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Conserved domains on  [gi|1039729429|ref|XP_017176928|]
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protein FAM178B isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CANIN super family cl20731
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
73-480 1.70e-156

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


The actual alignment was detected with superfamily member pfam14816:

Pssm-ID: 464331  Cd Length: 375  Bit Score: 454.13  E-value: 1.70e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429  73 SSGSSQCYINNLDYLLQEKREQALEQEWEQLLQQTHPRLKSSVCD----DNDDSDTEAVLMPEHRMLVEKFSVSLQVISP 148
Cdd:pfam14816   2 PSGGSVSYVNSLDYLLQEKREQARLQELEKLLLQDCRRGLLDLSEleslEEDSDDEEVDLTPEHRMFVERFSVSSQAIPD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 149 VHPGETVF-------LPRRHPLPcfLDSSRLKPHSPLEELFLRSSLPEQLSFLHNGLLSNLYLHAAdCPQPLLQWLFQLL 221
Cdd:pfam14816  82 VHPGETVFnlsdsgkLFNQHPLD--LRSSHLKPQSALEKLLLSSPPAQQLSLLTSGLLSNAYLHVP-CPVPLLRWLFQMM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 222 TWPPE--TSSRAFGLLWDLSIDGLFRQPDEDMHFWCPSLQEVKEVFSSLGAYNPALYPQGPFQHSASatrkqvttltcis 299
Cdd:pfam14816 159 SVHPEqiVSSQILSLLWDISLDNLFEQSDQDFHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSFN------------- 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 300 kgvervevldsghtirflflpslnrqkrwllwkddhqrdERVLESEASL--------DSQDPPQEVALDIKLNYIYKFLT 371
Cdd:pfam14816 226 ---------------------------------------ERDLLSEAQLseneqqnaGSVSPPFETLPEINLSNILKFLS 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 372 LCLLVRPVSYTDASILDLMELLCRAGLDVGLCLLPKTDLQQLLLLLLERIQEWPGKLQPLCCALSWVSDHHHNLLALVQF 451
Cdd:pfam14816 267 LCTLAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDWPTKLPELCCALSDLSDHHHNLLALVQL 346
                         410       420
                  ....*....|....*....|....*....
gi 1039729429 452 FLDVTPRGRQLRSQLSLVIIARMLGQQES 480
Cdd:pfam14816 347 FPDVTSRGRQLRRHLSLVIIAKLLDQQET 375
 
Name Accession Description Interval E-value
CANIN pfam14816
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
73-480 1.70e-156

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


Pssm-ID: 464331  Cd Length: 375  Bit Score: 454.13  E-value: 1.70e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429  73 SSGSSQCYINNLDYLLQEKREQALEQEWEQLLQQTHPRLKSSVCD----DNDDSDTEAVLMPEHRMLVEKFSVSLQVISP 148
Cdd:pfam14816   2 PSGGSVSYVNSLDYLLQEKREQARLQELEKLLLQDCRRGLLDLSEleslEEDSDDEEVDLTPEHRMFVERFSVSSQAIPD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 149 VHPGETVF-------LPRRHPLPcfLDSSRLKPHSPLEELFLRSSLPEQLSFLHNGLLSNLYLHAAdCPQPLLQWLFQLL 221
Cdd:pfam14816  82 VHPGETVFnlsdsgkLFNQHPLD--LRSSHLKPQSALEKLLLSSPPAQQLSLLTSGLLSNAYLHVP-CPVPLLRWLFQMM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 222 TWPPE--TSSRAFGLLWDLSIDGLFRQPDEDMHFWCPSLQEVKEVFSSLGAYNPALYPQGPFQHSASatrkqvttltcis 299
Cdd:pfam14816 159 SVHPEqiVSSQILSLLWDISLDNLFEQSDQDFHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSFN------------- 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 300 kgvervevldsghtirflflpslnrqkrwllwkddhqrdERVLESEASL--------DSQDPPQEVALDIKLNYIYKFLT 371
Cdd:pfam14816 226 ---------------------------------------ERDLLSEAQLseneqqnaGSVSPPFETLPEINLSNILKFLS 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 372 LCLLVRPVSYTDASILDLMELLCRAGLDVGLCLLPKTDLQQLLLLLLERIQEWPGKLQPLCCALSWVSDHHHNLLALVQF 451
Cdd:pfam14816 267 LCTLAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDWPTKLPELCCALSDLSDHHHNLLALVQL 346
                         410       420
                  ....*....|....*....|....*....
gi 1039729429 452 FLDVTPRGRQLRSQLSLVIIARMLGQQES 480
Cdd:pfam14816 347 FPDVTSRGRQLRRHLSLVIIAKLLDQQET 375
 
Name Accession Description Interval E-value
CANIN pfam14816
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
73-480 1.70e-156

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


Pssm-ID: 464331  Cd Length: 375  Bit Score: 454.13  E-value: 1.70e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429  73 SSGSSQCYINNLDYLLQEKREQALEQEWEQLLQQTHPRLKSSVCD----DNDDSDTEAVLMPEHRMLVEKFSVSLQVISP 148
Cdd:pfam14816   2 PSGGSVSYVNSLDYLLQEKREQARLQELEKLLLQDCRRGLLDLSEleslEEDSDDEEVDLTPEHRMFVERFSVSSQAIPD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 149 VHPGETVF-------LPRRHPLPcfLDSSRLKPHSPLEELFLRSSLPEQLSFLHNGLLSNLYLHAAdCPQPLLQWLFQLL 221
Cdd:pfam14816  82 VHPGETVFnlsdsgkLFNQHPLD--LRSSHLKPQSALEKLLLSSPPAQQLSLLTSGLLSNAYLHVP-CPVPLLRWLFQMM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 222 TWPPE--TSSRAFGLLWDLSIDGLFRQPDEDMHFWCPSLQEVKEVFSSLGAYNPALYPQGPFQHSASatrkqvttltcis 299
Cdd:pfam14816 159 SVHPEqiVSSQILSLLWDISLDNLFEQSDQDFHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSFN------------- 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 300 kgvervevldsghtirflflpslnrqkrwllwkddhqrdERVLESEASL--------DSQDPPQEVALDIKLNYIYKFLT 371
Cdd:pfam14816 226 ---------------------------------------ERDLLSEAQLseneqqnaGSVSPPFETLPEINLSNILKFLS 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729429 372 LCLLVRPVSYTDASILDLMELLCRAGLDVGLCLLPKTDLQQLLLLLLERIQEWPGKLQPLCCALSWVSDHHHNLLALVQF 451
Cdd:pfam14816 267 LCTLAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDWPTKLPELCCALSDLSDHHHNLLALVQL 346
                         410       420
                  ....*....|....*....|....*....
gi 1039729429 452 FLDVTPRGRQLRSQLSLVIIARMLGQQES 480
Cdd:pfam14816 347 FPDVTSRGRQLRRHLSLVIIAKLLDQQET 375
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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