86
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 282-363 1.44e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 1.44e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769   282 AQEKEPFSLTCLFSDDvleAEQRIQWYRDG-RLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQSAY 360
Cdd:smart00410    6 VKEGESVTLSCEASGS---PPPEVTWYKQGgKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSGTT 82


                    ...
gi 1039767769   361 VFI 363
Cdd:smart00410   83 LTV 85
IgI_Titin_like cd05747
Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the ...
 274-356 4.94e-04

Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain from the C-terminus of human titin x and similar proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is gigantic; depending on isoform composition it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone and appears to function similar to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 143224 [Multi-domain]  Cd Length: 92  Bit Score: 40.42  E-value: 4.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  274 TSVLKP--IFAQEKEPFSLTClfsDDVLEAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSP 351
Cdd:cd05747      5 TILTKPrsLTVSEGESARFSC---DVDGEPAPTVTWMREGQIIVSSQRHQITSTEYKSTFEISKVQMSDEGNYTVVVENS 81


                   ....*
gi 1039767769  352 FGPQE 356
Cdd:cd05747     82 EGKQE 86
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
604-705 6.27e-04

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 43.61  E-value: 6.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  604 PP--PAQVQAFRNTQTSVSLAWEPVDGGSELLGYYIYSreaGASEWQTVNNKpiqdTKFTVPGLRTGKEYDFCIRSVSEA 681
Cdd:COG3979      2 APtaPTGLTASNVTSSSVSLSWDASTDNVGVTGYDVYR---GGDQVATVTGL----TAWTVTGLTPGTEYTFTVGACDAA 74

                           90       100
                   ....*....|....*....|....*.
gi 1039767769  682 GV--GESSAATQPVRVKQALATPSAP 705
Cdd:COG3979     75 GNvsAASGTSTAMFGGSSTTLGSAEG 100
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 272-349 1.06e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.09  E-value: 1.06e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039767769  272 EFTSVLKPIFAQEKEPFSLTCLFSDDvleAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVS 349
Cdd:pfam13927    3 VITVSPSSVTVREGETVTLTCEATGS---PPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 170-245 1.43e-03

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 38.91  E-value: 1.43e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039767769  170 TVLLTCTVQGSPPFQVTWYKNDIRIDPrlfPAGKYRITNNygllTLEIMRCTVEDSATYTVLVKNAYGQASSFAKV 245
Cdd:cd20978     18 DVTLPCQVTGVPQPKITWLHNGKPLQG---PMERATVEDG----TLTIINVQPEDTGYYGCVATNEIGDIYTETLL 86
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 275-354 1.49e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 38.72  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  275 SVLKPIFAQEKEPFSLTCLFSDDVLEAEqrIQWYR-DGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFG 353
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSASTGSPGPD--VTWSKeGGTLIESLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGG 78


                   .
gi 1039767769  354 P 354
Cdd:pfam00047   79 S 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 155-241 1.57e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.53  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  155 WFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPrlfpagkyritnNYGLLTLEImrcTVEDSATYTVLVKN 234
Cdd:pfam13895    1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPPSYTWYKDGSAISS------------SPNFFTLSV---SAEDSGTYTCVARN 65


                   ....*..
gi 1039767769  235 AYGQASS 241
Cdd:pfam13895   66 GRGGKVS 72
fn3_2 pfam16893
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ...
 604-696 1.87e-03

Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.


Pssm-ID: 435634  Cd Length: 89  Bit Score: 38.72  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  604 PPPAQVQAFRN-TQTSVSLAWEPVD-GGSELLGYYIYSREagaSEWQTVNNkPIQDTKFTVPGLRTGKEYDFCIRSVSEA 681
Cdd:pfam16893    2 SPKAPVLKVRNvTQTSVVLEWDPLElGTAKLKSLDLYRNG---QRLGVIPN-PLTNTSTKLSGLSVDTEYTFQLVLRTTA 77

                           90
                   ....*....|....*
gi 1039767769  682 GVGESsaatQPVRVK 696
Cdd:pfam16893   78 GTYWS----NKIKVR 88
IgI_2_FGFRL1-like cd05856
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1 ...
 169-245 1.87e-03

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor like-1(FGFRL1). FGFRL1 is comprised of a signal peptide, three extracellular Ig-like modules, a transmembrane segment, and a short intracellular domain. FGFRL1 is expressed preferentially in skeletal tissues. Similar to FGF receptors, the expressed protein interacts specifically with heparin and with FGF2. FGFRL1 does not have a protein tyrosine kinase domain at its C-terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.


Pssm-ID: 409442  Cd Length: 92  Bit Score: 38.69  E-value: 1.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039767769  169 TTVLLTCTVQGSPPFQVTWYKNDIRIDPRLFPAGKYRitnnygLLTLEIMRCTVEDSATYTVLVKNAYGQASSFAKV 245
Cdd:cd05856     20 SSVRLKCVASGNPRPDITWLKDNKPLTPPEIGENKKK------KWTLSLKNLKPEDSGKYTCHVSNRAGEINATYKV 90
Ig_C5_MyBP-C cd05894
C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here ...
 173-245 2.51e-03

C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here are composed of the C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C). MyBP-C consists of repeated domains, Ig and fibronectin type 3, and various linkers. Three isoforms of MYBP-C exist: slow-skeletal (ssMyBP-C), fast-skeletal (fsMyBP-C), and cardiac (cMyBP-C). cMYBP-C has insertions between and inside domains and an additional cardiac-specific Ig domain at the N-terminus. For cMYBP_C an interaction has been demonstrated between this C5 domain and the Ig C8 domain.


Pssm-ID: 409475  Cd Length: 86  Bit Score: 38.28  E-value: 2.51e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039767769  173 LTCTVQGSPPFQVTWYKNDiriDPRLFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYG--QASSFAKV 245
Cdd:cd05894     15 LDVPISGEPAPTVTWSRGD---KAFTATEGRVRVESYKDLSSFVIEGAEREDEGVYTITVTNPVGedHASLFVKV 86
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 288-358 3.27e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 37.31  E-value: 3.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039767769  288 FSLTCLFSDDvleAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQS 358
Cdd:cd00096      1 VTLTCSASGN---PPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSASA 68
IgI_telokin-like cd20973
immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF ...
 159-247 3.63e-03

immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig) domain in telokin, the C-terminal domain of myosin light chain kinase which is identical to telokin, and similar proteins. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the telokin Ig domain lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409565 [Multi-domain]  Cd Length: 88  Bit Score: 37.94  E-value: 3.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767769  159 PLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIdprlfpAGKYRITNNY---GLLTLEIMRCTVEDSATYTVLVKNA 235
Cdd:cd20973      3 TLRDKEVVEGSAARFDCKVEGYPDPEVKWMKDDNPI------VESRRFQIDQdedGLCSLIISDVCGDDSGKYTCKAVNS 76

                           90
                   ....*....|..
gi 1039767769  236 YGQASSFAKVLI 247
Cdd:cd20973     77 LGEATCSAELTV 88
IgI_Titin_M1-like cd20927
Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains; The members ...
 184-247 7.19e-03

Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains; The members here are composed of the Immunoglobulin-like M1 I-set domain from Titin and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin-M1 domain lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409521  Cd Length: 90  Bit Score: 36.94  E-value: 7.19e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039767769  184 QVTWYKNdIRidpRLFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQASSFAKVLI 247
Cdd:cd20927     31 QVTWYFG-VR---QLENSEKYEITYEDGVAILYVKDITKFDDGTYRCKVVNDYGEDSSYAELFV 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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