|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
977-1252 |
4.53e-127 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 396.18 E-value: 4.53e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 977 SLRNLANLLQMPYGCGEQNMIILAPNIYTLRYLKETAQLTPAIQDTATSYLQSGYQGELNYRHRDGSFSTFG--YDASNT 1054
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGesDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1055 WLTAFVMRTFGLARSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDMKGGVDDNVTMTGYIVASLLEIGVPVTDP 1134
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1135 VITKALSFLRPLVGNLGNTYVTALLAYTFSLAGETRtRAQLLNSLRNTAISEGTTLHWSQTSSG----------DTLAVE 1204
Cdd:cd02897 161 VVEKALSCLEAALDSISDPYTLALAAYALTLAGSEK-RPEALKKLDELAISEDGTKHWSRPPPSeegpsyywqaPSAEVE 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1040685314 1205 ISAYVLLAVLTLQPvttANLGYANRIVNWLVAQQNPYGGFTSTQDTVV 1252
Cdd:cd02897 240 MTAYALLALLSAGG---EDLAEALPIVKWLAKQRNSLGGFSSTQDTVV 284
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
148-1251 |
1.04e-43 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 174.88 E-value: 1.04e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 148 FIQTDKPLYNPGQTVYFRVLTMSDKFEPQDQLySLVVVVEDNNNIRINQWTNVSSTNWILELSHTLNAEARVGTYTLKAY 227
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 228 IGDR--VISKRFNVKKYVLPKFDLTVNTPQKYSVADVGLKVEACGKYTYGQPVPG-----QVFVEVCRQRRP----YI-- 294
Cdd:COG2373 451 VDPKpaLGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlkvegEVTLRPARTAFPgypgYRfg 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 295 ---RDPKVTSVCLNETTwMNDTGCASLVLSTSTFFSTnfKNSLQnsFVVNVNVTEEGtGVVMSKSSTVSI---TFEVGkv 368
Cdd:COG2373 531 dpdEEFEPEELDLGEGT-LDADGKASLSLPLPDAPDA--PGPLR--ATVEASVFESG-GRPVTRSATVPVhpaDFYVG-- 602
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 369 tfVDLPKFYDY--GSTVNGKISVSDFGGNAISNK----VVYLLDR---------GQW---PNKVL-----FNVTTDESGF 425
Cdd:COG2373 603 --IRLPLFDGDpeGAPATFEVVAVDPDGKPVAGKglkvELYREEWryvwyksddGGWryeSQEKEepvaeGTLTTGADGP 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 426 ADFSLnTTNFPKANLILVASatPQTYRDSSSPYFATDyqvvqlSQAAAPDNPTYSDLSivsLQQPlkcgtTYPV--TVKY 503
Cdd:COG2373 681 ASLSL-TPVEWGRYRLEVKD--PDGGLATSVRFYAGG------NASWGAERPDRLELS---LDKE-----SYKPgeTAKL 743
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 504 TFvgeTGDYSADIIYMVMSRGVIvlhgfkTVQAFgsdTLTKGTVSFDLSVLAGMAPVVQILVFSVLPSQ-------TVVT 576
Cdd:COG2373 744 LI---QSPFAGRALVTVERDGVL------ETQWV---DVKGGGTTVEIPVTEDWAPNAYVSATLVRPGDstandmpARAY 811
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 577 GSASF--DTEKcFSNQVSLQfSPATAVPGEgsILTVSAQAGSLCG------LSAIDQSVLimqsggrlsaeamfgllpvr 648
Cdd:COG2373 812 GVAPLpvDPPA-RRLKVELT-APEKLRPGE--TLTVTVKVKGAAGkaaevtLAAVDEGIL-------------------- 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 649 ALHDYPPgvedqqgclkFRPLRAVPTDQAYNTfkgvgikiatnllvreppcltyrgqNYYSSFqggvspfsetGFAMVEN 728
Cdd:COG2373 868 NLTGYKT----------PDPLDFFYGKRALGV-------------------------ETRDLY----------GRLIGAF 902
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 729 IAAPAVLaaRVGGDS--SSSAVDVTIRTFFPETWIWQ-LANVGDSGSTSVPLTVPDTITTWDTEAFCLSSSGFGLAPPVL 805
Cdd:COG2373 903 GGAAGAL--RSGGDGalGRGGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDRFGSAEATV 980
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 806 LTAfQPFFLELTLPYSIIRGEFFELKATVFNYLSQCIKVQVTPTPSSNFTLKSlNDDHSYTLSANGRKTFKWDLSASVLG 885
Cdd:COG2373 981 TVR-KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEG-EATQTVTLAAGGRATVRFPLKAPDAG 1058
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 886 TLNVTVSAEASPsqelcDNDIVTVPssgrIDVVTRSLLVlaegvkrTFTRSWLLCPKGSMlseNVKITFPANIIKGSARC 965
Cdd:COG2373 1059 DAKVTVTATGGG-----ESDAREVE----LPVRPANPLV-------TRATSGVLAPGESW---TLPLDLPGGLRPGTGSL 1119
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 966 SVSV----IGDIMGRslrnLANLLQMPYGCGEQNMIILAPNIYTLRyLKETAQLTPAIQDTATSYLQSGYQGELNYRHRD 1041
Cdd:COG2373 1120 TLSLssspPLDLAGL----LRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSD 1194
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1042 GSFSTF-GYDASNTWLTAFVMRTFGLARSFTY-IDPNVLKGAKDWLigtqgsdgcfvQQGTLYHNDMKGGVDDNVTMTGY 1119
Cdd:COG2373 1195 GGFGLWpGGSESDPWLTAYATDFLLEAREAGYaVPDDALDRALDYL-----------RNYLRNPWEIEYDDAYRLAVRAY 1263
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1120 IVASLLEIGVPVTDpvitkALSFLRPLVGNLGNTYVTALLAYTFSLAGETRTRAQLLNSLRNTAISEGTTLHWSQTsSGD 1199
Cdd:COG2373 1264 ALYVLARAGKADLG-----DLRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYWYGD-YGS 1337
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|..
gi 1040685314 1200 TLavEISAYVLLAVLTLQPVTTAnlgyANRIVNWLVAQQNPyGGFTSTQDTV 1251
Cdd:COG2373 1338 PL--RDQALALALLAELGPDAPL----APKLARWLAKALKS-GRWLSTQETA 1382
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1370-1462 |
1.23e-23 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 96.48 E-value: 1.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1370 PTTNMVLVDIKLLSGFTADTSLLGSPPNfTPFVQRVDA-EGDHVLVYLQEVPKGvPVTFSIQLTQAVAVKNLKPAVINIY 1448
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGV-DPLIKRVETvDDGKVILYLDKLSGE-PLCFSFRAEQTFPVANLKPAPVKVY 78
|
90
....*....|....
gi 1040685314 1449 DYYQRSDRFETKYT 1462
Cdd:pfam07677 79 DYYEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
977-1252 |
4.53e-127 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 396.18 E-value: 4.53e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 977 SLRNLANLLQMPYGCGEQNMIILAPNIYTLRYLKETAQLTPAIQDTATSYLQSGYQGELNYRHRDGSFSTFG--YDASNT 1054
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGesDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1055 WLTAFVMRTFGLARSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDMKGGVDDNVTMTGYIVASLLEIGVPVTDP 1134
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1135 VITKALSFLRPLVGNLGNTYVTALLAYTFSLAGETRtRAQLLNSLRNTAISEGTTLHWSQTSSG----------DTLAVE 1204
Cdd:cd02897 161 VVEKALSCLEAALDSISDPYTLALAAYALTLAGSEK-RPEALKKLDELAISEDGTKHWSRPPPSeegpsyywqaPSAEVE 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1040685314 1205 ISAYVLLAVLTLQPvttANLGYANRIVNWLVAQQNPYGGFTSTQDTVV 1252
Cdd:cd02897 240 MTAYALLALLSAGG---EDLAEALPIVKWLAKQRNSLGGFSSTQDTVV 284
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
967-1252 |
3.91e-112 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 356.22 E-value: 3.91e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 967 VSVIGDIMGRSL----RNLANLLQMPYGCGEQNMIILAPNIYTLRYLKETAQLTPAIQDTATSYLQSGYQGELNYRHRDG 1042
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1043 SFSTFGYDASNTWLTAFVMRTFGLARSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDMKGGVDDNVTMTGYIVA 1122
Cdd:pfam07678 81 SYSAFGHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYVTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1123 SLLEI-----GVPVTDPVITKALSFL-RPLVGNLGNTYVTALLAYTFSLAGETRTRAQLLNSLRNTAISEGTTLHWSQ-- 1194
Cdd:pfam07678 161 ALLEAldingLLQRVHPSIRKALTYLeQAQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGNSRYWERde 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1040685314 1195 ----------TSSGDTLAVEISAYVLLAVLTLQpvttaNLGYANRIVNWLVAQQNPYGGFTSTQDTVV 1252
Cdd:pfam07678 241 ksdpqgvpeyPPQAPSLEVETTAYALLAYLLLG-----DLTYADPIVKWLTSQRNSHGGFSSTQDTVV 303
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
148-1251 |
1.04e-43 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 174.88 E-value: 1.04e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 148 FIQTDKPLYNPGQTVYFRVLTMSDKFEPQDQLySLVVVVEDNNNIRINQWTNVSSTNWILELSHTLNAEARVGTYTLKAY 227
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 228 IGDR--VISKRFNVKKYVLPKFDLTVNTPQKYSVADVGLKVEACGKYTYGQPVPG-----QVFVEVCRQRRP----YI-- 294
Cdd:COG2373 451 VDPKpaLGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlkvegEVTLRPARTAFPgypgYRfg 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 295 ---RDPKVTSVCLNETTwMNDTGCASLVLSTSTFFSTnfKNSLQnsFVVNVNVTEEGtGVVMSKSSTVSI---TFEVGkv 368
Cdd:COG2373 531 dpdEEFEPEELDLGEGT-LDADGKASLSLPLPDAPDA--PGPLR--ATVEASVFESG-GRPVTRSATVPVhpaDFYVG-- 602
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 369 tfVDLPKFYDY--GSTVNGKISVSDFGGNAISNK----VVYLLDR---------GQW---PNKVL-----FNVTTDESGF 425
Cdd:COG2373 603 --IRLPLFDGDpeGAPATFEVVAVDPDGKPVAGKglkvELYREEWryvwyksddGGWryeSQEKEepvaeGTLTTGADGP 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 426 ADFSLnTTNFPKANLILVASatPQTYRDSSSPYFATDyqvvqlSQAAAPDNPTYSDLSivsLQQPlkcgtTYPV--TVKY 503
Cdd:COG2373 681 ASLSL-TPVEWGRYRLEVKD--PDGGLATSVRFYAGG------NASWGAERPDRLELS---LDKE-----SYKPgeTAKL 743
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 504 TFvgeTGDYSADIIYMVMSRGVIvlhgfkTVQAFgsdTLTKGTVSFDLSVLAGMAPVVQILVFSVLPSQ-------TVVT 576
Cdd:COG2373 744 LI---QSPFAGRALVTVERDGVL------ETQWV---DVKGGGTTVEIPVTEDWAPNAYVSATLVRPGDstandmpARAY 811
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 577 GSASF--DTEKcFSNQVSLQfSPATAVPGEgsILTVSAQAGSLCG------LSAIDQSVLimqsggrlsaeamfgllpvr 648
Cdd:COG2373 812 GVAPLpvDPPA-RRLKVELT-APEKLRPGE--TLTVTVKVKGAAGkaaevtLAAVDEGIL-------------------- 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 649 ALHDYPPgvedqqgclkFRPLRAVPTDQAYNTfkgvgikiatnllvreppcltyrgqNYYSSFqggvspfsetGFAMVEN 728
Cdd:COG2373 868 NLTGYKT----------PDPLDFFYGKRALGV-------------------------ETRDLY----------GRLIGAF 902
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 729 IAAPAVLaaRVGGDS--SSSAVDVTIRTFFPETWIWQ-LANVGDSGSTSVPLTVPDTITTWDTEAFCLSSSGFGLAPPVL 805
Cdd:COG2373 903 GGAAGAL--RSGGDGalGRGGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDRFGSAEATV 980
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 806 LTAfQPFFLELTLPYSIIRGEFFELKATVFNYLSQCIKVQVTPTPSSNFTLKSlNDDHSYTLSANGRKTFKWDLSASVLG 885
Cdd:COG2373 981 TVR-KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEG-EATQTVTLAAGGRATVRFPLKAPDAG 1058
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 886 TLNVTVSAEASPsqelcDNDIVTVPssgrIDVVTRSLLVlaegvkrTFTRSWLLCPKGSMlseNVKITFPANIIKGSARC 965
Cdd:COG2373 1059 DAKVTVTATGGG-----ESDAREVE----LPVRPANPLV-------TRATSGVLAPGESW---TLPLDLPGGLRPGTGSL 1119
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 966 SVSV----IGDIMGRslrnLANLLQMPYGCGEQNMIILAPNIYTLRyLKETAQLTPAIQDTATSYLQSGYQGELNYRHRD 1041
Cdd:COG2373 1120 TLSLssspPLDLAGL----LRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSD 1194
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1042 GSFSTF-GYDASNTWLTAFVMRTFGLARSFTY-IDPNVLKGAKDWLigtqgsdgcfvQQGTLYHNDMKGGVDDNVTMTGY 1119
Cdd:COG2373 1195 GGFGLWpGGSESDPWLTAYATDFLLEAREAGYaVPDDALDRALDYL-----------RNYLRNPWEIEYDDAYRLAVRAY 1263
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1120 IVASLLEIGVPVTDpvitkALSFLRPLVGNLGNTYVTALLAYTFSLAGETRTRAQLLNSLRNTAISEGTTLHWSQTsSGD 1199
Cdd:COG2373 1264 ALYVLARAGKADLG-----DLRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYWYGD-YGS 1337
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|..
gi 1040685314 1200 TLavEISAYVLLAVLTLQPVTTAnlgyANRIVNWLVAQQNPyGGFTSTQDTV 1251
Cdd:COG2373 1338 PL--RDQALALALLAELGPDAPL----APKLARWLAKALKS-GRWLSTQETA 1382
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
759-847 |
1.57e-36 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 133.10 E-value: 1.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 759 TWIWQLANVGDSGSTSVPLTVPDTITTWDTEAFCLS-SSGFGLAPPVLLTAFQPFFLELTLPYSIIRGEFFELKATVFNY 837
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSpDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|
gi 1040685314 838 LSQCIKVQVT 847
Cdd:pfam00207 81 LDKCLKVRVR 90
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1370-1462 |
1.23e-23 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 96.48 E-value: 1.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1370 PTTNMVLVDIKLLSGFTADTSLLGSPPNfTPFVQRVDA-EGDHVLVYLQEVPKGvPVTFSIQLTQAVAVKNLKPAVINIY 1448
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGV-DPLIKRVETvDDGKVILYLDKLSGE-PLCFSFRAEQTFPVANLKPAPVKVY 78
|
90
....*....|....
gi 1040685314 1449 DYYQRSDRFETKYT 1462
Cdd:pfam07677 79 DYYEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
977-1252 |
4.53e-127 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 396.18 E-value: 4.53e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 977 SLRNLANLLQMPYGCGEQNMIILAPNIYTLRYLKETAQLTPAIQDTATSYLQSGYQGELNYRHRDGSFSTFG--YDASNT 1054
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGesDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1055 WLTAFVMRTFGLARSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDMKGGVDDNVTMTGYIVASLLEIGVPVTDP 1134
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1135 VITKALSFLRPLVGNLGNTYVTALLAYTFSLAGETRtRAQLLNSLRNTAISEGTTLHWSQTSSG----------DTLAVE 1204
Cdd:cd02897 161 VVEKALSCLEAALDSISDPYTLALAAYALTLAGSEK-RPEALKKLDELAISEDGTKHWSRPPPSeegpsyywqaPSAEVE 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1040685314 1205 ISAYVLLAVLTLQPvttANLGYANRIVNWLVAQQNPYGGFTSTQDTVV 1252
Cdd:cd02897 240 MTAYALLALLSAGG---EDLAEALPIVKWLAKQRNSLGGFSSTQDTVV 284
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
967-1252 |
3.91e-112 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 356.22 E-value: 3.91e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 967 VSVIGDIMGRSL----RNLANLLQMPYGCGEQNMIILAPNIYTLRYLKETAQLTPAIQDTATSYLQSGYQGELNYRHRDG 1042
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1043 SFSTFGYDASNTWLTAFVMRTFGLARSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDMKGGVDDNVTMTGYIVA 1122
Cdd:pfam07678 81 SYSAFGHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYVTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1123 SLLEI-----GVPVTDPVITKALSFL-RPLVGNLGNTYVTALLAYTFSLAGETRTRAQLLNSLRNTAISEGTTLHWSQ-- 1194
Cdd:pfam07678 161 ALLEAldingLLQRVHPSIRKALTYLeQAQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGNSRYWERde 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1040685314 1195 ----------TSSGDTLAVEISAYVLLAVLTLQpvttaNLGYANRIVNWLVAQQNPYGGFTSTQDTVV 1252
Cdd:pfam07678 241 ksdpqgvpeyPPQAPSLEVETTAYALLAYLLLG-----DLTYADPIVKWLTSQRNSHGGFSSTQDTVV 303
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
977-1252 |
2.66e-99 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 319.72 E-value: 2.66e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 977 SLRNLANLLQMPYGCGEQNMIILAPNIYTLRYLKETAQLTPAIQDTATSYLQSGYQGELNYRHRDGSFSTFG-YDASNTW 1055
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGnSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1056 LTAFVMRTFGLARSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDMKGGVDDNVTMTGYIVASLLEIGVPVtDPV 1135
Cdd:cd02891 81 LTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC-DAS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1136 ITKALSFLRPLVGNLGNTYVTALLAYTFSLAGETRTRAQLLNSLRNTAISEGTTLHWSQTSS---GDTLAVEISAYVLLA 1212
Cdd:cd02891 160 IEKALAYLETQLDGLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSLSWPgdyGSSLRVEATAYALLA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1040685314 1213 VLTLQpvttaNLGYANRIVNWLVAQQNPYGGFTSTQDTVV 1252
Cdd:cd02891 240 LLKLG-----DLEEAGPIAKWLAQQRNSGGGFLSTQDTVV 274
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
977-1252 |
4.25e-78 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 260.28 E-value: 4.25e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 977 SLRNLANLLQMPYGCGEQNMIILAPNIYTLRYLKETAQ---LTPAIQDTATSYLQSGYQGELNYRHRDGSFSTFGYDASN 1053
Cdd:cd02896 1 SPEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1054 TWLTAFVMRTFGLARSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDMKGGV---DDNVTMTGYIVASLLEI--- 1127
Cdd:cd02896 81 TWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQEArsi 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1128 ---GVPVTDPVITKALSFLRPLVGNLGNTYVTALLAYTFSLAGeTRTRAQLLNSLRNTAISEGTTLHWSQTSS------- 1197
Cdd:cd02896 161 cppEVQNLDQSIRKAISYLENQLPNLQRPYALAITAYALALAD-SPLSHAANRKLLSLAKRDGNGWYWWTIDSpywpvpg 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1040685314 1198 GDTLAVEISAYVLLAVLTLQpvttaNLGYANRIVNWLVAQQNPYGGFTSTQDTVV 1252
Cdd:cd02896 240 PSAITVETTAYALLALLKLG-----DIEYANPIARWLTEQRNYGGGFGSTQDTVV 289
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
977-1252 |
8.03e-59 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 205.09 E-value: 8.03e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 977 SLRNLANLLQMPYG--------CGEQNMIILAPNIYTLRYLKETAqltpaIQDTATSYLQSGYQGELNYRHRDGSFSTF- 1047
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWg 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1048 GYDASNTWLTAFVMRTFGLARSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNdmKGGVDDNVTMTGYIVASLLEI 1127
Cdd:cd00688 76 GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIALALL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1128 GVPVTDPVITKALSFLR--------PLVGNLGNTYVTALLAYTFSLAGETRTRA--QLLNSLRNTAISEGTTLHWSQTSS 1197
Cdd:cd00688 154 GKLDPDPLIEKALDYLLscqnydggFGPGGESHGYGTACAAAALALLGDLDSPDakKALRWLLSRQRPDGGWGEGRDRTN 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1040685314 1198 --GDTLAVEISAYVLLAVLTLQpvttaNLGYANRIVNWLVAQQNPYGGFTS-------TQDTVV 1252
Cdd:cd00688 234 klSDSCYTEWAAYALLALGKLG-----DLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVF 292
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
148-1251 |
1.04e-43 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 174.88 E-value: 1.04e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 148 FIQTDKPLYNPGQTVYFRVLTMSDKFEPQDQLySLVVVVEDNNNIRINQWTNVSSTNWILELSHTLNAEARVGTYTLKAY 227
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 228 IGDR--VISKRFNVKKYVLPKFDLTVNTPQKYSVADVGLKVEACGKYTYGQPVPG-----QVFVEVCRQRRP----YI-- 294
Cdd:COG2373 451 VDPKpaLGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlkvegEVTLRPARTAFPgypgYRfg 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 295 ---RDPKVTSVCLNETTwMNDTGCASLVLSTSTFFSTnfKNSLQnsFVVNVNVTEEGtGVVMSKSSTVSI---TFEVGkv 368
Cdd:COG2373 531 dpdEEFEPEELDLGEGT-LDADGKASLSLPLPDAPDA--PGPLR--ATVEASVFESG-GRPVTRSATVPVhpaDFYVG-- 602
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 369 tfVDLPKFYDY--GSTVNGKISVSDFGGNAISNK----VVYLLDR---------GQW---PNKVL-----FNVTTDESGF 425
Cdd:COG2373 603 --IRLPLFDGDpeGAPATFEVVAVDPDGKPVAGKglkvELYREEWryvwyksddGGWryeSQEKEepvaeGTLTTGADGP 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 426 ADFSLnTTNFPKANLILVASatPQTYRDSSSPYFATDyqvvqlSQAAAPDNPTYSDLSivsLQQPlkcgtTYPV--TVKY 503
Cdd:COG2373 681 ASLSL-TPVEWGRYRLEVKD--PDGGLATSVRFYAGG------NASWGAERPDRLELS---LDKE-----SYKPgeTAKL 743
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 504 TFvgeTGDYSADIIYMVMSRGVIvlhgfkTVQAFgsdTLTKGTVSFDLSVLAGMAPVVQILVFSVLPSQ-------TVVT 576
Cdd:COG2373 744 LI---QSPFAGRALVTVERDGVL------ETQWV---DVKGGGTTVEIPVTEDWAPNAYVSATLVRPGDstandmpARAY 811
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 577 GSASF--DTEKcFSNQVSLQfSPATAVPGEgsILTVSAQAGSLCG------LSAIDQSVLimqsggrlsaeamfgllpvr 648
Cdd:COG2373 812 GVAPLpvDPPA-RRLKVELT-APEKLRPGE--TLTVTVKVKGAAGkaaevtLAAVDEGIL-------------------- 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 649 ALHDYPPgvedqqgclkFRPLRAVPTDQAYNTfkgvgikiatnllvreppcltyrgqNYYSSFqggvspfsetGFAMVEN 728
Cdd:COG2373 868 NLTGYKT----------PDPLDFFYGKRALGV-------------------------ETRDLY----------GRLIGAF 902
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 729 IAAPAVLaaRVGGDS--SSSAVDVTIRTFFPETWIWQ-LANVGDSGSTSVPLTVPDTITTWDTEAFCLSSSGFGLAPPVL 805
Cdd:COG2373 903 GGAAGAL--RSGGDGalGRGGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDRFGSAEATV 980
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 806 LTAfQPFFLELTLPYSIIRGEFFELKATVFNYLSQCIKVQVTPTPSSNFTLKSlNDDHSYTLSANGRKTFKWDLSASVLG 885
Cdd:COG2373 981 TVR-KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEG-EATQTVTLAAGGRATVRFPLKAPDAG 1058
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 886 TLNVTVSAEASPsqelcDNDIVTVPssgrIDVVTRSLLVlaegvkrTFTRSWLLCPKGSMlseNVKITFPANIIKGSARC 965
Cdd:COG2373 1059 DAKVTVTATGGG-----ESDAREVE----LPVRPANPLV-------TRATSGVLAPGESW---TLPLDLPGGLRPGTGSL 1119
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 966 SVSV----IGDIMGRslrnLANLLQMPYGCGEQNMIILAPNIYTLRyLKETAQLTPAIQDTATSYLQSGYQGELNYRHRD 1041
Cdd:COG2373 1120 TLSLssspPLDLAGL----LRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSD 1194
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1042 GSFSTF-GYDASNTWLTAFVMRTFGLARSFTY-IDPNVLKGAKDWLigtqgsdgcfvQQGTLYHNDMKGGVDDNVTMTGY 1119
Cdd:COG2373 1195 GGFGLWpGGSESDPWLTAYATDFLLEAREAGYaVPDDALDRALDYL-----------RNYLRNPWEIEYDDAYRLAVRAY 1263
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1120 IVASLLEIGVPVTDpvitkALSFLRPLVGNLGNTYVTALLAYTFSLAGETRTRAQLLNSLRNTAISEGTTLHWSQTsSGD 1199
Cdd:COG2373 1264 ALYVLARAGKADLG-----DLRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYWYGD-YGS 1337
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|..
gi 1040685314 1200 TLavEISAYVLLAVLTLQPVTTAnlgyANRIVNWLVAQQNPyGGFTSTQDTV 1251
Cdd:COG2373 1338 PL--RDQALALALLAELGPDAPL----APKLARWLAKALKS-GRWLSTQETA 1382
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
759-847 |
1.57e-36 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 133.10 E-value: 1.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 759 TWIWQLANVGDSGSTSVPLTVPDTITTWDTEAFCLS-SSGFGLAPPVLLTAFQPFFLELTLPYSIIRGEFFELKATVFNY 837
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSpDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|
gi 1040685314 838 LSQCIKVQVT 847
Cdd:pfam00207 81 LDKCLKVRVR 90
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
482-630 |
6.86e-27 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 107.44 E-value: 6.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 482 LSIVSLQQPLKCGTTYPVTVKYTFVGEtgDYSADIIYMVMSRGVIVLHGFKtvqafgsdtltKGTVSFDLSVLAGMAPVV 561
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGT--VERDGFTYLVLSKGQIVVVGRG-----------GVTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1040685314 562 QILVFSV---LPSQTVVTGSASFDTEKCFSNQVSLQFSPATAVPGEGSILTVSAQAGSLCGLSAIDQSVLIM 630
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1370-1462 |
1.23e-23 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 96.48 E-value: 1.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 1370 PTTNMVLVDIKLLSGFTADTSLLGSPPNfTPFVQRVDA-EGDHVLVYLQEVPKGvPVTFSIQLTQAVAVKNLKPAVINIY 1448
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGV-DPLIKRVETvDDGKVILYLDKLSGE-PLCFSFRAEQTFPVANLKPAPVKVY 78
|
90
....*....|....
gi 1040685314 1449 DYYQRSDRFETKYT 1462
Cdd:pfam07677 79 DYYEPERRATTFYS 92
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
241-325 |
1.46e-19 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 84.25 E-value: 1.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 241 KYVLPKFDLTVNTPQKYSVADVGLKVEACGKYTYGQPVPGQVFVEVCRQRrpYIRDPKVTSVCLNettwMNDTGCASLVL 320
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKD--DSKRKCFESFSKE----LDKDGCGSASL 74
|
....*
gi 1040685314 321 STSTF 325
Cdd:pfam17791 75 STEEF 79
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
148-239 |
1.78e-17 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 78.90 E-value: 1.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040685314 148 FIQTDKPLYNPGQTVYFRVLTMSDKFEPQDQLYsLVVVVEDNNNIRINQWTNVSSTNWILELSHTLNAEARVGTYTLKAY 227
Cdd:pfam01835 3 FVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLP-VTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 1040685314 228 --IGDRVISKRFNV 239
Cdd:pfam01835 82 dgAGGSLGSGSFRV 95
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
368-435 |
1.94e-05 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 44.55 E-value: 1.94e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1040685314 368 VTFVDLPKFYDYGSTVNGKISVSDFGGNAISNKVVYLLDRGQWPNKvlfNVTTDESGFADFSLNTTNF 435
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQ---NLTTDEDGTAQFSINTPGN 65
|
|
| |
